Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury

British Journal of Pharmacology

Volumn 165, Issue 7, 2012, Pages 2378-2388

  Wang, Ying ^a,b   Zhao, Beilei ^a   Zhang, Yi ^b   Tang, Zhihui ^a   Shen, Qiang ^a   Zhang, Youyi ^a   Zhang, Weizhen ^a   Du, Jie ^b   Chien, Shu ^c,d   Wang, Nanping ^e  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

gene therapy; rapamycin; restenosis; smooth muscle cells; transcription

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 1C; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 BETA; KRUPPEL LIKE FACTOR 4; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; ARTERY INTIMA; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON OCCLUSION; BLOOD VESSEL INJURY; CAROTID ARTERY INJURY; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; KLF4 GENE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

ANGIOPLASTY, BALLOON; ANIMALS; BASE SEQUENCE; CAROTID ARTERY INJURIES; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE KNOCKDOWN TECHNIQUES; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84863268233     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01734.x     Document Type: Article

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