Growth and safety evaluation of infant formulae containing oligosaccharides derived from bovine milk: A randomized, double-blind, noninferiority trial

BMC Pediatrics

Volumn 14, Issue 1, 2014, Pages

  Meli, Ferdinando ^a   Puccio, Giuseppe ^a   Cajozzo, Cinzia ^a   Ricottone, Giovanni Licata ^a   Pecquet, Sophie ^b   Sprenger, Norbert ^b   Steenhout, Philippe ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

Bovine milk derived oligosaccharides; Healthy infants; Infant formula; Infant nutrition

Indexed keywords

BOVINE MILK DERIVED OLIGOSACCHARIDE; OLIGOSACCHARIDE; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTHROPOMETRY; ARTICLE; ARTIFICIAL MILK; BACTERIAL COUNT; BIFIDOBACTERIUM LONGUM; BOVINE; CHILD GROWTH; CLINICAL EVALUATION; CLOSTRIDIUM; COLIC; CONFIDENCE INTERVAL; CONTROLLED STUDY; CRYING; DOUBLE BLIND PROCEDURE; ELECTRODIALYSIS; FEMALE; FLATULENCE; HUMAN; INCIDENCE; INFANT; LACTOBACILLUS; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; SAFETY; SALIVATION; VOMITING; WEIGHT GAIN;

EID: 84928674999     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/s12887-014-0306-3     Document Type: Article

References (24)

1. Mountzouris KC, McCartney AL, Gibson GR: Intestinal microflora of human infants and current trends for its nutritional modulation. Br J Nutr 2002, 87:405-420.
2. Salminen SJ, Gueimonde M, Isolauri E: Probiotics that modify disease risk. J Nutr 2005, 135:1294-1298.
3. Newburg DS: Oligosaccharides in human milk and bacterial colonization. J Pediatr Gastroenterol Nutr 2000, 30(Suppl 2):S8-S17.
4. Kalliomaki M, Isolauri E: Role of intestinal flora in the development of allergy. Curr Opin Allergy Clin Immunol 2003, 3:15-20.
5. Gibson GR, Roberfroid MB: Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995, 125:1401-1412.
6. Newburg DS, Ruiz-Palacios GM, Morrow AL: Human milk glycans protect infants against enteric pathogens. Annu Rev Nutr 2005, 25:37-58.
7. Gyorgy P, Jeanloz RW, von Nicolai H, Zilliken F: Undialyzable growth factors for Lactobacillus bifidus var. pennsylvanicus. Protective effect of sialic acid bound to glycoproteins and oligosaccharides against bacterial degradation. Eur J Biochem 1974, 43:29-33.
8. Coppa GV, Pierani P, Zampini L, Carloni I, Carlucci A, Gabrielli O: Oligosaccharides in human milk during different phases of lactation. Acta Paediatr Suppl 1999, 88:89-94.
9. Lawley TD, Walker AW: Intestinal colonization resistance. Immunology 2013, 138:1-11.
10. Ninonuevo MR, Park Y, Yin H, Zhang J, Ward RE, Clowers BH, German JB, Freeman SL, Killeen K, Grimm R, Lebrilla CB: A strategy for annotating the human milk glycome. J Agric Food Chem 2006, 54:7471-7480.
11. Stahl B, Thurl S, Zeng J, Karas M, Hillenkamp F, Steup M, Sawatzki G: Oligosaccharides from human milk as revealed by matrix-assisted laser desorption/ionization mass spectrometry. Anal Biochem 1994, 223:218-226.
12. Ward RE, Ninonuevo M, Mills DA, Lebrilla CB, German JB: In vitro fermentability of human milk oligosaccharides by several strains of bifidobacteria. Mol Nutr Food Res 2007, 51:1398-1405.
13. Sela DA, Chapman J, Adeuya A, Kim JH, Chen F, Whitehead TR, Lapidus A, Rokhsar DS, Lebrilla CB, German JB, Price NP, Richardson PM, Mills DA: The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome. Proc Natl Acad Sci U S A 2008, 105:18964-18969.
14. Barile D, Tao N, Lebrilla CB, Coisson JD, Arlorio M, German JB: Permeate from cheese whey ultrafiltration is a source of milk oligosaccharides. Int Dairy J 2009, 19:524-530.
15. Gopal PK, Gill HS: Oligosaccharides and glycoconjugates in bovine milk and colostrum. Br J Nutr 2000, 84(Suppl 1):S69-S74.
16. Martin-Sosa S, Martin MJ, Garcia-Pardo LA, Hueso P: Sialyloligosaccharides in human and bovine milk and in infant formulae: variations with the progression of lactation. J Dairy Sci 2003, 86:52-59.
17. Zivkovic AM, Barile D: Bovine milk as a source of functional oligosaccharides for improving human health. Adv Nutr 2011, 2:284-289.
18. Austin S, Bénet T, Michaud J, Cuany D, Rohfritsch P. Determination of ß-galactooligosaccharides by liquid chromatography. Int J Anal Chem 2014, Article ID 768406, http://dx.doi.org/10.1155/2014/768406.
19. Savino F, Cordisco L, Tarasco V, Palumeri E, Calabrese R, Oggero R, Roos S, Matteuzzi D: Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial. Pediatrics 2010, 126:e526-e533.
20. US Food and Drug Administration: Clinical testing of infant formulas with respect to nutritional suitability for term infants [http://www.fda. gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/ InfantFormula/ucm170649.htm]
21. Puccio G, Cajozzo C, Meli F, Rochat F, Grathwohl D, Steenhout P: Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition 2007, 23:1-8.
22. World Health Organization Multicenter Growth Reference Study Group: Length/height-for-age, weight-for-age, weight-for-length, weight-forheight and body mass index-for-age: methods and development [http://www.who.int/childgrowth/standards/technical_report/en/]
23. Boehm G, Fanaro S, Jelinek J, Stahl B, Marini A: Prebiotic concept for infant nutrition. Acta Paediatr Suppl 2003, 91:64-67.
24. Knol J, Scholtens P, Kafka C, Steenbakkers J, Gro S, Helm K, Klarczyk M, Schopfer H, Bockler HM, Wells J: Colon microflora in infants fed formula with galacto-and fructo-oligosaccharides: more like breastfed infants. J Pediatr Gastroenterol Nutr 2005, 40:36-42.