Dysconnectivity within the default mode in first-episode schizophrenia: A stochastic dynamic causal modeling study with functional magnetic resonance imaging

Schizophrenia Bulletin

Volumn 41, Issue 1, 2015, Pages 144-153

  Bastos Leite, António J ^a   Ridgway, Gerard R ^b   Silveira, Celeste ^a,c   Norton, Andreia ^d   Reis, Salomé ^c   Friston, Karl J ^b  

^a University of Porto   (Portugal)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

^d Centro Hospitalar Universitario do Porto   (Portugal)

Author keywords

brain connectivity; default mode network; dysconnectivity; first episode schizophrenia; functional magnetic resonance imaging (fMRI); resting state; stochastic dynamic causal modeling (DCM)

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; CAUSAL MODELING; CLINICAL ARTICLE; CONTROLLED STUDY; DEFAULT MODE NETWORK; DSM-IV; DYNAMIC CAUSAL MODELING; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HUMAN; MALE; NEUROMODULATION; PHYLOGENY; POSTERIOR CINGULATE; PRIORITY JOURNAL; SCHIZOPHRENIA; STOCHASTIC MODEL; CASE CONTROL STUDY; CINGULATE GYRUS; EPIDEMIOLOGY; FRONTAL LOBE; IMAGE PROCESSING; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PATHOPHYSIOLOGY; STATISTICS; THEORETICAL MODEL; YOUNG ADULT;

ADULT; CASE-CONTROL STUDIES; CAUSALITY; FEMALE; FRONTAL LOBE; FUNCTIONAL NEUROIMAGING; GYRUS CINGULI; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MODELS, THEORETICAL; NEURAL PATHWAYS; PARIETAL LOBE; SCHIZOPHRENIA; STOCHASTIC PROCESSES; YOUNG ADULT;

EID: 84928789276     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbu080     Document Type: Article

References (53)

1. Silveira C, Marques-Teixeira J, de Bastos-Leite AJ. More than one century of schizophrenia: an evolving perspective. J Nerv Ment Dis. 2012;200:1054-1057.
2. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci. 1995;3:89-97.
3. Friston KJ. Schizophrenia and the disconnection hypothesis. Acta Psychiatr Scand Suppl. 1999;395:68-79.
4. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc Natl Acad Sci U S A. 2001;98:676-682.
5. Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD. Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry. 2007;164:450-457.
6. Whitfield-Gabrieli S, Thermenos HW, Milanovic S, et al. Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc Natl Acad Sci U S A. 2009;106:1279-1284.
7. Jafri MJ, Pearlson GD, Stevens M, Calhoun VD. A method for functional network connectivity among spatially independent resting-state components in schizophrenia. Neuroimage. 2008;39:1666-1681.
8. Orliac F, Naveau M, Joliot M, et al. Links among restingstate default-mode network, salience network, and symptomatology in schizophrenia. Schizophr Res. 2013;148:74-80.
9. Friston KJ, Harrison L, Penny W. Dynamic causal modelling. Neuroimage. 2003;19:1273-1302.
10. Penny WD, Stephan KE, Mechelli A, Friston KJ. Modelling functional integration: a comparison of structural equation and dynamic causal models. Neuroimage. 2004;23(suppl 1):S264-S274.
11. Friston KJ. Modalities, modes, and models in functional neuroimaging. Science. 2009;326:399-403.
12. Li B, Daunizeau J, Stephan KE, Penny W, Hu D, Friston K. Generalised filtering and stochastic DCM for fMRI. Neuroimage. 2011;58:442-457.
13. Fletcher PC, Frith CD. Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia. Nat Rev Neurosci. 2009;10:48-58.
14. Mumford D. On the computational architecture of the neocortex. II. The role of cortico-cortical loops. Biol Cybern. 1992;66:241-251.
15. Shipp S. The importance of being agranular: a comparative account of visual and motor cortex. Philos Trans R Soc Lond B Biol Sci. 2005;360:797-814.
16. Bastos AM, Usrey WM, Adams RA, Mangun GR, Fries P, Friston KJ. Canonical microcircuits for predictive coding. Neuron. 2012;76:695-711.
17. Adams RA, Shipp S, Friston KJ. Predictions not commands: active inference in the motor system. Brain Struct Funct. 2013;218:611-643.
18. Adams RA, Stephan KE, Brown HR, Frith CD, Friston KJ. The computational anatomy of psychosis. Front Psychiatry. 2013;4:47.
19. Brown H, Adams RA, Parees I, Edwards M, Friston K. Active inference, sensory attenuation and illusions. Cogn Process. 2013;14:411-427.
20. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry. 2003;160:13-23.
21. Kolb B, Mychasiuk R, Muhammad A, Li Y, Frost DO, Gibb R. Experience and the developing prefrontal cortex. Proc Natl Acad Sci U S A. 2012;109(suppl 2):17186-17193.
22. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. Washington, DC: American Psychiatric Press; 2000.
23. McGorry PD, Hickie IB, Yung AR, Pantelis C, Jackson HJ. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust N Z J Psychiatry. 2006;40:616-622.
24. Carpenter WT Jr, Heinrichs DW, Wagman AM. Deficit and nondeficit forms of schizophrenia: the concept. Am J Psychiatry. 1988;145:578-583.
25. Kay SR, Fiszbein A, Opler LA. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276.
26. Gardner DM, Murphy AL, O'Donnell H, Centorrino F, Baldessarini RJ. International consensus study of antipsychotic dosing. Am J Psychiatry. 2010;167:686-693.
27. Tulsky D, Zhu J, Ledbetter M. WAIS-III WMS-III Technical Manual. 3rd ed. San Antonio, TX: United States of America: Harcourt Brace & Company; 1997.
28. Norton A, Reis S, Bastos-Leite AJ, Silveira C, Andrade A. P02-350-functional brain connectivity and deactivation in new onset schizophrenia: a pilot study. Eur Psychiatry. 2011;26(suppl 1):946.
29. Stephan KE, Penny WD, Daunizeau J, Moran RJ, Friston KJ. Bayesian model selection for group studies. Neuroimage. 2009;46:1004-1017.
30. Li B, Wang X, Yao S, Hu D, Friston K. Task-Dependent Modulation of Effective Connectivity within the Default Mode Network. Front Psychol. 2012;3:206.
31. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage. 2012;59:2142-2154.
32. Van Dijk KR, Sabuncu MR, Buckner RL. The influence of head motion on intrinsic functional connectivity MRI. Neuroimage. 2012;59:431-438.
33. Corlett PR, Honey GD, Krystal JH, Fletcher PC. Glutamatergic model psychoses: prediction error, learning, and inference. Neuropsychopharmacology. 2011;36:294-315.
34. Pettersson-Yeo W, Allen P, Benetti S, McGuire P, Mechelli A. Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev. 2011;35:1110-1124.
35. Zhang H, Wei X, Tao H, et al. Opposite effective connectivity in the posterior cingulate and medial prefrontal cortex between first-episode schizophrenic patients with suicide risk and healthy controls. PLoS One. 2013;8:e63477.
36. Insel T, Cuthbert B, Garvey M, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167:748-751.
37. Ford JM, Mathalon DH, Heinks T, Kalba S, Faustman WO, Roth WT. Neurophysiological evidence of corollary discharge dysfunction in schizophrenia. Am J Psychiatry. 2001;158:2069-2071.
38. Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr Bull. 2009;35:549-562.
39. Harrison PJ. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain. 1999;122 (Pt 4):593-624.
40. Selemon LD, Goldman-Rakic PS. The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol Psychiatry. 1999;45:17-25.
41. Garey LJ, Ong WY, Patel TS, et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J Neurol Neurosurg Psychiatry. 1998;65:446-453.
42. Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry. 2000;57:65-73.
43. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005;10:40-68.
44. Baldeweg T, Klugman A, Gruzelier J, Hirsch SR. Mismatch negativity potentials and cognitive impairment in schizophrenia. Schizophr Res. 2004;69:203-217.
45. Baldeweg T, Klugman A, Gruzelier JH, Hirsch SR. Impairment in frontal but not temporal components of mismatch negativity in schizophrenia. Int J Psychophysiol. 2002;43:111-122.
46. Javitt DC, Grochowski S, Shelley AM, Ritter W. Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/ interdeviant interval. Electroencephalogr Clin Neurophysiol. 1998;108:143-153.
47. Rasser PE, Schall U, Todd J, et al. Gray matter deficits, mismatch negativity, and outcomes in schizophrenia. Schizophr Bull. 2011;37:131-140.
48. Stephan KE, Baldeweg T, Friston KJ. Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry. 2006;59:929-939.
49. Carpenter WT Jr. Schizophrenia: disease, syndrome, or dimensions? Fam Process. 2007;46:199-206.
50. Tandon R, Nasrallah HA, Keshavan MS. Schizophrenia, "just the facts" 4. Clinical features and conceptualization. Schizophr Res. 2009;110:1-23.
51. Tsuang MT, Stone WS, Faraone SV. Toward reformulating the diagnosis of schizophrenia. Am J Psychiatry. 2000;157:1041-1050.
52. Muthukumaraswamy SD, Carhart-Harris RL, Moran RJ, et al. Broadband cortical desynchronization underlies the human psychedelic state. J Neurosci. 2013;33:15171-15183.
53. Bartzokis G. Schizophrenia: breakdown in the well-regulated lifelong process of brain development and maturation. Neuropsychopharmacology. 2002;27:672-683.