Plasma cytokine expression in adolescent chronic fatigue syndrome

Brain, Behavior, and Immunity

Volumn 46, Issue , 2015, Pages 80-86

  Wyller, Vegard Bruun ^a,b,c   Sørensen, Øystein ^d   Sulheim, Dag ^a,e   Fagermoen, Even ^a,b   Ueland, Thor ^f,g   Mollnes, Tom Eirik ^a,h,i  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e Lillehammer County Hospital   (Norway)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF TROMSØ   (Norway)

^h NORDLAND HOSPITAL   (Norway)

ⁱ NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Adolescent; Chronic fatigue syndrome; Cytokine; Inflammation

Indexed keywords

CHEMOKINE; CYTOKINE; EOTAXIN; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR BB; RANTES; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

ADOLESCENT; AGE DISTRIBUTION; ARTICLE; CHALDER FATIGUE QUESTIONNAIRE; CHILD; CHRONIC FATIGUE SYNDROME; CLINICAL FEATURE; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; CYTOKINE PRODUCTION; DISABLED PERSON; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; EXPLORATORY RESEARCH; FEMALE; FUKUDA CRITERIA; FUNCTIONAL STATUS ASSESSMENT; HUMAN; IMMUNOASSAY; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIPLEX CYTOKINE ASSAY; NEUROIMMUNOLOGY; ONSET AGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEX ROLE; BLOOD; FATIGUE;

ADOLESCENT; CHILD; CYTOKINES; FATIGUE; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; MALE;

EID: 84928823726     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.12.025     Document Type: Article

References (48)

1. Arnett S.V., Clark I.A. Inflammatory fatigue and sickness behavior - lessons for the diagnosis and management of chronic fatigue syndrome. J. Affect. Disord. 2012, 141:130-142.
2. Banks R.E. Measurements of cytokines in clinical samples using immunoassays: problems and pitfalls. Crit. Rev. Clin. Lab. Sci. 2000, 37:131-182.
3. Bennett A.L., Chao C.C., Hu S., Buckwald D., Fagioli L.R., Schur P.H., Peterson P.K., Komaroff A.l. Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome. J. Clin. Immunol. 1997, 17:160-166.
4. Broderick G., Fuite J., Kreitz A., Vernon S.D., Klimas N., Fletcher M.A. A formal analysis of cytokine networks in chronic fatigue syndrome. Brain Behav. Immun. 2010, 24:1209-1217.
5. Broderick G., Katz B.Z., Fernandes H., Fletcher M.A., Klimas N., Smith F.A., O'Gorman M.R., Vernon S.D., Taylor R. Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue. J. Transl. Med. 2012, 10:191.
6. Brurberg K.G., Fønhus M.S., Larun L., Flottorp S., Malterud K. Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review. BMJ Open 2014, 4:e003973.
7. Carruthers B.M., van de Sande M.I., DeMeirleir K.L., Klimas N.G., Broderick G., et al. Myalgic encephalomyelitis: International consensus criteria. J. Intern. Med. 2011, 270:327-338.
8. Cella M., Chalder T. Measuring fatigue in clinical and community settings. J. Psychosom. Res. 2010, 69:17-22.
9. Chalder T., Berelowitz G., Pawlikowska T., et al. Development of a fatigue scale. J. Psychosom. Res. 1993, 37:147-153.
10. Crawley E.M., Emond A.M., Sterne J.A. Unidentified Chronic Fatigue Syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: surveillance outcomes from school-based clinics. BMJ Open 2011, 1:e000252.
11. Csardi G., Nepusz T. The igraph software package for complex network research 2006, InterJournal, Complex Systems, p. 1695.
12. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
13. De Luca J., Johnson S.K., Ellis S.P., Natelson B.H. Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease. J. Neurol. Neurosurg. Psychiatry 1997, 62:151-155.
14. Fletcher M.A., Zeng X.R., Barnes Z., Levis S., Klimas N.G. Plasmas cytokines in women with chronic fatigue syndrome. J. Transl. Med. 2009, 7:96.
15. Freeman L.C. Centrality in social networks I: conceptual clarification. Social Networks 1979, 1:215-239.
16. Fukuda K., Straus S.E., Hickie I., Sharpe M.C., Dobbins J.G., Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann. Int. Med. 1994, 121:953-959.
17. Godfrey E., Cleare A., Coddington A., Roberts A., Weinman J., Chalder T. Chronic fatigue syndrome in adolescents: do parental expectations of their child's intellectual ability match the child's ability?. J. Psychosom. Res. 2009, 67:165-168.
18. Haig-Ferguson A., Tucker P., Eaton N., Hunt L., Crawley E. Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy. Arch. Dis. Child. 2009, 94:757-762.
19. Jason L.A., Bell D.S., Rowe K., et al. A pediatric case definition for chronic fatigue syndrome. J. Chron. Fatigue Syndr. 2006, 13:1-44.
20. Kennedy G., Underwood C., Belch J.J. Physical and functional impact of chronic fatigue syndrome/myalgic encephalomyelitis in childhood. Pediatrics 2010, 125:e1324-e1330.
21. Klimas N.G., Broderick G., Fletcher M.A. Biomarkers for chronic fatigue. Brain Behav. Immun. 2012, 26:1202-1210.
22. Loge J.H., Loge J.H., Ekeberg O., Kaasa S. Fatigue in the general Norwegian population: normative data and associations. J. Psychosom. Res. 1998, 45:53-65.
23. Maes M., Twisk F.N., Ringel K. Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression. Psychother. Psychosom. 2012, 81:286-295.
24. Margolin A.A., Nemenman I., Basso K., Wiggins C., Stolovitsky G., Dalla Favera R., Califano A. ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics 2004, 7(Suppl. 1):S7.
25. Margolin A.A., Wang K., Lim W.K., Kustagi M., Nemanman I., Califano A. Reverse engineering cellular networks. Nat. Protoc. 2006, 1:663-672.
26. Martínez-Martínez L.A., Mora T., Varqas A., Fuentes-Iniestra M., Martínez-Lavin M. Sympathetic nervous system dysfunction in fibromialgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies. J. Clin. Rhematol. 2014, 20:146-150.
27. Missen A., Hollingwort W., Eaton N., Crawley E. The financial and psychological impacts on mothers of children with chronic fatigue syndrome (CFS/ME). Child Care Health Dev. 2012, 38:505-512.
28. Morris G., Berk M., Galecki P., Maes M. The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs). Mol. Neurobiol. 2014, 49:741-756.
29. National Institute for Health and Clinical Excellence: Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy). Diagnosis and management of CFS/ME in adults and children. London: NICE clinical guideline 2007, no. 53.
30. Nijhof S.L., Maijer K., Bleijenberg G., Uiterwaal C.S., Kimpen J.L., van der Putte E.M. Adolscent chronic fatigue syndrome: prevalence, incidence, and morbidity. Pediatrics 2011, 127:e1169-e1175.
31. Nijs J., Nees A., Paul L., De Kooning M., Ickmans K., Meeus M., Van Oosterwijck J. Altered immune responses to exercise in patients with chronic fatigue syndrome/myalgic encephalomyelitis: a systematic literature review. Exerc. Immunol. Rev. 2014, 20:94-116.
32. Nisenbaum R., Reyes M., Unger E.R., Reeves W.C. Factor analyses of symptoms among subjects with unexplained chronic fatigue: what can we learn about chronic fatigue syndrome?. J. Psychosom. Res. 2004, 56:171-178.
33. Peterson P.K., Sirr S.A., Grammith F.C., Schenck C.H., Pheley E.M., Hu S., Chao C.C. Effects of mild exercise on cytokines and cerebral blood flow in chronic fatigue syndrome patients. Clin. Diagn. Lab. Immunol. 1994, 1:222-226.
34. Papadopoulos A.S., Cleare A.J. Hypothalamic-pituitary-adrenal axis dysfunction in chronic fatigue syndrome. Nat. Rev. Endocrinol. 2011, 27(8):22-32.
35. Raison C.L., Lin J.M., Reeves W.C. Association of peripheral inflammatory markers with chronic fatigue in a population-based sample. Brain Behav. Immun. 2009, 23:327-337.
36. R: A language and environment for statistical computing 2008, R Development Core Team, R Foundation for Statistical Computing, Vienna.
37. Evidence based guidelines for the management of CFS/ME (chronic fatigue syndrome/myalgic encephalopathy) in children and young adults 2004, Royal College of Paediatrics and Child Health, Royal College of Paediatrics and Child Health, London.
38. Scutari M. Learning Bayesian networks with the bnlearn R package. J. Stat. Softw. 2010, 35:1-22.
39. Segal T.Y., Hindmarsh P.C., Viner R.M. Disturbed adrenal function in adolescents with chronic fatigue syndrome. J. Pediatr. Endocrinol. Metab. 2005, 18:295-301.
40. Sulheim D., Fargermoen E., Winger A., Andersen A.M., Godang K., Müller F., Rowe P.C., Saul J.P., Skovlund E., Øie M.G., Wyller V.B. Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized controlled trial. JAMA Pediatr. 2014, 168:351-360.
41. Sullivan P.F., Pedersen N.L., Jacks A., Evengård B. Chronic fatigue in a population sample: definitions and heterogeneity. Psychol. Med. 2005, 35:1337-1348.
42. Tanaka M., Fukuda S., Mizuno K., et al. Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan. Psychol. Rep. 2008, 103:682-690.
43. Vollmer-Conna U., Cameron B., Pavlonic D.H., Singletary K., Davenport T., Vernon S., Reeves W.C., Hickie I., Wakenfield D., Lloyd A.R. Postinfective fatigue syndrome is not associated with altered cytokine production. Clin. Infect. Dis. 2007, 45:732-735.
44. Wagner D., Nisenbaum R., Heim C., Jones J.F., Unger E.R., Reeves W.C. Psychometric properties of the CDC symptom inventory for assessment for Chronic Fatigue Syndrome. Popul. Health Metr. 2005, 3:8.
45. Wyller V.B., Barbieri R., Thaulow E., Saul J.P. Enhanced vagal withdrawal during mild orthostatic stress in adolescents with chronic fatigue. Ann. Noninvasive Electrocardiol. 2008, 13:67-73.
46. Wyller V.B., Due R., Saul J.P., Amlie J.P., Thaulow E. Usefulness of an abnormal cardiovascular response during low-grade head-up tilt-test for discriminating adolescents with chronic fatigue from healthy controls. Am. J. Cardiol. 2007, 99:997-1001.
47. Wyller V.B., Helland I.B. Relationship between autonomic cardiovascular control, case definition, clinical symptoms, and functional disability in adolescent chronic fatigue syndrome: an exploratory study. Biopsychosoc. Med. 2013, 7:5.
48. Wyller V.B., Saul J.P., Walløe L., Thaulow E. Sympathetic cardiovascular control during orthostatic stress and isometric exercise in adolescent chronic fatigue syndrome. Eur. J. Appl. Physiol. 2008, 102:623-632.