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Volumn 75, Issue 5, 2015, Pages 808-812

Redundancy: A critical obstacle to improving cancer therapy

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ANTINEOPLASTIC AGENT;

EID: 84928703381     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-3256     Document Type: Review
Times cited : (49)

References (45)
  • 5
    • 84907067643 scopus 로고    scopus 로고
    • Expanding the computational toolbox for mining cancer genomes
    • Ding L, Wendl MC, McMichael JF, Raphael BJ. Expanding the computational toolbox for mining cancer genomes. Nat Rev Genet 2014;15:556-70.
    • (2014) Nat Rev Genet , vol.15 , pp. 556-570
    • Ding, L.1    Wendl, M.C.2    McMichael, J.F.3    Raphael, B.J.4
  • 6
    • 84860692880 scopus 로고    scopus 로고
    • The dynamics of drug resistance: A mathematical perspective
    • Lavi O, Gottesman MM, Levy D. The dynamics of drug resistance: a mathematical perspective. Drug Resist Updat 2012;15:90-7.
    • (2012) Drug Resist Updat , vol.15 , pp. 90-97
    • Lavi, O.1    Gottesman, M.M.2    Levy, D.3
  • 7
    • 79952635505 scopus 로고    scopus 로고
    • Principles and strategies for developing network models in cancer
    • Pe'er D, Hacohen N. Principles and strategies for developing network models in cancer. Cell 2011;144:864-73.
    • (2011) Cell , vol.144 , pp. 864-873
    • Pe'er, D.1    Hacohen, N.2
  • 8
    • 84931569174 scopus 로고    scopus 로고
    • Cancer systems biology: Embracing complexity to develop better anticancer therapeutic strategies
    • Sep. 15, Epub ahead of print
    • Du W, Elemento O. Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies. Oncogene 2014 Sep. 15. [Epub ahead of print].
    • (2014) Oncogene
    • Du, W.1    Elemento, O.2
  • 10
    • 59349083179 scopus 로고    scopus 로고
    • Mechanisms of drug combinations: Interaction and network perspectives
    • Jia J, Zhu F, Ma X, Cao Z, Li Y, Chen YZ. Mechanisms of drug combinations: interaction and network perspectives. Nat Rev Drug Discov 2009;8:111-28.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 111-128
    • Jia, J.1    Zhu, F.2    Ma, X.3    Cao, Z.4    Li, Y.5    Chen, Y.Z.6
  • 11
    • 33745075558 scopus 로고    scopus 로고
    • Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
    • Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M. Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 2006;5:1136-44.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1136-1144
    • Smalley, K.S.1    Haass, N.K.2    Brafford, P.A.3    Lioni, M.4    Flaherty, K.T.5    Herlyn, M.6
  • 13
    • 84894483014 scopus 로고    scopus 로고
    • Simplifying the complexity of resistance heterogeneity in metastasis
    • Lavi O, Greene JM, Levy D, Gottesman MM. Simplifying the complexity of resistance heterogeneity in metastasis. Trends Mol Med 2014;20:129-36.
    • (2014) Trends Mol Med , vol.20 , pp. 129-136
    • Lavi, O.1    Greene, J.M.2    Levy, D.3    Gottesman, M.M.4
  • 15
    • 84918831563 scopus 로고    scopus 로고
    • Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma
    • Boussiotis VA. Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma. N Engl J Med 2014;371:2230-2.
    • (2014) N Engl J Med , vol.371 , pp. 2230-2232
    • Boussiotis, V.A.1
  • 17
    • 0035805255 scopus 로고    scopus 로고
    • Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
    • Ideker T, Thorsson V, Ranish JA, Christmas R, Buhler J, Eng JK, et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 2001;292:929-34.
    • (2001) Science , vol.292 , pp. 929-934
    • Ideker, T.1    Thorsson, V.2    Ranish, J.A.3    Christmas, R.4    Buhler, J.5    Eng, J.K.6
  • 18
    • 6944224154 scopus 로고    scopus 로고
    • Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes
    • Fong SS, Palsson BO. Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes. Nat Genet 2004;36:1056-8.
    • (2004) Nat Genet , vol.36 , pp. 1056-1058
    • Fong, S.S.1    Palsson, B.O.2
  • 19
    • 1542350073 scopus 로고    scopus 로고
    • Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study
    • Daran-Lapujade P, Jansen ML, Daran JM, van Gulik W, de Winde JH, Pronk JT. Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study. J Biol Chem 2004;279:9125-38.
    • (2004) J Biol Chem , vol.279 , pp. 9125-9138
    • Daran-Lapujade, P.1    Jansen, M.L.2    Daran, J.M.3    Van Gulik, W.4    De Winde, J.H.5    Pronk, J.T.6
  • 20
    • 73949135792 scopus 로고    scopus 로고
    • Mechanisms of multidrug resistance in cancer
    • Gillet JP, Gottesman MM. Mechanisms of multidrug resistance in cancer. Methods Mol Biol 2010;596:47-76.
    • (2010) Methods Mol Biol , vol.596 , pp. 47-76
    • Gillet, J.P.1    Gottesman, M.M.2
  • 21
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano H. Biological robustness. Nat Rev Genet 2004;5:826-37.
    • (2004) Nat Rev Genet , vol.5 , pp. 826-837
    • Kitano, H.1
  • 22
    • 77953807608 scopus 로고    scopus 로고
    • Abundant indispensable redundancies in cellular metabolic networks
    • Wang Z, Zhang J. Abundant indispensable redundancies in cellular metabolic networks. Genome Biol Evol 2009;1:23-33.
    • (2009) Genome Biol Evol , vol.1 , pp. 23-33
    • Wang, Z.1    Zhang, J.2
  • 23
    • 0028964465 scopus 로고
    • Cytokine signaling through nonreceptor protein tyrosine kinases
    • Taniguchi T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 1995;268:251-5.
    • (1995) Science , vol.268 , pp. 251-255
    • Taniguchi, T.1
  • 25
    • 0030625445 scopus 로고    scopus 로고
    • Genetic redundancy
    • Brookfield JF. Genetic redundancy. Adv Genet 1997;36:137-55.
    • (1997) Adv Genet , vol.36 , pp. 137-155
    • Brookfield, J.F.1
  • 27
    • 0030057803 scopus 로고    scopus 로고
    • Redundant control of ultrabithorax by zeste involves functional levels of zeste protein binding at the ultrabithorax promoter
    • Laney JD, Biggin MD. Redundant control of ultrabithorax by zeste involves functional levels of zeste protein binding at the ultrabithorax promoter. Development 1996;122:2303-11.
    • (1996) Development , vol.122 , pp. 2303-2311
    • Laney, J.D.1    Biggin, M.D.2
  • 29
    • 70349437076 scopus 로고    scopus 로고
    • P53 and E2f: Partners in life and death
    • Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer 2009;9:738-48.
    • (2009) Nat Rev Cancer , vol.9 , pp. 738-748
    • Polager, S.1    Ginsberg, D.2
  • 30
    • 0035936113 scopus 로고    scopus 로고
    • The E2F1-3 transcription factors are essential for cellular proliferation
    • Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 2001;414:457-62.
    • (2001) Nature , vol.414 , pp. 457-462
    • Wu, L.1    Timmers, C.2    Maiti, B.3    Saavedra, H.I.4    Sang, L.5    Chong, G.T.6
  • 31
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclin-dependent kinases
    • Sherr CJ, Roberts JM. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 2004;18:2699-711.
    • (2004) Genes Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 35
    • 79955043222 scopus 로고    scopus 로고
    • Regulation of modular Cyclin and CDK feedback loops by an E2F transcription oscillator in the mammalian cell cycle
    • Lavi O, Ginsberg D, Louzoun Y. Regulation of modular Cyclin and CDK feedback loops by an E2F transcription oscillator in the mammalian cell cycle. Math Biosci Eng 2011;8:445-61.
    • (2011) Math Biosci Eng , vol.8 , pp. 445-461
    • Lavi, O.1    Ginsberg, D.2    Louzoun, Y.3
  • 37
    • 84886279046 scopus 로고    scopus 로고
    • Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: Alterations in glutamine and beta-alanine metabolism
    • Budczies J, Brockmoller SF, Muller BM, Barupal DK, Richter-Ehrenstein C, Kleine-Tebbe A, et al. Comparative metabolomics of estrogen receptor positive and estrogen receptor negative breast cancer: alterations in glutamine and beta-alanine metabolism. J Proteomics 2013;94:279-88.
    • (2013) J Proteomics , vol.94 , pp. 279-288
    • Budczies, J.1    Brockmoller, S.F.2    Muller, B.M.3    Barupal, D.K.4    Richter-Ehrenstein, C.5    Kleine-Tebbe, A.6
  • 38
    • 79953663708 scopus 로고    scopus 로고
    • Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells
    • Cavill R, Kamburov A, Ellis JK, Athersuch TJ, Blagrove MS, Herwig R, et al. Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells. PLoS Comput Biol 2011;7:e1001113.
    • (2011) PLoS Comput Biol , vol.7 , pp. e1001113
    • Cavill, R.1    Kamburov, A.2    Ellis, J.K.3    Athersuch, T.J.4    Blagrove, M.S.5    Herwig, R.6
  • 40
    • 0029036955 scopus 로고
    • The search for synergy: A critical review from a response surface perspective
    • Greco WR, Bravo G, Parsons JC. The search for synergy: a critical review from a response surface perspective. Pharmacol Rev 1995;47:331-85.
    • (1995) Pharmacol Rev , vol.47 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 42
    • 84881087888 scopus 로고    scopus 로고
    • How to escape the cancer attractor: Rationale and limitations of multi-target drugs
    • Huang S, Kauffman S. How to escape the cancer attractor: rationale and limitations of multi-target drugs. Semin Cancer Biol 2013;23:270-8.
    • (2013) Semin Cancer Biol , vol.23 , pp. 270-278
    • Huang, S.1    Kauffman, S.2
  • 43
    • 84867554554 scopus 로고    scopus 로고
    • Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling
    • Jerby L, Ruppin E. Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling. Clin Cancer Res 2012;18:5572-84.
    • (2012) Clin Cancer Res , vol.18 , pp. 5572-5584
    • Jerby, L.1    Ruppin, E.2
  • 44
  • 45
    • 0034051465 scopus 로고    scopus 로고
    • Canalization in evolutionary genetics: A stabilizing theory?
    • Gibson G, Wagner G. Canalization in evolutionary genetics: a stabilizing theory? Bioessays 2000;22:372-80.
    • (2000) Bioessays , vol.22 , pp. 372-380
    • Gibson, G.1    Wagner, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.