Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 18, 2015, Pages 5815-5820

  Hathaway, Catherine K ^a   Gasim, Adil M H ^a   Grant, Ruriko ^a   Chang, Albert S ^a   Kim, Hyung Suk ^a   Madden, Victoria J ^a   Bagnell, C Robert ^a   Jennette, J Charles ^a   Smithies, Oliver ^a   Kakoki, Masao ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Aldosterone; Glomerular filtration rate; Glomerulosclerosis; Megalin; Nephrin

Indexed keywords

ALBUMIN; CREATININE; GLUCOSE; INSULIN; TRANSFORMING GROWTH FACTOR BETA1; UREA; WATER; ALBUMINOID; TGFB1 PROTEIN, MOUSE;

AKITA MOUSE; ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CREATININE CLEARANCE; DIABETIC NEPHROPATHY; DISEASE EXACERBATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENOTYPE; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; URINARY EXCRETION; WILD TYPE MOUSE; ALLELE; ANIMAL; C57BL MOUSE; CHEMISTRY; CROSS BREEDING; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; GENE EXPRESSION REGULATION; GLOMERULUS; KIDNEY; MALE; METABOLISM; PATHOLOGY; PHENOTYPE;

MUS;

ALBUMINS; ALBUMINURIA; ALLELES; ANIMALS; CREATININE; CROSSES, GENETIC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; FIBROSIS; GENE EXPRESSION REGULATION; GENOTYPE; GLUCOSE; KIDNEY; KIDNEY GLOMERULUS; MALE; MICE; MICE, INBRED C57BL; PHENOTYPE; PODOCYTES; TRANSFORMING GROWTH FACTOR BETA1; WATER;

EID: 84928911764     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504777112     Document Type: Article

References (29)

1. Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA (1993) Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 90(5):1814-1818.
2. Susztak K, Raff AC, Schiffer M, Böttinger EP (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55(1):225-233.
3. Herman-Edelstein M, et al. (2011) Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: A model for diabetic podocytopathy. Diabetes 60(6):1779-1788.
4. Zeisberg M, et al. (2003) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9(7):964-968.
5. Shull MM, et al. (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359(6397):693-699.
6. Kulkarni AB, et al. (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90(2): 770-774.
7. Kakoki M, et al. (2013) Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1. Proc Natl Acad Sci USA 110(14):5600-5605.
8. Yoshioka M, Kayo T, Ikeda T, Koizumi A (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46(5):887-894.
9. Kestilä M, et al. (1998) Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1(4):575-582.
10. Holzman LB, et al. (1999) Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56(4):1481-1491.
11. Boute N, et al. (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24(4):349-354.
12. Putaala H, Soininen R, Kilpeläinen P, Wartiovaara J, Tryggvason K (2001) The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10(1):1-8.
13. Christensen EI, Birn H (2001) Megalin and cubilin: Synergistic endocytic receptors in renal proximal tubule. Am J Physiol Renal Physiol 280(4):F562-F573.
14. Yammani RR, et al. (2002) Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation. Am J Physiol Regul Integr Comp Physiol 283(2):R339-R346.
15. Gekle M, et al. (2003) Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells. J Physiol 552(Pt 2):471-481.
16. Moestrup SK, et al. (1994) Binding and endocytosis of proteins mediated by epithelial gp330. Ann N Y Acad Sci 737:124-137.
17. Leheste JR, et al. (1999) Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 155(4):1361-1370.
18. Haymann JP, et al. (2000) Characterization and localization of the neonatal Fc receptor in adult human kidney. J Am Soc Nephrol 11(4):632-639.
19. Sarav M, et al. (2009) Renal FcRn reclaims albumin but facilitates elimination of IgG. J Am Soc Nephrol 20(9):1941-1952.
20. Loo DD, Zeuthen T, Chandy G, Wright EM (1996) Cotransport of water by the Na+/glucose cotransporter. Proc Natl Acad Sci USA 93(23):13367-13370.
21. Tucker BJ, Rasch R, Blantz RC (1993) Glomerular filtration and tubular reabsorption of albumin in preproteinuric and proteinuric diabetic rats. J Clin Invest 92(2):686-694.
22. Pagtalunan ME, et al. (1997) Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 99(2):342-348.
23. Tojo A, et al. (2001) Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Histochem Cell Biol 116(3):269-276.
24. Russo LM, et al. (2009) Impaired tubular uptake explains albuminuria in early diabetic nephropathy. J Am Soc Nephrol 20(3):489-494.
25. Dworniczak B, et al. (2007) Inducible Cre/loxP recombination in the mouse proximal tubule. Nephron, Exp Nephrol 106(1):e11-e20.
26. Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB (2003) Podocyte-specific expression of cre recombinase in transgenic mice. Genesis 35(1):39-42.
27. Takahashi N, Boysen G, Li F, Li Y, Swenberg JA (2007) Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate. Kidney Int 71(3):266-271.
28. Krege JH, Hodgin JB, Hagaman JR, Smithies O (1995) A noninvasive computerized tailcuff system for measuring blood pressure in mice. Hypertension 25(5):1111-1115.
29. Kim HS, Lee G, John SW, Maeda N, Smithies O (2002) Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration. Proc Natl Acad Sci USA 99(7):4602-4607.