Inhibition of the HER2-YB1-AR axis with lapatinib synergistically enhances enzalutamide anti-tumor efficacy in castration resistant prostate cancer

Oncotarget

Volumn 6, Issue 11, 2015, Pages 9086-9098

  Shiota, Masaki ^a   Bishop, Jennifer L ^a   Takeuchi, Ario ^a   Nip, Ka Mun ^a   Cordonnier, Thomas ^a   Beraldi, Eliana ^a   Kuruma, Hidetoshi ^a   Gleave, Martin E ^a   Zoubeidi, Amina ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Castration resistant prostate cancer; Enzalutamide; Her2; Lapatinib

Indexed keywords

ANDROGEN RECEPTOR; ENZALUTAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAPATINIB; MESSENGER RNA; Y BOX BINDING PROTEIN 1; AKT1 PROTEIN, HUMAN; ANDROGEN RECEPTOR ANTAGONIST; AR PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; ERBB2 PROTEIN, HUMAN; PHENYLTHIOHYDANTOIN; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; TUMOR PROTEIN; YBX1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AR GENE; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER RESISTANCE; CASTRATION RESISTANT PROSTATE CANCER; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HER2 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LNCAP CELL LINE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR BLOCKING; YB 1 GENE; ADENOCARCINOMA; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIVISION; DRUG EFFECTS; DRUG RESISTANCE; METABOLISM; NUDE MOUSE; ORCHIECTOMY; PATHOLOGY; PROSTATIC NEOPLASMS; PROTEIN PROCESSING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOCARCINOMA; ANDROGEN RECEPTOR ANTAGONISTS; ANIMALS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; HUMANS; MALE; MICE; MICE, NUDE; NEOPLASM PROTEINS; ORCHIECTOMY; PHENYLTHIOHYDANTOIN; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTORS, ANDROGEN; SIGNAL TRANSDUCTION; Y-BOX-BINDING PROTEIN 1;

EID: 84928720840     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3602     Document Type: Article

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