Recent increase in enterococci, viridans streptococci, Pseudomonas spp. and multiresistant strains among haematological patients, with a negative impact on outcome. Results of a 3-year surveillance study at a single institution

Scandinavian Journal of Infectious Diseases

Volumn 42, Issue 5, 2010, Pages 324-332

  Cattaneo, Chiara ^a   Casari, Salvatore ^b   Bracchi, Francesca ^a   Signorini, Liana ^b   Ravizzola, Giuseppe ^b   Borlenghi, Erika ^a   Re, Alessandro ^a   Manca, Nino ^b   Carosi, Giampiero ^b   Rossi, Giuseppe ^a  

^a UO Ematologia   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMPICILLIN; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ABSCESS; ACHROMOBACTER XYLOSOXIDANS; ACINETOBACTER; AEROCOCCUS; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; BACTERIUM ISOLATE; BACTEROIDES; CAMPYLOBACTER; CELLULITIS; CENTRAL VENOUS CATHETER; CLOSTRIDIUM DIFFICILE; CORYNEBACTERIUM DIPHTHERIAE; CYTOMEGALOVIRUS; DISEASE SURVEILLANCE; EGGERTHELLA LENTA; ENTEROBACTERIACEAE; ENTEROCOCCUS; ENTEROCOCCUS DURANS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEVER; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMATOLOGIC DISEASE; HUMAN; LEISHMANIA; MORAXELLA CATARRHALIS; MORTALITY; MYCOSIS; NEUTROPENIA; NOCARDIA; OCHROBACTRUM ANTHROPI; OUTCOME ASSESSMENT; PATHOGENESIS; PNEUMONIA; PREVOTELLA DISIENS; PROPIONIBACTERIUM; PROSPECTIVE STUDY; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS PUTIDA; RHIZOBIUM RADIOBACTER; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; STAPHYLOCOCCUS HOMINIS; STAPHYLOCOCCUS WARNERII; STENOTROPHOMONAS MALTOPHILIA; STREPTOCOCCUS GALLOLYTICUS; STREPTOCOCCUS MITIS; STREPTOCOCCUS PARASANGUINIS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS SALIVARIUS; STREPTOCOCCUS THERMOPHILUS; TOXOPLASMOSIS; URINARY TRACT INFECTION; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ENTEROCOCCUS; GRAM-POSITIVE BACTERIAL INFECTIONS; HEMATOLOGIC NEOPLASMS; HOSPITALS; HUMANS; ITALY; MYCOSES; PROSPECTIVE STUDIES; PSEUDOMONAS; PSEUDOMONAS INFECTIONS; TREATMENT OUTCOME; VIRIDANS STREPTOCOCCI;

EID: 77950810844     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365540903496569     Document Type: Article

References (26)

1. Oppenheim BA. The changing pattern of infection in neutropenic patients. J Antimicrob Chemother 1998;41 (Suppl D):7-11.
2. Gaytan-Martinez J, Mateos-Garcia E, Sanchez-Cortes E, Gonzalez-Llaven J, Casanova-Cardiel LJ, Fuentes-Allen JL. Microbiological findings in febrile neutropenia. Arch Med Res 2000;31:388-392
3. Zaas AK, Song X, Tucker P, Perl TM. Risk factors for development of vancomycin-resistant enterococcal bloodstream infection in patients with cancer who are colonized with vancomycin-resistant enterococci. Clin Infect Dis 2002;35: 1139-1146 (Pubitemid 35305860)
4. Harris AD, Samore MH, Lipsitch M, Kaye KS, Perencevich E, Carmeli Y. Control-group selection importance in studies of antimicrobial resistance: examples applied to Pseudomonas aeruginosa, enterococci, and Escherichia coli. Clin Infect Dis 2002;34:1558-1563 (Pubitemid 34615439)
5. Ohmagari N, Hanna H, Graviss L, Hackett B, Perego C, Gonzalez V, et al. Risk factors for infections with multidrugresistant Pseudomonas aeruginosa in patients with cancer. Cancer 2005;104:205-212 (Pubitemid 40847770)
6. Kern WV, Klose K, Jellen-Ritter AS, Oethinger M, Bohnert J, Kern P, et al. Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evaluation and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukaemia. Eur J Clin Microbiol Infect Dis 2005;24:111-118 (Pubitemid 40487379)
7. Viscoli C, Castagnola E. Treatment of febrile neutropenia: what is new? Curr Opin Infect Dis 2002;15:377-382 (Pubitemid 34816425)
8. Cattaneo C, Quaresmini G, Casari S, Capucci MA, Micheletti M, Brolenghi E, et al. Recent changes in bacterial epidemiology and the emergence of fluoroquinoloneresistant Escherichia coli among patients with haema tological malignancies: result of a prospective study on 823 patients at a single institution. J Antimicrob Chemother 2008;61: 721-728 (Pubitemid 351321152)
9. Micol JB, de Botton S, Guieze R, Coiteux V, Darre S, Dessein R, et al. An 18-case outbreak of drug-resistant Pseudomonas aeruginosa bacteraemia in haematology patients. Haematologica 2006;91:1134-1138 (Pubitemid 44204785)
10. Worth LJ, Thursky KA, Seymour JF, Slavin MA. Vancomycin-resistant Enterococcus faecium infection in patients with hematologic malignancy: patients with acute myeloid leukaemia are at high risk. Eur J Haematol 2007;79:226-233
11. Bach PB, Malak SF, Jurcic J, Gelfand SE, Eagan J, Little C, et al. Impact of infection by vancomycin-resistant Enterococcus on survival and resource utilization for patients with leukaemia. Infect Control Hosp Epidemiol 2004; 25:391-394
12. Hachem RY, Chemaly RF, Ahmar CA, Jiang Y, Boktour MR, Rjaili GA, et al. Colistin is effective in treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa in cancer patients. Antimicrob Agents Chemother 2007;51: 1905-1911 (Pubitemid 46903072)
13. Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, et al. 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 2002;34:730-751 (Pubitemid 34194843)
14. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2002;35:1281-1307 (Pubitemid 35448956)
15. Bauer KW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45:493-496
16. Paterson DL. The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin Infect Dis 2006;43:S43-8. (Pubitemid 44267139)
17. Kern WV, Andriof E, Oethinger M, Kern P, Hacker J, Marre R. Emergence of fluoroquinolone-resistant Escherichia coli at a cancer center. Antimicrob Agents Chemother 1994;38:681-687 (Pubitemid 24114001)
18. Peterson LR. Squeezing the antibiotic balloon: the impact of antimicrobial classes on emerging resistance. Clin Microbiol Infect 2005;11:4-16.
19. Velasco E, Byington R, Martins CA, Schirmer M, Dias LM, Goncalves VM. Comparative study of clinical characteristics of neutropenic and non-neutropenic adult cancer patients with bloodstream infections. Eur J Clin Microbiol Infect Dis 2006;25:1-7. (Pubitemid 43207321)
20. Brunet AS, Ploton C, Galambrun C, Pondarré C, Pages MP, Bleyzac N, et al. Low incidence of sepsis due to viridans streptococci in a ten-year retrospective study of pediatric acute myeloid leukaemia. Pediatr Blood Cancer 2006;47:765-772 (Pubitemid 44476752)
21. Razonable RR, Litzow MR, Khaliq Y, Piper KE, Rouse MS, Patel R. Bacteremia due to viridans group streptococci with diminished susceptibility to levofloxacin among neutropenic patients receiving levofloxacin prophylaxis. Clin Infect Dis 2002;34:1469-1474 (Pubitemid 34553706)
22. Marron A, Carratala J, Gonzalez-Barca E, Fernandez-Sevilla A, Alcaide F, Gudiol F. Serious complications of bacteremia caused by viridans streptococci in neutropenic patients with cancer. Clin Infect Dis 2000;31:1126-1130 (Pubitemid 32295438)
23. Todeschini G, Tecchio C, Borghero C, D'Emilio A, Pegoraro E, de Lalla F, et al. Association between Enterococcus bacteraemia and death in neutropenic patients with haematological malignancies. J Infect 2006;53: 266-273 (Pubitemid 44424268)
24. Ramphal R. Changes in the etiology of bacteremia in febrile neutropenic patients and the susceptibilities of the currently isolated pathogens. Clin Infect Dis 2004;39(Suppl 1): 25-31. (Pubitemid 38971472)
25. Gillespie TA, Johnson PR, Notman AW, Coia JE, Hanson MF. Eradication of a resistant Pseudomonas aeruginosa strain after a cluster of infections in a hematology/oncology unit. Clin Microbiol Infect 2000;6:125-130
26. Pagano L, Caira M, Candoni A, Offidani M, Fianchi L, Martino B, et al. The epidemiology of fungal infections in patients with hematological malignancies: the SEIFEM-2004 study. Haematologica 2006;91:1068-1075 (Pubitemid 44208634)