Updates in the perioperative and emergency management of non-vitamin K antagonist oral anticoagulants

Critical Care

Volumn 19, Issue 1, 2015, Pages

  Faraoni, David ^a   Levy, Jerrold H ^b   Albaladejo, Pierre ^c   Samama, Charles Marc ^d   Jebara, Samia ^e   Steib, Annick ^e   Godier, Anne ^e   Pernod, Gilles ^e   Belisle, Sylvain ^e   Blais, Normand ^e   Bonhomme, Fanny ^e   Borel Derlon, Annie ^e   Borg, Jeanne Yvonne ^e   Bosson, Jean Luc ^e   Collet, Jean Philippe ^e   Maistre, Emmanuel De ^e   Moerloose, Philippe De ^e   Fontana, Pierre ^e   Gruel, Yves ^e   Guay, Joanne ^e   Huet, Yann ^e   Ickx, Brigitte ^e   Jude, Brigitte ^e   Lasne, Dominique ^e   Longrois, Dan ^e   Hardy, Jean François ^e   Marret, Emmanuel ^e   Mismetti, Patrick ^e   Motte, Serge ^e   Nathan, Nathalie ^e   Rosencher, Nadia ^e   Jesel Morel, Laurence ^e   Schved, Jean Francois ^e   Schlumberger, Sylvie ^e   Sie, Pierre ^e   Susen, Sophie ^e   Van der Linden, Philippe ^e   Vincentelli, André ^e   Zufferey, Paul ^e   Cohen, Ariel ^e   Llau Pitarch, Juan V ^e   Vanbelle, Eric ^e   Legal, Gregoire ^e   Laporte, Sylvie ^e   Lecompte, Thomas Pierre ^e   Ozier, Yves ^e   Nguyen, Philippe ^e   Roullet, Stephanie ^e   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GRENOBLE UNIVERSITY HOSPITAL   (France)

^d Institut Cochin   (France)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; ANTICOAGULANT AGENT; ANTIDOTE; APIXABAN; DABIGATRAN ETEXILATE; PROTHROMBIN COMPLEX; RIVAROXABAN; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE; VITAMIN K GROUP;

ANTICOAGULATION; ARTICLE; BLEEDING; EMERGENCY CARE; HUMAN; INTRAOPERATIVE PERIOD; NONHUMAN; OPERATIVE BLOOD LOSS; PERIOPERATIVE PERIOD; POSTOPERATIVE HEMORRHAGE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RISK ASSESSMENT; ANTAGONISTS AND INHIBITORS; HEMORRHAGE; MEDICATION THERAPY MANAGEMENT; PROCEDURES; STOMATOLOGY; TRENDS;

ANTICOAGULANTS; ANTITHROMBINS; FACTOR XA INHIBITORS; HEMORRHAGE; HUMANS; MEDICATION THERAPY MANAGEMENT; ORAL MEDICINE; PERIOPERATIVE CARE; PYRAZOLES; PYRIDONES; RIVAROXABAN; VITAMIN K;

EID: 84928572910     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-015-0930-9     Document Type: Article

References (41)

1. Levy JH, Key NS, Azran MS. Novel oral anticoagulants: implications in the perioperative setting. Anesthesiology. 2010;113:726-45.
2. Levy JH, Faraoni D, Spring JL, Douketis JD, Samama CM. Managing new oral anticoagulants in the perioperative and intensive care unit setting. Anesthesiology. 2013;118:1466-74.
3. Majeed A, Hwang HG, Connolly SJ, Eikelboom JW, Ezekowitz MD, Wallentin L, et al. Management and outcomes of major bleeding during treatment with dabigatran or warfarin. Circulation. 2013;128:2325-32.
4. Beyer-Westendorf J, Forster K, Pannach S, Ebertz F, Gelbricht V, Thieme C, et al. Rates, management and outcome of bleeding complications during rivaroxaban therapy in daily care: results from the Dresden NOAC registry. Blood. 2014;124:955-62.
5. Healey JS, Eikelboom J, Douketis J, Wallentin L, Oldgren J, Yang S, et al. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial. Circulation. 2012;126:343-8.
6. Beyer-Westendorf J, Gelbricht V, Förster K, Ebertz F, Köhler C, Werth S, et al. Peri-interventional management of novel oral anticoagulants in daily care: results from the prospective Dresden NOAC registry. Eur Heart J. 2014;35:1888-96.
7. Levy JH. Role of coagulation factor concentrates for reversing dabigatran-related anticoagulation. Anesthesiology. 2014;120:1316-8.
8. Faraoni D, Samama CM, Ranucci M, Dietrich W, Levy J. Perioperative management of new oral anticoagulants: an international survey. Clinics Lab Med. 2014;34:637-54.
9. Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, et al. European Heart Rhythm Association practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace. 2013;15:625-51.
10. Stangier J, Rathgen K, Stähle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet. 2010;49:259-68.
11. Reilly PA, Lehr T, Haertter S, Connolly SJ, Yusuf S, Eikelboom JW, et al. The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY trial (Randomized Evaluation of Long-Term Anticoagulation Therapy). J Am Coll Cardiol. 2014;63:321-8.
12. Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, et al. Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (Randomized Evaluation of Long-term Anticoagulation Therapy) trial analysis. Circulation. 2014;129:961-70.
13. Kubitza D, Becka M, Mueck W, Halabi A, Maatouk H, Klause N, et al. Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor. Br J Clin Pharmacol. 2010;70:703-12.
14. Jungbauer L, Dobias C, Stöllberger C, Weidinger F. The frequency of prescription of P-glycoprotein-affecting drugs in atrial fibrillation. J Thromb Haemost. 2010;8:2069-70.
15. Kozek-Langenecker SA, Afshari A, Albaladejo P, Santullano CA, De Robertis E, Filipescu DC, et al. Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol. 2013;30:270-382.
16. Sié P, Samama CM, Godier A, Rosencher N, Steib A, Llau JV, et al. Surgery and invasive procedures in patients on long-term treatment with direct oral anticoagulants: thrombin or factor-Xa inhibitors. Recommendations of the Working Group on Perioperative Haemostasis and the French Study Group on Thrombosis and Haemostasis. Arch Cardiovasc Dis. 2013;106:382-93.
17. Baron TH, Kamath PS, McBane RD. Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med. 2013;368:2113-24.
18. Ferrandis R, Castillo J, de Andres J, Gomar C, Gomez-Luque A, Hidalgo F, et al. The perioperative management of new direct oral anticoagulants: a question without answers. Thromb Haemost. 2013;110:515-22.
19. Makris M, Van Veen JJ, Tait CR, Mumford AD, Laffan M. British Committee for Standards in Haematology. Guideline on the management of bleeding in patients on antithrombotic agents. Br J Haematol. 2013;160:35-46.
20. Lazo-Langner A, Lang ES, Douketis J. Clinical review: Clinical management of new oral anticoagulants: a structured review with emphasis on the reversal of bleeding complications. Crit Care. 2013;17:230.
21. Hawes EM, Deal AM, Funk-Adcock D, Gosselin R, Jeanneret C, Cook AM, et al. Performance of coagulation tests in patients on therapeutic doses of dabigatran: a cross-sectional pharmacodynamic study based on peak and trough plasma levels. J Thromb Haemost. 2013;11:1493-502.
22. Becker RC, Yang H, Barrett Y, Mohan P, Wang J, Wallentin L, et al. Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban - an oral, direct and selective factor Xa inhibitor. J Thromb Thrombolysis. 2011;32:183-7.
23. Pernod G, Albaladejo P, Godier A, Samama CM, Susen S, Gruel Y, et al. Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or factor-Xa inhibitors: proposals of the Working Group on Perioperative Haemostasis (GIHP) - March 2013. Arch Cardiovasc Dis. 2013;106:382-93.
24. Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis. 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;14:e227S-77S.
25. Lee FM, Chan AK, Lau KK, Chan HH. Reversal of new, factor-specific oral anticoagulants by rFVIIa, prothrombin complex concentrate and activated prothrombin complex concentrate: a review of animal and human studies. Thromb Res. 2014;133:705-13.
26. Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124:1573-9.
27. Marlu R, Hodaj E, Paris A, Albaladejo P, Cracowski JL, Pernod G. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost. 2012;108:217-24.
28. Díaz MQ, Borobia AM, Núñez MAR, Virto AMM, Fabra S, Casado MS, et al. Use of prothrombin complex concentrates for urgent reversal of dabigatran in the Emergency Department. Haematologica. 2013;98:e143-4.
29. Pragst I, Zeitler SH, Doerr B, Kaspereit FJ, Herzog E, Dickneite G, et al. Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model. J Thrombos Haemost. 2012;10:1841-8.
30. Godier A, Miclot A, Le Bonniec B, Durand M, Fischer AM, Emmerich J, et al. Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model. Anesthesiology. 2012;116:94-102.
31. Perzborn E, Gruber A, Tinel H, Marzec UM, Buetehorn U, Buchmueller A, et al. Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. Thromb Haemost. 2013;110:162-72.
32. Martin AC, Le Bonniec B, Fischer AM, Marchand-Leroux C, Gaussem P, Samama CM, et al. Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis. Int J Cardiol. 2013;168:4228-33.
33. Zhou W, Schwarting S, Illanes S, Liesz A, Middelhoff M, Zorn M, et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran. Stroke. 2011;42:3594-9.
34. Levi M, Moore K, Castillejos C, Kubitza D, Berkowitz S, Goldhaber S, et al. Comparison of three- and four-factor prothrombin complex concentrates on the anticoagulant effects of rivaroxaban in healthy volunteers. J Thromb Haemost. 2014;12:1428-36.
35. Levy JH, Spyropoulos AC, Samama CM, Douketis J. Direct oral anticoagulants. New drugs and new concepts. JACC Cardiovasc Interv. 2014;7:1333-51.
36. Dickneite G, Hoffman M. Reversing the new oral anticoagulants with prothrombin complex concentrates (PCCs): what is the evidence? Thromb Haemost. 2014;111:189-98.
37. Levi M, Levy JH, Andersen HF, Truloff D. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med. 2010;363:1791-800.
38. Schiele F, van Ryn J, Canada K, Newsome C, Sepulveda E, Park J, et al. A specific antidote for dabigatran: functional and structural characterization. Blood. 2013;121:3554-62.
39. Grottke O, van Ryn J, Spronk HM, Rossaint R. Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model. Crit Care. 2014;18:R27.
40. Khadzhynov D, Wagner F, Formella S, Wiegert E, Moschetti V, Slowinski T, et al. Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb Haemost. 2013;109:596-605.
41. Wang X, Mondal S, Wang J, Tirucherai G, Zhang D, Boyd RA, et al. Effect of activated charcoal on apixaban pharmacokinetics in healthy subjects. Am J Cardiovasc Drugs. 2014;14:147-54.