Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway

Journal of Ethnopharmacology

Volumn 168, Issue , 2015, Pages 349-355

  Ma, Chunhua ^a   Zhu, Lingpeng ^a   Wang, Jing ^a   He, He ^a   Chang, Xiayun ^a   Gao, Jin ^a   Shumin, Wang ^b   Yan, Tianhua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

LPS induced acute lung injury; PI3K Akt mTOR signaling pathway; Taraxacum mongolicum Hand. Mazz

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; HERBACEOUS AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; MYELOPEROXIDASE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; MTOR PROTEIN, MOUSE; PEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; TARGET OF RAPAMYCIN KINASE; WATER;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL COUNTING; CHINA; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; LIPOPOLYSACCHARIDE INDUCED ACUTE LUNG INJURY; LUNG EDEMA; LUNG HOMOGENATE; LUNG LAVAGE; LUNG PARENCHYMA; MEDICINAL PLANT; MOUSE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL; SIGNAL TRANSDUCTION; TARAXACUM MONGOLICUM; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DANDELION; DRUG EFFECTS; LEUKOCYTE COUNT; LUNG; METABOLISM; PATHOLOGY; PHYTOTHERAPY;

ANIMALIA; MUS; TARAXACUM MONGOLICUM;

ACUTE LUNG INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; FEMALE; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; LUNG; MICE, INBRED BALB C; PEROXIDASE; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TARAXACUM; TOR SERINE-THREONINE KINASES; WATER;

EID: 84928633983     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.03.068     Document Type: Article

References (24)

1. Aboudoulatif In vivo and in vitro toxicological evaluation of the hydroalcoholic leaf extract of Ageratum conyzoides L. (Asteraceae) J. Ethnopharmacol. 155 2014 1214 1218
2. V.U. Ahmad, S. Yasmeen, Z. Ali, M.A. Khan, M.I. Choudhary, F. Akhtar, G.A. Miana, and M. Zahid Taraxacin, a new guaianolide from Taraxacum wallichii J. Nat. Prod. 63 2000 1010 1011
3. V. Bhatia, H.M. Swami, and A.P. Kaur An intervention study to enhance AIDS awareness among underprivileged population in Chandigarh Indian J. Dermatol. Venereol. Leprol. 70 2 2004 87 91
4. P.P. Bradley, D.A. Priebat, R.D. Christensen, and G. Rothstein Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker J. Investig. Dermatol. 78 1982 206 209
5. Z. Chen, X. Zhang, X. Chu, X. Zhang, K. Song, Y. Jiang, L. Yu, and X. Deng Preventive effects of valnemulin on lipopolysaccharide induced acute lung injury in mice Inflammation 33 2010 306 314
6. J.A. Deane, and D.A. Fruman Phosphoinositide 3-kinase: diverse roles in immune cell activation Annu. Rev. Immunol. 22 2004 563 598
7. I.A. Giebelen, D.J. van Westerloo, G.J. LaRosa, A.F. de Vos, and T. van der Poll Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung Shock 28 2007 700 703
8. H.J. Jeon, H.J. Kang, H.J. Jung, Y.S. Kang, C.J. Lim, Y.M. Kim, and E.H. Park Antiinflammatory activity of Taraxacum officinale J. Ethnopharmacol. 115 2008 82 88
9. R. Katso, K. Okkenhaug, K. Ahmadi, S. White, J. Timms, and M.D. Waterfield Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer Annu. Rev. Cell Dev. Biol. 17 2001 615 675
10. Y. Kumazawa, K. Kawaguchi, and H. Takimoto Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha Curr. Pharm. Des. 12 2006 4271 4279
11. Y.L. Leu, Y.L. Wang, S.C. Huang, and L.S. Shi Chemical constituents from roots of Taraxacum formosanum Chem. Pharm. Bull. 53 2005 853 885
12. Song Minjung, and Park Hye-Jin Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages J. Ethnopharmacol. 154 2014 311 318
13. N. Nanashima, M. Akita, T. Yamada, T. Shimizu, H. Nakano, and Y. Fan The hairless phenotype of the Hirosaki hairless rat is due to the deletion of an 80-kb genomic DNA containing five basic keratin genes J. Biol. Chem. 283 2008 16868 16875
14. M.V. Parsey, R. Tuder, and E. Abraham Neutrophils are major contributors to intraparenchymal lung IL-1β expression after hemorrhage and endotoxemia J. Immunol. 160 1998 1007 1110
15. G.D. Rubenfeld Epidemiology of acute lung injury Crit. Care Med. 31 2003 S276 S284
16. M.D. Säemann, M. Haidinger, M. Hecking, W.H. Hörl, and T. Weichhart The multifunctional role of mTOR in innate immunity: implications for transplant immunity Am. J. Transplant. 9 12 2009 2655 2661
17. K. Schütz, R. Carle, and A. Schieber Taraxacum-a review on its phytochemical and pharmacological profile J. Ethnopharmacol. 107 2006 313 323
18. S.W. Seo, H.N. Koo, H.J. An, K.B. Kwon, B.C. Lim, E.A. Seo, D.G. Ryu, G. Moon, H.Y. Kim, H.M. Kim, and S.H. Hong Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats World J. Gastroenterol. 11 2005 597 599
19. R. Shenkar, and E. Abraham Mechanisms of lung neutrophil activation after hemorrhage or endotoxemia: roles of reactive oxygen intermediates, NF-κB, and cyclic AMP response element binding protein J. Immunol. 163 1999 954 962
20. T. Weichhart, and M.D. Säemann The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications Ann. Rheum. Dis. 67 2008 i70 i74
21. G.S. Worthen, C. Haslett, and A.J. Rees Neutrophil-mediated pulmonary vascular injury: synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimulion vascular permeability and neutrophil sequestration in the lung Am. Rev. Respir. Dis. 136 1987 19 28
22. F.u. Yunhe, L.i.u. Bo, and Feng Xiaosheng The effect of magnolol on the toll-like receptor 4/nuclear factor kappa B signaling pathway in lipopolysaccharide-induced acute lung injury in mice Eur. J. Pharmacol. 689 2012 255 261
23. Tianzhu Zhang, Y. Shihai, and D. Juan The effects of morin on lipopolysaccharide-induced acute lung injury by suppressing the lung NLRP3 inflammasome Inflammation 37 6 2014 1976 1983 2014
24. J. Zhan, Y. Wang, and C. Wang Protective effects of penehyclidine hydrochloride on septic mice and its mechanism Shock 28 2007 727 732