Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110a subunit of PI3 kinase

Oncotarget

Volumn 6, Issue 10, 2015, Pages 8062-8070

  Colamonici, Marco ^a   Blyth, Gavin ^a   Saleiro, Diana ^a   Szilard, Amy ^a   Bliss Moreau, Meghan ^a   Giles, Francis J ^a   Altman, Jessica K ^a,b   Beauchamp, Elspeth M ^a,b   Platanias, Leonidas C ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

AML; MTOR signaling; PI3 kinase

Indexed keywords

4 (4 AMINO 5 (7 METHOXY 1H INDOL 2 YL)IMIDAZO[5,1 F][1,2,4]TRIAZIN 7 YL)CYCLOHEXANECARBOXYLIC ACID; ALPELISIB; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; S6 KINASE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; MTOR PROTEIN, HUMAN; NVP-BYL719; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; TARGET OF RAPAMYCIN KINASE; THIAZOLE DERIVATIVE; TRIAZINE DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LEUKEMIA CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; GENETICS; LEUKEMIA, MYELOID, ACUTE; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE; U-937 CELL LINE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; LEUKEMIA, MYELOID, ACUTE; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; THIAZOLES; TOR SERINE-THREONINE KINASES; TRIAZINES; U937 CELLS;

EID: 84928413090     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3509     Document Type: Article

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