Sexual dysfunction related to drugs: A critical reviewPart IV: Cardiovascular drugs

Pharmacopsychiatry

Volumn 48, Issue 1, 2015, Pages 1-6

  La Torre, A ^b   Giupponi, G ^a   Duffy, D ^a   Conca, Andreas ^a   Catanzariti, D ^b  

^a S Maurizio Hospital   (Italy)

^b Ospedale di Rovereto   (Italy)

Author keywords

cardiovascular drugs; sexual dysfunction; sexual side effects; treatment emergent sexual dysfunction

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ALDOSTERONE ANTAGONIST; AMILORIDE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ATENOLOL; BENDROFLUMETHIAZIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETANIDINE; CARDIOVASCULAR AGENT; CARVEDILOL; CHLORTALIDONE; CLONIDINE; DIGOXIN; DISOPYRAMIDE; DIURETIC AGENT; EPLERENONE; GUANETHIDINE; HYDRALAZINE; HYDROCHLOROTHIAZIDE; LABETALOL; METHYLDOPA; METOPROLOL; NIFEDIPINE; PROPAFENONE; PROPRANOLOL; SPIRONOLACTONE; TRICHLORMETHIAZIDE; UNINDEXED DRUG; VERAPAMIL;

DRUG EFFECT; FEMALE SEXUAL DYSFUNCTION; HUMAN; MALE SEXUAL DYSFUNCTION; PRIORITY JOURNAL; REVIEW; SEXUAL DYSFUNCTION; SEXUAL FUNCTION; ANIMAL; BIBLIOGRAPHIC DATABASE; CHEMICALLY INDUCED; FEMALE; MALE; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; STATISTICS AND NUMERICAL DATA;

ANIMALS; CARDIOVASCULAR AGENTS; DATABASES, BIBLIOGRAPHIC; FEMALE; HUMANS; MALE; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 84928402176     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0034-1395515     Document Type: Review

References (109)

1. La Torre A., Giupponi G., Duffy DM U. et al. Sexual dysfunction related to psychotropic drugs: a critical review. Part I: antidepressants. Pharmacopsychiatry: 2013; 46 191 199
2. La Torre A., Conca A., Duffy DM U. et al. Sexual dysfunction related to psychotropic drugs: a critical review. Part II: antipsychotics. Pharmacopsychiatry: 2013; 46 201 208
3. La Torre A., Giupponi G., Duffy DM U. et al. Sexual dysfunction related to psychotropic drugs: a critical review. Part III: mood stabilizer and anxiolytic drugs. Pharmacopsychiatry: 2014; 47 1 6
4. WHO Collaborating Centre for Drug Statistics Methodology ATC. Structure and principles. Available on line at: http://www.whocc.no/atc/structure-and-principles/ (accessed on 10 May 2014)
5. Doumas M., Doumas S. Sexual dysfunction in essential hypertension: myth or reality? J Clin Hypertens: 2006; 8, 4 269 274
6. Doumas M., Tsiodras S., Tsakiris A. et al. Female sexual dysfunction in essential hypertension: a common problem being uncovered. J Hypertens: 2006; 24 2387 2392
7. Doumas M., Anyfanti P., Lazaridis N. Effects of antihypertensive therapy on female sexual dysfunction: clinically meaningful? J Hypertens: 2012; 30 1263 1264
8. Ma R., Yu J., Xu D. et al. Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. J Hypertens: 2012; 30 210 216
9. Douma S., Doumas M., Tsakiris A. et al. Male and female sexual dysfunction: is hypertension an innocent bystander or a major contributor? Rev Bras Hipertens: 2007; 14 139 147
10. WHO. International Classification of Diseases (ICD) and Related Health Problems 10th Revision (ICD-10). Available on line at: http://apps.who.int/classifications/icd10/browse/2010/en#/V (accessed on 10 May 2014)
11. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). American Psychiatric Publ: 2010
12. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington, VA: 2013
13. Rosen R., Riley A., Wagner G. et al. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology: 1997; 49 822 830
14. Rosen R., Brown C., Heiman J. et al. The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Mar Ther: 2000; 26 191 208
15. Rosen R. C. Assessment of sexual dysfunction in patients with benign prostatic hyperplasia. BJU Int: 2006; 97 02 29 33
16. Duncan L. E., Lewis C., Smith C. E. et al. Sex, drugs, and hypertension: a methodological approach for studying a sensitive subject. Int J Impot Res: 2001; 13 31 40
17. Prisant L. M., Carr A. A., Bottini P. B. et al. Sexual dysfunction with antihypertensive drugs. Arch Intern Med: 1994; 154 730 736
18. Bulpitt C. J., Dollery C. T. Side effects of hypotensive agents evaluated by a self-administered questionnaire. Br Med J: 1973; 3 485 490
19. Stoffer S. S., Hynes K. M., Jiang N-S et al. Digoxin and abnormal serum hormone levels. JAMA: 1973; 225 1643 1644
20. Bauer G. E., Baker J., Hunyor S. N. et al. Side-effects of antihypertensive treatment: a placebo-controlled study. Clin Sci Mol Med: 1978; 04 341s 344s
21. Stevenson J. G., Umstead G. S. Sexual dysfunction due to antihypertensive agents. Drug Intell Clin Pharm: 1984; 18 113 121
22. Baumhäkel M., Schlimmer N., Kratz M. et al. Cardiovascular risk, drugs and erectile function - a systematic analysis. Int J Clin Pract: 2011; 65 289 298
23. Doumas M., Douma S. The effect of antihypertensive drugs on erectile function: a proposed management algorithm. J Clin Hypertens: 2006; 8 359 364
24. Doumas M., Viigimaa M., Papademetriou V. Combined antihypertensive therapy and sexual dysfunction: terra incognita. Cardiology: 2013; 125 232 234
25. Düsing R. Sexual dysfunction in male patients with hypertension. Drugs: 2005; 65 773 786
26. Finger W. W., Slagle M. A. Male sexual dysfunction: pathophysiology and treatment. Informa Medical. 2009; edited by Kandeel F. R.
27. Fogari R., Zoppi A. Effects of antihypertensive therapy on sexual activity in hypertensive men. Curr Hypertens Rep: 2002; 4 202 210
28. Fogari R., Zoppi A. Effects of antihypertensive agents on quality of life in the elderly. Drugs Aging: 2004; 21 377 393
29. Garko B., Ogunsina M. O., Danbauchi S. S. Sexual dysfunction in hypertensive patients: implications for therapy. Ann Afr Med: 2005; 4 46 51
30. Giuliano F., Droupy S. La iatrogénie médicamenteuse en médecine sexuelle. Prog Urol: 2013; 23 804 810
31. Krause W. Drugs Compromising Male Sexual Health. Springer-Verlag Berlin Heidelberg: 2008
32. Manolis A., Doumas M. Antihypertensive treatment and sexual dysfunction. Curr Hypertens Rep: 2012; 14 285 292
33. Manolis A., Doumas M. Sexual dysfunction: the 'prima ballerina' of hypertension-related quality-of-life complications. J Hypertens: 2008; 26 2074 2084
34. Nicolai MP J., Liem S. S., Both S. et al. A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice. Neth Heart J: 2014; 22 11
35. Shindel A. W., Kishore S., Lue T. F. Drugs designed to improve endothelial function: effects on erectile dysfunction. Curr Pharm Des: 2008; 14 3758 3767
36. Erdmann E. Safety and tolerability of beta-blockers: prejudices and reality. Eur Heart J Suppl: 2009; 11 A21 A25
37. Ko D. T., Hebert P. R., Coffey C. S. et al. Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA: 2002; 288 351 357
38. Ferrario C. M., Levy P. Sexual dysfunction in patients with hypertension: implications for therapy. J Clin Hypertens: 2002; 4 424 432
39. Blumentals W. A., Brown R. R., Gomez-Caminero A. Antihypertensive treatment and erectile dysfunction in a cohort of type II diabetes patients. Int J Impot Res: 2003; 15 314 317
40. Shiri R., Koskimäki J., Häkkinen J. et al. Cardiovascular drug use and the incidence of erectile dysfunction. Int J Impot Res: 2006; 19 208 212
41. Javaroni V., Neves M. F. Erectile dysfunction and hypertension: impact on cardiovascular risk and treatment. Int J Hypertens: 2012; Article ID 627278, 11 pages 10.1155/2012/627278
42. Gupta S., Salimpour P., Saenz de Tejada I. et al. A possible mechanism for alteration of human erectile function by digoxin: inhibition of corpus cavernosum sodium/potassium adenosine triphosphatase activity. J Urol: 1998; 159 1529 1536
43. Kley H. K., Muller A., Peerenboom H. et al. Digoxin does not alter plasma steroid levels in health men. Clin Pharmacol Ther: 1982; 32 12 17
44. Kley H. K., Abendroth H., Hehrmann R. et al. No effect of digitalis on sex and adrenal hormones in healthy subjects and in patients with congestive heart failure. Klin Wochenschr: 1984; 62 65 73
45. Tanner L. A., Bosco L. A. Gynecomastia associated with calcium cannel blocker therapy. Arch Intern Med: 1988; 148, 2 379 380
46. Zarren H. S., Black P. M. Unilateral gynecomastia and impotence during low-dose spironolactone administration in men. Mil Med: 1975; 140 417 419
47. Handler J. Managing erectile dysfunction in hypertensive patients. J Clin Hypertens: 2011; 13 450 453
48. Silvestri A., Galetta P., Cerquetani E. et al. Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. Eur Heart J: 2003; 24 1928 1932
49. Bansal S. Sexual dysfunction in hypertensive men. a critical review of the literature. Hypertension: 1988; 12 1 10
50. Viigimaa M., Doumas M., Vlachopoulos C. et al. Hypertension and sexual dysfunction: time to act. J Hyperten: 2011; 29 403 407
51. Viigimaa M., Lazaridis A., Doumas M. Management of sexual dysfunction in hypertensive patients. Cardiol Clin Prac: 2012; 53 60
52. Hackett G., Kell P., Ralph D. et al. British Society for Sexual Medicine guidelines on the management of erectile dysfunction. J Sex Med: 2008; 5 1841 1865
53. Hackett G. Hypertensive medication and erectile dysfunction. Cardiovas Therap: 2010; 28 5 7
54. Karavitakis M., Komninos C., Theodorakis P. N. et al. Evaluation of sexual function in hypertensive men receiving treatment: a review of current guidelines recommendation. J Sex Med: 2011; 8 2405 2414
55. Nicolai M. P., Both S., Liem S. S. et al. Discussing sexual function in the cardiology practice. Clin Res Cardiol: 2013; 102 329 336
56. Nicolai MP J., Liem S. S., Both S. et al. What do cardiologists know about the effects of cardiovascular agents on sexual function? A survey among Dutch cardiologists. Part I. Neth Heart J: 2013; 21 540 544
57. Rastogi S., Rodriguez J. J., Kapur V. et al. Why do patients with heart failure suffer from erectile dysfunction? A critical review and suggestions on how to approach this problem. Int J Impot Res: 2005; 17 01 S25 S36
58. Papatsoris A. G., Korantzopoulos P. G. Hypertension, antihypertensive therapy, and erectile dysfunction. Angiology: 2006; 57 47 52
59. Llisterri Caro J. L., Sánchez Sánchez F., Brotons Muntó F. Disfunción sessuale en la hipertensión arteriosa. Hipertensión 03/: 2005; 22 10.1016/S0212-8241 71543-71547
60. Mas M. Hipertensión arterial, medicación antihipertensiva y disfunción eréctil: una perspectiva basada en la evidencia. Rev Int Androl: 2005; 3 13 30
61. Simonsen U. Interactions between drugs for erectile dysfunction and drugs for cardiovascular disease. International J Impot Res: 2002; 14 178 188
62. Ker J. A. Hypertension and sexual dysfunction. S Afr Fam Pract: 2012; 54 117 118
63. Medical Research Council Working Party on Mild to Moderate Hypertension Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. Report of Medical Research Council Working Party on Mild to Moderate Hypertension. Lancet: 1981; 2, 8246 539 543
64. Croog S. H., Levine S., Sudilovsky A. et al. Sexual symptoms in hypertensive patients. A clinical trial of antihypertensive medications. Arch Intern Med: 1988; 148 788 794
65. Croog S. H., Levine S., Testa M. A. et al. The effects of antihypertensive therapy on the quality of life. N Engl J Med: 1986; 314 1657 1664
66. Hogan M. J., Wallin J. D., Baer R. M. Antihypertensive therapy and male sexual dysfunction. Psychosomatics: 1980; 21 234 237
67. Moss H. B., Procci W. R. Sexual dysfunction associated with oral antihypertensive medication: a critical survey of the literature. Gen Hosp Psychiatry: 1982; 4 121 129
68. Duncan L., Bateman D. N. Sexual function in women. Do antihypertensive drugs have an impact? Drug Saf: 1993; 8 225 234
69. Hodge R. H., Harward M. P., West M. S. et al. Sexual function of women taking antihypertensive agents. J Gen Intern Med: 1991; 6 290 294
70. Grimm R. H. Jr, Ga Grandits, Prineas R. J. et al. Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS). Hypertension: 1997; 29 8 14
71. Brixius K., Middeke M., Lichtenthal A. et al. Nitrix oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men. Clin Exp Pharmacol Physiol: 2007; 34 327 331
72. Franzen D., Metha A., Seifert N. et al. Effects of beta blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study. Int J Impot Res: 2001; 13 348 351
73. Pérez-Stable E. J., Halliday R., Gardiner P. S. et al. The effects of propranolol on cognitive function and quality of life: a randomized trial among patients with diastolic hypertension. Am J Med: 2000; 108, 5 359 365
74. Boydak B., Nalbantgil S., Fici F. et al. A randomised comparison of the effects of nebivolol and atenolol with and without chlorthalidone on the sexual function of hyperthensive men. Clin Drug Invest: 2005; 25 409
75. Fogari R., Preti P., Derosa G. et al. Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men. Eur J Clin Pharmacol: 2002; 58 177 180
76. Fogari R., Zoppi A., Corradi L. et al. Sexual function in hypertensive males treated with lisinopril or atenolol: a cross-over study. Am J Hypertens: 1998; 11 1244 1247
77. Suzuki H., Tominaga T., Kumagai H. et al. Effects of first-line antihypertensive agents on sexual function and sex hormones. J Hypertens: 1988; 6 S649 S651
78. Wassertheil-Smoller S., Blaufox M. D., Oberman A. et al. Effect of antihypertensives on sexual function and quality of life: the TAIM Study. Ann Intern Med: 1991; 114 613 620
79. Fogari R., Preti P., Zoppi A. et al. Effect of valsartan and atenolol on sexual behavior in hypertensive postmenopausal women. Am J Hypertens: 2004; 17 77 81
80. Doumas M., Tsakiris A., Douma S. et al. Beneficial effects of switching from beta-blockers to nebivolol on the erectile function of hypertensive patients. Asian J Androl: 2006; 8 177 182
81. Cordero A., Bertomeu-Martínez V., Mazón P. et al. Erectile dysfunction in high-risk hypertensive patients treated with beta-blockade agents. Cardiovasc Ther: 2010; 28 15 22
82. Cheng J. W. Nebivolol: a third-generation beta-blocker for hypertension. Clin Ther: 2009; 31 447 462
83. Van Bortel L. M., Bulpitt C. J., Fici F. Quality of life and antihypertensive effect with nebivolol and losartan. Am J Hypertens: 2005; 18 1060 1066
84. Prisant L. M., Weir M. R., Frishman W. H. et al. Self reported sexual dysfunction in men and women treated with bisoprolol, hydrochlorothiazide, enalapril, amlodipine, placebo, or bisoprolol/hydrochlorothiazide. J Clin Hypertens: 1999; 1 22 26
85. Riley A. J., Riley E. J. The effect of labetalol and propanolol on the pressor response to sexual arousal in women. Br J Clin Pharmacol: 1981; 12 341 344
86. Fogari R., Zoppi A., Poletti L. et al. Sexual activity in hypertensive men treated with valsartan or carvedilol: a crossover study. Am J Hypertens: 2001; 14 27 31
87. Chang S. W., Fine R., Siegel D. et al. The impact of diuretic therapy on reported sexual function. Arch Intern Med: 1991; 151 2402 2408
88. Kroner B. A., Mulligan T., Briggs G. C. Effect of frequently prescribed cardiovascular medications on sexual function: a pilot study. Ann Pharmacother: 1993; 27 1329 1332
89. Williams G. H., Croog S. H., Levine S. et al. Impact of antihypertensive therapy on the quality of life: effect of hydrochlorothiazide. J Hypertens: 1987; 5 29 35
90. Ogihara T., Kuramoto K. Effect of long-term treatment with antihypertensive drugs on quality of life of elderly patients with hypertension: a double-blind comparative study between a calcium antagonist and a diuretic. NICS-EH Study Group. National Intervention Cooperative Study in Elderly Hypertensives. Hypertens Res: 2000; 23 33 37
91. Stessman J., Ben-Ishai D. Chlortalidone-induced impotence. Br Med J: 1980; 281 714
92. Epstein M., Calhoun D. A. Aldosterone blockers (mineralocorticoid receptor antagonism) and potassium-sparing diuretics. J Clin Hypertens: 2011; 13 644 648
93. Greenblatt D. J., Koch-Weser J. Gynecomastia and ED: complication of spironolactone. JAMA: 1973; 223 82 85
94. Pitt B., Zannad F., Remme W. J. et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med: 1999; 341 709 717
95. Pitt B., Remme W. J., Zannad F. et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med: 2003; 348 1309 1321
96. Bellmann O., Ochs H. R., Knuchel M. et al. Evaluation of the hypothalamic-pituitary effects of digoxin. J Clin Pharmacol: 1984; 24 474 479
97. Neri A., Aygen M., Zukerman Z. et al. Subjective assessment of sexual dysfunction of patients on long-term administration of digoxin. Arch Sex Behav: 1980; 9 343 347
98. Neri A., Zukerman Z., Aygen M. et al. The effect of long-term administration of digoxin on plasma androgens and sexual dysfunction. J Sex Marital Ther: 1987; 13 58 63
99. McHaffie D. J., Guz A., Johnston A. Impotence in patient on disopyramide. Lancet: 1977; 1 859
100. Korst H. A., Brandes J. W., Littmann K. P. Disturbances of potency and spermiogenesis due to propafenon. Dtsch Med Wochenschr: 1980; 105 1187 1189
101. Omvik P., Thaulow E., Herland O. B. et al. Double-blind, parallel, comparative study on quality of life during treatment with amlodipine or enalapril in mild or moderate hypertensive patients: a multicentre study. J Hypertens: 1993; 11 103 113
102. Bohm M., Baumhakel M., Teo K. et al. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials. Circulation: 2010; 121 1439 1446
103. Chen Y., Cui S., Lin H. et al. Losartan improves erectile dysfunction in diabetic patients: a clinical trial. Int J Impot Res: 2012; 24 217 220
104. Della Chiesa A., Pfiffner D., Meier B. et al. Sexual activity in hypertensive men. J Hum Hypertens: 2003; 17 515 521
105. Düsing R. Effect of the angiotensin II antagonist valsartan on sexual function in hypertensive men. Blood Press Suppl: 2003; 2 29 34
106. Baumhakel M., Schlimmer N., Bohm M. Effect of irbesartan on erectile function in patients with hypertension and metabolic syndrome. Int J Impot Res: 2008; 20 493 500
107. Segal R. L., Bivalacqua T. J., Burnett A. L. Irbesartan promotes erection recovery after nerve-sparing radical retropubic prostatectomy: a retrospective long-term analysis. BJU Int: 2012; 110 1782 1786
108. Yang L., Yu J., Ma R. et al. The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology: 2013; 125 235 241
109. Dombrowski R. C., Romeo J. H., Aron D. C. Verapamil-induced hyperprolactinaemia complicated by a pituitary incidentaloma. Ann Pharmacother: 1995; 29 999 1001