A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model

Blood

Volumn 121, Issue 21, 2013, Pages 4355-4358

  Zanesi, Nicola ^a   Balatti, Veronica ^a   Riordan, Jesse ^b   Burch, Aaron ^a   Rizzotto, Lara ^a   Palamarchuk, Alexey ^a   Cascione, Luciano ^a,c   Lagana, Alessandro ^a   Dupuy, Adam J ^b   Croce, Carlo M ^a   Pekarsky, Yuri ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B BETA; NF KAPPA B KINASE; NF-KAPPA B KINASE; NFKB1 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLEEPING BEAUTY TRANSPOSASE, HUMAN; TAB2 PROTEIN, MOUSE; TCL1 PROTEIN, MOUSE; TRANSPOSASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRD3 GENE; CHRONIC LYMPHATIC LEUKEMIA; CONFORMATION; CONTROLLED STUDY; FUCA1 GENE; GENE; GENE ACTIVATION; GENE INSERTION; GENE OVEREXPRESSION; GENETIC SCREENING; GENOTYPE; MAP3K14 GENE; MOUSE; MUTAGENESIS; NFKB1 GENE; NFKBID GENE; NONHUMAN; ONCOGENE; ONCOGENE TCL1; PRIORITY JOURNAL; PROGENY; RARG GENE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TAB2 GENE; TRANSPOSON; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; METABOLISM; METHODOLOGY; MORTALITY; PHYSIOLOGY; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, LEUKEMIC; GENETIC TESTING; KAPLAN-MEIER ESTIMATE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MICE; MICE, TRANSGENIC; MUTAGENESIS, INSERTIONAL; NF-KAPPA B P50 SUBUNIT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSPOSASES;

MLCS; MLOWN;

EID: 84880420282     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-02-486035     Document Type: Article

References (23)

1. Sgambati M, Linet M, Devesa S. Chronic lymphocytic leukemia, epidemiological, familial, and genetic aspects. In: Cheson B, ed. Chronic Lymphocytic Leukemias. 2nd ed. New York: Marcel Dekker; 2001:33-62.
2. Bullrich F, Croce C. Molecular biology of chronic lymphocytic leukemia. In: Cheson B, ed. Chronic Lymphocytic Leukemias. 2nd ed. New York: Marcel Dekker; 2001:9-32.
3. Bichi R, Shinton SA, Martin ES, et al. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA. 2002;99(10):6955-6960.
4. Pekarsky Y, Santanam U, Cimmino A, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 2006;66(24):11590-11593.
5. Pekarsky Y, Zanesi N, Croce CM. Molecular basis of CLL. Semin Cancer Biol. 2010;20(6):370-376.
6. Dupuy AJ, Akagi K, Largaespada DA, Copeland NG, Jenkins NA. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature. 2005;436(7048): 221-226.
7. Dupuy AJ, Rogers LM, Kim J, et al. A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res. 2009;69(20):8150-8156.
8. Starr TK, Scott PM, Marsh BM, et al. A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci USA. 2011; 108(14):5765-5770.
9. Keng VW, Villanueva A, Chiang DY, et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol. 2009;27(3):264-274.
10. Palamarchuk A, Yan PS, Zanesi N, et al. Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL). Proc Natl Acad Sci USA. 2012; 109(7):2555-2560.
11. Efanov A, Zanesi N, Nazaryan N, et al. CD51 CD231 leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia. 2010;24(5):970-975.
12. Brett BT, Berquam-Vrieze KE, Nannapaneni K, Huang J, Scheetz TE, Dupuy AJ. Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. PLoS ONE. 2011;6(9):e24668.
13. Meyer R, Hatada EN, Hohmann HP, et al. Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha. Proc Natl Acad Sci USA. 1991;88(3): 966-970.
14. Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000; 5(4):649-658.
15. Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 1997; 385(6616):540-544.
16. Yuan ZQ, Feldman RI, Sun M, et al. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. J Biol Chem. 2002;277(33):29973-29982.
17. Yamamoto M, Takeda K. Role of nuclear IkappaB proteins in the regulation of host immune responses. J Infect Chemother. 2008;14(4): 265-269.
18. Such E, Cervera J, Valencia A, et al. A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia. Blood. 2011;117(1):242-245.
19. van Wageningen S, Breems-de Ridder MC, Nigten J, et al. Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha. Blood. 2008;111(3):1634-1643.
20. Pekarsky Y, Palamarchuk A, Maximov V, et al. Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL. Proc Natl Acad Sci USA. 2008;105(50):19643-19648.
21. Palamarchuk A, Efanov A, Nazaryan N, et al. 13q14 deletions in CLL involve cooperating tumor suppressors. Blood. 2010;115(19):3916-3922.
22. Gaudio E, Spizzo R, Paduano F, et al. Tcl1 interacts with Atm and enhances NF-kB activation in hematologic malignancies. Blood. 2012;119(1): 180-187.
23. Zanesi N, Balatti V, Bottoni A, Croce CM, Pekarsky Y. Novel insights in molecular mechanisms of CLL. Curr Pharm Des. 2012; 18(23):3363-3372.