메뉴 건너뛰기




Volumn 16, Issue 3, 2015, Pages 129-135

The long journey of TCL1 transgenic Mice: Lessons learned in the last 15 years

Author keywords

B Cell; Chronic lymphocytic leukemia (CLL); Em TCL1; Lck TCL1; Mouse models

Indexed keywords

B LYMPHOCYTE RECEPTOR; DACTINOMYCIN; INHIBITOR OF DIFFERENTIATION 4; INHIBITOR OF DIFFERENTIATION PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE LYN; PROTEIN KINASE SYK INHIBITOR; PROTEIN P53; RAG1 PROTEIN; UNCLASSIFIED DRUG; ONCOPROTEIN; TCL1 PROTEIN, MOUSE;

EID: 84928385305     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: 10.3727/105221615X14181438356256     Document Type: Review
Times cited : (10)

References (53)
  • 2
    • 0035839946 scopus 로고    scopus 로고
    • The role of TCL1 in human T-cell leukemia
    • Pekarsky Y, Hallas C, Croce CM. The role of TCL1 in human T-cell leukemia. Oncogene 2001; 20(40):5638-56343.
    • (2001) Oncogene , vol.20 , Issue.40 , pp. 5638-56343
    • Pekarsky, Y.1    Hallas, C.2    Croce, C.M.3
  • 5
    • 0031694094 scopus 로고    scopus 로고
    • Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia
    • Takizawa J, Suzuki R, Kuroda H, Utsunomiya A, Kagami Y, Joh T, et al. Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia. jpn j Cancer Res 1998; 89(7):712-718.
    • (1998) Jpn J Cancer Res , vol.89 , Issue.7 , pp. 712-718
    • Takizawa, J.1    Suzuki, R.2    Kuroda, H.3    Utsunomiya, A.4    Kagami, Y.5    Joh, T.6
  • 6
    • 0034655156 scopus 로고    scopus 로고
    • Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues
    • Narducci MG, Pescarmona E, Lazzeri C, Signoretti S, Lavinia AM, Remotti D, et al. Regulation of TCL1 expression in B- and T-cell lymphomas and reactive lymphoid tissues. Cancer Res 2000; 60(8):2095-2100.
    • (2000) Cancer Res , vol.60 , Issue.8 , pp. 2095-2100
    • Narducci, M.G.1    Pescarmona, E.2    Lazzeri, C.3    Signoretti, S.4    Lavinia, A.M.5    Remotti, D.6
  • 11
    • 84905970939 scopus 로고    scopus 로고
    • Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy
    • Simonetti G, Bertilaccio MT, Ghia P, Klein U. Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy. Blood 2014; 124(7):1010-1019.
    • (2014) Blood , vol.124 , Issue.7 , pp. 1010-1019
    • Simonetti, G.1    Bertilaccio, M.T.2    Ghia, P.3    Klein, U.4
  • 12
    • 31544471656 scopus 로고    scopus 로고
    • Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhe-matopoietic malignancies in Emu-TCL1 transgenic mice
    • Zanesi N, Aqeilan R, Drusco A, Kaou M, Sevignani C, Costinean S, et al. Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhe-matopoietic malignancies in Emu-TCL1 transgenic mice. Cancer Res 2006; 66(2):915-920.
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 915-920
    • Zanesi, N.1    Aqeilan, R.2    Drusco, A.3    Kaou, M.4    Sevignani, C.5    Costinean, S.6
  • 14
    • 0033636528 scopus 로고    scopus 로고
    • The protooncogene TCL1 is an Akt kinase coactivator
    • Laine J, Kunstle G, Obata T, Sha M, Noguchi M. The protooncogene TCL1 is an Akt kinase coactivator. Mol Cell 2000; 6(2):395-407.
    • (2000) Mol Cell , vol.6 , Issue.2 , pp. 395-407
    • Laine, J.1    Kunstle, G.2    Obata, T.3    Sha, M.4    Noguchi, M.5
  • 15
    • 33747181341 scopus 로고    scopus 로고
    • Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia
    • Johnson AJ, Lucas DM, Muthusamy N, Smith LL, Edwards RB, De Lay MD, et al. Characterization of the TCL-1 transgenic mouse as a preclinical drug development tool for human chronic lymphocytic leukemia. Blood 2006; 108(4):1334-1338.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1334-1338
    • Johnson, A.J.1    Lucas, D.M.2    Muthusamy, N.3    Smith, L.L.4    Edwards, R.B.5    De Lay, M.D.6
  • 16
    • 33746817989 scopus 로고    scopus 로고
    • B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
    • Yan XJ, Albesiano E, Zanesi N, Yancopoulos S, Sawyer A, Romano E, et al. B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2006; 103(31):11713-11718.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.31 , pp. 11713-11718
    • Yan, X.J.1    Albesiano, E.2    Zanesi, N.3    Yancopoulos, S.4    Sawyer, A.5    Romano, E.6
  • 17
    • 33846883742 scopus 로고    scopus 로고
    • B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII
    • Abrams ST, Lakum T, Lin K, jones GM, Treweeke AT, Farahani M, et al. B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII. Blood 2007; 109(3):1193-1201.
    • (2007) Blood , vol.109 , Issue.3 , pp. 1193-1201
    • Abrams, S.T.1    Lakum, T.2    Lin, K.3    Jones, G.M.4    Treweeke, A.T.5    Farahani, M.6
  • 18
    • 63849093256 scopus 로고    scopus 로고
    • PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: Validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia
    • Holler C, Pinon jD, Denk U, Heyder C, Hofbauer S, Greil R, et al. PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: Validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. Blood 2009; 113(12):2791-2794.
    • (2009) Blood , vol.113 , Issue.12 , pp. 2791-2794
    • Holler, C.1    Pinon, J.D.2    Denk, U.3    Heyder, C.4    Hofbauer, S.5    Greil, R.6
  • 19
    • 64049104989 scopus 로고    scopus 로고
    • Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia
    • Wu QL, Zierold C, Ranheim EA. Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia. Blood 2009; 113(13):3031-3039.
    • (2009) Blood , vol.113 , Issue.13 , pp. 3031-3039
    • Wu, Q.L.1    Zierold, C.2    Ranheim, E.A.3
  • 20
    • 0038359353 scopus 로고    scopus 로고
    • Caught up in a Wnt storm: Wnt signaling in cancer
    • Giles RH, van Es jH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 2003; 1653(1):1-24.
    • (2003) Biochim Biophys Acta , vol.1653 , Issue.1 , pp. 1-24
    • Giles, R.H.1    Van Es, J.H.2    Clevers, H.3
  • 21
    • 0033711624 scopus 로고    scopus 로고
    • Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    • Reya T, O'Riordan M, Okamura R, Devaney E, Willert K, Nusse R, et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 2000; 13(1):15-24.
    • (2000) Immunity , vol.13 , Issue.1 , pp. 15-24
    • Reya, T.1    O'Riordan, M.2    Okamura, R.3    Devaney, E.4    Willert, K.5    Nusse, R.6
  • 22
    • 62149149441 scopus 로고    scopus 로고
    • The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo
    • Lucas DM, Edwards RB, Lozanski G, West DA, Shin jD, Vargo MA, et al. The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo. Blood 2009; 113(19):4656-4666.
    • (2009) Blood , vol.113 , Issue.19 , pp. 4656-4666
    • Lucas, D.M.1    Edwards, R.B.2    Lozanski, G.3    West, D.A.4    Shin, J.D.5    Vargo, M.A.6
  • 23
    • 0025775062 scopus 로고
    • Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
    • Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, et al. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. j Natl Cancer Inst 1991; 83(11):757-766.
    • (1991) J Natl Cancer Inst , vol.83 , Issue.11 , pp. 757-766
    • Monks, A.1    Scudiero, D.2    Skehan, P.3    Shoemaker, R.4    Paull, K.5    Vistica, D.6
  • 24
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G, Ramsay AG, Holderried TA, Zahrieh D, Le Dieu R, Liu F, et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci USA 2009; 106(15):6250-6255.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.15 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3    Zahrieh, D.4    Le Dieu, R.5    Liu, F.6
  • 25
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128(4):683-692.
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 26
    • 69449100327 scopus 로고    scopus 로고
    • Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia
    • Chen SS, Raval A, Johnson AJ, Hertlein E, Liu TH, Jin VX, et al. Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2009; 106(32):13433-13438.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.32 , pp. 13433-13438
    • Chen, S.S.1    Raval, A.2    Johnson, A.J.3    Hertlein, E.4    Liu, T.H.5    Jin, V.X.6
  • 27
    • 20044372326 scopus 로고    scopus 로고
    • In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    • Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, et al. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 2005; 115(3):755-764.
    • (2005) J Clin Invest , vol.115 , Issue.3 , pp. 755-764
    • Messmer, B.T.1    Messmer, D.2    Allen, S.L.3    Kolitz, J.E.4    Kudalkar, P.5    Cesar, D.6
  • 28
    • 73349098730 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
    • Enzler T, Kater AP, Zhang W, Widhopf GF, 2nd, Chuang HY, Lee J, et al. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood 2009; 114(20):4469-4476.
    • (2009) Blood , vol.114 , Issue.20 , pp. 4469-4476
    • Enzler, T.1    Kater, A.P.2    Zhang, W.3    Widhopf, G.F.4    Chuang, H.Y.5    Lee, J.6
  • 29
    • 33750121336 scopus 로고    scopus 로고
    • RhoHGTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development
    • Gu Y, Chae HD, Siefring jE, jasti AC, Hildeman DA, Williams DA. RhoHGTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat Immunol 2006; 7(11):1182-1190.
    • (2006) Nat Immunol , vol.7 , Issue.11 , pp. 1182-1190
    • Gu, Y.1    Chae, H.D.2    Siefring, J.E.3    Jasti, A.C.4    Hildeman, D.A.5    Williams, D.A.6
  • 30
    • 74249108856 scopus 로고    scopus 로고
    • Involvement of RhoHGTPase in the development of B-cell chronic lymphocytic leukemia
    • Sanchez-Aguilera A, Rattmann I, Drew DZ, Muller LU, Summey V, Lucas DM, et al. Involvement of RhoHGTPase in the development of B-cell chronic lymphocytic leukemia. Leukemia 2010; 24(1):97-104.
    • (2010) Leukemia , vol.24 , Issue.1 , pp. 97-104
    • Sanchez-Aguilera, A.1    Rattmann, I.2    Drew, D.Z.3    Muller, L.U.4    Summey, V.5    Lucas, D.M.6
  • 31
    • 78149309123 scopus 로고    scopus 로고
    • HS1 has a central role in the trafficking and homing of leukemic B cells
    • Scielzo C, Bertilaccio MT, Simonetti G, Dagklis A, ten Hacken E, Fazi C, et al. HS1 has a central role in the trafficking and homing of leukemic B cells. Blood 2010; 116(18):3537-3546.
    • (2010) Blood , vol.116 , Issue.18 , pp. 3537-3546
    • Scielzo, C.1    Bertilaccio, M.T.2    Simonetti, G.3    Dagklis, A.4    Ten Hacken, E.5    Fazi, C.6
  • 32
    • 84891849709 scopus 로고    scopus 로고
    • Loss of p53 and altered miR15-a/16-1short right arrowMCL-1 pathway in CLL: Insights from TCL1-Tg:P53(-/-) mouse model and primary human leukemia cells
    • Liu J, Chen G, Feng L, Zhang W, Pelicano H, Wang F, et al. Loss of p53 and altered miR15-a/16-1short right arrowMCL-1 pathway in CLL: Insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells. Leukemia 2014; 28(1):118-128.
    • (2014) Leukemia , vol.28 , Issue.1 , pp. 118-128
    • Liu, J.1    Chen, G.2    Feng, L.3    Zhang, W.4    Pelicano, H.5    Wang, F.6
  • 33
    • 78751682784 scopus 로고    scopus 로고
    • Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL
    • Chen SS, Claus R, Lucas DM, Yu L, Qian J, Ruppert AS, et al. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood 2011; 117(3):862-871.
    • (2011) Blood , vol.117 , Issue.3 , pp. 862-871
    • Chen, S.S.1    Claus, R.2    Lucas, D.M.3    Yu, L.4    Qian, J.5    Ruppert, A.S.6
  • 34
    • 79960691639 scopus 로고    scopus 로고
    • Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
    • Bertilaccio MT, Simonetti G, Dagklis A, Rocchi M, Rodriguez TV, Apollonio B, et al. Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models. Blood 2011; 118(3):660-669.
    • (2011) Blood , vol.118 , Issue.3 , pp. 660-669
    • Bertilaccio, M.T.1    Simonetti, G.2    Dagklis, A.3    Rocchi, M.4    Rodriguez, T.V.5    Apollonio, B.6
  • 35
    • 84880474898 scopus 로고    scopus 로고
    • Accelerated progression of chronic lymphocytic leukemia in Emu-TCL1 mice expressing catalytically inactive RAG1
    • S1-16
    • Nganga VK, Palmer VL, Naushad H, Kassmeier MD, Anderson DK, Perry GA, et al. Accelerated progression of chronic lymphocytic leukemia in Emu-TCL1 mice expressing catalytically inactive RAG1. Blood 2013; 121(19):3855-3866, S1-16.
    • (2013) Blood , vol.121 , Issue.19 , pp. 3855-3866
    • Nganga, V.K.1    Palmer, V.L.2    Naushad, H.3    Kassmeier, M.D.4    Anderson, D.K.5    Perry, G.A.6
  • 36
    • 84893502005 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model
    • Lascano V, Guadagnoli M, Schot jG, Luijks DM, Guikema jE, Cameron K, et al. Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model. Blood 2013; 122(24):3960-3963.
    • (2013) Blood , vol.122 , Issue.24 , pp. 3960-3963
    • Lascano, V.1    Guadagnoli, M.2    Schot, J.G.3    Luijks, D.M.4    Guikema, J.E.5    Cameron, K.6
  • 37
    • 84892611828 scopus 로고    scopus 로고
    • ROR1 can interact with TCL1 and enhance leukemogenesis in Emu-TCL1 transgenic mice
    • Widhopf GF, 2nd, Cui B, Ghia EM, Chen L, Messer K, Shen Z, et al. ROR1 can interact with TCL1 and enhance leukemogenesis in Emu-TCL1 transgenic mice. Proc Natl Acad Sci USA 2014; 111(2):793-798.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.2 , pp. 793-798
    • Widhopf, G.F.1    Cui, B.2    Ghia, E.M.3    Chen, L.4    Messer, K.5    Shen, Z.6
  • 38
    • 84873542962 scopus 로고    scopus 로고
    • Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor
    • Reinart N, Nguyen PH, Boucas J, Rosen N, Kvasnicka HM, Heukamp L, et al. Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor. Blood 2013; 121(5):812-821.
    • (2013) Blood , vol.121 , Issue.5 , pp. 812-821
    • Reinart, N.1    Nguyen, P.H.2    Boucas, J.3    Rosen, N.4    Kvasnicka, H.M.5    Heukamp, L.6
  • 39
    • 84881015517 scopus 로고    scopus 로고
    • CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia
    • Fedorchenko O, Stiefelhagen M, Peer-Zada AA, Barthel R, Mayer P, Eckei L, et al. CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood 2013; 121(20):4126-4136.
    • (2013) Blood , vol.121 , Issue.20 , pp. 4126-4136
    • Fedorchenko, O.1    Stiefelhagen, M.2    Peer-Zada, A.A.3    Barthel, R.4    Mayer, P.5    Eckei, L.6
  • 40
    • 84880420282 scopus 로고    scopus 로고
    • A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model
    • Zanesi N, Balatti V, Riordan J, Burch A, Rizzotto L, Palamarchuk A, et al. A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model. Blood 2013; 121(21):4355-4358.
    • (2013) Blood , vol.121 , Issue.21 , pp. 4355-4358
    • Zanesi, N.1    Balatti, V.2    Riordan, J.3    Burch, A.4    Rizzotto, L.5    Palamarchuk, A.6
  • 41
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 2005; 436(7048):221-226.
    • (2005) Nature , vol.436 , Issue.7048 , pp. 221-226
    • Dupuy, A.J.1    Akagi, K.2    Largaespada, D.A.3    Copeland, N.G.4    Jenkins, N.A.5
  • 42
    • 77952424509 scopus 로고    scopus 로고
    • CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation
    • Efanov A, Zanesi N, Nazaryan N, Santanam U, Palamarchuk A, Croce CM, et al. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 2010; 24(5):970-975.
    • (2010) Leukemia , vol.24 , Issue.5 , pp. 970-975
    • Efanov, A.1    Zanesi, N.2    Nazaryan, N.3    Santanam, U.4    Palamarchuk, A.5    Croce, C.M.6
  • 43
    • 84863138658 scopus 로고    scopus 로고
    • Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)
    • Palamarchuk A, Yan PS, Zanesi N, Wang L, Rodrigues B, Murphy M, et al. Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci USA 2012; 109(7):2555-2560.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.7 , pp. 2555-2560
    • Palamarchuk, A.1    Yan, P.S.2    Zanesi, N.3    Wang, L.4    Rodrigues, B.5    Murphy, M.6
  • 44
    • 84873567628 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function
    • DiLillo DJ, Weinberg JB, Yoshizaki A, Horikawa M, Bryant JM, Iwata Y, et al. Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. Leukemia 2013; 27(1):170-182.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 170-182
    • DiLillo, D.J.1    Weinberg, J.B.2    Yoshizaki, A.3    Horikawa, M.4    Bryant, J.M.5    Iwata, Y.6
  • 45
    • 80052482371 scopus 로고    scopus 로고
    • Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL
    • Hofbauer JP, Heyder C, Denk U, Kocher T, Holler C, Trapin D, et al. Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL. Leukemia 2011; 25(9):1452-1458.
    • (2011) Leukemia , vol.25 , Issue.9 , pp. 1452-1458
    • Hofbauer, J.P.1    Heyder, C.2    Denk, U.3    Kocher, T.4    Holler, C.5    Trapin, D.6
  • 46
    • 83055186737 scopus 로고    scopus 로고
    • AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia
    • Motiwala T, Zanesi N, Datta J, Roy S, Kutay H, Checovich AM, et al. AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia. Blood 2011; 118(23):6132-6140.
    • (2011) Blood , vol.118 , Issue.23 , pp. 6132-6140
    • Motiwala, T.1    Zanesi, N.2    Datta, J.3    Roy, S.4    Kutay, H.5    Checovich, A.M.6
  • 47
    • 84864542591 scopus 로고    scopus 로고
    • Overexpression of TCL1 activates the endoplasmic reticulum stress response: A novel mechanism of leukemic progression in mice
    • Kriss CL, Pinilla-Ibarz JA, Mailloux AW, Powers JJ, Tang CH, Kang CW, et al. Overexpression of TCL1 activates the endoplasmic reticulum stress response: A novel mechanism of leukemic progression in mice. Blood 2012; 120(5):1027-1038.
    • (2012) Blood , vol.120 , Issue.5 , pp. 1027-1038
    • Kriss, C.L.1    Pinilla-Ibarz, J.A.2    Mailloux, A.W.3    Powers, J.J.4    Tang, C.H.5    Kang, C.W.6
  • 48
    • 84904326052 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease
    • Mittal AK, Chaturvedi NK, Rai KJ, Gilling-Cutucache CE, Nordgren TM, Moragues M, et al. Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease. Mol Med 2014; 20(1):290-301.
    • (2014) Mol Med , vol.20 , Issue.1 , pp. 290-301
    • Mittal, A.K.1    Chaturvedi, N.K.2    Rai, K.J.3    Gilling-Cutucache, C.E.4    Nordgren, T.M.5    Moragues, M.6
  • 49
    • 84915745531 scopus 로고    scopus 로고
    • Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation
    • Heinig K, Gatjen M, Grau M, Stache V, Anagnostopoulos I, Gerlach K, et al. Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation. Cancer Discov 2014.
    • (2014) Cancer Discov
    • Heinig, K.1    Gatjen, M.2    Grau, M.3    Stache, V.4    Anagnostopoulos, I.5    Gerlach, K.6
  • 50
    • 78649759107 scopus 로고    scopus 로고
    • The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling
    • Suljagic M, Longo PG, Bennardo S, Perlas E, Leone G, Laurenti L, et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood 2010; 116(23):4894-4905.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4894-4905
    • Suljagic, M.1    Longo, P.G.2    Bennardo, S.3    Perlas, E.4    Leone, G.5    Laurenti, L.6
  • 51
    • 84871213835 scopus 로고    scopus 로고
    • Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia
    • Merkel O, Wacht N, Sifft E, Melchardt T, Hamacher F, Kocher T, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia 2012; 26(12):2508-2516.
    • (2012) Leukemia , vol.26 , Issue.12 , pp. 2508-2516
    • Merkel, O.1    Wacht, N.2    Sifft, E.3    Melchardt, T.4    Hamacher, F.5    Kocher, T.6
  • 52
    • 84897901864 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)
    • Woyach JA, Bojnik E, Ruppert AS, Stefanovski MR, Goettl VM, Smucker KA, et al. Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL). Blood 2014; 123(8): 1207-1213.
    • (2014) Blood , vol.123 , Issue.8 , pp. 1207-1213
    • Woyach, J.A.1    Bojnik, E.2    Ruppert, A.S.3    Stefanovski, M.R.4    Goettl, V.M.5    Smucker, K.A.6
  • 53
    • 84928405738 scopus 로고    scopus 로고
    • OSU-T315: A novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells
    • Liu TM, Ling Y, Woyach jA, Beckwith K, Yeh YY, Hertlein E, et al. OSU-T315: A novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood 2014.
    • (2014) Blood
    • Liu, T.M.1    Ling, Y.2    Woyach, J.A.3    Beckwith, K.4    Yeh, Y.Y.5    Hertlein, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.