Iron interventions in children from low-income and middle-income populations: Benefits and risks

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 18, Issue 3, 2015, Pages 289-294

  Baumgartner, Jeannine ^a   Barth Jaeggi, Tanja ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b ETH ZURICH   (Switzerland)

Author keywords

children; development; efficacy; gut microbiota; iron; morbidity

Indexed keywords

IRON;

CHILD GROWTH; CLINICAL TRIAL (TOPIC); COGNITION; ENTERITIS; HUMAN; INTESTINE FLORA; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON THERAPY; LOWEST INCOME GROUP; META ANALYSIS (TOPIC); MORBIDITY; REVIEW; RISK BENEFIT ANALYSIS; SYSTEMATIC REVIEW (TOPIC); TREATMENT OUTCOME; ADVERSE EFFECTS; ANEMIA, IRON-DEFICIENCY; CHEMICALLY INDUCED; CHILD; COMPLICATION; DEFICIENCY; DEVELOPING COUNTRY; DIET SUPPLEMENTATION; DRUG EFFECTS; DYSBIOSIS; GASTROENTERITIS; GROWTH; INFECTION; RISK ASSESSMENT;

ANEMIA, IRON-DEFICIENCY; CHILD; COGNITION; DEVELOPING COUNTRIES; DIETARY SUPPLEMENTS; DYSBIOSIS; GASTROENTERITIS; GROWTH; HUMANS; INFECTION; IRON; RISK ASSESSMENT;

EID: 84928480549     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000168     Document Type: Review

References (41)

1. WHO. Guideline: Intermittent Iron Supplementation in Preschool and School-Aged Children. Geneva: WHO; 2011.
2. Pasricha SR, Drakesmith H, Black J, et al. Control of iron deficiency anemia in low-and middle-income countries. Blood 2013; 121:2607-2617.
3. Low M, Farrell A, Biggs BA, Pasricha SR. Effects of daily iron supplementation in primary-school-aged children: systematic review and meta-analysis of randomized controlled trials. CMAJ 2013; 185:E791-E802.
4. Black MM. Integrated strategies needed to prevent iron deficiency and to promote early child development. J Trace Elem Med Biol 2012; 26:120-123.
5. Pasricha SR, Hayes E, Kalumba K, Biggs BA. Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-analysis of randomised controlled trials. Lancet Glob Health 2013; 1:e77-e86.
6. Thompson J, Biggs BA, Pasricha SR. Effects of daily iron supplementation in 2-to 5-year-old children: systematic review and meta-analysis. Pediatrics 2013; 131:739-753.
7. De-Regil LM, Jefferds ME, Sylvetsky AC, Dowswell T. Intermittent iron supplementation for improving nutrition and development in children under 12 years of age. Cochrane Database Syst Rev 2011; CD009085.
8. Pena-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Intermittent oral iron supplementation during pregnancy. Cochrane Database Syst Rev 2012; 7:CD009997.
9. Hawamdeh HM, Rawashdeh M, Aughsteen AA. Comparison between once weekly, twice weekly, and daily oral iron therapy in Jordanian children suffering from iron deficiency anemia. Matern Child Health J 2013; 17:368-373.
10. Coutinho GG, Cury PM, Cordeiro JA. Cyclical iron supplementation to reduce anemia among Brazilian preschoolers: a randomized controlled trial. BMC Public Health 2013; 13:21.
11. Kapil U, Sachdev HP, Dwivedi SN, et al. Relative efficacy of weekly and two differing doses of daily iron-folate supplementation in improving hemoglobin in mild and moderately anemic children between 3 and 5 years of age: a cluster randomized trial. Eur J Clin Nutr 2013; 67:343-347.
12. Rousham EK, Uzaman B, Abbott D, et al. The effect of a school-based iron intervention on the haemoglobin concentration of school children in northwest Pakistan. Eur J Clin Nutr 2013; 67:1188-1192.
13. Hieu NT, Sandalinas F, de Sesmaisons A, et al. Multimicronutrient-fortified biscuits decreased the prevalence of anaemia and improved iron status, whereas weekly iron supplementation only improved iron status in Vietnamese school children. Br J Nutr 2012; 108:1419-1427.
14. Zhang L, Kleiman-Weiner M, Luo R, et al. Multiple micronutrient supplementation reduces anemia and anxiety in rural China's elementary school children. J Nutr 2013; 143:640-647.
15. Barth-Jaeggi T, Moretti D, Kvalsvig J, et al. In-home fortification with 2.5mg iron as NaFeEDTA does not reduce anaemia but increases weight gain: a randomised controlled trial in Kenyan infants. Matern Child Nutr 2014. [Epub ahead of print]
16. Soofi S, Cousens S, Iqbal SP, et al. Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial. Lancet 2013; 382: 29-40.
17. Baumgartner J, Smuts CM, Malan L, et al. Effects of iron and n-3 fatty acid supplementation, alone and in combination, on cognition in school children: a randomized, double-blind, placebo-controlled intervention in South Africa. Am J Clin Nutr 2012; 96:1327-1338.
18. Lozoff B, Castillo M, Clark KM, Smith JB. Iron-fortified vs low-iron infant formula: developmental outcome at 10 years. Arch Pediatr Adolesc Med 2012; 166:208-215.
19. Lozoff B, Castillo M, Clark KM, et al. Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age. J Nutr 2014; 144:838-845.
20. Murray-Kolb LE, Khatry SK, Katz J, et al. Preschool micronutrient supplementation effects on intellectual and motor function in school-aged Nepalese children. Arch Pediatr Adolesc Med 2012; 166:404-410.
21. Surkan PJ, Siegel EH, Patel SA, et al. Effects of zinc and iron supplementation fail to improve motor and language milestone scores of infants and toddlers. Nutrition 2013; 29:542-548.
22. Smuts CM, Greeff J, Kvalsvig J, et al. Long-chain n-3 PUFA supplementation decreases physical activity during class time in iron-deficient South African school children. Br J Nutr 2015; 113:212-224.
23. Ebenezer R, Gunawardena K, Kumarendran B, et al. Cluster-randomised trial of the impact of school-based deworming and iron supplementation on the cognitive abilities of schoolchildren in Sri Lanka's plantation sector. Trop Med Int Health 2013; 18:942-951.
24. Olney DK, Kariger PK, Stoltzfus RJ, et al. Developmental effects of micronutrient supplementation and malaria in Zanzibari children. Early Hum Dev 2013; 89:667-674.
25. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006; 367:133-143.
26. Fontaine O. Conclusions and recommendations of the WHO Consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas. Food Nutr Bull 2007; 28:S621-S627.
27. Chen K, Chen XR, Zhang L, et al. Effect of simultaneous supplementation of vitamin A and iron on diarrheal and respiratory tract infection in preschool children in Chengdu City, China. Nutrition 2013; 29:1197-1203.
28. Malan L, Baumgartner J, Calder PC, et al. N-3 long-chain polyunsaturated fatty acids reduce respiratory morbidity caused by iron supplementation in iron-deficient South African school children: a randomized, double-blind, placebo-controlled intervention. Am J Clin Nutr 2014. [Epub ahead of print]
29. Zlotkin S, Newton S, Aimone AM, et al. Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trial. JAMA 2013; 310:938-947.
30. Gwamaka M, Kurtis JD, Sorensen BE, et al. Iron deficiency protects against severe Plasmodium falciparum malaria and death in young children. Clin Infect Dis 2012; 54:1137-1144.
31. Jonker FA, Calis JC, van Hensbroek MB, et al. Iron status predicts malaria risk in Malawian preschool children. PLoS One 2012; 7:e42670.
32. Clark MA, Goheen MM, Fulford A, et al. Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. Nature Commun 2014; 5:4446.
33. Kortman GA, Raffatellu M, Swinkels DW, Tjalsma H. Nutritional iron turned inside out: intestinal stress from a gut microbial perspective. FEMS Microbiol Rev 2014; 38:1202-1234.
34. Dostal A, Gagnon M, Chassard C, et al. Salmonella adhesion, invasion and cellular immune responses are differentially affected by iron concentrations in a combined in vitro gut fermentation-cell model. PLoS One 2014; 9:e93549.
35. Kortman GA, Boleij A, Swinkels DW, Tjalsma H. Iron availability increases the pathogenic potential of Salmonella typhimurium and other enteric pathogens at the intestinal epithelial interface. PLoS One 2012; 7:e29968.
36. Zimmermann MB, Chassard C, Rohner F, et al. The effects of iron fortification on the gut microbiota in African children: a randomized controlled trial in Cote d'Ivoire. Am J Clin Nutr 2010; 92:1406-1415.
37. Dostal A, Baumgartner J, Riesen N, et al. Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African children. Br J Nutr 2014; 112:547-556.
38. Jaeggi T, Kortman GA, Moretti D, et al. Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 2014. [Epub ahead of print]
39. van Santen S, de Mast Q, Swinkels DW, van der Ven AJ. The iron link between malaria and invasive nontyphoid Salmonella infections. Trends Parasitol 2013; 29:220-227.
40. Goldsmith JR, Sartor RB. The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol 2014; 49:785-798.
41. Winter SE, Lopez CA, Baumler AJ. The dynamics of gut-associated microbial communities during inflammation. EMBO Rep 2013; 14:319-327.