Erectile dysfunction and hypertension: Impact on cardiovascular risk and treatment

International Journal of Hypertension

Volumn 2012, Issue , 2012, Pages

  Javaroni, Valter ^a,b   Neves, Mario Fritsch ^a,b  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b HOSPITAL UNIVERSITÁRIO PEDRO ERNESTO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G),N(G) DIMETHYLARGININE; NEBIVOLOL; PHOSPHODIESTERASE V INHIBITOR; RAMIPRIL; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SILDENAFIL; TADALAFIL; TELMISARTAN; THIAZIDE DIURETIC AGENT;

AGING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMORBIDITY; DIABETES MELLITUS; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; OBESITY; PATHOPHYSIOLOGY; PENIS ERECTION; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; REVIEW; RISK FACTOR; SEDENTARY LIFESTYLE; SEXUAL BEHAVIOR; SEXUAL SATISFACTION; SMOKING; VASCULAR DISEASE;

EID: 84868293625     PISSN: 20900384     EISSN: 20900392     Source Type: Journal    
DOI: 10.1155/2012/627278     Document Type: Review

References (92)

1. NIH Consensus Conference. Impotence, NIH consensus development panel on impotence. Journal of the American Medical Association 1993 270 1 83 90
2. Fisher W. A., Rosen R. C., Mollen M., Brock G., Karlin G., Pommerville P., Goldstein I., Bangerter K., Bandel T. J., Derogatis L. R., Sand M., Improving the sexual quality of life of couples affected by erectile dysfunction: a double-blind, randomized, placebo-controlled trial of vardenafil. Journal of Sexual Medicine 2005 2 5 699 708 2-s2.0-28444489736 10.1111/j.1743-6109.2005.00119.x (Pubitemid 41742930)
3. Lewis R. W., Fugl-Meyer K. S., Corona G., Hayes R. D., Laumann E. O., Moreira E. D., Rellini A. H., Segraves T., Definitions/epidemiology/risk factors for sexual dysfunction. Journal of Sexual Medicine 2010 7 4 1598 1607 2-s2.0-77955257328 10.1111/j.1743-6109.2010.01778.x
4. Jackson G., Prevention of cardiovascular disease by the early identification of erectile dysfunction. International Journal of Impotence Research 2008 20 2, supplement S9 S14 2-s2.0-55849115598 10.1038/ijir.2008.47
5. Feldman H. A., Goldstein I., Hatzichristou D. G., Krane R. J., McKinlay J. B., Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Journal of Urology 1994 151 1 54 61 2-s2.0-0028036149 (Pubitemid 24046934)
6. Moreira E. D. Jr., Abdo C. H. N., Torres E. B., Lôbo C. F. L., Fittipaldi J. A. S., Prevalence and correlates of erectile dysfunction: results of the Brazilian study of sexual behavior. Urology 2001 58 4 583 588 2-s2.0-0034801218 10.1016/S0090-4295(01)01274-2 (Pubitemid 32904503)
7. Speel T. G. W., Van Langen H., Meuleman E. J. H., Cormio L., The risk of coronary heart disease in men with erectile dysfunction. European Urology 2003 44 3 366 371 2-s2.0-0041857960 10.1016/S0302-2838(03)00304-X (Pubitemid 37051708)
8. Goldstein I., Lue T. F., Padma-Nathan H., Rosen R. C., Steersand W. D., Wicker P. A., Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. The New England Journal of Medicine 1998 338 20 1397 1404 (Pubitemid 28221980)
9. Carson C. C., Erectile dysfunction in the 21st century: whom we can treat, whom we cannot treat and patient education. International Journal of Impotence Research 2002 14 1, supplement S29 S34 2-s2.0-0036193044 10.1038/sj/ijir/3900804 (Pubitemid 34215247)
10. Jackson G., Boon N., Eardley I., Kirby M., Dean J., Hackett G., Montorsi P., Montorsi F., Vlachopoulos C., Kloner R., Sharlip I., Miner M., Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus. International Journal of Clinical Practice 2010 64 7 848 857 2-s2.0-77952726042 10.1111/j.1742-1241.2010.02410.x
11. Hatzimouratidis K., Amar E., Eardley I., Giuliano F., Hatzichristou D., Montorsi F., Vardi Y., Wespes E., European Association of Urology, Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. European Urology 2010 57 5 804 814
12. Solomon H., Man J. W., Jackson G., Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003 89 3 251 254 2-s2.0-0037370885 (Pubitemid 36241528)
13. Montorsi P., Ravagnani P. M., Galli S., Salonia A., Briganti A., Werba J. P., Montorsi F., Association between erectile dysfunction and coronary artery disease: matching the right target with the right test in the right patient. European Urology 2006 50 4 721 731 2-s2.0-33748311881 10.1016/j.eururo.2006.07. 015 (Pubitemid 44332685)
14. Aversa A., Bruzziches R., Francomano D., Natali M., Gareri P., Spera G., Endothelial dysfunction and erectile dysfunction in the aging man. International Journal of Urology 2010 17 1 38 47 2-s2.0-74049092278 10.1111/j.1442-2042.2009. 02426.x
15. Fusco F., Razzoli E., Imbimbo C., Rossi A., Verze P., Mirone V., A new era in the treatment of erectile dysfunction: chronic phosphodiesterase type 5 inhibition. British Journal of Urology International 2010 105 12 1634 1639 2-s2.0-77952829688 10.1111/j.1464-410X.2010.09244.x
16. Miner M. M., martinminer@brown.edu Erectile dysfunction: a harbinger or consequence: does its detection lead to a window of curability? Journal of Andrology 2011 32 2 125 134 10.2164/jandrol.110.011338
17. Virag R., Bouilly P., Frydman D., Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet 1985 1 8422 181 184
18. Bocchio M., Scarpelli P., Necozione S., Pelliccione F., Spartera C., Francavilla F., Francavilla S., Penile duplex pharmaco-ultrasonography of cavernous arteries in men with erectile dysfunction and generalized atherosclerosis. International Journal of Andrology 2006 29 4 496 501 2-s2.0-33745947929 10.1111/j.1365-2605.2006.00688.x (Pubitemid 44060733)
19. Kim S. W., Paick J. S., Park D. W., Chae I. H., Oh B. H., Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction. Urology 2001 58 3 441 445 2-s2.0-0034859637 10.1016/S0090-4295(01)01210-9 (Pubitemid 32816366)
20. Montorsi P., Montorsi F., Schulman C. C., Is erectile dysfunction the 'tip of the lceberg' of a systemic vascular disorder? European Urology 2003 44 3 352 354 2-s2.0-0037752795 10.1016/S0302-2838(03)00307-5 (Pubitemid 37051705)
21. Lue T. F., Erectile dysfunction. New England Journal of Medicine 2000 342 24 1802 1813 2-s2.0-0034660235 10.1056/NEJM200006153422407 (Pubitemid 30390241)
22. Lue T. F., Giuliano F., Montorsi F., Rosen R. C., Andersson K. E., Althof S., Christ G., Hatzichristou D., Hirsch M., Kimoto Y., Lewis R., McKenna K., MacMahon C., Morelas A., Mulcahy J., Padman-Nathan H., Pryor J., Saenz De Tejada I., Shabsigh R., Wagner G., Summary on the recommendations on sexual dysfunctions in men. Journal of Sexual Medicine 2004 1 1 6 23 2-s2.0-20144378083 10.1111/j.1743-6109.2004.10104.x (Pubitemid 40424662)
23. Moreland R. B., Pathophysiology of erectile dysfunction: the contributions of trabecular structure to function and the role of functional antagonism. International Journal of Impotence Research 2000 12 4 S39 S46 2-s2.0-0033776013
24. Sáenz de Tejada I., Angulo J., Cellek S., González-Cadavid N., Heaton J., Pickard R., Simonsen U., Pathophysiology of erectile dysfunction. Journal of Sexual Medicine 2005 2 1 26 39 2-s2.0-16444387316 10.1111/j.1743-6109.2005.20103.x (Pubitemid 40476058)
25. Bocchio M., Desideri G., Scarpelli P., Necozione S., Properzi G., Spartera C., Francavilla F., Ferri C., Francavilla S., Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage. Journal of Urology 2004 171 4 1601 1604 2-s2.0-1642372291 10.1097/01.ju.0000116325.06572.85 (Pubitemid 38365430)
26. Inman B. A., Sauver J. L. S., Jacobson D. J., Mcgree M. E., Nehra A., Lieber M. M., Roger V. L., Jacobsen S. J., A population-based, longitudinal study of erectile dysfunction and future coronary artery disease. Mayo Clinic Proceedings 2009 84 2 109 113 2-s2.0-61449149483
27. Wierzbicki A. S., Solomon H., Lumb P. J., Lyttle K., Lambert-Hammill M., Jackson G., Asymmetric dimethyl arginine levels correlate with cardiovascular risk factors in patients with erectile dysfunction. Atherosclerosis 2006 185 2 421 425 2-s2.0-33644514607 10.1016/j.atherosclerosis.2005.06.025
28. Aversa A., Proietti M., Bruzziches R., Salsano F., Spera G., The penile vasculature in systemic sclerosis: a duplex ultrasound study. Journal of Sexual Medicine 2006 3 3 554 558 2-s2.0-33645967807 10.1111/j.1743-6109.2005.00169.x
29. Araujo A. B., Hall S. A., Ganz P., Chiu G. R., Rosen R. C., Kupelian V., Travison T. G., McKinlay J. B., Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the framingham risk score? Journal of the American College of Cardiology 2010 55 4 350 356 2-s2.0-74049084413 10.1016/j.jacc.2009.08.058
30. Bacon C. G., Mittleman M. A., Kawachi I., Giovannucci E., Glasser D. B., Rimm E. B., A prospective study of risk factors for erectile dysfunction. Journal of Urology 2006 176 1 217 221 2-s2.0-33744543965 10.1016/S0022-5347(06) 00589-1 (Pubitemid 43815415)
31. Gratzke C., Angulo J., Chitaley K., Dai Y. T., Kim N. N., Paick J. S., Simonsen U., Ückert S., Wespes E., Andersson K. E., Lue T. F., Stief C. G., Anatomy, physiology, and pathophysiology of erectile dysfunction. Journal of Sexual Medicine 2010 7 1 445 475 2-s2.0-74249112406 10.1111/j.1743-6109.2009. 01624.x
32. Taskin U., Yigit O., Acioglu E., Aricigil M., Toktas G., Guzelhan Y., Erectile dysfunction in severe sleep apnea patients and response to CPAP. International Journal of Impotence Research 2010 22 2 134 139 2-s2.0-77949655732 10.1038/ijir.2009.54
33. Burchardt M., Burchardt T., Baer L., Kiss A. J., Pawar R. V., Shabsigh A., De La Taille A., Hayek O. R., Shabsigh R., Hypertension is associated with severe erectile dysfunction. Journal of Urology 2000 164 4 1188 1191 2-s2.0-0033822704
34. Grimm R. H. Jr., Grandits G. A., Prineas R. J., McDonald R. H., Lewis C. E., Flack J. M., Yunis C., Svendsen K., Liebson P. R., Elmer P. J., Stamler J., Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women: treatment of mild hypertension study (TOMHS). Hypertension 1997 29 1 8 14 2-s2.0-0342275202 (Pubitemid 27078334)
35. Newman H. F., Marcus H., Erectile dysfunction in diabetes and hypertension. Urology 1985 26 2 135 137 2-s2.0-0022321197 (Pubitemid 17067742)
36. Jensen J., Lendorf A., Stimpel H., Frost J., Ibsen H., Rosenkilde P., The prevalence and etiology of impotence in 101 male hypertensive outpatients. American Journal of Hypertension 1999 12 3 271 275 2-s2.0-0033104344 10.1016/S0895-7061(98)00225-8 (Pubitemid 29147352)
37. Giuliano F. A., Leriche A., Jaudinot E. O., De Gendre A. S., Prevalence of erectile dysfunction among 7689 patients with diabetes or hypertension, or both. Urology 2004 64 6 1196 1201 2-s2.0-10644227616 10.1016/j.urology.2004.08. 059 (Pubitemid 39647065)
38. Doumas M., Tsakiris A., Douma S., Grigorakis A., Papadopoulos A., Hounta A., Tsiodras S., Dimitriou D., Giamarellou H., Factors affecting the increased prevalence of erectile dysfunction in greek hypertensive compared with normotensive subjects. Journal of Andrology 2006 27 3 469 477 2-s2.0-33646374166 10.2164/jandrol.04191 (Pubitemid 43667997)
39. Mittawae B., El-Nashaar A. R., Fouda A., Magdy M., Shamloul R., Incidence of erectile dysfunction in 800 hypertensive patients: a multicenter Egyptian national study. Urology 2006 67 3 575 578 2-s2.0-33644762896 10.1016/j.urology.2005.09.040 (Pubitemid 43343546)
40. Chang S. T., Chu C. M., Hsu J. T., Lin P. C., Shee J. J., Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity. International Journal of Impotence Research 2009 21 2 116 121 2-s2.0-62449119204 10.1038/ijir.2009.1
41. Thompson I. M., Tangen C. M., Goodman P. J., Probstfield J. L., Moinpour C. M., Coltman C. A., Erectile dysfunction and subsequent cardiovascular disease. Journal of the American Medical Association 2005 294 23 2996 3002 2-s2.0-29144533834 10.1001/jama.294.23.2996 (Pubitemid 41817661)
42. Baumhäkel M., magnus@baumhaekel.de Schlimmer N., Kratz M., Hacket G., Jackson G., Böhm M., Cardiovascular risk, drugs and erectile functiona systematic analysis. International Journal of Clinical Practice 2011 65 3 289 298 10.1111/j.1742-1241.2010.02563.x
43. Silvestri A., Galetta P., Cerquetani E., Marazzi G., Patrizi R., Fini M., Rosano G. M. C., Report of erectile dysfunction after therapy with beta-blockers is related to patient knowledge of side effects and is reversed by placebo. European Heart Journal 2003 24 21 1928 1932 2-s2.0-0142209279 10.1016/j.ehj.2003.08.016 (Pubitemid 37322702)
44. Böhm M., Baumhäkel M., Probstfield J. L., Schmieder R., Yusuf S., Zhao F., Koon T., Sexual function, satisfaction, and association of erectile dysfunction with cardiovascular disease and risk factors in cardiovascular high-risk patients: substudy of the ongoing telmisartan alone and in combination with Ramipril global endpoint trial/telmisartan randomized assessment study in ACE-intolerant subjects with cardiovascular disease (ONTARGET/TRANSCEND). American Heart Journal 2007 154 1 94 101 2-s2.0-34250303501 10.1016/j.ahj.2007. 03.024 (Pubitemid 46924800)
45. Bansal S., Sexual dysfunction in hypertensive men. A critical review of the literature. Hypertension 1988 12 1 1 10 2-s2.0-0023753078
46. Erden I., Ozhan H., Ordu S., Yalcin S., Caglar O., Kayikci A., The effect of non-dipper pattern of hypertension on erectile dysfunction. Blood Pressure 2010 19 4 249 253 2-s2.0-77955329977 10.3109/08037050903576734
47. Derby C. A., Barbour M. M., Hume A. L., McKinlay J. B., Drug therapy and prevalence of erectile dysfunction in the Massachusetts male aging study cohort. Pharmacotherapy 2001 21 6 676 683 2-s2.0-0034982344 (Pubitemid 32506483)
48. Böhm M., Baumhäkel M., Teo K., Sleight P., Probstfield J., Gao P., Mann J. F., Diaz R., Dagenais G. R., Jennings G. L. R., Liu L., Jansky P., Yusuf S., Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both: the ongoing telmisartan alone and in combination with ramipril global endpoint trial/telmisartan randomized assessment study in ace intolerant subjects with cardiovascular disease (ontarget/transcend) Trials. Circulation 2010 121 12 1439 1446 2-s2.0-77950197562 10.1161/CIRCULATIONAHA.109.864199
49. Baumhäkel M., magnus@baumhaekel.de Schlimmer N., Büyükafşar K., Arikan O., Böhm M., Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein E-knockout mice. Journal of Pharmacology and Experimental Therapeutics 2008 325 3 818 823 10.1124/jpet.107.135681 (Pubitemid 351728031)
50. Toblli J. E., Cao G., Casas G., Mazza O. N., In vivo and in vitro effects of nebivolol on penile structures in hypertensive rats. American Journal of Hypertension 2006 19 12 1226 1232 2-s2.0-33845233684 10.1016/j.amjhyper.2006.05. 016 (Pubitemid 44856250)
51. Fogari R., Zoppi A., Effect of antihypertensive agents on quality of life in the elderly. Drugs and Aging 2004 21 6 377 393 2-s2.0-2342631217 10.2165/00002512-200421060-00003 (Pubitemid 38608506)
52. Düsing R., Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs. Drugs 2005 65 6 773 786 2-s2.0-17844396904 10.2165/00003495-200565060-00005 (Pubitemid 40593626)
53. Jeremy J. Y., Angelini G. D., Khan M., Mikhailidis D. P., Morgan R. J., Thompson C. S., Bruckdorfer K. R., Naseem K. M., Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovascular Research 2000 46 1 50 54 2-s2.0-0034099331 10.1016/S0008-6363(00)00009-2 (Pubitemid 30155944)
54. Taddei S., Virdis A., Mattei P., Ghiadoni L., Gennari A., Fasolo C. B., Sudano I., Salvetti A., Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 1995 91 7 1981 1987 2-s2.0-0028907886
55. Agarwal A., Nandipati K. C., Sharma R. K., Zippe C. D., Raina R., Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction. Journal of Andrology 2006 27 3 335 347 2-s2.0-33646371004 10.2164/jandrol.05136 (Pubitemid 43667981)
56. Jin L., Lagoda G., Leite R., Webb R. C., Burnett A. L., NADPH oxidase activation: a mechanism of hypertension-associated erectile dysfunction. Journal of Sexual Medicine 2008 5 3 544 551 2-s2.0-40349113071 10.1111/j.1743-6109. 2007.00733.x (Pubitemid 351337880)
57. Behr-Roussel D., Bernabe J., Compagnie S., Rupin A., Verbeuren T. J., Alexandre L., Giuliano F., Distinct mechanisms implicated in atherosclerosis-induced erectile dysfunction in rabbits. Atherosclerosis 2002 162 2 355 362 2-s2.0-0036238784 10.1016/S0021-9150(01)00740-7 (Pubitemid 34457941)
58. Perticone F., Sciacqua A., Maio R., Perticone M., Maas R., Boger R. H., Tripepi G., Sesti G., Zoccali C., Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension. Journal of the American College of Cardiology 2005 46 3 518 523 2-s2.0-22844443807 10.1016/j.jacc.2005. 04.040 (Pubitemid 41040296)
59. Romero J. C., Reckelhoff J. F., Role of angiotensin and oxidative stress in essential hypertension. Hypertension 1999 34 4 943 949 10.1161/01.HYP.34.4. 943 (Pubitemid 29501328)
60. Kloner R., Erectile dysfunction and hypertension. International Journal of Impotence Research 2007 19 3 296 302 2-s2.0-34247850865 10.1038/sj.ijir. 3901527 (Pubitemid 46701457)
61. Montorsi P., Ravagnani P. M., Galli S., Rotatori F., Veglia F., Briganti A., Salonia A., Dehò F., Rigatti P., Montorsi F., Fiorentini C., Association between erectile dysfunction and coronary artery disease. Role of coronary clinical presentation and extent of coronary vessels involvement: the COBRA trial. European Heart Journal 2006 27 22 2632 2639 2-s2.0-33749827701 10.1093/eurheartj/ehl142 (Pubitemid 44729861)
62. Vlachopoulos C., Aznaouridis K., Ioakeimidis N., Rokkas K., Tsekoura D., Vasiliadou C., Stefanadi E., Askitis A., Stefanadis C., Arterial function and intima-media thickness in hypertensive patients with erectile dysfunction. Journal of Hypertension 2008 26 9 1829 1836 2-s2.0-58149236953 10.1097/HJH.0b013e3283050886
63. Solomon H., Man J. W., Wierzbicki A. S., Jackson G., Relation of erectile dysfunction to angiographic coronary artery disease. American Journal of Cardiology 2003 91 2 230 231 2-s2.0-0037300595 10.1016/S0002-9149(02)03113-2 (Pubitemid 36084310)
64. Prisant L. M., Loebl D. H., Waller J. L., Arterial elasticity and erectile dysfunction in hypertensive men. Journal of Clinical Hypertension 2006 8 11 768 774 2-s2.0-39049176320 10.1111/j.1524-6175.2006.05575.x
65. Chung S. D., Chen Y. K., Lin H. C., Lin H. C., Increased risk of stroke among men with erectile dysfunction: a nationwide population-based study. Journal of Sexual Medicine 2011 8 1 240 246 2-s2.0-78650765099 10.1111/j.1743-6109.2010.01973.x
66. Luscher T. F., Barton M., Biology of the endothelium. Clinical Cardiology 1997 20 12, supplement II3 II10 (Pubitemid 28009557)
67. Kaiser D. R., Billups K., Mason C., Wetterling R., Lundberg J. L., Bank A. J., Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. Journal of the American College of Cardiology 2004 43 2 179 184 2-s2.0-1042275866 10.1016/j.jacc.2003.07.042 (Pubitemid 38201141)
68. Bivalacqua T. J., Liu T., Musicki B., Champion H. C., Burnett A. L., Endothelial nitric oxide synthase keeps erection regulatory function balance in the penis. European Urology 2007 51 6 1732 1740 2-s2.0-34247369430 10.1016/j.eururo.2006.10.061 (Pubitemid 46634738)
69. Burnett A. L., Nitric oxide in the penis: physiology and pathology. Journal of Urology 1997 157 1 320 324 2-s2.0-0031060411 (Pubitemid 26414983)
70. Kim J. H., Klyachkin M. L., Svendsen E., Davies M. G., Hagen P. O., Carson C. C. III, Experimental hypercholesterolemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. Journal of Urology 1994 151 1 198 205 2-s2.0-0027958541 (Pubitemid 24046973)
71. Rosen R. C., Riley A., Wagner G., Osterloh I. H., Kirkpatrick J., Mishra A., The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997 49 6 822 830 2-s2.0-0030926566 10.1016/S0090-4295(97)00238-0 (Pubitemid 27246947)
72. Rosen R. C., Cappelleri J. C., Smith M. D., Lipsky J., Peñ B. M., Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. International Journal of Impotence Research 1999 11 6 319 326 2-s2.0-0033373460 (Pubitemid 30052683)
73. Jackson G., Rosen R. C., Kloner R. A., Kostis J. B., The second Princeton consensus on sexual dysfunction and cardiac risk: new guidelines for sexual medicine. Journal of Sexual Medicine 2006 3 1 28 36 2-s2.0-33645744784 10.1111/j.1743-6109.2005.00196.x
74. Kostis J. B., Jackson G., Rosen R., Barrett-Connor E., Billups K., Burnett A. L., Carson C., Cheitlin M., Debusk R., Fonseca V., Ganz P., Goldstein I., Guay A., Hatzichristou D., Hollander J. E., Hutter A., Katz S., Kloner R. A., Mittleman M., Montorsi F., Montorsi P., Nehra A., Sadovsky R., Shabsigh R., Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference). American Journal of Cardiology 2005 96 12 85M 93M (Pubitemid 43017226)
75. Gazzaruso C., Giordanetti S., De Amici E., Bertone G., Falcone C., Geroldi D., Fratino P., Solerte S. B., Garzaniti A., Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients. Circulation 2004 110 1 22 26 2-s2.0-3042856279 10.1161/01.CIR.0000133278.81226.C9 (Pubitemid 38880129)
76. Stern S., Symptoms other than chest pain may be important in the diagnosis of silent ischemia, or the sounds of silence Circulation 2005 111 24 e435 437 2-s2.0-32844456331
77. Debusk R., Drory Y., Goldstein I., Jackson G., Kaul S., Kimmel S. E., Kostis J. B., Kloner R. A., Lakin M., Meston C. M., Mittleman M., Muller J. E., Padma-Nathan H., Rosen R. C., Stein R. A., Zusman R., Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton consensus panel. American Journal of Cardiology 2000 86 2 62 68 2-s2.0-0034691697 (Pubitemid 30438819)
78. Zusman R. M., Morales A., Glasser D. B., Osterloh I. H., Overall cardiovascular profile of sildenafil citrate. American Journal of Cardiology 1999 83 5 35C 44C 2-s2.0-0033522214 (Pubitemid 29122756)
79. Vardi Y., Klein L., Nassar S., Sprecher E., Gruenwald I., Effects of sildenafil citrate (viagra) on blood pressure in normotensive and hypertensive men. Urology 2002 59 5 747 752 2-s2.0-0036242933 10.1016/S0090-4295(02)01510-8 (Pubitemid 34461989)
80. Kloner R. A., Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction. Circulation 2004 110 19 3149 3155 2-s2.0-8544233528 10.1161/01.CIR.0000146906.42375.D3 (Pubitemid 39492012)
81. Kloner R. A., Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on α -blocker interactions. American Journal of Cardiology 2005 96 12 42M 46M 2-s2.0-29544435476 10.1016/j.amjcard.2005.07.011 (Pubitemid 43017217)
82. Scranton R. E., Lawler E., Botteman M., Chittamooru S., Gagnon D., Lew R., Harnett J., Gaziano J. M., Effect of Treating Erectile Dysfunction on Management of Systolic Hypertension. American Journal of Cardiology 2007 100 3 459 463 2-s2.0-34447650434 10.1016/j.amjcard.2007.03.045 (Pubitemid 47094695)
83. Hatzichristou D., Moysidis K., Apostolidis A., Bekos A., Tzortzis V., Hatzimouratidis K., Ioannidis E., Sildenafil failures may be due to inadequate patient instructions and follow-up: a study on 100 non-responders. European Urology 2005 47 4 518 522 2-s2.0-14844348851 10.1016/j.eururo.2004.12.005 (Pubitemid 40357900)
84. Park K., Ku J. H., Kim S. W., Paick J. S., Risk factors in predicting a poor response to sildenafil citrate in elderly men with erectile dysfunction. British Journal of Urology International 2005 95 3 366 370 2-s2.0-14144250622 10.1111/j.1464-410X.2005.05301.x (Pubitemid 40283125)
85. Javaroni V., drjavaroni2000@yahoo.com.br Queiroz-Miguez M., Abreu-Casanova M., Oigman W., Neves M. F., Brachial flow-mediated dilation correlates with vardenafil response in hypertensive men with vasculogenic erectile dysfunction. Urology 2011 78 2 368 374 10.1016/j.urology.2011.02.070
86. Karavitakis M., markoskaravitakis@yahoo.gr Komninos C., Theodorakis P. N., Politis V., Lefakis G., Mitsios K., Koritsiadis S., Doumanis G., Evaluation of sexual function in hypertensive men receiving treatment: a review of current guidelines recommendation. Journal of Sexual Medicine 2011 8 9 2405 2414 10.1111/j.1743-6109.2011.02342.x
87. Seftel A. D., Sun P., Swindle R., The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. Journal of Urology 2004 171 6 2341 2345 2-s2.0-2442476233 10.1097/01.ju.0000125198.32936.38 (Pubitemid 38625466)
88. Manolis A., Doumas M., Sexual dysfunction: the prima ballerina of hypertension-related quality-of-life complications. Journal of Hypertension 2008 26 11 2074 2084 2-s2.0-56049105155 10.1097/HJH.0b013e32830dd0c6
89. Moncada I., Martínez-Jabaloyas J. M., Rodriguez-Vela L., Gutiérrez P. R., Giuliano F., Koskimaki J., Farmer I. S., Renedo V. P., Schnetzler G., Emotional changes in men treated with sildenafil citrate for erectile dysfunction: a double-blind, placebo-controlled clinical trial. Journal of Sexual Medicine 2009 6 12 3469 3477 2-s2.0-77950876035 10.1111/j.1743-6109. 2009.01514.x
90. Lamina S., Okoye C. G., Dagogo T. T., Managing erectile dysfunction in hypertension: the effects of a continuous training programme on biomarker of inflammation. British Journal of Urology International 2009 103 9 1218 1221 2-s2.0-64249158737 10.1111/j.1464-410X.2008.08254.x
91. Solomon H., Man J., Wierzbicki A. S., O'Brien T., Jackson G., Erectile dysfunction: cardiovascular risk and the role of the cardiologist. International Journal of Clinical Practice 2003 57 2 96 99 2-s2.0-0037347857 (Pubitemid 36372561)
92. Jackson G., Erectile dysfunction and hypertension. International Journal of Clinical Practice 2002 56 7 491 493 2-s2.0-0036733506