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Volumn 26, Issue , 2015, Pages 24-31

Toxoplasma's ways of manipulating the host transcriptome via secreted effectors

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANE PROTEIN; CELL PROTEIN; GLUCOCORTICOID; GRA16 PROTEIN; GRA24 PROTEIN; ROP16 PROTEIN; STAT1 PROTEIN; TRANSCRIPTOME; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

EID: 84928608634     PISSN: 13695274     EISSN: 18790364     Source Type: Journal    
DOI: 10.1016/j.mib.2015.04.003     Document Type: Review
Times cited : (68)

References (38)
  • 1
    • 80054792189 scopus 로고    scopus 로고
    • Toxoplasma gondii effectors are master regulators of the inflammatory response
    • Melo M.B., Jensen K.D., Saeij J.P. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol. 2011, 27:487-495.
    • (2011) Trends Parasitol. , vol.27 , pp. 487-495
    • Melo, M.B.1    Jensen, K.D.2    Saeij, J.P.3
  • 2
    • 84904734509 scopus 로고    scopus 로고
    • Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection
    • Sturge C.R., Yarovinsky F. Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection. Infect Immun. 2014, 82:3090-3097.
    • (2014) Infect Immun. , vol.82 , pp. 3090-3097
    • Sturge, C.R.1    Yarovinsky, F.2
  • 3
    • 84923060802 scopus 로고    scopus 로고
    • The gut mucosal immune response to Toxoplasma gondii
    • Cohen S.B., Denkers E.Y. The gut mucosal immune response to Toxoplasma gondii. Parasite Immunol. 2015, 37:108-117.
    • (2015) Parasite Immunol. , vol.37 , pp. 108-117
    • Cohen, S.B.1    Denkers, E.Y.2
  • 5
    • 34247140278 scopus 로고    scopus 로고
    • Toxoplasma gondii dysregulates IFN-gamma-inducible gene expression in human fibroblasts: insights from a genome-wide transcriptional profiling
    • Kim S.K., Fouts A.E., Boothroyd J.C. Toxoplasma gondii dysregulates IFN-gamma-inducible gene expression in human fibroblasts: insights from a genome-wide transcriptional profiling. J. Immunol. 2007, 178:5154-5165.
    • (2007) J. Immunol. , vol.178 , pp. 5154-5165
    • Kim, S.K.1    Fouts, A.E.2    Boothroyd, J.C.3
  • 6
    • 33846322896 scopus 로고    scopus 로고
    • Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue
    • Saeij J.P., Coller S., Boyle J.P., Jerome M.E., White M.W., Boothroyd J.C. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007, 445:324-327.
    • (2007) Nature , vol.445 , pp. 324-327
    • Saeij, J.P.1    Coller, S.2    Boyle, J.P.3    Jerome, M.E.4    White, M.W.5    Boothroyd, J.C.6
  • 8
    • 84906259458 scopus 로고    scopus 로고
    • Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure
    • Sinclair S.H., Rennoll-Bankert K.E., Dumler J.S. Effector bottleneck: microbial reprogramming of parasitized host cell transcription by epigenetic remodeling of chromatin structure. Front. Genet. 2014, 5:274.
    • (2014) Front. Genet. , vol.5 , pp. 274
    • Sinclair, S.H.1    Rennoll-Bankert, K.E.2    Dumler, J.S.3
  • 9
    • 84897850450 scopus 로고    scopus 로고
    • Pathogens hijack the epigenome: a new twist on host-pathogen interactions
    • Silmon de Monerri N.C., Kim K. Pathogens hijack the epigenome: a new twist on host-pathogen interactions. Am. J. Pathol. 2014, 184:897-911.
    • (2014) Am. J. Pathol. , vol.184 , pp. 897-911
    • Silmon de Monerri, N.C.1    Kim, K.2
  • 10
    • 59849096943 scopus 로고    scopus 로고
    • Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation
    • Leng J., Butcher B.A., Egan C.E., Abi Abdallah D.S., Denkers E.Y. Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation. J. Immunol. 2009, 182:489-497.
    • (2009) J. Immunol. , vol.182 , pp. 489-497
    • Leng, J.1    Butcher, B.A.2    Egan, C.E.3    Abi Abdallah, D.S.4    Denkers, E.Y.5
  • 11
    • 70449568923 scopus 로고    scopus 로고
    • Toxoplasma gondii inhibits covalent modification of histone H3 at the IL-10 promoter in infected macrophages
    • Leng J., Denkers E.Y. Toxoplasma gondii inhibits covalent modification of histone H3 at the IL-10 promoter in infected macrophages. PLoS ONE 2009, 4:e7589.
    • (2009) PLoS ONE , vol.4 , pp. e7589
    • Leng, J.1    Denkers, E.Y.2
  • 13
    • 84867751254 scopus 로고    scopus 로고
    • Modulation of innate immunity by Toxoplasma gondii virulence effectors
    • This excellent review describes how parasite-derived effectors modulate immune responses and likely virulence in mice model
    • Hunter C.A., Sibley L.D. Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat. Rev. Microbiol. 2012, 10:766-778. This excellent review describes how parasite-derived effectors modulate immune responses and likely virulence in mice model.
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 766-778
    • Hunter, C.A.1    Sibley, L.D.2
  • 15
    • 77956538745 scopus 로고    scopus 로고
    • Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6
    • Ong Y.C., Reese M.L., Boothroyd J.C. Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J. Biol. Chem. 2010, 285:28731-28740.
    • (2010) J. Biol. Chem. , vol.285 , pp. 28731-28740
    • Ong, Y.C.1    Reese, M.L.2    Boothroyd, J.C.3
  • 16
    • 84871122856 scopus 로고    scopus 로고
    • Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation
    • Rosowski E.E., Saeij J.P. Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFNγ induced gene expression and STAT1 phosphorylation. PLoS ONE 2012, 7:e51448.
    • (2012) PLoS ONE , vol.7 , pp. e51448
    • Rosowski, E.E.1    Saeij, J.P.2
  • 17
    • 84877835069 scopus 로고    scopus 로고
    • Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15
    • Jensen K.D., Hu K., Whitmarsh R.J., Hassan M.A., Julien L., Lu D., Chen L., Hunter C.A., Saeij J.P. Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect. Immun. 2013, 81:2156-2167.
    • (2013) Infect. Immun. , vol.81 , pp. 2156-2167
    • Jensen, K.D.1    Hu, K.2    Whitmarsh, R.J.3    Hassan, M.A.4    Julien, L.5    Lu, D.6    Chen, L.7    Hunter, C.A.8    Saeij, J.P.9
  • 18
    • 78651504365 scopus 로고    scopus 로고
    • Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein
    • Rosowski E.E., Lu D., Julien L., Rodda L., Gaiser R.A., Jensen K.D., Saeij J.P. Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. J. Exp. Med. 2011, 208:195-212.
    • (2011) J. Exp. Med. , vol.208 , pp. 195-212
    • Rosowski, E.E.1    Lu, D.2    Julien, L.3    Rodda, L.4    Gaiser, R.A.5    Jensen, K.D.6    Saeij, J.P.7
  • 19
    • 84907201011 scopus 로고    scopus 로고
    • Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6
    • The authors show here that previously identified dense granule protein GRA6, known for its association with nanotubular structures in the PV, interacts directly with host Calcium modulating ligand (CAMLG) through its polymorphic C-terminal region to modulate NFAT4 activity. Thus, this paper confirms that vacuolar dense granule proteins could act as parasite-derived effector by altering host gene expression
    • Ma J.S., Sasai M., Ohshima J., Lee Y., Bando H., Takeda K., Yamamoto M. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6. J. Exp. Med. 2014, 211:2013-2032. The authors show here that previously identified dense granule protein GRA6, known for its association with nanotubular structures in the PV, interacts directly with host Calcium modulating ligand (CAMLG) through its polymorphic C-terminal region to modulate NFAT4 activity. Thus, this paper confirms that vacuolar dense granule proteins could act as parasite-derived effector by altering host gene expression.
    • (2014) J. Exp. Med. , vol.211 , pp. 2013-2032
    • Ma, J.S.1    Sasai, M.2    Ohshima, J.3    Lee, Y.4    Bando, H.5    Takeda, K.6    Yamamoto, M.7
  • 20
    • 84900454698 scopus 로고    scopus 로고
    • GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response
    • Shastri A.J., Marino N.D., Franco M., Lodoen M.B., Boothroyd J.C. GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response. Infect. Immun. 2014, 82:2595-2605.
    • (2014) Infect. Immun. , vol.82 , pp. 2595-2605
    • Shastri, A.J.1    Marino, N.D.2    Franco, M.3    Lodoen, M.B.4    Boothroyd, J.C.5
  • 21
    • 84876391823 scopus 로고    scopus 로고
    • Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression
    • This study reports the discovery of GRA16, the first dense granule to be released from the dense granules and exported beyond the vacuole-containing parasites into the host cell nucleus where the protein contributes to reshape the host transcriptome
    • Bougdour A., Durandau E., Brenier-Pinchart M.P., Ortet P., Barakat M., Kieffer S., Curt-Varesano A., Curt-Bertini R.L., Bastien O., Coute Y., Pelloux H., Hakimi M.A. Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression. Cell Host Microbe. 2013, 13:489-500. This study reports the discovery of GRA16, the first dense granule to be released from the dense granules and exported beyond the vacuole-containing parasites into the host cell nucleus where the protein contributes to reshape the host transcriptome.
    • (2013) Cell Host Microbe. , vol.13 , pp. 489-500
    • Bougdour, A.1    Durandau, E.2    Brenier-Pinchart, M.P.3    Ortet, P.4    Barakat, M.5    Kieffer, S.6    Curt-Varesano, A.7    Curt-Bertini, R.L.8    Bastien, O.9    Coute, Y.10    Pelloux, H.11    Hakimi, M.A.12
  • 22
    • 84885444878 scopus 로고    scopus 로고
    • A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
    • This study describes how GRA24, following its release in the host cell, triggers activation of the MAP kinase p38α, leading to a broad inflammatory response which eventually leads to control parasite burden at the site of infection
    • Braun L., Brenier-Pinchart M.P., Yogavel M., Curt-Varesano A., Curt-Bertini R.L., Hussain T., Kieffer-Jaquinod S., Coute Y., Pelloux H., Tardieux I., Sharma A., Belrhali H., Bougdour A., Hakimi M.A. A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation. J. Exp. Med. 2013, 210:2071-2086. This study describes how GRA24, following its release in the host cell, triggers activation of the MAP kinase p38α, leading to a broad inflammatory response which eventually leads to control parasite burden at the site of infection.
    • (2013) J. Exp. Med. , vol.210 , pp. 2071-2086
    • Braun, L.1    Brenier-Pinchart, M.P.2    Yogavel, M.3    Curt-Varesano, A.4    Curt-Bertini, R.L.5    Hussain, T.6    Kieffer-Jaquinod, S.7    Coute, Y.8    Pelloux, H.9    Tardieux, I.10    Sharma, A.11    Belrhali, H.12    Bougdour, A.13    Hakimi, M.A.14
  • 24
    • 84893839615 scopus 로고    scopus 로고
    • Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression
    • Bougdour A., Tardieux I., Hakimi M.A. Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression. Cell. Microbiol. 2014, 16:334-343.
    • (2014) Cell. Microbiol. , vol.16 , pp. 334-343
    • Bougdour, A.1    Tardieux, I.2    Hakimi, M.A.3
  • 26
    • 84885462754 scopus 로고    scopus 로고
    • CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection
    • The authors have identified glucocorticoids as important regulators of Th1 cell responses in mice infected with T. gondii
    • Kugler D.G., Mittelstadt P.R., Ashwell J.D., Sher A., Jankovic D. CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection. J. Exp. Med. 2013, 210:1919-1927. The authors have identified glucocorticoids as important regulators of Th1 cell responses in mice infected with T. gondii.
    • (2013) J. Exp. Med. , vol.210 , pp. 1919-1927
    • Kugler, D.G.1    Mittelstadt, P.R.2    Ashwell, J.D.3    Sher, A.4    Jankovic, D.5
  • 29
    • 79958695985 scopus 로고    scopus 로고
    • Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation
    • This paper demonstrates a cross-talk between a rhoptry protein, ROP16 and a dense granule protein, GRA15 that contributes to macrophage polarization early during Toxoplasma infection.
    • Jensen K.D., Wang Y., Wojno E.D., Shastri A.J., Hu K., Cornel L., Boedec E., Ong Y.C., Chien Y.H., Hunter C.A., Boothroyd J.C., Saeij J.P. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. Cell Host Microbe. 2011, 9:472-483. This paper demonstrates a cross-talk between a rhoptry protein, ROP16 and a dense granule protein, GRA15 that contributes to macrophage polarization early during Toxoplasma infection.
    • (2011) Cell Host Microbe. , vol.9 , pp. 472-483
    • Jensen, K.D.1    Wang, Y.2    Wojno, E.D.3    Shastri, A.J.4    Hu, K.5    Cornel, L.6    Boedec, E.7    Ong, Y.C.8    Chien, Y.H.9    Hunter, C.A.10    Boothroyd, J.C.11    Saeij, J.P.12
  • 32
    • 84902318220 scopus 로고    scopus 로고
    • Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions
    • Hagai T., Azia A., Babu M.M., Andino R. Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions. Cell Rep. 2014, 7:1729-1739.
    • (2014) Cell Rep. , vol.7 , pp. 1729-1739
    • Hagai, T.1    Azia, A.2    Babu, M.M.3    Andino, R.4
  • 33
    • 84904469894 scopus 로고    scopus 로고
    • A million peptide motifs for the molecular biologist
    • Tompa P., Davey N.E., Gibson T.J., Babu M.M. A million peptide motifs for the molecular biologist. Mol. Cell. 2014, 55:161-169.
    • (2014) Mol. Cell. , vol.55 , pp. 161-169
    • Tompa, P.1    Davey, N.E.2    Gibson, T.J.3    Babu, M.M.4
  • 34
    • 84963980075 scopus 로고    scopus 로고
    • How pathogens use linear motifs to perturb host cell networks
    • Via A., Uyar B., Brun C., Zanzoni A. How pathogens use linear motifs to perturb host cell networks. Trends Biochem. Sci. 2015, 40:36-48.
    • (2015) Trends Biochem. Sci. , vol.40 , pp. 36-48
    • Via, A.1    Uyar, B.2    Brun, C.3    Zanzoni, A.4
  • 35
    • 70350208780 scopus 로고    scopus 로고
    • The evolutionary conundrum of pathogen mimicry
    • Elde N.C., Malik H.S. The evolutionary conundrum of pathogen mimicry. Nat. Rev. Microbiol. 2009, 7:787-797.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 787-797
    • Elde, N.C.1    Malik, H.S.2
  • 36
    • 84924106975 scopus 로고    scopus 로고
    • Systems-based analysis of the Sarcocystis neurona genome identifies pathways that contribute to a heteroxenous life cycle
    • This study presents the first genome sequence of Sarcocystis neurona, a coccidia that develops in host cell cytoplasm without forming a vacuole. S. neurona genome is missing most of the GRA- and ROP-encoding genes and therefore makes a fantastic tool for comparative genomics to identify bona fide Toxoplasma-specific effectors
    • Blazejewski T., Nursimulu N., Pszenny V., Dangoudoubiyam S., Namasivayam S., Chiasson M.A., Chessman K., Tonkin M., Swapna L.S., Hung S.S., Bridgers J., Ricklefs S.M., Boulanger M.J., Dubey J.P., Porcella S.F., Kissinger J.C., Howe D.K., Grigg M.E., Parkinson J. Systems-based analysis of the Sarcocystis neurona genome identifies pathways that contribute to a heteroxenous life cycle. MBio 2015, 6:e02445-e2514. This study presents the first genome sequence of Sarcocystis neurona, a coccidia that develops in host cell cytoplasm without forming a vacuole. S. neurona genome is missing most of the GRA- and ROP-encoding genes and therefore makes a fantastic tool for comparative genomics to identify bona fide Toxoplasma-specific effectors.
    • (2015) MBio , vol.6 , pp. e02445-e2514
    • Blazejewski, T.1    Nursimulu, N.2    Pszenny, V.3    Dangoudoubiyam, S.4    Namasivayam, S.5    Chiasson, M.A.6    Chessman, K.7    Tonkin, M.8    Swapna, L.S.9    Hung, S.S.10    Bridgers, J.11    Ricklefs, S.M.12    Boulanger, M.J.13    Dubey, J.P.14    Porcella, S.F.15    Kissinger, J.C.16    Howe, D.K.17    Grigg, M.E.18    Parkinson, J.19
  • 37
    • 84897438251 scopus 로고    scopus 로고
    • Infection by Toxoplasma gondii specifically induces host c-Myc and the genes this pivotal transcription factor regulates
    • Franco M., Shastri A.J., Boothroyd J.C. Infection by Toxoplasma gondii specifically induces host c-Myc and the genes this pivotal transcription factor regulates. Eukaryot. Cell. 2014, 13:483-493.
    • (2014) Eukaryot. Cell. , vol.13 , pp. 483-493
    • Franco, M.1    Shastri, A.J.2    Boothroyd, J.C.3
  • 38
    • 53649111607 scopus 로고    scopus 로고
    • Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor
    • Phelps E.D., Sweeney K.R., Blader I.J. Toxoplasma gondii rhoptry discharge correlates with activation of the early growth response 2 host cell transcription factor. Infect. Immun. 2008, 76:4703-4712.
    • (2008) Infect. Immun. , vol.76 , pp. 4703-4712
    • Phelps, E.D.1    Sweeney, K.R.2    Blader, I.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.