메뉴 건너뛰기




Volumn 15, Issue 1, 2014, Pages

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is KCa3.1-dependent

Author keywords

Differentiation; Fibrosis; Idiopathic pulmonary fibrosis (IPF); Ion channel; KCa3.1; Lung; Myofibroblast; Smad 2; Smad 3

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; ALPHA SMOOTH MUSCLE ACTIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; POTASSIUM CHANNEL KCA3.1; SENICAPOC; SMAD2 PROTEIN; SMAD3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84928678504     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/s12931-014-0155-5     Document Type: Article
Times cited : (47)

References (46)
  • 1
    • 0031965748 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification
    • Katzenstein AL, Myers JL: Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification. Am J Respir Crit Care Med. 1998, 157 (4 Pt 1): 1301-1315. 10.1164/ajrccm.157.4.9707039.
    • (1998) Am J Respir Crit Care Med , vol.157 , Issue.4 , pp. 1301-1315
    • Katzenstein, A.L.1    Myers, J.L.2
  • 6
    • 33751234953 scopus 로고    scopus 로고
    • Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK
    • Gribbin J, Hubbard RB, Le Jeune I, Smith CJ, West J, Tata LJ: Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax. 2006, 61 (11): 980-985. 10.1136/thx.2006.062836.
    • (2006) Thorax , vol.61 , Issue.11 , pp. 980-985
    • Gribbin, J.1    Hubbard, R.B.2    Le Jeune, I.3    Smith, C.J.4    West, J.5    Tata, L.J.6
  • 7
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman M, King TE, Pardo A: Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med. 2001, 134 (2): 136-151. 10.7326/0003-4819-134-2-200101160-00015.
    • (2001) Ann Intern Med , vol.134 , Issue.2 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 8
    • 0036277026 scopus 로고    scopus 로고
    • Myofibroblasts and mechano-regulation of connective tissue remodelling
    • Tomasek J, Gabbiani G, Hinz B, Chaponnier C, Brown R: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002, 3 (5): 349-363. 10.1038/nrm809.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , Issue.5 , pp. 349-363
    • Tomasek, J.1    Gabbiani, G.2    Hinz, B.3    Chaponnier, C.4    Brown, R.5
  • 9
    • 33846907788 scopus 로고    scopus 로고
    • Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts
    • Sanders YY, Kumbla P, Hagood JS: Enhanced myofibroblastic differentiation and survival in Thy-1(-) lung fibroblasts. Am J Respir Cell Mol Biol. 2007, 36 (2): 226-235. 10.1165/rcmb.2006-0178OC.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , Issue.2 , pp. 226-235
    • Sanders, Y.Y.1    Kumbla, P.2    Hagood, J.S.3
  • 10
    • 33847084614 scopus 로고    scopus 로고
    • Formation and function of the myofibroblast during tissue repair
    • Hinz B: Formation and function of the myofibroblast during tissue repair. J Invest Dermatol. 2007, 127 (3): 526-537. 10.1038/sj.jid.5700613.
    • (2007) J Invest Dermatol , vol.127 , Issue.3 , pp. 526-537
    • Hinz, B.1
  • 11
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G: Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 1993, 122 (1): 103-111. 10.1083/jcb.122.1.103.
    • (1993) J Cell Biol , vol.122 , Issue.1 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 12
    • 0024511977 scopus 로고
    • Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins
    • Skalli O, Schurch W, Seemayer T, Lagace R, Montandon D, Pittet B, Gabbiani G: Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. Lab Invest. 1989, 60 (2): 275-285.
    • (1989) Lab Invest , vol.60 , Issue.2 , pp. 275-285
    • Skalli, O.1    Schurch, W.2    Seemayer, T.3    Lagace, R.4    Montandon, D.5    Pittet, B.6    Gabbiani, G.7
  • 13
    • 33744914050 scopus 로고    scopus 로고
    • Evolving concepts of apoptosis in idiopathic pulmonary fibrosis
    • Thannickal VJ, Horowitz JC: Evolving concepts of apoptosis in idiopathic pulmonary fibrosis. Proc Am Thorac Soc. 2006, 3: 350-356. 10.1513/pats.200601-001TK.
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 350-356
    • Thannickal, V.J.1    Horowitz, J.C.2
  • 14
    • 0025729855 scopus 로고
    • The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis
    • Kuhn C, McDonald JA: The roles of the myofibroblast in idiopathic pulmonary fibrosis. Ultrastructural and immunohistochemical features of sites of active extracellular matrix synthesis. Am J Pathol. 1991, 138 (5): 1257-1265.
    • (1991) Am J Pathol , vol.138 , Issue.5 , pp. 1257-1265
    • Kuhn, C.1    McDonald, J.A.2
  • 15
    • 33847676783 scopus 로고    scopus 로고
    • Fibroblasts and myofibroblasts: their source, function and role in disease
    • McAnulty RJ: Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol. 2007, 39 (4): 666-671. 10.1016/j.biocel.2006.11.005.
    • (2007) Int J Biochem Cell Biol , vol.39 , Issue.4 , pp. 666-671
    • McAnulty, R.J.1
  • 16
    • 0027955331 scopus 로고
    • Fibroblasts, myofibroblasts, and wound contraction
    • Grinnell F: Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994, 124 (4): 401-404. 10.1083/jcb.124.4.401.
    • (1994) J Cell Biol , vol.124 , Issue.4 , pp. 401-404
    • Grinnell, F.1
  • 17
    • 0021051565 scopus 로고
    • Myofibroblasts in Central Giant-Cell Granuloma of the Jaws - an Ultrastructural-Study
    • Ellabban NG, Lee KW: Myofibroblasts in Central Giant-Cell Granuloma of the Jaws - an Ultrastructural-Study. Histopathology. 1983, 7 (6): 907-918. 10.1111/j.1365-2559.1983.tb02305.x.
    • (1983) Histopathology , vol.7 , Issue.6 , pp. 907-918
    • Ellabban, N.G.1    Lee, K.W.2
  • 18
    • 0042831330 scopus 로고    scopus 로고
    • Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression
    • Hu B, Wu Z, Phan SH: Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Am J Respir Cell Mol Biol. 2003, 29 (3): 397-404. 10.1165/rcmb.2003-0063OC.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , Issue.3 , pp. 397-404
    • Hu, B.1    Wu, Z.2    Phan, S.H.3
  • 19
    • 33847210725 scopus 로고    scopus 로고
    • Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation
    • Gu L, Zhu Y, Yang X, Guo Z, Xu W, Tian X: Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol Sin. 2007, 28 (3): 382-391. 10.1111/j.1745-7254.2007.00468.x.
    • (2007) Acta Pharmacol Sin , vol.28 , Issue.3 , pp. 382-391
    • Gu, L.1    Zhu, Y.2    Yang, X.3    Guo, Z.4    Xu, W.5    Tian, X.6
  • 21
    • 82755174128 scopus 로고    scopus 로고
    • Genomic Differences Distinguish the Myofibroblast Phenotype of Distal Lung from Airway Fibroblasts
    • Zhou X, Wu W, Hu H, Milosevic J, Konishi K, Kaminski N, Wenzel SE: Genomic Differences Distinguish the Myofibroblast Phenotype of Distal Lung from Airway Fibroblasts. Am J Respir Cell Mol Biol. 2011, 46 (6): 1256-1262. 10.1165/rcmb.2011-0065OC.
    • (2011) Am J Respir Cell Mol Biol , vol.46 , Issue.6 , pp. 1256-1262
    • Zhou, X.1    Wu, W.2    Hu, H.3    Milosevic, J.4    Konishi, K.5    Kaminski, N.6    Wenzel, S.E.7
  • 24
    • 84885407930 scopus 로고    scopus 로고
    • Ca3.1 ameliorates renal fibrosis through the TGF-beta1/Smad pathway in diabetic mice
    • Ca3.1 ameliorates renal fibrosis through the TGF-beta1/Smad pathway in diabetic mice. Diabetes. 2013, 62 (8): 2923-2934. 10.2337/db13-0135.
    • (2013) Diabetes , vol.62 , Issue.8 , pp. 2923-2934
    • Huang, C.1    Shen, S.2    Ma, Q.3    Chen, J.4    Gill, A.5    Pollock, C.A.6    Chen, X.7
  • 26
    • 0035026949 scopus 로고    scopus 로고
    • Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression
    • Ramos C, Montaño M, García-Alvarez J, Ruiz V, Uhal BD, Selman M, Pardo A: Fibroblasts from Idiopathic Pulmonary Fibrosis and Normal Lungs Differ in Growth Rate, Apoptosis, and Tissue Inhibitor of Metalloproteinases Expression. Am J Respir Cell Mol Biol. 2001, 24 (5): 591-598. 10.1165/ajrcmb.24.5.4333.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , Issue.5 , pp. 591-598
    • Ramos, C.1    Montaño, M.2    García-Alvarez, J.3    Ruiz, V.4    Uhal, B.D.5    Selman, M.6    Pardo, A.7
  • 28
    • 13244254138 scopus 로고    scopus 로고
    • Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition
    • Pilewski JM, Liu LX, Henry AC, Knauer AV, Feghali-Bostwick CA: Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am J Pathol. 2005, 166 (2): 399-407. 10.1016/S0002-9440(10)62263-8.
    • (2005) Am J Pathol , vol.166 , Issue.2 , pp. 399-407
    • Pilewski, J.M.1    Liu, L.X.2    Henry, A.C.3    Knauer, A.V.4    Feghali-Bostwick, C.A.5
  • 29
    • 78649742699 scopus 로고    scopus 로고
    • Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced TGF-(beta) Signaling and (alpha)-SMA Expression
    • Pechkovsky DV, Hackett TL, An SS, Shaheen F, Murray LA, Knight DA: Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced TGF-(beta) Signaling and (alpha)-SMA Expression. Am J Respir Cell Mol Biol. 2010, 43 (6): 641-651. 10.1165/rcmb.2009-0318OC.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , Issue.6 , pp. 641-651
    • Pechkovsky, D.V.1    Hackett, T.L.2    An, S.S.3    Shaheen, F.4    Murray, L.A.5    Knight, D.A.6
  • 31
    • 0034608869 scopus 로고    scopus 로고
    • Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant
    • Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG: Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci U S A. 2000, 97 (14): 8151-8156. 10.1073/pnas.97.14.8151.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.14 , pp. 8151-8156
    • Wulff, H.1    Miller, M.J.2    Hansel, W.3    Grissmer, S.4    Cahalan, M.D.5    Chandy, K.G.6
  • 32
    • 0037443501 scopus 로고    scopus 로고
    • ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice
    • Stocker JW, De Franceschi L, McNaughton-Smith GA, Corrocher R, Beuzard Y, Brugnara C: ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003, 101 (6): 2412-2418. 10.1182/blood-2002-05-1433.
    • (2003) Blood , vol.101 , Issue.6 , pp. 2412-2418
    • Stocker, J.W.1    De Franceschi, L.2    McNaughton-Smith, G.A.3    Corrocher, R.4    Beuzard, Y.5    Brugnara, C.6
  • 34
    • 33750019000 scopus 로고    scopus 로고
    • Ca3.1 K+ channels are required for human lung mast cell migration
    • Ca3.1 K+ channels are required for human lung mast cell migration. Thorax. 2006, 61 (10): 880-885. 10.1136/thx.2006.060319.
    • (2006) Thorax , vol.61 , Issue.10 , pp. 880-885
    • Cruse, G.1    Duffy, S.M.2    Brightling, C.E.3    Bradding, P.4
  • 35
    • 43949135885 scopus 로고    scopus 로고
    • Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes
    • Hu L, Pennington M, Jiang Q, Whartenby KA, Calabresi PA: Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes. J Immunol. 2007, 179 (7): 4563-4570. 10.4049/jimmunol.179.7.4563.
    • (2007) J Immunol , vol.179 , Issue.7 , pp. 4563-4570
    • Hu, L.1    Pennington, M.2    Jiang, Q.3    Whartenby, K.A.4    Calabresi, P.A.5
  • 38
    • 78649502848 scopus 로고    scopus 로고
    • Reactive Oxygen Species Are Required for Maintenance and Differentiation of Primary Lung Fibroblasts in Idiopathic Pulmonary Fibrosis
    • Bocchino M, Agnese S, Fagone E, Svegliati S, Grieco D, Vancheri C, Gabrielli A, Sanduzzi A, Avvedimento EV: Reactive Oxygen Species Are Required for Maintenance and Differentiation of Primary Lung Fibroblasts in Idiopathic Pulmonary Fibrosis. Plos One. 2010, 5 (11): e14003-10.1371/journal.pone.0014003.
    • (2010) Plos One , vol.5 , Issue.11
    • Bocchino, M.1    Agnese, S.2    Fagone, E.3    Svegliati, S.4    Grieco, D.5    Vancheri, C.6    Gabrielli, A.7    Sanduzzi, A.8    Avvedimento, E.V.9
  • 39
    • 67651232689 scopus 로고    scopus 로고
    • Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
    • Coward WR, Watts K, Feghali-Bostwick CA, Knox A, Pang L: Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol Cell Biol. 2009, 29 (15): 4325-4339. 10.1128/MCB.01776-08.
    • (2009) Mol Cell Biol , vol.29 , Issue.15 , pp. 4325-4339
    • Coward, W.R.1    Watts, K.2    Feghali-Bostwick, C.A.3    Knox, A.4    Pang, L.5
  • 44
    • 0033780420 scopus 로고    scopus 로고
    • Inactivation of Smad-transforming growth factor beta signaling by Ca2+-calmodulin-dependent protein kinase II
    • Wicks SJ, Lui S, Abdel-Wahab N, Mason RM, Chantry A: Inactivation of Smad-transforming growth factor beta signaling by Ca2+-calmodulin-dependent protein kinase II. Mol Cell Biol. 2000, 20 (21): 8103-8111. 10.1128/MCB.20.21.8103-8111.2000.
    • (2000) Mol Cell Biol , vol.20 , Issue.21 , pp. 8103-8111
    • Wicks, S.J.1    Lui, S.2    Abdel-Wahab, N.3    Mason, R.M.4    Chantry, A.5
  • 45
    • 58149239730 scopus 로고    scopus 로고
    • Phospho-control of TGF-beta superfamily signaling
    • Wrighton KH, Lin X, Feng X: Phospho-control of TGF-beta superfamily signaling. Cell Res. 2009, 19 (1): 8-20. 10.1038/cr.2008.327.
    • (2009) Cell Res , vol.19 , Issue.1 , pp. 8-20
    • Wrighton, K.H.1    Lin, X.2    Feng, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.