Effect of face mask dead volume, respiratory rate, and tidal volume on inhaled albuterol delivery

Pediatric Pulmonology

Volumn 45, Issue 3, 2010, Pages 224-229

  Chavez, Alma ^a,b   McCracken, Andy ^a   Berlinski, Ariel ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Breathing simulation; Inhalation spacer; Mask dead space; Metered dose inhaler; Valved holding chamber

Indexed keywords

SALBUTAMOL;

ARTICLE; BREATHING PATTERN; BREATHING RATE; DRUG DELIVERY SYSTEM; FACE MASK; METERED DOSE INHALER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIMULATOR; SPECTROPHOTOMETRY; TIDAL VOLUME;

ADMINISTRATION, INHALATION; ALBUTEROL; BRONCHODILATOR AGENTS; CHILD, PRESCHOOL; EQUIPMENT DESIGN; HUMANS; INFANT; MASKS; MODELS, ANATOMIC; NEBULIZERS AND VAPORIZERS; RESPIRATORY DEAD SPACE; RESPIRATORY RATE; TIDAL VOLUME;

EID: 77449113062     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.21156     Document Type: Article

References (19)

1. Fok TF, Lam K, Ng PC, Leung TF, So HK, Cheung KL, Wong W. Delivery of salbutamol to nonventilated preterm infants by metered-dose inhaler, jet nebulizer, and ultrasonic nebulizer. Eur Respir J 1998;12:159-164.
2. Deerojanawong J, Manuyakorn W, Prapphal N, Harnruthakorn C, Sritippayawan S, Samransamruajkit R. Randomized controlled trial of salbutamol aerosol therapy via metered dose inhalerspacer vs. jet nebulizer in young children with wheezing. Pediatr Pulmonol 2005;39:466-472.
3. Amirav I, Newhouse MT. Review of optimal characteristics of face-masks for valved-holding chambers (VHCs). Pediatr Pulmonol 2008;43:268-274.
4. Erzinger S, Schueepp KG, Brooks-Wildhaber J, Devadason SG, Wildhaber JH. Facemasks and aerosol delivery in vivo. J Aerosol Med 2007;20:S78-S83, discussion S83-S84.
5. Amirav I, Newhouse MT. Aerosol therapy with valved holding chambers in young children: importance of the facemask seal. Pediatrics 2001;108:389-394.
6. Janssens HM, Tiddens HA. Facemasks and aerosol delivery by metered dose inhaler-valved holding chamber in young children: a tight seal makes the difference. J Aerosol Med 2007;20:S59-S63, discussion S63-S65.
7. Everard ML, Clark AR, Milner AD. Drug delivery from holding chambers with attached facemask. Arch Dis Child 1992;67:580-585.
8. Amirav I, Mansour Y, Mandelberg A, Bar-Ilan I, Newhouse MT. Redesigned face mask improves "real life" aerosol delivery for nebuchamber. Pediatr Pulmonol 2004;37:172-177.
9. Shah SA, Berlinski AB, Rubin BK. Force-dependent static dead space of face masks used with holding chambers. Respir Care 2006;51:140-144.
10. Amirav I, Newhouse MT. Dead space variability of face masks for valved holding chambers. Isr Med Assoc J 2008;10:224-226.
11. Janssens HM, Krijgsman A, Verbraak TF, Hop WC, de Jongste JC, Tiddens HA. Determining factors of aerosol deposition for four pMDI-spacer combinations in an infant upper airway model. J Aerosol Med 2004;17:51-61.
12. Dubus JC, Anhoj J. Inhaled steroid delivery from small-volume holding chambers depends on age, holding chamber, and interface in children. J Aerosol Med 2004;17:225-230.
13. Onhoj J, Thorsson L, Bisgaard H. Lung deposition of inhaled drugs increases with age. Am J Respir Crit Care Med 2000;162: 1819-1822.
14. Morton RW, Mitchell JP. Design of facemasks for delivery of aerosol-based medication via pressurized metered dose inhaler with valved holding chamber: key issues that affect performance. J Aerosol Med 2007;20:S29-S42, discussion S42-S45.
15. Smaldone GC, Berg E, Nikander K. Variation in pediatric aerosol delivery: importance of facemask. J Aerosol Med 2005;18:354-363.
16. Esposito-Festen JE, Ates B, van Vliet FJ, Verbraak AF, de Jongste JC, Tiddens HA. Effect of a facemask leak on aerosol delivery from a pMDI-spacer system. J Aerosol Med 2004;17:1-6.
17. Turpeinen M, Nikander K, Malmberg LP, Pelkonen A. Metered dose inhaler add-on devices: is the inhaled mass of drug dependent on the size of the infant? J Aerosol Med 1999;12: 171-176.
18. Barry PW, O'Callaghan C. The output of budesonide from spacer devices assessed under simulated breathing conditions. J Allergy Clin Immunol 1999;104:1205-1210.
19. Everard ML. Ethical aspects of using radiolabelling in aerosol research. Arch Dis Child 2003;88:659-661.