Characterization of metabolically healthy obese Brazilians and cardiovascular risk prediction

Nutrition

Volumn 31, Issue 6, 2015, Pages 827-833

  de Castro Pimentel, Aline ^a   Scorsatto, Mauara ^a   Moraes de Oliveira, Gláucia Maria ^a   Rosa, Glorimar ^a   Luiz, Ronir Raggio ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cardiovascular disease; Framingham score; Metabolic alterations; Metabolically healthy obese individual; Obesity

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL; URIC ACID; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL;

ADULT; ARTICLE; BODY COMPOSITION; BRAZILIAN; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FAT MASS; FEMALE; FRAMINGHAM RISK SCORE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OBESITY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ADIPOSE TISSUE; BLOOD; BODY MASS; CARDIOVASCULAR DISEASES; COMPLICATION; INSULIN RESISTANCE; METABOLICALLY BENIGN OBESITY; METABOLISM; MIDDLE AGED; REFERENCE VALUE; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; BIOMARKERS; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; OBESITY, METABOLICALLY BENIGN; REFERENCE VALUES; RISK FACTORS; TRIGLYCERIDES; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 84928561391     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2014.12.024     Document Type: Article

References (36)

1. IASO/IOTF-International association for the study of obesity/international obesity taskforce. Obesity the global epidemic. Accessed January 16,2015. http://www.iaso.org/iotf/obesity/obesitytheglobalepidemic/.
2. IBGE - Instituto brasileiro de geografia estatística. Pesquisa de orçamentos familiares 2008 to 2009-Antropometria e estado nutricional de crianças, adolescentes e adultos no Brasil 2010, IBGE, Rio de Janeiro.
3. Karelis A.D. Metabolically healthy but obese individuals. Lancet 2008, 372:1281-1283.
4. Karelis A.D., St-Pierre D.H., Conus F., Rabasa-Lhoret R., Poehlman E.T. Metabolic and body composition factors in subgroups of obesity: what do we know?. J Clin Endocrinol Metab 2004, 89:2569-2575.
5. Sims E.A. Are there persons who are obese, but metabolically healthy?. Metabolism 2001, 50:1499-1504.
6. Blüher P.M. The distinction of metabolically "healthy" from "unhealthy" obese individuals. Curr Opin Lipidol 2010, 21:38-43.
7. Messier V., Karelis A.D., Prud'homme D., Primeau V., Rabasa-Lhoret R. Identifying metabolically healthy but obese individuals in sedentary postmenopausal women. Obesity (Silver Spring) 2010, 18:911-917.
8. Pataky Z., Makoundou V., Nilsson P., Gabriel R.S., Lalic K., Muscelli E., et al. Metabolic normality in overweight and obese subjects. Which parameters? Which risks?. Int J Obes (Lond) 2011, 35:1208-1215.
9. Arnlöv J., Ingelsson E., Sundström J., Lind L. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle aged men. Circulation 2010, 121:230-236.
10. Kuk J., Ardern C.I. Are metabolically normal but obese individuals at lower risk for all-cause mortality?. Diabetes Care 2009, 32:2297-2299.
11. Hinnouho G.M., Czernichow S., Dugravot A., Batty G.D., Kivimaki M., Singh-Manoux A. Metabolically healthy obesity and risk of mortality: does thedefinition of metabolic health matter?. Diabetes Care 2013, 36:2294-2300.
12. Hamer M., Stamatakis E. Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J Clin Endocrinol Metab 2012, 97:2482-2488.
13. Calori G., Lattuada G., Piemonti L., Garancini M.P., Ragogna F., Villa M., et al. Prevalence, metabolic features, and prognosis of metabolically healthy obese Italian individuals: the Cremona study. Diabetes Care 2011, 34:210-215.
14. Brindle P., Beswick A., Fahey T., Ebrahom S. Accuracy and impact of risk assessment in the primary prevention of cardiovascular disease: a systematic review. Heart 2006, 92:1752-1759.
15. D'Agostino R.B., Vasan R.S., Pencina M.J., Wolf P.A., Cobain M., Massaro J.M., et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008, 117:743-753.
16. World Health Organization Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. Technical Report Series No. 854 1995, WHO, Geneva.
17. Preis S.R., Massaro J.M., Hoffmann U., D'Agostino R.B., Levy D., Robins S.J., et al. Neck circumference as a novel measure of cardiometabolic risk: the Framingham Heart Study. J Clin Endocrinol Metab 2010, 95:3701-3710.
18. Faria S.L., Faria O.P., Cardeal M.D., Ito M.K. Validation study of multifrequency bioelectrical impedance with dual-energy X-ray absorptiometry among obese patients. Obes Surg 2014, 24:1476-1480.
19. Sociedade Brasileira de Cardiologia/Sociedade Brasileira de Hipertensão/Sociedade Brasileira de Nefrologia VI Diretrizes brasileiras de hipertensão arterial. Arq Bras Cardiol 2010, 95(Suppl 1):1-51.
20. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
21. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
22. Meigs J.B., Wilson P.W., Fox C.S., Vasan R.S., Nathan D.M., Sullivan L.M., et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006, 91:2906-2912.
23. Rega-Kaun G., Kaun C., Wojta J. More than a simple storage organ: adipose tissue as a source of adipokines involved in cardiovascular disease. Thromb Haemost 2013, 110:641-650.
24. Ogorodnikova A.D., Kim K., McGinn A.P., Muntner P., Khan U., Wildman R.P. Incident cardiovascular disease events in metabolically benign obese individuals. Obesity (Silver Spring) 2012, 20:651-659.
25. Yoo H.K., Choi E.Y., Park E.W., Cheong Y.S., Bae R.A. Comparison of metabolic characteristics of metabolically healthy but obese middle-aged men according to different criteria. Korean J Fam Med 2013, 34:19-26.
26. Lind L., Siegbahn A., Ingelsson E., Substrom J., Arnlov J. A detailed cardiovascular characterization of obesity without the metabolic syndrome. Arterioscler Thromb Vasc Biol 2011, 31:e27-34.
27. Stefan N., Häring H., Hu F., Schulze M.B. Metabolically healthy obesity: epidemiology, mechanisms and clinical implications. Lancet Diabetes Endocrinol 2013, 1:152-162.
28. Stefan N., Kantartzis K., Machann J., Schick F., Thamer C., Rittig K., et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 2008, 168:1609-1616.
29. Coen P.M., Dube J.J., Amati F., Stefanovic-Racic M., Ferrell R.E., Toledo F.G., et al. Insulin resistance is associated with higher intramyocellular triacylglycerols in type I but not type II myocytes concomitant with higher ceramide content. Diabetes 2010, 59:80-88.
30. Montague C.T., O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 2000, 49:883-888.
31. Després J.P., Lemieux I., Bergeron J., Pibarot P., Mathieu P., Larose E., et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 2008, 28:1039-1049.
32. Boden G. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes 2011, 8:139-143.
33. Ortega F.B., Lee D., Katzmarzyk P.T., Ruiz J.R., Sui X., Church T.S., et al. The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur Heart J 2013, 34:389-397.
34. Cena H., Fonte M.L., Turconi G. Relationship between smoking and metabolic syndrome. Nutr Rev 2011, 69:745-753.
35. Dervaux N., Wubuli M., Megnien J.L., Chironi G., Simon A. Comparative associations of adiposity measures with cardiometabolic risk burden in asymptomatic subjects. Atherosclerosis 2008, 201:413-417.
36. Gómez-Ambrosi J., Silva C., Galofré J.C., Escalada J., Santos S., Gil M.J., et al. Body adiposity and type 2 diabetes: increased risk with a high body fat percentage even having a normal BMI. Obesity (Silver Spring) 2011, 19:1439-1444.