Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats

BMC Neuroscience

Volumn 16, Issue 1, 2015, Pages

  Takeuchi, Satoru ^a   Nagatani, Kimihiro ^a   Otani, Naoki ^a   Nawashiro, Hiroshi ^b   Sugawara, Takashi ^c   Wada, Kojiro ^a   Mori, Kentaro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b Tokorozawa Loyal Hospital   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; Hydrogen rich water; Oxidative stress; Spontaneously hypertensive stroke prone rats

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALBUMIN; GELATINASE A; GELATINASE B; HYDROGEN; REACTIVE OXYGEN METABOLITE; WATER; 8-HYDROXY-2'-DEOXYADENOSINE; ALBUMINOID; DEOXYADENOSINE DERIVATIVE; DRINKING WATER; MMP2 PROTEIN, RAT; MMP9 PROTEIN, RAT; NEUROPROTECTIVE AGENT;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN CORTEX; BRAIN HEMORRHAGE; BRAIN INFARCTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOTOR ACTIVITY; NONHUMAN; OVERALL SURVIVAL; OXIDATIVE STRESS; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; ZYMOGRAPHY; ANIMAL; BLOOD PRESSURE; BODY WEIGHT; DRUG EFFECTS; HYPERTENSION; METABOLISM; MORTALITY; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPONTANEOUSLY HYPERTENSIVE RAT; STROKE;

ADMINISTRATION, ORAL; ALBUMINS; ANIMALS; BLOOD PRESSURE; BLOOD-BRAIN BARRIER; BODY WEIGHT; CEREBRAL CORTEX; DEOXYADENOSINES; DRINKING WATER; HIPPOCAMPUS; HYDROGEN; HYPERTENSION; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS, INBRED SHR; STROKE;

EID: 84928557474     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-015-0165-3     Document Type: Article

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