메뉴 건너뛰기




Volumn 166, Issue 4, 2015, Pages 361-367

Mobile genetic elements in Clostridium difficile and their role in genome function

Author keywords

Bacteriophage; Conjugative transposon; Horizontal gene transfer; PaLoc; Tn5397; Tn916

Indexed keywords

CLOSTRIDIUM TOXIN; LINCOMYCIN; MACROLIDE; MIKAMYCIN B; TETRACYCLINE; VIRULENCE FACTOR; BACTERIAL TOXIN;

EID: 84928564816     PISSN: 09232508     EISSN: 17697123     Source Type: Journal    
DOI: 10.1016/j.resmic.2014.12.005     Document Type: Article
Times cited : (58)

References (62)
  • 1
    • 33745550745 scopus 로고    scopus 로고
    • The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
    • Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N., Stabler R., et al. The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet 2006, 38:779-786.
    • (2006) Nat Genet , vol.38 , pp. 779-786
    • Sebaihia, M.1    Wren, B.W.2    Mullany, P.3    Fairweather, N.F.4    Minton, N.5    Stabler, R.6
  • 2
    • 34547760719 scopus 로고    scopus 로고
    • Sequence-based analysis of pQBR103; a representative of a unique, transfer-proficient mega plasmid resident in the microbial community of sugar beet
    • Tett A., Spiers A.J., Crossman L.C., Ager D., Ciric L., Dow J.M., et al. Sequence-based analysis of pQBR103; a representative of a unique, transfer-proficient mega plasmid resident in the microbial community of sugar beet. ISME J 2007, 1:331-340.
    • (2007) ISME J , vol.1 , pp. 331-340
    • Tett, A.1    Spiers, A.J.2    Crossman, L.C.3    Ager, D.4    Ciric, L.5    Dow, J.M.6
  • 4
    • 0023761369 scopus 로고
    • Characterization of a nosocomial Clostridium difficile outbreak by using plasmid profile typing and clindamycin susceptibility testing
    • Clabots C.R., Peterson L.R., Gerding D.N. Characterization of a nosocomial Clostridium difficile outbreak by using plasmid profile typing and clindamycin susceptibility testing. J Infect Dis 1988, 158:731-736.
    • (1988) J Infect Dis , vol.158 , pp. 731-736
    • Clabots, C.R.1    Peterson, L.R.2    Gerding, D.N.3
  • 6
    • 0036430107 scopus 로고    scopus 로고
    • Conjugative transfer of clostridial shuttle vectors from Escherichia coli to Clostridium difficile through circumvention of the restriction barrier
    • Purdy D., O'Keeffe T.A., Elmore M., Herbert M., McLeod A., Bokori-Brown M., et al. Conjugative transfer of clostridial shuttle vectors from Escherichia coli to Clostridium difficile through circumvention of the restriction barrier. Mol Microbiol 2002, 46:439-452.
    • (2002) Mol Microbiol , vol.46 , pp. 439-452
    • Purdy, D.1    O'Keeffe, T.A.2    Elmore, M.3    Herbert, M.4    McLeod, A.5    Bokori-Brown, M.6
  • 9
    • 76649121515 scopus 로고    scopus 로고
    • A mariner-based transposon system for invivo random mutagenesis of Clostridium difficile
    • Cartman S.T., Minton N.P. A mariner-based transposon system for invivo random mutagenesis of Clostridium difficile. Appl Environ Microbiol 2010, 6:1103-1109.
    • (2010) Appl Environ Microbiol , vol.6 , pp. 1103-1109
    • Cartman, S.T.1    Minton, N.P.2
  • 10
    • 0017688583 scopus 로고
    • An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA
    • Chow L.T., Gelinas R.E., Broker T.R., Roberts R.J. An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell 1977, 12:1-8.
    • (1977) Cell , vol.12 , pp. 1-8
    • Chow, L.T.1    Gelinas, R.E.2    Broker, T.R.3    Roberts, R.J.4
  • 11
    • 0018237185 scopus 로고
    • The precursor of mouse β-globin messenger RNA contains two intervening RNA sequences
    • Kinniburgh A., Mertz J., Ross J. The precursor of mouse β-globin messenger RNA contains two intervening RNA sequences. Cell 1978, 14:681-693.
    • (1978) Cell , vol.14 , pp. 681-693
    • Kinniburgh, A.1    Mertz, J.2    Ross, J.3
  • 12
    • 0001423441 scopus 로고
    • Intervening sequence in the thymidylate synthase gene of bacteriophage T4
    • Chu F.K., Maley G.F., Maley F., Belfort M. Intervening sequence in the thymidylate synthase gene of bacteriophage T4. Proc Natl Acad Sci U S A 1984, 81:3049-3053.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 3049-3053
    • Chu, F.K.1    Maley, G.F.2    Maley, F.3    Belfort, M.4
  • 13
    • 0029616336 scopus 로고
    • Mechanisms of intron mobility
    • Belfort M., Perlman P.S. Mechanisms of intron mobility. J Biological Chem 1995, 270:30237-30240.
    • (1995) J Biological Chem , vol.270 , pp. 30237-30240
    • Belfort, M.1    Perlman, P.S.2
  • 14
    • 0030603250 scopus 로고    scopus 로고
    • A group II intron in a conjugative transposon from the gram-positive bacterium, Clostridium difficile
    • Mullany P., Pallen M., Wilks M., Stephen J.R., Tabaqchali S. A group II intron in a conjugative transposon from the gram-positive bacterium, Clostridium difficile. Gene 1996, 174:145-150.
    • (1996) Gene , vol.174 , pp. 145-150
    • Mullany, P.1    Pallen, M.2    Wilks, M.3    Stephen, J.R.4    Tabaqchali, S.5
  • 15
    • 0035140135 scopus 로고    scopus 로고
    • Demonstration that the group II intron from the clostridial conjugative transposon Tn5397 undergoes splicing invivo
    • Roberts A.P., Braun V., von Eichel-Streiber C., Mullany P. Demonstration that the group II intron from the clostridial conjugative transposon Tn5397 undergoes splicing invivo. J Bacteriol 2001, 183:1296-1299.
    • (2001) J Bacteriol , vol.183 , pp. 1296-1299
    • Roberts, A.P.1    Braun, V.2    von Eichel-Streiber, C.3    Mullany, P.4
  • 16
    • 80051832374 scopus 로고    scopus 로고
    • Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile
    • Brouwer M.S., Warburton P.J., Roberts A.P., Mullany P., Allan E. Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile. PLoS One 2011, 6:e23014.
    • (2011) PLoS One , vol.6 , pp. e23014
    • Brouwer, M.S.1    Warburton, P.J.2    Roberts, A.P.3    Mullany, P.4    Allan, E.5
  • 17
    • 84896731107 scopus 로고    scopus 로고
    • Alternative splicing of a group II intron in a surface layer protein gene in Clostridium tetani
    • McNeil B.A., Simon D.M., Zimmerly S. Alternative splicing of a group II intron in a surface layer protein gene in Clostridium tetani. Nucleic Acids Res 2014, 42:1959-1969.
    • (2014) Nucleic Acids Res , vol.42 , pp. 1959-1969
    • McNeil, B.A.1    Simon, D.M.2    Zimmerly, S.3
  • 18
    • 0035199354 scopus 로고    scopus 로고
    • Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria
    • Karberg M., Guo H., Zhong J., Coon C., Perutka J., Lamberwitz A.M. Group II introns as controllable gene targeting vectors for genetic manipulation of bacteria. Nat Biotechnol 2001, 19:1162-1167.
    • (2001) Nat Biotechnol , vol.19 , pp. 1162-1167
    • Karberg, M.1    Guo, H.2    Zhong, J.3    Coon, C.4    Perutka, J.5    Lamberwitz, A.M.6
  • 19
    • 0033933847 scopus 로고    scopus 로고
    • A chimeric ribozyme in Clostridium difficile combines features of group I introns and insertion elements
    • Braun V., Mehlig M., Moos M., Rupnik M., Kalt B., Mahony D.E., et al. A chimeric ribozyme in Clostridium difficile combines features of group I introns and insertion elements. Mol Microbiol 2000, 36:1447-1459.
    • (2000) Mol Microbiol , vol.36 , pp. 1447-1459
    • Braun, V.1    Mehlig, M.2    Moos, M.3    Rupnik, M.4    Kalt, B.5    Mahony, D.E.6
  • 20
    • 77954761569 scopus 로고    scopus 로고
    • Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow
    • Wozniak R.A., Waldor M.K. Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol 2010, 8:552-563.
    • (2010) Nat Rev Microbiol , vol.8 , pp. 552-563
    • Wozniak, R.A.1    Waldor, M.K.2
  • 21
    • 79960946351 scopus 로고    scopus 로고
    • Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance
    • Roberts A.P., Mullany P. Tn916-like genetic elements: a diverse group of modular mobile elements conferring antibiotic resistance. FEMS Microbiol Rev 2011, 35:856-871.
    • (2011) FEMS Microbiol Rev , vol.35 , pp. 856-871
    • Roberts, A.P.1    Mullany, P.2
  • 22
    • 66249099218 scopus 로고    scopus 로고
    • A modular master on the move: the Tn916 family of mobile genetic elements
    • Roberts A.P., Mullany P. A modular master on the move: the Tn916 family of mobile genetic elements. Trends Microbiol 2009, 17:251-258.
    • (2009) Trends Microbiol , vol.17 , pp. 251-258
    • Roberts, A.P.1    Mullany, P.2
  • 23
    • 84891609711 scopus 로고    scopus 로고
    • Regulation of CTnDOT conjugative transfer is a complex and highly coordinated series of events
    • e00569-13
    • Waters J.L., Salyers A.A. Regulation of CTnDOT conjugative transfer is a complex and highly coordinated series of events. MBio 2013, 4. e00569-13.
    • (2013) MBio , vol.4
    • Waters, J.L.1    Salyers, A.A.2
  • 24
    • 77952168929 scopus 로고    scopus 로고
    • Evolutionary dynamics of Clostridium difficile over short and long time scales
    • He M., Sebaihia M., Lawley T.D., Stabler R.A., Dawson L.F., Martin, et al. Evolutionary dynamics of Clostridium difficile over short and long time scales. Proc Natl Acad Sci U S A 2010, 107:7527-7532.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7527-7532
    • He, M.1    Sebaihia, M.2    Lawley, T.D.3    Stabler, R.A.4    Dawson, L.F.M.5
  • 25
    • 84861220095 scopus 로고    scopus 로고
    • In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes
    • Brouwer M.S., Roberts A.P., Mullany P., Allan E. In silico analysis of sequenced strains of Clostridium difficile reveals a related set of conjugative transposons carrying a variety of accessory genes. Mob Genet Elem 2012, 2:8-12.
    • (2012) Mob Genet Elem , vol.2 , pp. 8-12
    • Brouwer, M.S.1    Roberts, A.P.2    Mullany, P.3    Allan, E.4
  • 26
    • 0023233783 scopus 로고
    • Homology of a transferable tetracycline resistance determinant of Clostridium difficile with Streptococcus (Enterococcus) faecalis transposon Tn916
    • Hächler H., Kayser F.H., Berger-Bächi B. Homology of a transferable tetracycline resistance determinant of Clostridium difficile with Streptococcus (Enterococcus) faecalis transposon Tn916. Antimicrobial Agents Chemother 1987, 7:1033-1038.
    • (1987) Antimicrobial Agents Chemother , vol.7 , pp. 1033-1038
    • Hächler, H.1    Kayser, F.H.2    Berger-Bächi, B.3
  • 27
    • 0025281082 scopus 로고
    • Genetic analysis of a tetracycline resistance element from Clostridium difficile and its conjugal transfer to and from Bacillus subtilis
    • Mullany P., Wilks M., Lamb I., Clayton C., Wren B., Tabaqchali S. Genetic analysis of a tetracycline resistance element from Clostridium difficile and its conjugal transfer to and from Bacillus subtilis. J Gen Microbiol 1990, 136:1343-1349.
    • (1990) J Gen Microbiol , vol.136 , pp. 1343-1349
    • Mullany, P.1    Wilks, M.2    Lamb, I.3    Clayton, C.4    Wren, B.5    Tabaqchali, S.6
  • 28
    • 78049292276 scopus 로고    scopus 로고
    • Demonstration of conjugative transposon (Tn5397)-mediated horizontal gene transfer between Clostridium difficile and Enterococcus faecalis
    • Jasni A.S., Mullany P., Hussain H., Roberts A.P. Demonstration of conjugative transposon (Tn5397)-mediated horizontal gene transfer between Clostridium difficile and Enterococcus faecalis. Antimicrobial Agents Chemother 2010, 54:4924-4926.
    • (2010) Antimicrobial Agents Chemother , vol.54 , pp. 4924-4926
    • Jasni, A.S.1    Mullany, P.2    Hussain, H.3    Roberts, A.P.4
  • 30
    • 0035015178 scopus 로고    scopus 로고
    • Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules
    • Roberts A.P., Johanesen P.A., Lyras D., Mullany P., Rood J.I. Comparison of Tn5397 from Clostridium difficile, Tn916 from Enterococcus faecalis and the CW459tet(M) element from Clostridium perfringens shows that they have similar conjugation regions but different insertion and excision modules. Microbiology 2001, 147:1243-1251.
    • (2001) Microbiology , vol.147 , pp. 1243-1251
    • Roberts, A.P.1    Johanesen, P.A.2    Lyras, D.3    Mullany, P.4    Rood, J.I.5
  • 31
    • 0034462083 scopus 로고    scopus 로고
    • The large resolvase TndX is required and sufficient for integration and excision of derivatives of the novel conjugative transposon Tn5397
    • Wang H., Mullany P. The large resolvase TndX is required and sufficient for integration and excision of derivatives of the novel conjugative transposon Tn5397. J Bacteriol 2000, 23:6577-6583.
    • (2000) J Bacteriol , vol.23 , pp. 6577-6583
    • Wang, H.1    Mullany, P.2
  • 32
    • 33745447767 scopus 로고    scopus 로고
    • The conjugative transposon Tn5397 has a strong preference for integration into its Clostridium difficile target site
    • Wang H., Smith M.C., Mullany P. The conjugative transposon Tn5397 has a strong preference for integration into its Clostridium difficile target site. J Bacteriol 2006, 13:4871-4878.
    • (2006) J Bacteriol , vol.13 , pp. 4871-4878
    • Wang, H.1    Smith, M.C.2    Mullany, P.3
  • 33
    • 0020419109 scopus 로고
    • Involvement of cyclic AMP and its receptor protein in filamentation of an Escherichia coli fic mutant
    • Utsumi R., Nakamoto Y., Kawamukai M., Himeno M., Komano T. Involvement of cyclic AMP and its receptor protein in filamentation of an Escherichia coli fic mutant. J Bacteriol 1982, 151:807-812.
    • (1982) J Bacteriol , vol.151 , pp. 807-812
    • Utsumi, R.1    Nakamoto, Y.2    Kawamukai, M.3    Himeno, M.4    Komano, T.5
  • 34
    • 84896710338 scopus 로고    scopus 로고
    • The many faces of Fic: structural and functional aspects of Fic enzymes
    • Garcia-Pino A., Zenkin N., Loris R. The many faces of Fic: structural and functional aspects of Fic enzymes. Trends Biochem Sci 2014, 39:121-129.
    • (2014) Trends Biochem Sci , vol.39 , pp. 121-129
    • Garcia-Pino, A.1    Zenkin, N.2    Loris, R.3
  • 35
    • 84861154088 scopus 로고    scopus 로고
    • Behaviour and target site selection of conjugative transposon Tn916 in two different strains of toxigenic Clostridium difficile
    • Mullany P., Williams R., Langridge G.C., Turner D.J., Whalan R., Clayton C., et al. Behaviour and target site selection of conjugative transposon Tn916 in two different strains of toxigenic Clostridium difficile. Appl Environ Microbiol 2012, 7:2147-2153.
    • (2012) Appl Environ Microbiol , vol.7 , pp. 2147-2153
    • Mullany, P.1    Williams, R.2    Langridge, G.C.3    Turner, D.J.4    Whalan, R.5    Clayton, C.6
  • 36
    • 0028298861 scopus 로고
    • Gene cloning in Clostridium difficile using Tn916 as a shuttle conjugative transposon
    • Mullany P., Wilks M., Puckey L., Tabaqchali S. Gene cloning in Clostridium difficile using Tn916 as a shuttle conjugative transposon. Plasmid 1994, 3:320-323.
    • (1994) Plasmid , vol.3 , pp. 320-323
    • Mullany, P.1    Wilks, M.2    Puckey, L.3    Tabaqchali, S.4
  • 38
    • 0038349278 scopus 로고    scopus 로고
    • Efficient sporulation in Clostridium difficile requires disruption of the sigmaK gene
    • Haraldsen J.D., Sonenshein A.L. Efficient sporulation in Clostridium difficile requires disruption of the sigmaK gene. Mol Microbiol 2003, 48:811-821.
    • (2003) Mol Microbiol , vol.48 , pp. 811-821
    • Haraldsen, J.D.1    Sonenshein, A.L.2
  • 39
    • 0023681023 scopus 로고
    • Molecular cloning and genetic analysis of a chloramphenicol acetyltransferase determinant from Clostridium difficile
    • Wren B.W., Mullany P., Clayton C., Tabaqchali S. Molecular cloning and genetic analysis of a chloramphenicol acetyltransferase determinant from Clostridium difficile. Not Found In Database 1988, 32:1213-1217.
    • (1988) Not Found In Database , vol.32 , pp. 1213-1217
    • Wren, B.W.1    Mullany, P.2    Clayton, C.3    Tabaqchali, S.4
  • 40
    • 0031808781 scopus 로고    scopus 로고
    • Chloramphenicol resistance in Clostridium difficile is encoded on Tn4453 transposons that are closely related to Tn4451 from Clostridium perfringens
    • Lyras D., Storie C., Huggins A.S., Crellin P.K., Bannam T.L., Rood J.I. Chloramphenicol resistance in Clostridium difficile is encoded on Tn4453 transposons that are closely related to Tn4451 from Clostridium perfringens. Antimicrobial Agents Chemother 1998, 42:1563-1567.
    • (1998) Antimicrobial Agents Chemother , vol.42 , pp. 1563-1567
    • Lyras, D.1    Storie, C.2    Huggins, A.S.3    Crellin, P.K.4    Bannam, T.L.5    Rood, J.I.6
  • 42
    • 0028922657 scopus 로고
    • Transfer of macrolide-lincosamide-streptogramin B (MLS) resistance in Clostridium difficile is linked to a gene homologous with toxin A and is mediated by a conjugative transposon, Tn5398
    • Mullany P., Wilks M., Tabaqchali S. Transfer of macrolide-lincosamide-streptogramin B (MLS) resistance in Clostridium difficile is linked to a gene homologous with toxin A and is mediated by a conjugative transposon, Tn5398. J Antimicrob Chemother 1995, 2:305-315.
    • (1995) J Antimicrob Chemother , vol.2 , pp. 305-315
    • Mullany, P.1    Wilks, M.2    Tabaqchali, S.3
  • 43
    • 0023215246 scopus 로고
    • Genetic characterization of a Clostridium difficile erythromycin-clindamycin resistance determinant that is transferable to Staphylococcus aureus
    • Hächler H., Berger-Bächi B., Kayser F.H. Genetic characterization of a Clostridium difficile erythromycin-clindamycin resistance determinant that is transferable to Staphylococcus aureus. Antimicrobial Agents Chemother 1987, 7:1039-1045.
    • (1987) Antimicrobial Agents Chemother , vol.7 , pp. 1039-1045
    • Hächler, H.1    Berger-Bächi, B.2    Kayser, F.H.3
  • 44
    • 0034769457 scopus 로고    scopus 로고
    • Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile
    • Farrow K.A., Lyras D., Rood J.I. Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile. Microbiology 2001, 147:2717-2728.
    • (2001) Microbiology , vol.147 , pp. 2717-2728
    • Farrow, K.A.1    Lyras, D.2    Rood, J.I.3
  • 45
    • 84915733904 scopus 로고    scopus 로고
    • Inter- and intraspecies transfer of a Clostridium difficile conjugative transposon conferring resistance to MLSB
    • Wasels F., Monot M., Spigaglia P., Barbanti F., Ma L., Bouchier C., et al. Inter- and intraspecies transfer of a Clostridium difficile conjugative transposon conferring resistance to MLSB. Microb Drug Resist 2014, 20:555-560.
    • (2014) Microb Drug Resist , vol.20 , pp. 555-560
    • Wasels, F.1    Monot, M.2    Spigaglia, P.3    Barbanti, F.4    Ma, L.5    Bouchier, C.6
  • 46
    • 0029842597 scopus 로고    scopus 로고
    • The phage-like element PBSX and part of the skin element, which are resident at different locations on the Bacillus subtilis chromosome, are highly homologous
    • Krogh S., O'Reilly M., Nolan N., Devine K.M. The phage-like element PBSX and part of the skin element, which are resident at different locations on the Bacillus subtilis chromosome, are highly homologous. Microbiology 1996, 142(Pt 8):2031-2040.
    • (1996) Microbiology , vol.142 , pp. 2031-2040
    • Krogh, S.1    O'Reilly, M.2    Nolan, N.3    Devine, K.M.4
  • 47
    • 84887306016 scopus 로고    scopus 로고
    • The spore differentiation pathway in the enteric pathogen Clostridium difficile
    • Pereira F.C., Saujet L., Tomé A.R., Serrano M., Monot M., Couture-Tosi E., et al. The spore differentiation pathway in the enteric pathogen Clostridium difficile. PLoS Genet 2013, 9:e1003782.
    • (2013) PLoS Genet , vol.9 , pp. e1003782
    • Pereira, F.C.1    Saujet, L.2    Tomé, A.R.3    Serrano, M.4    Monot, M.5    Couture-Tosi, E.6
  • 48
    • 84899684470 scopus 로고    scopus 로고
    • Clostridium difficile phages: still difficult?
    • Hargreaves K.R., Clokie M.R. Clostridium difficile phages: still difficult?. Front Microbiol 2014, 5:184.
    • (2014) Front Microbiol , vol.5 , pp. 184
    • Hargreaves, K.R.1    Clokie, M.R.2
  • 49
    • 70450170283 scopus 로고    scopus 로고
    • Bacteriophage-mediated toxin gene regulation in Clostridium difficile
    • Govind R., Vediyappan G., Rolfe R.D., Dupuy B., Fralick J.A. Bacteriophage-mediated toxin gene regulation in Clostridium difficile. J Virol 2009, 83:12037-12045.
    • (2009) J Virol , vol.83 , pp. 12037-12045
    • Govind, R.1    Vediyappan, G.2    Rolfe, R.D.3    Dupuy, B.4    Fralick, J.A.5
  • 50
    • 79958160416 scopus 로고    scopus 로고
    • Prophage-stimulated toxin production in Clostridium difficile NAP1/027 lysogens
    • Sekulovic O., Meessen-Pinard M., Fortier L.C. Prophage-stimulated toxin production in Clostridium difficile NAP1/027 lysogens. J Bacteriol 2011, 193:2726-2734.
    • (2011) J Bacteriol , vol.193 , pp. 2726-2734
    • Sekulovic, O.1    Meessen-Pinard, M.2    Fortier, L.C.3
  • 51
    • 84881602189 scopus 로고    scopus 로고
    • Determination of the attP and attB sites of phage CD27 from Clostridium difficile NCTC 12727
    • Williams R., Meader E., Mayer M., Narbad A., Roberts A.P., Mullany P. Determination of the attP and attB sites of phage CD27 from Clostridium difficile NCTC 12727. J Med Microbiol 2013, 62:1439-1443.
    • (2013) J Med Microbiol , vol.62 , pp. 1439-1443
    • Williams, R.1    Meader, E.2    Mayer, M.3    Narbad, A.4    Roberts, A.P.5    Mullany, P.6
  • 52
    • 84891648569 scopus 로고    scopus 로고
    • Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains
    • e00840-13
    • Goh S., Hussain H., Chang B.J., Emmett W., Riley T.V., Mullany P. Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains. MBio 2013, 4. e00840-13.
    • (2013) MBio , vol.4
    • Goh, S.1    Hussain, H.2    Chang, B.J.3    Emmett, W.4    Riley, T.V.5    Mullany, P.6
  • 53
    • 84868623569 scopus 로고    scopus 로고
    • Evidence of invivo prophage induction during Clostridium difficile infection
    • Meessen-Pinard M., Sekulovic O., Fortier L.C. Evidence of invivo prophage induction during Clostridium difficile infection. Appl Environ Microbiol 2012 Nov, 78(21):7662-7670.
    • (2012) Appl Environ Microbiol , vol.78 , Issue.21 , pp. 7662-7670
    • Meessen-Pinard, M.1    Sekulovic, O.2    Fortier, L.C.3
  • 54
    • 84880755457 scopus 로고    scopus 로고
    • Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an invitro human colon model system
    • Meader E., Mayer M.J., Steverding D., Carding S.R., Narbad A. Evaluation of bacteriophage therapy to control Clostridium difficile and toxin production in an invitro human colon model system. Anaerobe 2013, 22:25-30.
    • (2013) Anaerobe , vol.22 , pp. 25-30
    • Meader, E.1    Mayer, M.J.2    Steverding, D.3    Carding, S.R.4    Narbad, A.5
  • 55
    • 0030605226 scopus 로고    scopus 로고
    • Definition of the single integration site of the pathogenicity locus in Clostridium difficile
    • Braun V., Hundsberger T., Leukel P., Sauerborn M., von Eichel-Streiber C. Definition of the single integration site of the pathogenicity locus in Clostridium difficile. Gene 1996, 181:29-38.
    • (1996) Gene , vol.181 , pp. 29-38
    • Braun, V.1    Hundsberger, T.2    Leukel, P.3    Sauerborn, M.4    von Eichel-Streiber, C.5
  • 56
    • 0035826910 scopus 로고    scopus 로고
    • Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor
    • Mani N., Dupuy B. Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor. Proc Natl Acad Sci 2001, 98:5844-5849.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 5844-5849
    • Mani, N.1    Dupuy, B.2
  • 57
    • 84859902559 scopus 로고    scopus 로고
    • Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivation of the tcdE gene
    • Olling A., Seehase S., Minton N.P., Tatge H., Schröter S., Kohlscheen S., et al. Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivation of the tcdE gene. Microb Pathog 2012, 52:92-100.
    • (2012) Microb Pathog , vol.52 , pp. 92-100
    • Olling, A.1    Seehase, S.2    Minton, N.P.3    Tatge, H.4    Schröter, S.5    Kohlscheen, S.6
  • 58
    • 84864073540 scopus 로고    scopus 로고
    • Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE
    • Govind R., Dupuy B. Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE. PLoS Pathog 2012, 8:e1002727.
    • (2012) PLoS Pathog , vol.8 , pp. e1002727
    • Govind, R.1    Dupuy, B.2
  • 59
    • 84863792386 scopus 로고    scopus 로고
    • Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production
    • Cartman S.T., Kelly M.L., Heeg D., Heap J.T., Minton N.P. Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production. Appl Environ Microbiol 2012, 78:4683-4690.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 4683-4690
    • Cartman, S.T.1    Kelly, M.L.2    Heeg, D.3    Heap, J.T.4    Minton, N.P.5
  • 60
    • 84865074510 scopus 로고    scopus 로고
    • TcdC does not significantly repress toxin expression in Clostridium difficile 630δErm
    • Bakker D., Smits W.K., Kuijper E.J., Corver J. TcdC does not significantly repress toxin expression in Clostridium difficile 630δErm. PLoS One 2012, 7:e43247.
    • (2012) PLoS One , vol.7 , pp. e43247
    • Bakker, D.1    Smits, W.K.2    Kuijper, E.J.3    Corver, J.4
  • 61
    • 84886255455 scopus 로고    scopus 로고
    • Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers
    • Brouwer M.S., Roberts A.P., Hussain H., Williams R.J., Allan E., Mullany P. Horizontal gene transfer converts non-toxigenic Clostridium difficile strains into toxin producers. Nat Commun 2013, 4:2601.
    • (2013) Nat Commun , vol.4 , pp. 2601
    • Brouwer, M.S.1    Roberts, A.P.2    Hussain, H.3    Williams, R.J.4    Allan, E.5    Mullany, P.6
  • 62
    • 84866313203 scopus 로고    scopus 로고
    • Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects
    • Villano S.A., Seiberling M., Tatarowicz W., Monnot-Chase E., Gerding D.N. Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects. Antimicrobial Agents Chemother 2012, 10:5224-5229.
    • (2012) Antimicrobial Agents Chemother , vol.10 , pp. 5224-5229
    • Villano, S.A.1    Seiberling, M.2    Tatarowicz, W.3    Monnot-Chase, E.4    Gerding, D.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.