Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 17, 2015, Pages E2245-E2252

  Kaplan, Anna ^a   Gaschler, Michael M ^a   Dunn, Denise E ^b   Colligan, Ryan ^a   Brown, Lewis M ^a   Iii, Arthur G Palmer ^a   Lo, Donald C ^b   Stockwell, Brent R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Drug; Inhibitor; Neuroprotection; Protein disulfide isomerase; Small molecule

Indexed keywords

CYTOCHROME P450; HUNTINGTIN; ISOMERASE INHIBITOR; LEAD OPTIMIZED COMPOUND 14; NEUROPROTECTIVE AGENT; PROTEIN DISULFIDE ISOMERASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HTT PROTEIN, HUMAN; NERVE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN SLICE; CELL CULTURE; CELL VIABILITY; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG OXIDATION; DRUG POTENCY; DRUG STABILITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; INTRINSIC CLEARANCE; ISOTHERMAL TITRATION CALORIMETRY; LIVER MICROSOME; MICROSOME; MOUSE; NEUROLOGIC DISEASE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OXIDATION KINETICS; OXIDATION REDUCTION REACTION; PC12 CELL LINE; PLASMA; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; SINGLE DRUG DOSE; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; CORPUS STRIATUM; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALIA;

ANIMALS; CATALYTIC DOMAIN; CORPUS STRIATUM; ENZYME INHIBITORS; MICE; MICROSOMES, LIVER; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; PC12 CELLS; PROTEIN DISULFIDE-ISOMERASES; RATS;

EID: 84928579889     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1500439112     Document Type: Article

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