Derivation and Validation of a Scoring System to Identify Patients with Bacteremia and Hematological Malignancies at Higher Risk for Mortality

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Tumbarello, Mario ^a   Trecarichi, Enrico Maria ^a   Caira, Morena ^a   Candoni, Anna ^b   Pastore, Domenico ^c   Cattaneo, Chiara ^d   Fanci, Rosa ^e   Nosari, Annamaria ^f   Spadea, Antonio ^g   Busca, Alessandro ^h   Vianelli, Nicola ⁱ   Spanu, Teresa ^a   Pagano, Livio ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d UO Ematologia   (Italy)

^e CAREGGI UNIVERSITY HOSPITAL   (Italy)

^f OSPEDALE NIGUARDA CA GRANDA   (Italy)

^g REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^h MOLINETTE HOSPITAL   (Italy)

ⁱ UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE KIDNEY FAILURE; AGE; AGED; ARTICLE; BACTEREMIA; CANCER STAGING; CANCER SURVIVOR; CLINICAL CLASSIFICATION; COMORBIDITY; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HEMATOLOGIC MALIGNANCY; HIGH RISK PATIENT; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPENIA; NONHUMAN; PATIENT IDENTIFICATION; RISK ASSESSMENT; SCORING SYSTEM; VALIDATION STUDY;

ADULT; AGED; BACTEREMIA; COHORT STUDIES; CROSS INFECTION; FEMALE; HEMATOLOGIC NEOPLASMS; HUMANS; ITALY; MALE; MEDICAL ONCOLOGY; MIDDLE AGED; ODDS RATIO; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; RISK; ROC CURVE;

BACTERIA (MICROORGANISMS);

EID: 84871290963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051612     Document Type: Article

References (30)

1. Gaytán-Martínez J, Mateos-García E, Sánchez-Cortés E, González-Llaven J, Casanova-Cardiel LJ, et al. (2000) Microbiological findings in febrile neutropenia. Arch Med Res 31: 388-392.
2. Klastersky J, (1998) Current attitudes for therapy of febrile neutropenia with consideration to cost-effectiveness. Curr Opin Oncol 10: 284-290.
3. Madani TA, (2000) Clinical infections and bloodstream isolates associated with fever in patients undergoing chemotherapy for acute myeloid leukemia. Infection 28: 367-373.
4. Serody JS, (2000) Fever in immunocompromised patients. N Engl J Med 342: 217-218.
5. Worth LJ, Slavin MA, (2009) Bloodstream infections in haematology: risks and new challenges for prevention. Blood Rev 23: 113-122.
6. Pagano L, Caira M, Rossi G, Tumbarello M, Fanci R, et al. (2012) A prospective survey of febrile events in hematological malignancies. Ann Hematol 91: 767-774.
7. Collin BA, Leather HL, Wingard JR, Ramphal R, (2001) Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis 33: 947-953.
8. Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB, (2003) Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 36: 1103-1110.
9. Wisplinghoff H, Cornely OA, Moser S, Bethe U, Stützer H, et al. (2003) Outcomes of nosocomial bloodstream infections in adult neutropenic patients: a prospective cohort and matched case-control study. Infect Control Hosp Epidemiol 24: 905-911.
10. Safdar A, Rodriguez GH, Balakrishnan M, Tarrand JJ, Rolston KV, (2006) Changing trends in etiology of bacteremia in patients with cancer. Eur J Clin Microbiol Infect Dis 25: 522-526.
11. Tumbarello M, Spanu T, Caira M, Trecarichi EM, Laurenti L, et al. (2009) Factors associated with mortality in bacteremic patients with hematologic malignancies. Diagn Microbiol Infect Dis 64: 320-326.
12. Trecarichi EM, Tumbarello M, Caira M, Candoni A, Cattaneo C, et al. (2011) Multidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematologic malignancies. Haematologica 96: e1-3.
13. Trecarichi EM, Tumbarello M, Spanu T, Caira M, Fianchi L, et al. (2009) Incidence and clinical impact of extended-spectrum-beta-lactamase (ESBL) production and fluoroquinolone resi stance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies. J Infect 58: 299-307.
14. Dettenkofer M, Wenzler-Röttele S, Babikir R, Bertz H, Ebner W, et al. (2005) Surveillance of nosocomial sepsis and pneumonia in patients with a bone marrow or peripheral blood stem cell transplant: a multicenter project. Clin Infect Dis 40: 926-931.
15. Russell JA, (2006) Management of sepsis. N Engl J Med 355: 1699-1713.
16. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM, (1988) CDC definitions for nosocomial infections, 1988. Am J Infect Control 16: 128-140.
17. Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, et al. (2002) Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 137: 791-797.
18. Charlson ME, Pompei P, Ales KL, MacKenzie CR, (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40: 373-383.
19. Tumbarello M, Trecarichi EM, Bassetti M, De Rosa FG, Spanu T, et al. (2011) Identifying patients harboring extended-spectrum-beta-lactamase-producing Enterobacteriaceae on hospital admission: derivation and validation of a scoring system. Antimicrob Agents Chemother 55: 3485-3490.
20. Hatamabadi HR, Darbandsar Mazandarani P, Abdalvand A, Arhami Dolatabadi A, Amini A, et al. (2012) Evaluation of the Acute Physiology and Chronic Health Evaluation III in predicting the prognosis of patients admitted to Emergency Department, in need of intensive care unit. Am J Emerg Med 30: 1141-1145.
21. Hwang SY, Lee JH, Lee YH, Hong CK, Sung AJ, et al. (2012) Comparison of the Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II scoring system, and Trauma and Injury Severity Score method for predicting the outcomes of intensive care unit trauma patients. Am J Emerg Med 30: 749-753.
22. Rhee JY, Kwon KT, Ki HK, Shin SY, Jung DS, et al. (2009) Scoring systems for prediction of mortality in patients with intensive care unit-acquired sepsis: a comparison of the Pitt bacteremia score and the Acute Physiology and Chronic Health Evaluation II scoring systems. Shock 31: 146-150.
23. Hampshire PA, Welch CA, McCrossan LA, Francis K, Harrison DA, (2009) Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care 13: R137.
24. Soares M, Silva UV, Teles JM, Silva E, Caruso P, et al. (2010) Validation of four prognostic scores in patients with cancer admitted to Brazilian intensive care units: results from a prospective multicenter study. Intensive Care Med 36: 1188-1195.
25. Paganini HR, Aguirre C, Puppa G, Garbini C, Javier RG, et al. (2007) A prospective, multicentric scoring system to predict mortality in febrile neutropenic children with cancer. Cancer 109: 2572-2579.
26. Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, et al. (2000) The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol 18: 3038-3051.
27. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, et al. (2011) Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America. Clin Infect Dis 52: 427-431.
28. Klastersky J, Ameye L, Maertens J, Georgala A, Muanza F, et al. (2007) Bacteraemia in febrile neutropenic cancer patients. Int J Antimicrob Agents 30 (Suppl 1) (): S51-59.
29. Tumbarello M, Sali M, Trecarichi EM, Leone F, Rossi M, et al. (2008) Bloodstream infections caused by extended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy. Antimicrob Agents Chemother 52: 3244-3252.
30. Tumbarello M, Sanguinetti M, Montuori E, Trecarichi EM, Posteraro B, et al. (2007) Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 51: 1987-1994.