2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: Vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2353-2361

  Tilley, Andrew J ^a   Zanatta, Shannon D ^a   Qin, Cheng Xue ^b   Kim, In Kyeom ^c   Seok, Young Mi ^c   Stewart, Alastair ^b   Woodman, Owen L ^d   Williams, Spencer J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Kyungpook National University School of Medicine   (South Korea)

^d RMIT UNIVERSITY   (Australia)

Author keywords

Kinase inhibitor; Phytoestrogens; Polyphenols; Vascular pharmacology

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 (4 TERT BUTYLDIMETHYLSILOXYPHENYL)ACETALDEHYDE; 2 MORPHOLINOISOFLA 3 ENE DERIVATIVE; 3 (4' HYDROXYPHENYL)CHROMAN; 4 BENZYLOXYPHENYLACETALDEHYDE; 4' BENZYLOXY 2 MORPHOLINOISOFLAV 3 ENE; 4'7 DI TERT BUTYLDIMETHYLSILYLOXY 2 MORPHOLINOISOFLAV 3 ENE; 4'7 DI TERT BUTYLDIMETHYLSILYLOXYISOFLAV 3 ENE; 4'7 DIBENZYLOXY 2 MORPHOLINOISOFLAV 3 ENE; 7 BENZYLOXY 2 MORPHOLINOISOFLAV 3 ENE; 7 HYDROXY 3 PHENYLCHROMAN; ACETALDEHYDE; EQUOL; ESTROGEN RECEPTOR; FULVESTRANT; IDRONOXIL; ISOFLAV 2 ENE; ISOFLAVAN; ISOFLAVAN DERIVATIVE; ISOFLAVENE; ISOFLAVENE DERIVATIVE; ISOFLAVONE DERIVATIVE; ISOPHENOXODIOL; MORPHOLINE; PHENYLACETALDEHYDE; PHENYLEPHRINE; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SALICYLALDEHYDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DEOXYGENATION; DISEASE COURSE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROXYLATION; MALE; NONHUMAN; ONE POT SYNTHESIS; OXYGENATION; POLYMERIZATION; RAT; STRUCTURE ACTIVITY RELATION; VASOCONSTRICTION; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; EQUOL; ISOFLAVONES; MALE; MORPHOLINES; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RHO-ASSOCIATED KINASES; VASOCONSTRICTION; VASODILATOR AGENTS;

RATTUS;

EID: 84863418623     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.008     Document Type: Article

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