Breathing easier: Addressing the challenges of aerosolizing medications to infants and preschoolers

Respiratory Medicine

Volumn 108, Issue 8, 2014, Pages 1069-1074

  Goralski, Jennifer L ^a   Davis, Stephanie D ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adherence; Infants; MDI; Medication; Nebulizer; Preschoolers

Indexed keywords

AEROSOL; ARTICLE; BREATHING; CHILD; COOPERATION; DRUG DELIVERY SYSTEM; GROUPS BY AGE; HUMAN; INFANT; MEDICATION COMPLIANCE; PARTICLE SIZE; PATIENT EDUCATION; PRESCHOOL CHILD; PRIORITY JOURNAL; ADMINISTRATION AND DOSAGE; INHALATIONAL DRUG ADMINISTRATION; LUNG DISEASES; NEBULIZER; PATIENT SATISFACTION;

AEROSOL; RESPIRATORY TRACT AGENT;

ADMINISTRATION, INHALATION; AEROSOLS; CHILD, PRESCHOOL; HUMANS; INFANT; LUNG DISEASES; NEBULIZERS AND VAPORIZERS; PATIENT EDUCATION AS TOPIC; PATIENT SATISFACTION; RESPIRATORY SYSTEM AGENTS;

EID: 84928701917     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2014.06.004     Document Type: Review

References (48)

1. P. Zarogoulidis, K. Darwiche, W. Hohenforst-Schmidt, H. Huang, Q. Li, and L. Freitag et al. Inhaled gene therapy in lung cancer: proof-of-concept for nano-oncology and nanobiotechnology in the management of lung cancer Future Oncol 9 8 2013 1171 1194
2. V.B. Pai, and M.C. Nahata Efficacy and safety of aerosolized tobramycin in cystic fibrosis Pediatr Pulmonol 32 4 2001 314 327
3. S.D. Davis, L.A. Fordham, A.S. Brody, T.L. Noah, G.Z. Retsch-Bogart, and B.F. Qaqish et al. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis Am J Respir Crit Care Med 175 9 2007 943 950
4. S.D. Davis, M. Rosenfeld, G.S. Kerby, L. Brumback, M.H. Kloster, and J.D. Acton et al. Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints Am J Respir Crit Care Med 182 11 2010 1387 1397
5. S.M. Stick, S. Brennan, C. Murray, T. Douglas, B.S. von Ungern-Sternberg, and L.W. Garratt et al. Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening J Pediatr 155 5 2009 623 628 e1
6. D.E. Brown, J.E. Pittman, M.W. Leigh, L. Fordham, and S.D. Davis Early lung disease in young children with primary ciliary dyskinesia Pediatr Pulmonol 43 5 2008 514 516
7. B.W. Ramsey, S. Banks-Schlegel, F.J. Accurso, R.C. Boucher, G.R. Cutting, and J.F. Engelhardt et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report Am J Respir Crit Care Med 185 8 2012 887 892
8. J.B. Fink Delivery of inhaled drugs for infants and small children: a commentary on present and future needs Clin Ther 34 11 2012 S36 S45
9. B.L. Laube, H.M. Janssens, F.H. de Jongh, S.G. Devadason, R. Dhand, and P. Diot et al. What the pulmonary specialist should know about the new inhalation therapies Eur Respir J 37 6 2011 1308 1331
10. J.D. Brain, and P.A. Valberg Deposition of aerosol in the respiratory tract Am Rev Respir Dis 120 6 1979 1325 1373
11. I. Albuquerque-Silva, L. Vecellio, M. Durand, J. Avet, D. Le Pennec, and M. de Monte et al. Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons PloS One 9 4 2014 e95456
12. R.N. Dalby, S. Somaraju, V.S. Chavan, and D. Jarvis Evaluation of aerosol drug output from the OptiChamber and AeroChamber spacers in a model system J Asthma Off J Assoc Care Asthma 35 2 1998 173 177
13. M.B. Dolovich, R.C. Ahrens, D.R. Hess, P. Anderson, R. Dhand, and J.L. Rau et al. Device selection and outcomes of aerosol therapy: evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology Chest 127 1 2005 335 371
14. B. Sleath, G.X. Ayala, C. Gillette, D. Williams, S. Davis, and G. Tudor et al. Provider demonstration and assessment of child device technique during pediatric asthma visits Pediatrics 127 4 2011 642 648
15. I. Amirav, and M.T. Newhouse Review of optimal characteristics of face-masks for valved-holding chambers (VHCs) Pediatr Pulmonol 43 3 2008 268 274
16. G.C. Smaldone, E. Berg, and K. Nikander Variation in pediatric aerosol delivery: importance of facemask J Aerosol Med Off J Int Soc Aerosols Med 18 3 2005 354 363
17. I. Amirav, and M.T. Newhouse Deposition of small particles in the developing lung Paediatr Respir Rev 13 2 2012 73 78
18. A. Chavez, A. McCracken, and A. Berlinski Effect of face mask dead volume, respiratory rate, and tidal volume on inhaled albuterol delivery Pediatr Pulmonol 45 3 2010 224 229
19. H.L. Chua, G.G. Collis, A.M. Newbury, K. Chan, G.D. Bower, and P.D. Sly et al. The influence of age on aerosol deposition in children with cystic fibrosis Eur Respir J 7 12 1994 2185 2191
20. I. Amirav, and M.T. Newhouse Aerosol therapy with valved holding chambers in young children: importance of the facemask seal Pediatrics 108 2 2001 389 394
21. D.W. Cockcroft, D.W. MacCormack, S.M. Tarlo, F.E. Hargreave, and L.D. Pengelly Nasal airway inspiratory resistance Am Rev Respir Dis 119 6 1979 921 926
22. M.H. Becquemin, D.L. Swift, A. Bouchikhi, M. Roy, and A. Teillac Particle deposition and resistance in the noses of adults and children Eur Respir J 4 6 1991 694 702
23. M.L. Everard, J.G. Hardy, and A.D. Milner Comparison of nebulised aerosol deposition in the lungs of healthy adults following oral and nasal inhalation Thorax 48 10 1993 1045 1046
24. Y. Zhou, M. Guo, J. Xi, H. Irshad, and Y.S. Cheng Nasal deposition in infants and children J Aerosol Med Pulm Drug Deliv 86 0 2013 1 7
25. R. Iles, P. Lister, and A.T. Edmunds Crying significantly reduces absorption of aerosolised drug in infants Arch Dis Child 81 2 1999 163 165
26. M.L. Everard Trying to deliver aerosols to upset children is a thankless task Arch Dis Child 82 5 2000 428
27. H.L. Lin, G.H. Wan, Y.H. Chen, J.B. Fink, W.Q. Liu, and K.Y. Liu Influence of nebulizer type with different pediatric aerosol masks on drug deposition in a model of a spontaneously breathing small child Respir Care 57 11 2012 1894 1900
28. G. Murakami, T. Igarashi, Y. Adachi, M. Matsuno, Y. Adachi, and M. Sawai et al. Measurement of bronchial hyperreactivity in infants and preschool children using a new method Ann Allergy 64 4 1990 383 387
29. A. Tal, H. Golan, N. Grauer, M. Aviram, D. Albin, and M.R. Quastel Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction J Pediatr 128 4 1996 479 484
30. H.L. Lin, R.D. Restrepo, D.S. Gardenhire, and J.L. Rau Effect of face mask design on inhaled mass of nebulized albuterol, using a pediatric breathing model Respir Care 52 8 2007 1021 1026
31. M.M. Mansour, and G.C. Smaldone Blow-by as potential therapy for uncooperative children: an in-vitro study Respir Care 57 12 2012 2004 2011
32. S.A. Shah, A.B. Berlinski, and B.K. Rubin Force-dependent static dead space of face masks used with holding chambers Respir Care 51 2 2006 140 144
33. H.M. Janssens, E.C. van der Wiel, A.F. Verbraak, J.C. de Jongste, P.J. Merkus, and H.A. Tiddens Aerosol therapy and the fighting toddler: is administration during sleep an alternative? J Aerosol Med Off J Int Soc Aerosols Med 16 4 2003 395 400
34. J. Esposito-Festen, H. Ijsselstijn, W. Hop, F. van Vliet, J. de Jongste, and H. Tiddens Aerosol therapy by pressured metered-dose inhaler-spacer in sleeping young children: to do or not to do? Chest 130 2 2006 487 492
35. I. Amirav, I. Balanov, M. Gorenberg, D. Groshar, and A.S. Luder Nebuliser hood compared to mask in wheezy infants: aerosol therapy without tears! Arch Dis Child 88 8 2003 719 723
36. I. Amirav, A. Luder, A. Chleechel, M.T. Newhouse, and M. Gorenberg Lung aerosol deposition in suckling infants Arch Dis Child 97 6 2012 497 501
37. M.E. Bollinger, K.E. Mudd, A. Boldt, V.D. Hsu, M.G. Tsoukleris, and A.M. Butz Prescription fill patterns in underserved children with asthma receiving subspecialty care Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol 111 3 2013 185 189
38. V. Vaidya, R. Gupte, and R. Balkrishnan Failure to refill essential prescription medications for asthma among pediatric medicaid beneficiaries with persistent asthma Patient Prefer adherence 7 2013 21 26
39. P.S. McNamara, P. McCormack, A.J. McDonald, L. Heaf, and K.W. Southern Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis J Cyst Fibros Off J Eur Cyst Fibros Soc 8 4 2009 258 263
40. M. Molimard, C. Raherison, S. Lignot, F. Depont, A. Abouelfath, and N. Moore Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care J Aerosol Med Off J Int Soc Aerosols Med 16 3 2003 249 254
41. British Thoracic Society Scottish Intercollegiate Guidelines N British guideline on the management of asthma Thorax 63 Suppl. 4 2008 iv1 121
42. S. Naar-King, P. Lam, D. Ellis, J.M. Bruzzese, and E. Secord Asthma medication device skills in high-risk African American adolescents J Asthma Off J Assoc Care Asthma 50 6 2013 579 582
43. B.K. Rubin Pediatric aerosol therapy: new devices and new drugs Respir care 56 9 2011 1411 1421 discussion 21-3
44. P. McCormack, K.W. Southern, and P.S. McNamara New nebulizer technology to monitor adherence and nebulizer performance in cystic fibrosis J Aerosol Med Pulm Drug Deliv 25 6 2012 307 309
45. K.C. Kesser, and D.E. Geller New aerosol delivery devices for cystic fibrosis Respir care 54 6 2009 754 767 discussion 67-8
46. P. McCormack, P.S. McNamara, and K.W. Southern A randomised controlled trial of breathing modes for adaptive aerosol delivery in children with cystic fibrosis J Cyst Fibros Off J Eur Cyst Fibros Soc 10 5 2011 343 349
47. J. Denyer, I. Prince, E. Dixon, P. Agent, J. Pryor, and M. Hodson Evaluation of the Target Inhalation Mode (TIM) breathing maneuver in simulated nebulizer therapy in patients with cystic fibrosis J Aerosol Med Pulm Drug Deliv 23 Suppl. 1 2010 S29 S36
48. J. Denyer, A. Black, K. Nikander, T. Dyche, and I. Prince Domiciliary experience of the Target Inhalation Mode (TIM) breathing maneuver in patients with cystic fibrosis J Aerosol Med Pulm Drug Deliv 23 Suppl. 1 2010 S45 S54