Higenamine 4′-O-β-d-glucoside in the lotus plumule induces glucose uptake of L6 cells through β2-adrenergic receptor

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3317-3321

  Kato, Eisuke ^a   Inagaki, Yosuke ^b   Kawabata, Jun ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Research and Development Department Nippon Supplement Inc   (Japan)

Author keywords

Diabetes mellitus; Glucose uptake; Hypoglycemic effect; Nelumbo nucifera Gaertn.; 2 Adrenergic receptor agonist

Indexed keywords

ANTIDIABETIC AGENT; BETA 2 ADRENERGIC RECEPTOR; HIGENAMINE 4' O BETA DEXTRO GLUCOSIDE; INSULIN; METHANOL; NELUMBO NUCIFERA EXTRACT; UNCLASSIFIED DRUG; (6-(4-(2-PIPERIDIN-1-YLETHOXY)PHENYL))-3-PYRIDIN-4-YLPYRAZOLO(1,5-A)PYRIMIDINE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALKALOID; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHROMONE DERIVATIVE; GLUCOSE; GLUCOSIDE; HIGENAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROPRANOLOL; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GLUCOSE TRANSPORT; MYOTUBE; NELUMBO NUCIFERA; PLANT SEED; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; NELUMBO; SKELETAL MUSCLE CELL;

NELUMBO NUCIFERA;

ADRENERGIC ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ALKALOIDS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE; CHROMONES; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSIDES; HYPOGLYCEMIC AGENTS; MICE; MORPHOLINES; MUSCLE FIBERS, SKELETAL; NELUMBO; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT EXTRACTS; PROPRANOLOL; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; RECEPTORS, ADRENERGIC, BETA-2; SEEDS; SIGNAL TRANSDUCTION; TETRAHYDROISOQUINOLINES;

EID: 84928631947     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.054     Document Type: Article

References (19)

1. R. Retnakaran, C.A. Cull, K.I. Thorne, A.I. Adler, and R.R. Holman Diabetes 55 2006 1832
2. I.M. Stratton, A.I. Adler, H.A. Neil, D.R. Matthews, S.E. Manley, C.A. Cull, D. Hadden, R.C. Turner, and R.R. Holman BMJ 321 2000 405
3. C.S. Fox, S. Coady, P.D. Sorlie, D. Levy, J.B. Meigs, R.B.D. Agostino, P.W.F. Wilson, and P.J. Savage JAMA 292 2004 2495
4. S.S. Mani, I.P. Subramanian, S.S. Pillai, and K. Muthusamy Biol. Trace Elem. Res. 138 2010 226
5. P.K. Mukherjee, D. Mukherjee, A.K. Maji, S. Rai, and M. Heinrich J. Pharm. Pharmacol. 61 2009 407
6. C.-M. Liu, C.-L. Kao, H.-M. Wu, W.-J. Li, C.-T. Huang, H.-T. Li, and C.-Y. Chen Molecules 19 2014 17829
7. P.K. Mukherjee, K. Saha, M. Pal, and B.P. Saha J. Ethnopharmacol. 58 1997 207
8. T. Zhou, D. Luo, X. Li, and Y. Luo J. Med. Plants Res. 3 2009 290
9. C.F. Huang, Y.W. Chen, C.Y. Yang, H.Y. Lin, T. Way, W. Chiang, and S.H. Liu J. Agric. Food Chem. 59 2011 1087
10. H.P. Wu, T.N. Lu, N.Y. Hsu, and C.C. Chang Eur. J. Org. Chem. 2013 2013 2898
11. V.R. Hegde, P. Dai, C. Ladislaw, M.G. Patel, M.S. Puar, and J.A. Pachter Bioorg. Med. Chem. Lett. 7 1997 1207
12. N. Yamamoto, T. Sato, K. Kawasaki, S. Murosaki, and Y. Yamamoto Anal. Biochem. 351 2006 139
13. Y. Kashiwada, A. Aoshima, Y. Ikeshiro, Y.P. Chen, H. Furukawa, M. Itoigawa, T. Fujioka, K. Mihashi, L.M. Cosentino, S.L. Morris-Natschke, and K.H. Lee Bioorg. Med. Chem. 13 2005 443
14. H. Koshiyama, H. Ohkuma, H. Kawaguchi, H.-Y. Hsu, and Y.-P. Chen Chem. Pharm. Bull. (Tokyo) 18 1970 2564
15. T. Pesnot, M.C. Gershater, J.M. Ward, and H.C. Hailes Chem. Commun. (Camb) 2011 3242
16. A.J. Tilley, S.D. Zanatta, C.X. Qin, I.K. Kim, Y.M. Seok, A. Stewart, O.L. Woodman, and S.J. Williams Bioorg. Med. Chem. 20 2012 2353
17. J. Nevzorova, T. Bengtsson, B.A. Evans, and R.J. Summers Br. J. Pharmacol. 137 2002 9
18. J. Nevzorova, B.A. Evans, T. Bengtsson, and R.J. Summers Br. J. Pharmacol. 147 2006 446
19. M. Sato, N. Dehvari, A.I. Oberg, O.S. Dallner, A.L. Sandström, J.M. Olsen, R.I. Csikasz, R.J. Summers, D.S. Hutchinson, and T. Bengtsson Diabetes 63 2014 4115