Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Liu, Changchang ^a   DeRoo, Elise P ^a,b,c   Stecyk, Catherine ^a,d   Wolsey, Margaret ^a   Szuchnicki, Mateusz ^a   Hagos, Engda G ^a  

^a Assistant Professor in the University Libraries   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d TUFTS UNIVERSITY   (United States)

Author keywords

Apoptosis; Autophagy; Autophagy related genes; DNA damage; Kr ppel like Factor 4; Mammalian target of rapamycin; Mouse embryonic fibroblasts

Indexed keywords

ATG7 PROTEIN; BALANCED SALT SOLUTION; CYCLIN DEPENDENT KINASE INHIBITOR 1A; HISTONE H2AX; KRUPPEL LIKE FACTOR 4; LC3II PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN; RAPAMYCIN; UNCLASSIFIED DRUG; KRUPPEL LIKE FACTOR; SERUM-FREE MEDIUM; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; CONFOCAL MICROSCOPY; DNA DAMAGE; EMBRYO; EMBRYO CELL; EMBRYONIC FIBROBLAST; FIBROBLAST; FLOW CYTOMETRY; GENOMIC INSTABILITY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; STARVATION; TRYPAN BLUE ASSAY; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENE SILENCING; MAMMALIAN EMBRYO; METABOLISM; PHARMACOLOGY; SERUM-FREE MEDIUM;

MAMMALIA;

ANIMALS; APOPTOSIS; AUTOPHAGY; CULTURE MEDIA, SERUM-FREE; DNA DAMAGE; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE, INBRED C57BL; MODELS, BIOLOGICAL; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84928816420     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-015-0373-6     Document Type: Article

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