Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites

ACS Chemical Biology

Volumn 10, Issue 4, 2015, Pages 1145-1154

  Howard, Brittany L ^a   Harvey, Katherine L ^b,d   Stewart, Rebecca J ^c,d   Azevedo, Mauro F ^b   Crabb, Brendan S ^a,b,d   Jennings, Ian G ^a   Sanders, Paul R ^b   Manallack, David T ^a   Thompson, Philip E ^a   Tonkin, Christopher J ^c,d   Gilson, Paul R ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b BURNET INSTITUTE   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE; GLUTATHIONE TRANSFERASE; HYDROLASE; LACTATE DEHYDROGENASE; PHOSPHODIESTERASE INHIBITOR; ZAPRINAST; 5-BENZYL-3-ISOPROPYL-1H-PYRAZOLO(4,3-D)PYRIMIDIN-7(6H)-ONE; ANTIPROTOZOAL AGENT; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIMIDINONE DERIVATIVE;

APICOMPLEXA; ARTICLE; BINDING SITE; ENZYME ACTIVATION; EXOCYTOSIS; GAMETOCYTE; HYDROLYSIS; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TOXOPLASMA GONDII; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; FEMALE; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; SYNTHESIS; TOXOPLASMA;

PLASMODIUM FALCIPARUM; TOXOPLASMA GONDII;

ANTIPROTOZOAL AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIC AMP; CYCLIC GMP; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; PLASMODIUM FALCIPARUM; PURINONES; PYRAZOLES; PYRIMIDINONES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURAL HOMOLOGY, PROTEIN; TOXOPLASMA;

EID: 84928469099     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb501004q     Document Type: Article

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