Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults

Journal of Nutrition

Volumn 145, Issue 4, 2015, Pages 701-707

  Deac, Oana M ^a   Mills, James L ^b   Shane, Barry ^c   Midttun, Øivind ^d   Ueland, Per M ^e   Brosnan, John T ^f   Brosnan, Margaret E ^f   Laird, Eamon ^a   Gibney, Eileen R ^g   Fan, Ruzong ^b   Wang, Yifan ^b   Brody, Lawrence C ^h   Molloy, Anne M ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BEVITAL AS   (Norway)

^e HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^f MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^g UNIVERSITY COLLEGE DUBLIN   (Ireland)

^h NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

3 hydroxykynurenine; Kynurenine; Protein; Pyridoxal 5' phosphate; Tryptophan; Vitamin b 6

Indexed keywords

3 HYDROXYANTHRANILIC ACID; 3 HYDROXYKYNURENINE; ALCOHOL; ANTHRANILIC ACID; ARGININE; ESSENTIAL AMINO ACID; KYNURENIC ACID; KYNURENINE; METHIONINE; ORAL CONTRACEPTIVE AGENT; PYRIDOXINE; TRYPTOPHAN; XANTHURENIC ACID; 3-HYDROXYKYNURENINE; ANTHRANILIC ACID DERIVATIVE; BIOLOGICAL MARKER; PYRIDOXAL 5 PHOSPHATE;

ADULT; ALCOHOLISM; ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG BLOOD LEVEL; DRUG DEGRADATION; FEMALE; HUMAN; HUMAN EXPERIMENT; LIFESTYLE; MALE; NORMAL HUMAN; SEX DIFFERENCE; SMOKING; VITAMIN SUPPLEMENTATION; YOUNG ADULT; ADOLESCENT; ANALOGS AND DERIVATIVES; BLOOD; DIET SUPPLEMENTATION; METABOLISM; QUESTIONNAIRE;

3-HYDROXYANTHRANILIC ACID; ADOLESCENT; ADULT; ARGININE; BIOMARKERS; DIETARY SUPPLEMENTS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; KYNURENIC ACID; KYNURENINE; LIFE STYLE; MALE; METHIONINE; ORTHO-AMINOBENZOATES; PYRIDOXAL PHOSPHATE; SEX FACTORS; SURVEYS AND QUESTIONNAIRES; TRYPTOPHAN; VITAMIN B 6; XANTHURENATES; YOUNG ADULT;

EID: 84928525355     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.114.203091     Document Type: Article

References (51)

1. Chuang SC, Fanidi A, Ueland PM, Relton C, Midttun O, Vollset SE, Gunter MJ, Seckl MJ, Travis RC, Wareham N, et al. Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk. Cancer Epidemiol Biomarkers Prev 2014;23:461-8.
2. Guillemin GJ. Quinolinic acid: neurotoxicity. FEBS J 2012;279:1355.
3. Zádori D, Klivenyi P, Vamos E, Fulop F, Toldi J, Vecsei L. Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies. J Neural Transm 2009;116:1403-9.
4. Oxenkrug G. Insulin resistance and dysregulation of tryptophankynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways. Mol Neurobiol 2013;48:294-301.
5. Le Floc'h N, Otten W, Merlot E. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 2011;41:1195-205.
6. Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012;13:465-77.
7. Mándi Y, Vecsei L. The kynurenine system and immunoregulation. J Neural Transm 2012;119:197-209.
8. Lima S, Kumar S, Gawandi V, Momany C, Phillips RS. Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. J Med Chem 2009;52:389-96.
9. Paul L, Ueland PM, Selhub J. Mechanistic perspective on the relationship between pyridoxal 5#-phosphate and inflammation. Nutr Rev 2013;71:239-44.
10. Plecko B. Pyridoxine and pyridoxalphosphate-dependent epilepsies. Handb Clin Neurol 2013;113:1811-7.
11. Ciorba MA. Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond. Am J Clin Nutr 2013;98:863-4.
12. Midttun O, Ulvik A, Ringdal Pedersen E, Ebbing M, Bleie O, Schartum-Hansen H, Nilsen RM, Nygard O, Ueland PM. Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. J Nutr 2011;141:611-7.
13. Ulvik A, Theofylaktopoulou D, Midttun O, Nygard O, Eussen SJ, Ueland PM. Substrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status. Am J Clin Nutr 2013;98:934-40.
14. Andrzejewska-Buczko J, Pawlak D, Tankiewicz A, Matys T, Buczko W. Possible involvement of kynurenamines in the pathogenesis of cataract in diabetic patients. Med Sci Monit 2001;7:742-5.
15. Munipally PK, Agraharm SG, Valavala VK, Gundae S, Turlapati NR. Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients. Arch Physiol Biochem 2011;117:254-8.
16. Clarke G, Fitzgerald P, Cryan JF, Cassidy EM, Quigley EM, Dinan TG. Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort. BMC Gastroenterol 2009;9:6.
17. Colín-González AL, Maldonado PD, Santamaria A. 3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the central nervous system. Neurotoxicology 2013;34:189-204.
18. Adams S, Braidy N, Bessede A, Brew BJ, Grant R, Teo C, Guillemin GJ. The kynurenine pathway in brain tumor pathogenesis. Cancer Res 2012;72:5649-57.
19. Theofylaktopoulou D, Midttun O, Ulvik A, Ueland PM, Tell GS, Vollset SE, Nygard O, Eussen SJ. A community based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. Clin Exp Immunol 2013;173:121-30.
20. Mills JL, Carter TC, Scott JM, Troendle JF, Gibney ER, Shane B, Kirke PN, Ueland PM, Brody LC, Molloy AM. Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status? Am J Clin Nutr 2011;94:495-500.
21. Stone N, Pangilinan F, Molloy AM, Shane B, Scott JM, Ueland PM, Mills JL, Kirke PN, Sethupathy P, Brody LC. Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PLoS ONE 2011;6:e21851.
22. Desch KC, Ozel AB, Siemieniak D, Kalish Y, Shavit JA, Thornburg CD, Sharathkumar AA, McHugh CP, Laurie CC, Crenshaw A, et al. Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proc Natl Acad Sci USA 2013;110:588-93.
23. Midttun Ø, Hustad S, Ueland PM. Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 2009;23:1371-9.
24. Connor Gorber S, Schofield-Hurwitz S, Hardt J, Levasseur G, Tremblay M. The accuracy of self-reported smoking: a systematic review of the relationship between self-reported and cotinine-assessed smoking status. Nicotine Tob Res 2009;11:12-24.
25. The R Project for Statistical Computing [Internet]. [cited 2014 Nov 17]. Available from: http://www.r-project.org/.
26. Berg J, Lane V. Pathology Harmony; a pragmatic and scientific approach to unfounded variation in the clinical laboratory. Ann Clin Biochem 2011;48:195-7.
27. Miller LT, Leklem JE, Shultz TD. The effect of dietary protein on the metabolism of vitamin B-6 in humans. J Nutr 1985;115:1663-72.
28. Lotto V, Choi SW, Friso S. Vitamin B-6: a challenging link between nutrition and inflammation in CVD. Br J Nutr 2011;106:183-95.
29. Eussen SJ, Vollset SE, Hustad S, Midttun O, Meyer K, Fredriksen A, Ueland PM, Jenab M, Slimani N, Boffetta P, et al. Plasma vitamins B2, B-6, and B12, and related genetic variants as predictors of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2010;19:2549-61.
30. Ulvik A, Midttun O, Pedersen ER, Eussen SJ, Nygard O, Ueland PM. Evidence for increased catabolism of vitamin B-6 during systemic inflammation. Am J Clin Nutr 2014;100:250-5.
31. Pedersen ER, Midttun O, Ueland PM, Schartum-Hansen H, Seifert R, Igland J, Nordrehaug JE, Ebbing M, Svingen G, Bleie O, et al. Systemic markers of interferon-gamma-mediated immune activation and longterm prognosis in patients with stable coronary artery disease. Arterioscler Thromb Vasc Biol 2011;31:698-704.
32. Rose DP, Braidman IP. Oral contraceptives, depression, and aminoacid metabolism. Lancet 1970;1:1117-8.
33. Brin M. Abnormal tryptophan metabolism in pregnancy and with the oral contraceptive pil. II. Relative levels of vitamin B 6-vitamers in cord and maternal blood. Am J Clin Nutr 1971;24:704-8.
34. Nilsen RM, Bjorke-Monsen AL, Midttun O, Nygard O, Pedersen ER, Ulvik A, Magnus P, Gjessing HK, Vollset SE, Ueland PM. Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia. Obstet Gynecol 2012;119:1243-50.
35. Friso S, Jacques PF, Wilson PW, Rosenberg IH, Selhub J. Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 2001;103:2788-91.
36. Kelly PJ, Kistler JP, Shih VE, Mandell R, Atassi N, Barron M, Lee H, Silveira S, Furie KL. Inflammation, homocysteine, and vitamin B-6 status after ischemic stroke. Stroke 2004;35:12-5.
37. Gori AM, Sofi F, Corsi AM, Gazzini A, Sestini I, Lauretani F, Bandinelli S, Gensini GF, Ferrucci L, Abbate R. Predictors of vitamin B-6 and folate concentrations in older persons: the InCHIANTI study. Clin Chem 2006;52:1318-24.
38. Malmauret L, Leblanc J, Cuvelier I, Verger P. Dietary intakes and vitamin status of a sample of homeless people in Paris. Eur J Clin Nutr 2002;56:313-20.
39. Brown RR, Rose DP, Leklem JE, Linkswiler H, Anand R. Urinary 4-pyridoxic acid, plasma pyridoxal phosphate, and erythrocyte aminotransferase levels in oral contraceptive users receiving controlled intakes of vitamin B-6. Am J Clin Nutr 1975;28:10-9.
40. Aly HE, Donald EA, Simpson MH. Oral contraceptives and vitamin B-6 metabolism. Am J Clin Nutr 1971;24:297-303.
41. Price SA, Rose DP, Toseland PA. Effects of dietary vitamin B 6 deficiency and oral contraceptives on the spontaneous urinary excretion of 3-hydroxyanthranilic acid. Am J Clin Nutr 1972;25:494-8.
42. Mason M, Ford J, Wu HL. Effects of steroid and nonsteroid metabolites on enzyme conformation and pyridoxal phosphate binding. Ann N Y Acad Sci 1969;166:170-83.
43. Brin M. Abnormal tryptophan metabolism in pregnancy and with the oral contraceptive pill. I. Specific effects of an oral estrogenic contraceptive steroid on the tryptophan oxygenase and two aminotransferase activities in livers of ovariectomized-adrenalectomized rats. Am J Clin Nutr 1971;24:699-703.
44. Shibata K. Urine 3-hydroxykynurenine is higher during the postovulatory phase than in the preovulatory phase indicating a higher vitamin B6 requirement. Biosci Biotechnol Biochem 2014;78:1757-60.
45. Vermaak WJ, Ubbink JB, Barnard HC, Potgieter GM, van Jaarsveld H, Groenewald AJ. Vitamin B-6 nutrition status and cigarette smoking. Am J Clin Nutr 1990;51:1058-61.
46. Morris MS, Sakakeeny L, Jacques PF, Picciano MF, Selhub J. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr 2010;140:103-10.
47. Ulvik A, Ebbing M, Hustad S, Midttun O, Nygard O, Vollset SE, Bonaa KH, Nordrehaug JE, Nilsen DW, Schirmer H, et al. Long-and shortterm effects of tobacco smoking on circulating concentrations of B vitamins. Clin Chem 2010;56:755-63.
48. Mangge H, Becker K, Fuchs D, Gostner JM. Antioxidants, inflammation and cardiovascular disease. World J Cardiol. 2014;6:462-77.
49. Gostner J, Ciardi C, Becker K, Fuchs D, Sucher R. Immunoregulatory impact of food antioxidants. Curr Pharm Des 2014;20:840-9.
50. Ulvik A, Midttun Ø, Pedersen ER, Nygård O, Ueland PM. Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris. Am J Clin Nutr 2012;95:1072-8.
51. Leklem JE. Quantitative aspects of tryptophan metabolism in humans and other species: a review. Am J Clin Nutr 1971;24:659-72.