Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced Infectivity

PLoS Neglected Tropical Diseases

Volumn 9, Issue 3, 2015, Pages

  Castillo Acosta, Víctor M ^a   Ruiz Pérez, Luis M ^a   Van Damme, Els J M ^b   Balzarini, Jan ^c   González Pacanowska, Dolores ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b GHENT UNIVERSITY   (Belgium)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLUTININ; ALPHA METHYL MANNOSIDE; CARBOHYDRATE BINDING PROTEIN; ENDOGLYCOSIDASE; GLYCAN DERIVATIVE; GLYCOSIDASE; MANNOSE; MANNOSE OLIGOSACCHARIDE; N ACETYLGLUCOSAMINE; N GLYCAN; STINGING NETTLE AGGLUTININ; TRANSFERRIN; UNCLASSIFIED DRUG; VARIANT SURFACE GLYCOPROTEIN; VARIANT SURFACE GLYCOPROTEIN 221; PLANT LECTIN; STINGING NETTLE LECTIN;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DEATH; CONTROLLED STUDY; CYTOKINESIS; DNA SYNTHESIS; EC50; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION; GENETIC RECOMBINATION; GLYCOSYLATION; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE TEST; LECTIN BINDING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BLOTTING; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SURVIVAL; URTICA DIOICA; VIRULENCE; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DRUG EFFECTS; METABOLISM; PATHOGENICITY; TRYPANOSOMA BRUCEI BRUCEI;

ACETYLGLUCOSAMINE; ANIMALS; CELL LINE; ENDOCYTOSIS; FEMALE; GLYCOSYLATION; MICE; MICE, INBRED BALB C; PLANT LECTINS; TRYPANOSOMA BRUCEI BRUCEI; VARIANT SURFACE GLYCOPROTEINS, TRYPANOSOMA; VIRULENCE;

EID: 84928807283     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003612     Document Type: Article

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