Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis

Nature Communications

Volumn 6, Issue , 2015, Pages

  Tichet, Mélanie ^a,b   Prodhomme, Virginie ^a,b   Fenouille, Nina ^a,b   Ambrosetti, Damien ^b,c   Mallavialle, Aude ^a,b   Cerezo, Michael ^b,d   Ohanna, Mickaël ^b,d   Audebert, Stéphane ^e   Rocchi, Stéphane ^b,d   Giacchero, Damien ^b,f   Boukari, Fériel ^a,b,f   Allegra, Maryline ^b,d   Chambard, Jean Claude ^b,d   Lacour, Jean Philippe ^b,f   Michiels, Jean François ^b,c   Borg, Jean Paul ^e   Deckert, Marcel ^a,b   Tartare Deckert, Sophie ^a,b  

^a CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c UNIVERSITY HOSPITAL OF NICE   (France)

^d INSERM   (France)

^e AIX MARSEILLE UNIVERSITY   (France)

^f CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEONECTIN; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; SPARC PROTEIN, HUMAN;

CANCER; GENE EXPRESSION; LESION; PROTEOMICS; PUBLIC HEALTH; SECRETION; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM; EXTRAVASATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CAPILLARY; LUNG METASTASIS; MELANOMA; METASTATIC MELANOMA; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; CAPILLARY PERMEABILITY; CASE CONTROL STUDY; LUNG TUMOR; METABOLISM; METASTASIS; NUDE MOUSE; PARACRINE SIGNALING; PATHOLOGY; SECONDARY; SECRETION (PROCESS); TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; CAPILLARY PERMEABILITY; CASE-CONTROL STUDIES; CELL LINE, TUMOR; ENDOTHELIUM, VASCULAR; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE, NUDE; NEOPLASM METASTASIS; OSTEONECTIN; PARACRINE COMMUNICATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84928803712     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7993     Document Type: Article

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