Preterm cord blood CD4+ T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4+ T cells in bronchopulmonary dysplasia

Human Immunology

Volumn 76, Issue 5, 2015, Pages 329-338

  Misra, Ravi S ^a   Shah, Syed ^a   Fowell, Deborah J ^b   Wang, Hongyue ^b   Scheible, Kristin ^a   Misra, Sara K ^a   Huyck, Heidie ^a   Wyman, Claire P ^a   Ryan, Rita M ^c   Reynolds, Anne Marie ^d   Mariani, Thomas J ^a,b   Katzman, Philip J ^b   Pryhuber, Gloria S ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY AT BUFFALO   (United States)

Author keywords

Bronchopulmonary dysplasia; CD4+ T cells; Chorioamnionitis; Cord blood mononuclear cell; IL 6

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CD4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL VIABILITY; CHORIOAMNIONITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; GESTATIONAL AGE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFANT; INFLAMMATION; LUNG DYSPLASIA; MONONUCLEAR CELL; OXYGEN CONSUMPTION; PHENOTYPE; PREMATURITY; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD; CELL CULTURE; COMPARATIVE STUDY; FEMALE; FETUS BLOOD; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; NEWBORN; PREGNANCY; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD4; BRONCHOPULMONARY DYSPLASIA; CELLS, CULTURED; CHORIOAMNIONITIS; FEMALE; FETAL BLOOD; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INFANT, NEWBORN; INFLAMMATION MEDIATORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-6; PREGNANCY; PREMATURE BIRTH; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84928585569     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2015.03.007     Document Type: Article

References (53)

1. Fanaroff A.A., et al. Trends in neonatal morbidity and mortality for very low birthweight infants. Am. J. Obstet. Gynecol. 2007, 196(2):147. e1-8.
2. Wong P.M., et al. Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia. Eur. Respir. J. 2008, 32(2):321-328.
3. Baraldi E., et al. Pulmonary function until two years of life in infants with bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 1997, 155(1):149-155.
4. Chan K.N., et al. Lung function in children of low birth weight. Arch. Dis. Child. 1989, 64(9):1284-1293.
5. Kennedy J.D., et al. Effects of birthweight and oxygen supplementation on lung function in late childhood in children of very low birth weight. Pediatr. Pulmonol. 2000, 30(1):32-40.
6. M. Sell, et al., One-year follow-up of 273 infants with birth weights of 700 to 1100 grams after prophylactic treatment of respiratory distress syndrome with synthetic surfactant or air placebo, American Exosurf Neonatal Study Group I, J. Pediatr. 126(5 Pt 2) (1995) pp. S20-S25.
7. Jobe A.H., Ikegami M. Prevention of bronchopulmonary dysplasia. Curr. Opin. Pediatr. 2001, 13(2):124-129.
8. Gigley J.P., et al. T cell exhaustion in protozoan disease. Trends Parasitol. 2012, 28(9):377-384.
9. Lee D.C., et al. CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J. Virol. 2010, 84(17):8790-8798.
10. Murai M., et al. Regulatory T-cell stability and plasticity in mucosal and systemic immune systems. Mucosal Immunol. 2010, 3(5):443-449.
11. Akbari O., et al. Role of regulatory T cells in allergy and asthma. Curr. Opin. Immunol. 2003, 15(6):627-633.
12. Dirix V., Vermeulen F., Mascart F. Maturation of CD4+ regulatory T lymphocytes and of cytokine secretions in infants born prematurely. J. Clin. Immunol. 2013, 33(6):1126-1133.
13. Takahata Y., et al. CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp. Hematol. 2004, 32(7):622-629.
14. Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 2003, 4(4):330-336.
15. Liu M.F., et al. Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand. J. Immunol. 2004, 59(2):198-202.
16. Sakaguchi S., et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001, 182:18-32.
17. Viscardi R.M., et al. Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants. Pediatr. Res. 2004, 55(6):1009-1017.
18. Hartling L., Liang Y., Lacaze-Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch. Dis. Child. Fetal Neonatal Ed. 2012, 97(1):F8-F17.
19. Goldenberg R.L., Hauth J.C., Andrews W.W. Intrauterine infection and preterm delivery. N. Engl. J. Med. 2000, 342(20):1500-1507.
20. Stevens T.P., et al. Effect of cumulative oxygen exposure on respiratory symptoms during infancy among VLBW infants without bronchopulmonary dysplasia. Pediatr. Pulmonol. 2010, 45(4):371-379.
21. Van Marter L.J., et al. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J. Pediatr. 2002, 140(2):171-176.
22. Aghai Z.H., et al. Impact of histological chorioamnionitis on tracheal aspirate cytokines in premature infants. Am. J. Perinatol. 2012, 29(7):567-572.
23. Watterberg K.L., et al. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 1996, 97(2):210-215.
24. Kallapur S.G., et al. Intra-amniotic IL-1beta induces fetal inflammation in rhesus monkeys and alters the regulatory T cell/IL-17 balance. J. Immunol. 2013, 191(3):1102-1109.
25. Wolfs T.G., et al. IL-1alpha mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut. PLoS ONE 2011, 6(3):e18355.
26. Xiong H., Zhou C., Qi G. Proportional changes of CD4+CD25+Foxp3+ regulatory T cells in maternal peripheral blood during pregnancy and labor at term and preterm. Clin. Invest. Med. 2010, 33(6):E422.
27. Camperio C., et al. CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes. Immunol. Lett. 2014, 158(1-2):134-142.
28. Baker P.J., et al. CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect. Immun. 1999, 67(6):2804-2809.
29. Linhares U.C., et al. The ex vivo production of IL-6 and IL-21 by CD4+ T cells is directly associated with neurological disability in neuromyelitis optica patients. J. Clin. Immunol. 2013, 33(1):179-189.
30. Scheible K., et al. Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection. Cytometry A 2012, 81(11):937-949.
31. Diggle P.J., Liang K.Y., Zeger S.L. Analysis of Longitudinal Data 1994, Oxford University Press.
32. Jobe A.H., Bancalari E. Bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 2001, 163(7):1723-1729.
33. Tita A.T., Andrews W.W. Diagnosis and management of clinical chorioamnionitis. Clin. Perinatol. 2010, 37(2):339-354.
34. Newton E.R. Chorioamnionitis and intraamniotic infection. Clin. Obstet. Gynecol. 1993, 36(4):795-808.
35. Greenberg M.B., et al. A first look at chorioamnionitis management practice variation among US obstetricians. Infect. Dis. Obstet. Gynecol. 2012, 2012:628362.
36. Smulian J.C., et al. Clinical chorioamnionitis and histologic placental inflammation. Obstet. Gynecol. 1999, 94(6):1000-1005.
37. Gotsch F., et al. The fetal inflammatory response syndrome. Clin. Obstet. Gynecol. 2007, 50(3):652-683.
38. Yoon B.H., et al. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am. J. Obstet. Gynecol. 1997, 177(4):825-830.
39. Durant L.R., et al. Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice. J. Virol. 2013, 87(20):10946-10954.
40. Yi J.S., Cox M.A., Zajac A.J. T-cell exhaustion: characteristics, causes and conversion. Immunology 2010, 129(4):474-481.
41. Zhang F., et al. Elevated IL-6 receptor expression on CD4+ T cells contributes to the increased Th17 responses in patients with chronic hepatitis B. Virol. J. 2011, 8:270.
42. Boyce T.G., et al. Rates of hospitalization for respiratory syncytial virus infection among children in medicaid. J. Pediatr. 2000, 137(6):865-870.
43. Juntti H., et al. Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection. J. Allergy Clin. Immunol. 2009, 124(1):52-58. e1-2.
44. Carbonell-Estrany X., et al. Rehospitalization because of respiratory syncytial virus infection in premature infants younger than 33 weeks of gestation: a prospective study. IRIS Study Group. Pediatr. Infect. Dis. J. 2000, 19(7):592-597.
45. Horn S.D., Smout R.J. Effect of prematurity on respiratory syncytial virus hospital resource use and outcomes. J. Pediatr. 2003, 143(5 Suppl):S133-S141.
46. Luciano A.A., et al. Preterm labor and chorioamnionitis are associated with neonatal T cell activation. PLoS ONE 2011, 6(2):e16698.
47. Hughson A., et al. Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes 2011, 60(8):2125-2133.
48. Herrath J., et al. The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function. Eur. J. Immunol. 2011, 41(8):2279-2290.
49. Weitkamp J.H., et al. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut 2013, 62(1):73-82.
50. Dingle B.M., et al. FoxP3(+) regulatory T cells attenuate experimental necrotizing enterocolitis. PLoS ONE 2013, 8(12):e82963.
51. Ge Q., et al. Naive to memory T-cell differentiation during homeostasis-driven proliferation. Microbes Infect. 2002, 4(5):555-558.
52. Sheu T.T., et al. Premature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic mice. PLoS ONE 2014, 9(2):e89379.
53. Sauce D., et al. Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults. J. Immunol. 2012, 189(12):5541-5548.