The Genetics of Impulsivity: Evidence for the Heritability of Delay Discounting

Biological Psychiatry

Volumn 77, Issue 10, 2015, Pages 887-894

  Anokhin, Andrey P ^a   Grant, Julia D ^a   Mulligan, Richard C ^a   Heath, Andrew C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Decision making; Delay discounting; Endophenotype; Heritability; Reward; Twins

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; DELAY DISCOUNTING; DIZYGOTIC TWINS; ENDOPHENOTYPE; FEMALE; GENETIC ANALYSIS; GENETIC CORRELATION; HEREDITY; HERITABILITY; HUMAN; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; MONEY; MONOZYGOTIC TWINS; PRIORITY JOURNAL; STRUCTURAL EQUATION MODELING; TEST RETEST RELIABILITY; PHENOTYPE; PHYSIOLOGY; REWARD; TWINS;

ADOLESCENT; DELAY DISCOUNTING; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; MALE; PHENOTYPE; REWARD;

EID: 84928726777     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.10.022     Document Type: Article

References (59)

1. B. Reynolds A review of delay-discounting research with humans: Relations to drug use and gambling Behav Pharmacol 17 2006 651 667
2. G. Ainslie Specious reward: A behavioral theory of impulsiveness and impulse control Psychol Bull 82 1975 463 496
3. J. Monterosso, and G. Ainslie Beyond discounting: Possible experimental models of impulse control Psychopharmacology (Berl) 146 1999 339 347
4. M.W. Johnson, and W.K. Bickel Within-subject comparison of real and hypothetical money rewards in delay discounting J Exp Anal Behav 77 2002 129 146
5. G.J. Madden, A.M. Begotka, B.R. Raiff, and L.L. Kastern Delay discounting of real and hypothetical rewards Exp Clin Psychopharmacol 11 2003 139 145
6. G.J. Madden, B.R. Raiff, C.H. Lagorio, A.M. Begotka, A.M. Mueller, D.J. Hehli, and A.A. Wegener Delay discounting of potentially real and hypothetical rewards: II. Between- and within-subject comparisons Exp Clin Psychopharmacol 12 2004 251 261
7. A.K. Matusiewicz, A.E. Carter, R.D. Landes, and R. Yi Statistical equivalence and test-retest reliability of delay and probability discounting using real and hypothetical rewards Behav Processes 100 2013 116 122
8. F. Baker, M.W. Johnson, and W.K. Bickel Delay discounting in current and never-before cigarette smokers: Similarities and differences across commodity, sign, and magnitude J Abnorm Psychol 112 2003 382 392
9. R.C. Beck, and M.F. Triplett Test-retest reliability of a group-administered paper-pencil measure of delay discounting Exp Clin Psychopharmacol 17 2009 345 355
10. M.W. Johnson, W.K. Bickel, and F. Baker Moderate drug use and delay discounting: A comparison of heavy, light, and never smokers Exp Clin Psychopharmacol 15 2007 187 194
11. K.N. Kirby One-year temporal stability of delay-discount rates Psychon Bull Rev 16 2009 457 462
12. Y. Ohmura, T. Takahashi, N. Kitamura, and P. Wehr Three-month stability of delay and probability discounting measures Exp Clin Psychopharmacol 14 2006 318 328
13. C.A. Simpson, and R.E. Vuchinich Reliability of a measure of temporal discounting Psychol Rec 50 2000 3 16
14. R.R. Smits, J.S. Stein, P.S. Johnson, A.L. Odum, and G.J. Madden Test-retest reliability and construct validity of the Experiential Discounting Task Exp Clin Psychopharmacol 21 2013 155 163
15. J.W. Dalley, A.C. Mar, D. Economidou, and T.W. Robbins Neurobehavioral mechanisms of impulsivity: Fronto-striatal systems and functional neurochemistry Pharmacol Biochem Behav 90 2008 250 260
16. S. Luo, G. Ainslie, D. Pollini, L. Giragosian, and J.R. Monterosso Moderators of the association between brain activation and farsighted choice Neuroimage 59 2012 1469 1477
17. J. Peters, and C. Buchel The neural mechanisms of inter-temporal decision-making: Understanding variability Trends Cogn Sci 15 2011 227 239
18. A.R. Hariri, S.M. Brown, D.E. Williamson, J.D. Flory, H. de Wit, and S.B. Manuck Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity J Neurosci 26 2006 13213 13217
19. M.W. Johnson, and W.K. Bickel An algorithm for identifying nonsystematic delay-discounting data Exp Clin Psychopharmacol 16 2008 264 274
20. A. Verdejo-Garcia, A.J. Lawrence, and L. Clark Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies Neurosci Biobehav Rev 32 2008 777 810
21. J.L. Perry, and M.E. Carroll The role of impulsive behavior in drug abuse Psychopharmacology (Berl) 200 2008 1 26
22. J. MacKillop, M.T. Amlung, L.R. Few, L.A. Ray, L.H. Sweet, and M.R. Munafo Delayed reward discounting and addictive behavior: A meta-analysis Psychopharmacology (Berl) 216 2011 305 321
23. W.K. Bickel, M.N. Koffarnus, L. Moody, and A.G. Wilson The behavioral- and neuro-economic process of temporal discounting: A candidate behavioral marker of addiction Neuropharmacology 76 2014 518 527
24. J. Mackillop Integrating behavioral economics and behavioral genetics: Delayed reward discounting as an endophenotype for addictive disorders J Exp Anal Behav 99 2013 14 31
25. J.W. Dalley, B.J. Everitt, and T.W. Robbins Impulsivity, compulsivity, and top-down cognitive control Neuron 69 2011 680 694
26. F.T. Crews, and C.A. Boettiger Impulsivity, frontal lobes and risk for addiction Pharmacol Biochem Behav 93 2009 237 247
27. K.R. Hamilton, and M.N. Potenza Relations among delay discounting, addictions, and money mismanagement: Implications and future directions Am J Drug Alcohol Abuse 38 2012 30 42
28. R.D. Rogers, F.G. Moeller, A.C. Swann, and L. Clark Recent research on impulsivity in individuals with drug use and mental health disorders: Implications for alcoholism Alcohol Clin Exp Res 34 2010 1319 1333
29. W.K. Bickel, and R. Yi Temporal discounting as a measure of executive function: Insights from the competing neuro-behavioral decision system hypothesis of addiction Adv Health Econ Health Serv Res 20 2008 289 309
30. J. Audrain-McGovern, D. Rodriguez, L.H. Epstein, J. Cuevas, K. Rodgers, and E.P. Wileyto Does delay discounting play an etiological role in smoking or is it a consequence of smoking? Drug Alcohol Depend 103 2009 99 106
31. J. MacKillop, and C.W. Kahler Delayed reward discounting predicts treatment response for heavy drinkers receiving smoking cessation treatment Drug Alcohol Depend 104 2009 197 203
32. S. Krishnan-Sarin, B. Reynolds, A.M. Duhig, A. Smith, T. Liss, and A. McFetridge Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers Drug Alcohol Depend 88 2007 79 82
33. G.W. Story, I. Vlaev, B. Seymour, A. Darzi, and R.J. Dolan Does temporal discounting explain unhealthy behavior? A systematic review and reinforcement learning perspective Front Behav Neurosci 8 2014 76
34. L.H. Epstein, S.J. Salvy, K.A. Carr, K.K. Dearing, and W.K. Bickel Food reinforcement, delay discounting and obesity Physiol Behav 100 2010 438 445
35. A.P. Anokhin, S. Golosheykin, J.D. Grant, and A.C. Heath Heritability of delay discounting in adolescence: A longitudinal twin study Behav Genet 41 2011 175 183
36. S.H. Mitchell The genetic basis of delay discounting and its genetic relationship to alcohol dependence Behav Processes 87 2011 10 17
37. T. Insel, B. Cuthbert, M. Garvey, R. Heinssen, D.S. Pine, and K. Quinn, et al. Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders Am J Psychiatry 167 2010 748 751
38. B.N. Cuthbert, and T.R. Insel Toward the future of psychiatric diagnosis: The seven pillars of RDoC BMC Med 11 2013 126
39. C.J. Wilhelm, and S.H. Mitchell Strain differences in delay discounting using inbred rats Genes Brain Behav 8 2009 426 434
40. J.B. Richards, D.R. Lloyd, B. Kuehlewind, L. Militello, M. Paredez, L. Solberg Woods, and A.A. Palmer Strong genetic influences on measures of behavioral-regulation among inbred rat strains Genes Brain Behav 12 2013 490 502
41. S.H. Mitchell, J.M. Reeves, N. Li, and T.J. Phillips Delay discounting predicts behavioral sensitization to ethanol in outbred WSC mice Alcohol Clin Exp Res 30 2006 429 437
42. B.G. Oberlin, and N.J. Grahame High-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task Alcohol Clin Exp Res 33 2009 1294 1303
43. S.H. Mitchell Measures of impulsivity in cigarette smokers and non-smokers Psychopharmacology (Berl) 146 1999 455 464
44. S.H. Mitchell, and V.B. Wilson The subjective value of delayed and probabilistic outcomes: Outcome size matters for gains but not for losses Behav Processes 83 2010 36 40
45. J. Myerson, L. Green, and M. Warusawitharana Area under the curve as a measure of discounting J Exp Anal Behav 76 2001 235 243
46. J.E. Mazur An adjusting procedure for studying delayed reinforcement M.L. Commons, J.E. Mazur, J.A. Nevin, H. Rachlin, Qualitative Analyses of Behavior 1987 Erlbaum Hillsdale, NJ 55 73
47. M.C. Neale, S.M. Boker, G. Xie, and H.H. Maes Mx: Statistical Modeling 6th ed. 2002 Virginia Commonwealth University, Department of Psychiatry Richmond, VA
48. M.C. Neale, and L.R. Cardon Methodology for Genetic Studies of Twins and Families 1992 Kluwer Academic Publishers Dordrecht, The Netherlands
49. F.V. Rijsdijk, and P.C. Sham Analytic approaches to twin data using structural equation models Brief Bioinform 3 2002 119 133
50. P. Sham Statistics in Human Genetics 1998 Oxford University Press New York
51. R.E. Weller, K.B. Avsar, J.E. Cox, M.A. Reid, D.M. White, and A.C. Lahti Delay discounting and task performance consistency in patients with schizophrenia Psychiatry Res 215 2014 286 293
52. W.K. Bickel, D.P. Jarmolowicz, E.T. Mueller, M.N. Koffarnus, and K.M. Gatchalian Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence Pharmacol Ther 134 2012 287 297
53. H. Lin, and L.H. Epstein Living in the moment: Effects of time perspective and emotional valence of episodic thinking on delay discounting Behav Neurosci 128 2014 12 19
54. S.M. McClure, D.I. Laibson, G. Loewenstein, and J.D. Cohen Separate neural systems value immediate and delayed monetary rewards Science 306 2004 503 507
55. R.M. Carter, J.R. Meyer, and S.A. Huettel Functional neuroimaging of intertemporal choice models: A review J Neurosci Psychol Econ 3 2010 27 45
56. D.T. Eisenberg, J. Mackillop, M. Modi, J. Beauchemin, D. Dang, and S.A. Lisman, et al. Examining impulsivity as an endophenotype using a behavioral approach: A DRD2 TaqI A and DRD4 48-bp VNTR association study Behav Brain Funct 3 2007 2
57. M.J. White, B.R. Lawford, C.P. Morris, and R.M. Young Interaction between DRD2 C957T polymorphism and an acute psychosocial stressor on reward-related behavioral impulsivity Behav Genet 39 2009 285 295
58. C.A. Boettiger, J.M. Mitchell, V.C. Tavares, M. Robertson, G. Joslyn, M. D'Esposito, and H.L. Fields Immediate reward bias in humans: Fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype J Neurosci 27 2007 14383 14391
59. Y. Paloyelis, P. Asherson, M.A. Mehta, S.V. Faraone, and J. Kuntsi DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls Neuropsychopharmacology 35 2010 2414 2426