Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervicovaginal mucus

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 4, 2015, Pages 2215-2222

  Bouchemal, Kawthar ^a   Aka Any Grah, Armelle ^a,b   Dereuddre Bosquet, Nathalie ^c   Martin, Loïc ^d   Lievin Le Moal, Vanessa ^e   Le Grand, Roger ^c   Nicolas, Valérie ^a   Gibellini, Davide ^f   Lembo, David ^g   Poüs, Christian ^a   Koffi, Armand ^b   Ponchel, Gilles ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITÉ FÉLIX HOUPHOUËT BOIGNY   (Côte d’Ivoire)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^d SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^e UNIVERSITÉ PARIS SUD   (France)

^f UNIVERSITY OF VERONA   (Italy)

^g UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ETHYLENE OXIDE; HYDROXYPROPYLMETHYLCELLULOSE; M 48U 1; POLOXAMER; PROPYLENE OXIDE; UNCLASSIFIED DRUG; CD4 ANTIGEN; FLUORESCENT DYE; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; HYDROGEL; MACROGOL DERIVATIVE; PEO-PPO-PEO; PROPANEDIOL DERIVATIVE;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CELL VIABILITY; CONTROLLED STUDY; DIFFUSION COEFFICIENT; FEMALE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEL; HYDROPHOBICITY; IC50; LOW TEMPERATURE; MACACA FASCICULARIS; MICELLIZATION; MUCOADHESION; NONHUMAN; PARTICLE SIZE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SHEAR RATE; SURFACE CHARGE; TRANSITION TEMPERATURE; UTERINE CERVIX MUCUS; VIRUS ATTACHMENT; VIRUS PARTICLE; ANIMAL; CHEMISTRY; DIFFUSION; DRUG EFFECTS; FLOW KINETICS; HIV INFECTIONS; PHARMACOLOGY; SYNTHESIS; VIROLOGY; VISCOSITY;

ANIMALS; ANTI-HIV AGENTS; ANTIGENS, CD4; CERVIX MUCUS; DIFFUSION; FEMALE; FLUORESCENT DYES; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; HYDROGELS; HYPROMELLOSE DERIVATIVES; MACACA FASCICULARIS; POLOXAMER; POLYETHYLENE GLYCOLS; PROPYLENE GLYCOLS; RHEOLOGY; VISCOSITY;

EID: 84928911229     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03503-14     Document Type: Article

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