Nuclear Pore Basket Proteins Are Tethered to the Nuclear Envelope and Can Regulate Membrane Curvature

Developmental Cell

Volumn 33, Issue 3, 2015, Pages 285-298

  Mészáros, Noémi ^a   Cibulka, Jakub ^a   Mendiburo, Maria Jose ^a   Romanauska, Anete ^a   Schneider, Maren ^a   Köhler, Alwin ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; LIPOSOME; NUCLEOPORIN; NUP1 PROTEIN, S CEREVISIAE; NUP60 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CELL FREE SYSTEM; CELL NUCLEUS MEMBRANE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; GENE INTERACTION; HUMAN; LIPID BILAYER; MEMBRANE BINDING; MEMBRANE STRUCTURE; NONHUMAN; NUCLEAR IMPORT; NUCLEAR PORE; NUCLEAR PORE COMPLEX; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SEDIMENTATION; STOICHIOMETRY; SURFACE PROPERTY; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE; YEAST; YEAST CELL; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; NUCLEAR ENVELOPE; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84928814147     PISSN: 15345807     EISSN: 18781551     Source Type: Journal    
DOI: 10.1016/j.devcel.2015.02.017     Document Type: Article

References (34)

1. Alber F., Dokudovskaya S., Veenhoff L.M., Zhang W., Kipper J., Devos D., Suprapto A., Karni-Schmidt O., Williams R., Chait B.T., et al. The molecular architecture of the nuclear pore complex. Nature 2007, 450:695-701.
2. Bastos R., Lin A., Enarson M., Burke B. Targeting and function in mRNA export of nuclear pore complex protein Nup153. J.Cell Biol. 1996, 134:1141-1156.
3. Beck M., Lucić V., Förster F., Baumeister W., Medalia O. Snapshots of nuclear pore complexes in action captured by cryo-electron tomography. Nature 2007, 449:611-615.
4. Bogerd A.M., Hoffman J.A., Amberg D.C., Fink G.R., Davis L.I. nup1 mutants exhibit pleiotropic defects in nuclear pore complex function. J.Cell Biol. 1994, 127:319-332.
5. Brohawn S.G., Leksa N.C., Spear E.D., Rajashankar K.R., Schwartz T.U. Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science 2008, 322:1369-1373.
6. Chadrin A., Hess B., San Roman M., Gatti X., Lombard B., Loew D., Barral Y., Palancade B., Doye V. Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. J.Cell Biol. 2010, 189:795-811.
7. D'Angelo M.A., Hetzer M.W. Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol. 2008, 18:456-466.
8. D'Angelo M.A., Anderson D.J., Richard E., Hetzer M.W. Nuclear pores form de novo from both sides of the nuclear envelope. Science 2006, 312:440-443.
9. Dawson T.R., Lazarus M.D., Hetzer M.W., Wente S.R. ER membrane-bending proteins are necessary for de novo nuclear pore formation. J.Cell Biol. 2009, 184:659-675.
10. Debler E.W., Ma Y., Seo H.S., Hsia K.C., Noriega T.R., Blobel G., Hoelz A. A fence-like coat for the nuclear pore membrane. Mol. Cell 2008, 32:815-826.
11. Denning D., Mykytka B., Allen N.P., Huang L., Al Burlingame, Rexach M. The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. J.Cell Biol. 2001, 154:937-950.
12. Devos D., Dokudovskaya S., Alber F., Williams R., Chait B.T., Sali A., Rout M.P. Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol. 2004, 2:e380.
13. Doucet C.M., Talamas J.A., Hetzer M.W. Cell cycle-dependent differences in nuclear pore complex assembly in metazoa. Cell 2010, 141:1030-1041.
14. Drin G., Casella J.F., Gautier R., Boehmer T., Schwartz T.U., Antonny B. A general amphipathic α-helical motif for sensing membrane curvature. Nat. Struct. Mol. Biol. 2007, 14:138-146.
15. Feuerbach F., Galy V., Trelles-Sticken E., Fromont-Racine M., Jacquier A., Gilson E., Olivo-Marin J.C., Scherthan H., Nehrbass U. Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat. Cell Biol. 2002, 4:214-221.
16. Floch A.G., Tareste D., Fuchs P., Chadrin A., Naciri I., Leger T., Schlenstedt G., Palancade B., Doye V. Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin- and lipid-binding. J.Cell Sci. 2014.
17. Hoelz A., Debler E.W., Blobel G. The structure of the nuclear pore complex. Annu. Rev. Biochem. 2011, 80:613-643.
18. Kenna M.A., Petranka J.G., Reilly J.L., Davis L.I. Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex. Mol. Cell. Biol. 1996, 16:2025-2036.
19. Kupke T., Di Cecco L., Müller H.M., Neuner A., Adolf F., Wieland F., Nickel W., Schiebel E. Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication. EMBO J. 2011, 30:3337-3352.
20. Makio T., Stanton L.H., Lin C.C., Goldfarb D.S., Weis K., Wozniak R.W. The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J.Cell Biol. 2009, 185:459-473.
21. Marelli M., Lusk C.P., Chan H., Aitchison J.D., Wozniak R.W. A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope. J.Cell Biol. 2001, 153:709-724.
22. McMahon H.T., Gallop J.L. Membrane curvature and mechanisms of dynamic cell membrane remodelling. Nature 2005, 438:590-596.
23. Miao M., Ryan K.J., Wente S.R. The integral membrane protein Pom34p functionally links nucleoporin subcomplexes. Genetics 2006, 172:1441-1457.
24. Niepel M., Molloy K.R., Williams R., Farr J.C., Meinema A.C., Vecchietti N., Cristea I.M., Chait B.T., Rout M.P., Strambio-De-Castillia C. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Mol. Biol. Cell 2013, 24:3920-3938.
25. Onischenko E., Stanton L.H., Madrid A.S., Kieselbach T., Weis K. Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance. J.Cell Biol. 2009, 185:475-491.
26. Patel S.S., Rexach M.F. Discovering novel interactions at the nuclear pore complex using bead halo: a rapid method for detecting molecular interactions of high and low affinity at equilibrium. Mol. Cell. Proteomics 2008, 7:121-131.
27. Pyhtila B., Rexach M. A gradient of affinity for the karyopherin Kap95p along the yeast nuclear pore complex. J.Biol. Chem. 2003, 278:42699-42709.
28. Rexach M. Piecing together nuclear pore complex assembly during interphase. J.Cell Biol. 2009, 185:377-379.
29. Rothballer A., Kutay U. Poring over pores: nuclear pore complex insertion into the nuclear envelope. Trends Biochem. Sci. 2013, 38:292-301.
30. Ryan K.J., McCaffery J.M., Wente S.R. The Ran GTPase cycle is required for yeast nuclear pore complex assembly. J.Cell Biol. 2003, 160:1041-1053.
31. Strambio-De-Castillia C., Niepel M., Rout M.P. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat. Rev. Mol. Cell Biol. 2010, 11:490-501.
32. Vollmer B., Schooley A., Sachdev R., Eisenhardt N., Schneider A.M., Sieverding C., Madlung J., Gerken U., Macek B., Antonin W. Dimerization and direct membrane interaction of Nup53 contribute to nuclear pore complex assembly. EMBO J. 2012, 31:4072-4084.
33. Wente S.R., Blobel G. A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic. J.Cell Biol. 1993, 123:275-284.
34. Wozniak R.W., Blobel G., Rout M.P. POM152 is an integral protein of the pore membrane domain of the yeast nuclear envelope. J.Cell Biol. 1994, 125:31-42.