Effects of daily iron supplementation in 2- to 5-year-old children: Systematic review and meta-analysis

Pediatrics

Volumn 131, Issue 4, 2013, Pages 739-753

  Thompson, Jane ^a   Biggs, Beverley Ann ^b   Pasricha, Sant Rayn ^b,c  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH MEDICAL CENTRE   (Australia)

Author keywords

Anemia; Child; Iron; Meta analysis; Preschool; Systematic review

Indexed keywords

ALBENDAZOLE; ASCORBIC ACID; CYANOCOBALAMIN; EDETATE IRON; FERRIC AMMONIUM CITRATE; FERRITIN; FERROUS SULFATE; FOLIC ACID; HEMOGLOBIN; IRON; MEBENDAZOLE; MULTIVITAMIN; PLACEBO; PYRIMETHAMINE; RETINOL; SULFADOXINE; TRANSFERRIN; ZINC;

ANEMIA; COGNITIVE DEVELOPMENT; DRUG SAFETY; GROWTH; HEMATOCRIT; HUMAN; INFECTION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON THERAPY; MEAN CORPUSCULAR VOLUME; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW;

ANEMIA, IRON-DEFICIENCY; BIOLOGICAL MARKERS; CHILD DEVELOPMENT; CHILD, PRESCHOOL; COGNITION; DIETARY SUPPLEMENTS; DRUG ADMINISTRATION SCHEDULE; FERRITINS; GROWTH; HEMOGLOBINS; HUMANS; IRON; MODELS, STATISTICAL; TRACE ELEMENTS; TREATMENT OUTCOME;

EID: 84876000829     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-2256     Document Type: Review

References (63)

1. Benoist B, McLean E, Egli I, Cogswell M. Worldwide Prevalence of Anaemia 1993-2005. Geneva, Switzerland: World Health Organization; 2008
2. WHO/UNICEF/UNU. Iron Deficiency Anaemia: Assessment, Prevention, and Control. A Guide for Programme Managers. Geneva, Switzerland: World Health Organization; 2001
3. Wharton BA. Iron deficiency in children: detection and prevention. Br J Haematol. 1999;106(2):270-280
4. Chaparro CM. Setting the stage for child health and development: prevention of iron deficiency in early infancy. J Nutr. 2008;138 (12):2529-2533
5. Pasricha SR, Shet AS, Black JF, Sudarshan H, Prashanth NS, Biggs BA. Vitamin B-12, folate, iron, and vitamin A concentrations in rural Indian children are associated with continued breastfeeding, complementary diet, and maternal nutrition. Am J Clin Nutr. 2011;94(5):1358-1370
6. Brewer C, Harrower M. Statcompiler beta. Available at: www.statcompiler.com. Accessed February 6, 2012
7. Bortolini GA, Vitolo MR. Relationship between iron deficiency and anemia in children younger than 4 years. J Pediatr (Rio J). 2010;86(6):488-492
8. George J, Yiannakis M, Main B, et al. Genetic hemoglobin disorders, infection, and deficiencies of iron and vitamin A determine anemia in young Cambodian children. J Nutr. 2012;142(4):781-787
9. Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. N Engl J Med. 2004;351(8):799-807
10. Schellenberg D, Menendez C, Kahigwa E, et al. African children with malaria in an area of intense Plasmodium falciparum transmission: features on admission to the hospital and risk factors for death. Am J Trop Med Hyg. 1999;61(3):431-438
11. Gidding SS, Dennison BA, Birch LL, et al; American Heart Association. Dietary recommendations for children and adolescents: a guide for practitioners. Pediatrics. 2006;117(2):544-559
12. Stoltzfus RJ, Dreyfuss ML. Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. Washington, DC: International Life Sciences Institute; 1998
13. Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood: health benefits and risks. Am J Clin Nutr. 2006;84(6):1261-1276
14. Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4 suppl):S560-S571
15. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet. 2006;367 (9505):133-143
16. Goddard AF, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anaemia. Brit Med J. 2000;46(suppl 3-4):IV1-IV5
17. De-Regil LM, Jefferds ME, Sylvetsky AC, Dowswell T. Intermittent iron supplementation for improving nutrition and development in children under 12 years of age. Cochrane Database Syst Rev. 2011;12 (12):CD009085
18. World Health Organization. Intermittent iron supplementation for preschool and school age children. e-Library of Evidence for Nutrition Actions (eLENA). Available at: www.who.int/elena/titles/iron-infants/en/index.html. Accessed October 6, 2011
19. Pena-Rosas JP, De-Regil LM, Rogers LM, Bopardikar A, Panisset U. Translating research into action: WHO evidence-informed guidelines for safe and effective micro-nutrient interventions. J Nutr. 2012;142(1): 197S-204S
20. Higgins JP, Altman DG, Sterne JA. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. 5.1 ed. Oxford, United Kingdom: The Cochrane Collaboration; 2011
21. Lawless JW, Latham MC, Stephenson LS, Kinoti SN, Pertet AM. Iron supplementation improves appetite and growth in anemic Kenyan primary school children. J Nutr. 1994;124(5):645-654
22. Mejía LA, Chew F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Am J Clin Nutr. 1988;48(3):595-600
23. Yang Q. Yin Sa, Zhao X, An Jg. [Effect of daily or once weekly iron supplementation on growth and iron status of preschool children] Wei Sheng Yen Chiu. 2004;33(2):205-207
24. Angle CR, McIntire MS. Blood lead of iron deficient children increase following iron supplementation. Pediat Res. 1975;9(4)
25. Adish A. Risk Factors and an Assessment of Control Strategies for Iron Deficiency Anemia in Children in Northern Ethiopia. Montreal, Canada, McGill University; 1997
26. Dossa RA, Ategbo EA, de Koning FL, van Raaij JM, Hautvast JG. Impact of iron supplementation and deworming on growth performance in preschool Beninese children. Eur J Clin Nutr. 2001;55(4):223-228
27. Rosado JL, López P, Muñoz E, Martinez H, Allen LH. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. Am J Clin Nutr. 1997;65(1):13-19
28. Stoltzfus RJ, Kvalsvig JD, Chwaya HM, et al. Effects of iron supplementation and an-thelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study. BMJ. 2001;323(7326):1389-1393
29. Bhatia D, Seshadri S. Growth performance in anemia and following iron supplementation. Indian Pediatr. 1993;30(2):195-200
30. Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children. Ann Trop Paediatr. 1989;9(1):17-23
31. Ukoumunne OC, Gulliford MC, Chinn S, Sterne JAC, Burney PG. Methods for evaluating area-wide and organisation-based interventions in health and health care: a systematic review. Health Technol Assess. 1999;3(5):iii-92
32. Yurdakök K, Temiz F, Yalçin SS, Gümrük F. Efficacy of daily and weekly iron supplementation on iron status in exclusively breast-fed infants. J Pediatr Hematol Oncol. 2004;26(5):284-288
33. National Bureau of Statistics (NBS) [Tanzania] and ORC Macro. Tanzania: 2004-05 Demographic and Health Survey - Key Findings. Calverton, MD: NBS and ORC Macro.; 2005
34. Kramer MS, Aboud F, Mironova E, et al; Promotion of Breastfeeding Intervention Trial (PROBIT) Study Group. Breastfeeding and child cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008;65(5):578-584
35. Mitra AK, Akramuzzaman SM, Fuchs GJ, Rahman MM, Mahalanabis D. Long-term oral supplementation with iron is not harmful for young children in a poor community of Bangladesh. J Nutr. 1997;127 (8):1451-1455
36. Metallinos-Katsaras E, Valassi-Adam E, Dewey KG, Lönnerdal B, Stamoulakatou A, Pollitt E. Effect of iron supplementation on cognition in Greek preschoolers. Eur J Clin Nutr. 2004;58(11):1532-1542
37. Deinard AS, List A, Lindgren B, Hunt JV, Chang PN. Cognitive deficits in iron-deficient and iron-deficient anemic children. J Pediatr. 1986;108(5 Pt 1):681-689
38. Soewondo S, Husaini M, Pollitt E. Effects of iron deficiency on attention and learning processes in preschool children: Bandung, Indonesia. Am J Clin Nutr. 1989;50(3 suppl): 667-673; discussion 673-664.
39. Angeles IT, Schultink WJ, Matulessi P, Gross R, Sastroamidjojo S. Decreased rate of stunting among anemic Indonesian preschool children through iron supplementation. Am J Clin Nutr. 1993;58(3):339-342
40. Smith AW, Hendrickse RG, Harrison C, Hayes RJ, Greenwood BM. Iron-deficiency anaemia and its response to oral iron: report of a study in rural Gambian children treated at home by their mothers. Ann Trop Paediatr. 1989;9(1):6-16
41. van Hensbroek MB, Morris-Jones S, Meisner S, et al. Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Trans R Soc Trop Med Hyg. 1995;89(6):672-676
42. Nwanyanwu OC, Ziba C, Kazembe PN, Gamadzi G, Gandwe J, Redd SC. The effect of oral iron therapy during treatment for Plasmodium falciparum malaria with sulphadoxine-pyrimethamine on Malawian children under 5 years of age. Ann Trop Med Parasitol. 1996;90(6):589-595
43. Guyatt G, Oxman AD, Akl EA, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64(4):383-394
44. Gera T, Sachdev HP, Nestel P, Sachdev SS. Effect of iron supplementation on haemoglobin response in children: systematic review of randomised controlled trials. J Pediatr Gastroenterol Nutr. 2007;44(4):468-486
45. Gera T, Sachdev HP. Effect of iron supplementation on incidence of infectious illness in children: systematic review. BMJ. 2002; 325(7373):1142
46. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials. Public Health Nutr. 2005;8(2):117-132
47. Falkingham M, Abdelhamid A, Curtis P, Fairweather-Tait S, Dye L, Hooper L. The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J. 2010;9(4):4
48. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials. Public Health Nutr. 2006;9 (7):904-920
49. Gera T, Sachdev HP, Nestel P. Effect of iron supplementation on physical performance in children and adolescents: systematic review of randomized controlled trials. Indian Pediatr. 2007;44(1):15-24
50. Pasricha SR, Flecknoe-Brown SC, Allen KJ, et al. Diagnosis and management of iron deficiency anaemia: a clinical update. Med J Aust. 2010;193(9):525-532
51. Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002;123(3):835-844
52. Logan S, Martins S, Gilbert R. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database Syst Rev. 2001; (2):CD001444
53. Szajewska H, Ruszczynski M, Chmielewska A. Effects of iron supplementation in non-anemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials. Am J Clin Nutr. 2010;91(6): 1684-1690
54. Chapter 29: Power analysis for meta-analysis. In: Borenstein M, Hedges LV, Higgins JPT, Rothstein HR, eds. Introduction to Meta-Analysis. New York: Wiley; 2009
55. Okebe JU, Yahav D, Shbita R, Paul M. Oral iron supplements for children in malaria-endemic areas. Cochrane Database Syst Rev. 2011; (10):CD006589
56. Gara SN, Madaki AJ, Thacher TD. A comparison of iron and folate with folate alone in hematologic recovery of children treated for acute malaria. Am J Trop Med Hyg. 2010;83(4):843-847
57. Rahman MM, Akramuzzaman SM, Mitra AK, Fuchs GJ, Mahalanabis D. Long-term supplementation with iron does not enhance growth in malnourished Bangladeshi children. J Nutr. 1999;129(7):1319-1322
58. Pereira SM, Begum A, Baker SJ. Studies in iron supplementation of preschool children. Br J Nutr. 1978;39(3):493-499
59. Allen LH, Rosado JL, Casterline JE, et al. Lack of hemoglobin response to iron supplementation in anemic mexican preschoolers with multiple micronutrient deficiencies. Am J Clin Nutr. 2000;71(6):1485-1494
60. Muñoz EC, Rosado JL, López P, Furr HC, Allen LH. Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. Am J Clin Nutr. 2000; 71(3):789-794
61. Mebrahtu T, Stoltzfus RJ, Chwaya HM, et al. Low-dose daily iron supplementation for 12 months does not increase the prevalence of malarial infection or density of parasites in young Zanzibari children. J Nutr. 2004; 134(11):3037-3041
62. Stoltzfus RJ, Chway HM, Montresor A, et al. Low dose daily iron supplementation improves iron status and appetite but not anemia, whereas quarterly anthelminthic treatment improves growth, appetite and anemia in Zanzibari preschool children. J Nutr. 2004;134(2):348-356
63. Soewondo, S. The effect of iron deficiency and mental stimulation on Indonesian children9s cognitive performance and development. Kobe J Med Sci. 1995;41(1-2):1-17