Current epidemiology and antimicrobial resistance data for bacterial bloodstream infections in patients with hematologic malignancies: An Italian multicentre prospective survey

Clinical Microbiology and Infection

Volumn 21, Issue 4, 2015, Pages 337-343

  Trecarichi, E M ^a   Pagano, L ^a   Candoni, A ^c   Pastore, D ^d   Cattaneo, C ^e   Fanci, R ^f   Nosari, A ^g   Caira, M ^a   Spadea, A ^b   Busca, A ^h   Vianelli, N ⁱ   Tumbarello, M ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

^d POLICLINICO   (Italy)

^e UO Ematologia   (Italy)

^f CAREGGI UNIVERSITY HOSPITAL   (Italy)

^g OSPEDALE NIGUARDA CA GRANDA   (Italy)

^h MOLINETTE HOSPITAL   (Italy)

ⁱ UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Antimicrobial resistance; Bacterial bloodstream infections; Epidemiology; Hematologic cancer; Mortality; Multidrug resistance

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; CARBAPENEM DERIVATIVE; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; GENTAMICIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; TEICOPLANIN; VANCOMYCIN;

ACINETOBACTER BAUMANNII; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLOODSTREAM INFECTION; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; CONTROLLED STUDY; ENTEROBACTER CLOACAE; ENTEROCOCCUS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEMALE; HEMATOLOGIC MALIGNANCY; HODGKIN DISEASE; HUMAN; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; AGED; BACTEREMIA; CLASSIFICATION; CLINICAL TRIAL; COMPLICATION; DRUG EFFECTS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMATOLOGIC DISEASE; ISOLATION AND PURIFICATION; ITALY; MICROBIOLOGY; MIDDLE AGED; TERTIARY CARE CENTER;

ACINETOBACTER BAUMANNII; BACTERIA (MICROORGANISMS); ENTEROBACTERIACEAE; KLEBSIELLA PNEUMONIAE; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA;

ADULT; AGED; BACTEREMIA; DRUG RESISTANCE, BACTERIAL; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMATOLOGIC NEOPLASMS; HUMANS; ITALY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TERTIARY CARE CENTERS;

EID: 84928546728     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2014.11.022     Document Type: Article

References (24)

1. Wisplinghoff H., Cornely O.A., Moser S., Bethe U., Stützer H., Salzberger B., et al. Outcomes of nosocomial bloodstream infections in adult neutropenic patients: a prospective cohort and matched case-control study. Infect Control Hosp Epidemiol 2003, 24:905-911.
2. Wisplinghoff H., Seifert H., Wenzel R.P., Edmond M.B. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 2003, 36:1103-1110.
3. Tumbarello M., Trecarichi E.M., Caira M., Candoni A., Pastore D., Cattaneo C., et al. HeMABIS (Hematological Malignancies Associated Bacterial Infections Surveillance), Italy. Derivation and validation of a scoring system to identify patients with bacteremia and hematological malignancies at higher risk for mortality. PLoS One 2012, 7:e51612.
4. Montassier E., Batard E., Gastinne T., Potel G., de La Cochetière M.F. Recent changes in bacteremia in patients with cancer: a systematic review of epidemiology and antibiotic resistance. Eur J Clin Microbiol Infect Dis 2013, 32:841-850.
5. Trecarichi E.M., Tumbarello M., Spanu T., Caira M., Fianchi L., Chiusolo P., et al. Incidence and clinical impact of extended-spectrum-beta-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies. JInfect 2009, 58:299-307.
6. Pagano L., Caira M., Rossi G., Tumbarello M., Fanci R., Garzia M.G., et al. Aprospective survey of febrile events in hematological malignancies. Ann Hematol 2012, 91:767-774. Hema e-Chart Group, Italy.
7. Trecarichi E.M., Tumbarello M. Antimicrobial-resistant Gram-negative bacteria in febrile neutropenic patients with cancer: current epidemiology and clinical impact. Curr Opin Infect Dis 2014, 27:200-210.
8. Cattaneo C., Casari S., Bracchi F., Signorini L., Ravizzola G., Borlenghi E., et al. Recent increase in enterococci, viridans streptococci, Pseudomonas spp. and multiresistant strains among haematological patients, with a negative impact on outcome. Results of a 3-year surveillance study at a single institution. Scand J Infect Dis 2010, 42:324-332.
9. Gudiol C., Bodro M., Simonetti A., Tubau F., González-Barca E., Cisnal M., et al. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients. Clin Microbiol Infect 2013, 19:474-479.
10. Bucaneve G., Micozzi A., Menichetti F., Martino P., Dionisi M.S., Martinelli G., et al. Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Infection Program. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. NEngl J Med 2005, 353:977-987.
11. O'Grady N.P., Alexander M., Dellinger E.P., Gerberding J.L., Heard S.O., Maki D.G., et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm Rep 2002, 51(RR-10):1-29.
12. European Centre for Disease Prevention and Control (ECDC) Healthcare-associated infections 2008, Available at:, ECDC, Stockholm, Sweden, [accessed 15.12.08]. http://ecdc.europa.eu/en/activities/surveillance/HAI/Documents/2008_HAI_%20special_chapter.pdf.
13. Magiorakos A.P., Srinivasan A., Carey R.B., Carmeli Y., Falagas M.E., Giske C.G., et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012, 18:268-281.
14. Mikulska M., Viscoli C., Orasch C., Livermore D.M., Averbuch D., Cordonnier C., et al. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. JInfect 2014, 68:321-331. Fourth European Conference on Infections in Leukemia Group (ECIL-4), a joint venture of EBMT, EORTC, ICHS, ELN and ESGICH/ESCMID.
15. Pagano L., Tacconelli E., Tumbarello M., Laurenti L., Mele L., Spanu T., et al. Teicoplanin-resistant coagulase-negative staphylococcal bacteraemia in patients with haematological malignancies: a problem of increasing importance. JAntimicrob Chemother 1997, 40:738-740.
16. Cattaneo C., Antoniazzi F., Casari S., Ravizzola G., Gelmi M., Pagani C., et al. P.aeruginosa bloodstream infections among hematological patients: an old or new question?. Ann Hematol 2012, 91:1299-1304.
17. Trecarichi E.M., Tumbarello M., Caira M., Candoni A., Cattaneo C., Pastore D., et al. Multidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematologic malignancies. Haematologica 2011, 96. e1-3.
18. Chen C.Y., Tsay W., Tang J.L., Tien H.F., Chen Y.C., Chang S.C., et al. Epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia. Epidemiol Infect 2010, 138:1044-1051.
19. Elting L.S., Rubenstein E.B., Rolston K.V., Bodey G.P. Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials. Clin Infect Dis 1997, 25:247-259.
20. Samonis G., Vardakas K.Z., Maraki S., Tansarli G.S., Dimopoulou D., Kofteridis D.P., et al. Aprospective study of characteristics and outcomes of bacteremia in patients with solid organ or hematologic malignancies. Support Care Cancer 2013, 21:2521-2526.
21. Poon L.M., Jin J., Chee Y.L., Ding Y., Lee Y.M., Chng W.J., et al. Risk factors for adverse outcomes and multidrug-resistant Gram-negative bacteraemia in haematology patients with febrile neutropenia in a Singaporean university hospital. Singapore Med J 2012, 53:720-725.
22. Kjellander C., Björkholm M., Cherif H., Kalin M., Giske C.G. Hematological: low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study. Eur J Haematol 2012, 88:422-430.
23. Tumbarello M., Spanu T., Caira M., Trecarichi E.M., Laurenti L., Montuori E., et al. Factors associated with mortality in bacteremic patients with hematologic malignancies. Diagn Microbiol Infect Dis 2009, 64:320-326.
24. Averbuch D., Orasch C., Cordonnier C., Livermore D.M., Mikulska M., Viscoli C., et al. European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia. Haematologica 2013, 98:1826-1835. ECIL4, a joint venture of EBMT, EORTC, ICHS, ESGICH/ESCMID and ELN.