Chronic hepatitis B: Role of anti-platelet therapy in inflammation control

Cellular and Molecular Immunology

Volumn 12, Issue 3, 2015, Pages 264-268

  Aiolfi, Roberto ^a   Sitia, Giovanni ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

anti platelet drugs; CD81 T cells; chronic hepatitis B; hepatocellular carcinoma; platelets

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL;

ACUTE HEPATITIS; ANTICOAGULANT THERAPY; CANCER RISK; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHRONIC HEPATITIS B; CHRONIC LIVER DISEASE; HEPATITIS B VIRUS; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; INFLAMMATORY CELL; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER PARENCHYMA; NONHUMAN; REVIEW; RISK REDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOSIS; VIRUS CARCINOGENESIS; ANIMAL; BLOOD; CARCINOMA, HEPATOCELLULAR; COMPLICATION; CYTOTOXICITY; DRUG EFFECTS; FIBROSIS; HEPATITIS B, CHRONIC; IMMUNOLOGY; LIVER; LIVER NEOPLASMS; PATHOLOGY; PRECLINICAL STUDY; THROMBOCYTE; VIROLOGY;

HEPATITIS B VIRUS;

ANIMALS; BLOOD PLATELETS; CARCINOMA, HEPATOCELLULAR; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; DRUG EVALUATION, PRECLINICAL; FIBROSIS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INFLAMMATION; LIVER; LIVER NEOPLASMS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS;

EID: 84928885894     PISSN: 16727681     EISSN: 20420226     Source Type: Journal    
DOI: 10.1038/cmi.2014.124     Document Type: Review

References (35)

1. Schmitt A, Guichard J, Masse JM, Debili N, Cramer EM. Of mice and men: comparison of the ultrastructure of megakaryocytes and platelets. Exp Hematol 2001; 29: 1295-1302.
2. Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002; 8: 1227-1234.
3. Diacovo TG, Puri KD, Warnock RA, Springer TA, von Andrian UH. Platelet-mediated lymphocyte delivery to high endothelial venules. Science 1996; 273: 252-255.
4. Henn V, Slupsky JR, Grafe M, Anagnostopoulos I, Forster R, Muller-Berghaus G et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591-594.
5. Burger PC, Wagner DD. Platelet P-selectin facilitates atherosclerotic lesion development. Blood 2003; 101: 2661-2666.
6. Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR et al. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 2003; 19: 9-19.
7. Andonegui G, Kerfoot SM, McNagny K, Ebbert KV, Patel KD, Kubes P. Platelets express functional Toll-like receptor-4. Blood 2005; 106: 2417-2423.
8. Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med 2005; 11: 1167-1169.
9. Clark SR, MaAC, Tavener SA, McDonald B, Goodarzi Z, KellyMMet al. Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 2007; 13: 463-469.
10. McMorran BJ, Marshall VM, de Graaf C, Drysdale KE, Shabbar M, Smyth GK et al. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science 2009; 323: 797-800.
11. Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, WeinblattME et al. Platelets amplify inflammation in arthritis via collagendependent microparticle production. Science 2010; 327: 580-583.
12. Swaim AF, Field DJ, Fox-Talbot K, Baldwin WM 3rd, Morrell CN. Platelets contribute to allograft rejection through glutamate receptor signaling. J Immunol 2010; 185: 6999-7006.
13. Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z et al. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res 2012; 110: 1202-1210.
14. Elzey BD, Sprague DL, Ratliff TL. The emerging role of platelets in adaptive immunity. Cell Immunol 2005; 238: 1-9.
15. Jenne CN, Urrutia R, Kubes P. Platelets: bridging hemostasis, inflammation, and immunity. Int J Lab Hematol 2013; 35: 254-261.
16. Semple JW, Italiano JE Jr, Freedman J. Platelets and the immune continuum. Nat Rev Immunol 2011; 11: 264-274.
17. von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 2007; 100: 27-40.
18. Ruggeri ZM, Mendolicchio GL. Adhesion mechanisms in platelet function. Circ Res 2007; 100: 1673-1685.
19. van Gils JM, Zwaginga JJ, Hordijk PL. Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leuk Biol 2009; 85: 195-204.
20. Rendu F, Brohard-Bohn B. The platelet release reaction: granules' constituents, secretion and functions. Platelets 2001; 12: 261-273.
21. Blair P, Flaumenhaft R. Platelet alpha-granules: basic biology and clinical correlates. Blood Rev 2009; 23: 177-189.
22. McNicol A, Israels SJ. Platelet dense granules: structure, function and implications for haemostasis. Thromb Res 1999; 95: 1-18.
23. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S et al. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 2005; 122: 379-391.
24. Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV et al. Platelets prevent IFN-Alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci USA 2008; 105: 629-634.
25. Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 2002; 22: 913-922.
26. Cattaneo M. Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance. Arterioscler Thromb Vasc Biol 2004; 24: 1980-1987.
27. Iannacone M, Sitia G, Narvaiza I, Ruggeri ZM, Guidotti LG. Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus. Clin Vaccine Immunol 2007; 14: 1532-1535.
28. Nakamoto Y, Guidotti LG, Kuhlen CV, Fowler P, Chisari FV. Immune pathogenesis of hepatocellular carcinoma. J Exp Med 1998; 188: 341-350.
29. Guidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006; 1: 23-61.
30. Guerrieri F, Belloni L, Pediconi N, Levrero M. Molecular mechanisms of HBV-Associated hepatocarcinogenesis. Semin Liver Dis 2013; 33: 147-156.
31. Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F et al. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci USA 2012; 109: E2165-E2172.
32. Smyth SS, Reis ED, Zhang W, Fallon JT, Gordon RE, Coller BS. Beta3-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1 hour after injury. Circulation 2001; 103: 2501-2507.
33. Sitia G, Iannacone M, Guidotti LG. Anti-platelet therapy in the prevention of hepatitis B virus-Associated hepatocellular carcinoma. J Hepatol 2013; 59: 1135-1138.
34. Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med 2011; 365: 147-156.
35. Sahasrabuddhe VV, Gunja MZ, Graubard BI, Trabert B, Schwartz LM, Park Y et al. Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. J Natl Cancer Inst 2012; 104: 1808-1814.