메뉴 건너뛰기




Volumn 40, Issue 1, 2014, Pages 51-55

Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification

Author keywords

ABCC6; Cardiovascular disease; Chronic kidney disease

Indexed keywords

MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 6; CALCIUM; FETUIN A; PHOSPHATE; ABC TRANSPORTER; ABCC6 PROTEIN, MOUSE; AHSG PROTEIN, MOUSE; AHSG PROTEIN, RAT; MRP6 PROTEIN, RAT; MULTIDRUG RESISTANCE PROTEIN;

EID: 84928348463     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000365014     Document Type: Article
Times cited : (27)

References (37)
  • 1
    • 0242441465 scopus 로고    scopus 로고
    • Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    • Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al: Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension 2003; 42: 1050-1065
    • (2003) Hypertension , vol.42 , pp. 1050-1065
    • Sarnak, M.J.1    Levey, A.S.2    Schoolwerth, A.C.3    Coresh, J.4    Culleton, B.5    Hamm, L.L.6
  • 2
    • 64949130692 scopus 로고    scopus 로고
    • The emerging role of phosphate in vascular calcification
    • Giachelli CM: The emerging role of phosphate in vascular calcification. Kidney Int 2009; 75: 890-897
    • (2009) Kidney Int , vol.75 , pp. 890-897
    • Giachelli, C.M.1
  • 3
    • 39049096394 scopus 로고    scopus 로고
    • Mechanisms of vascular calcification in chronic kidney disease
    • Moe S, Chen N: Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 2008; 19: 213-216
    • (2008) J Am Soc Nephrol , vol.19 , pp. 213-216
    • Moe, S.1    Chen, N.2
  • 4
    • 84875271197 scopus 로고    scopus 로고
    • Clinical detection, risk factors, and cardiovascular consequences of medial arterial calcification: A pattern of vascular injury associated with aberrant mineral metabolism
    • Lau WL, Ix JH: Clinical detection, risk factors, and cardiovascular consequences of medial arterial calcification: A pattern of vascular injury associated with aberrant mineral metabolism. Semin Nephrol 2013; 33: 93-105
    • (2013) Semin Nephrol , vol.33 , pp. 93-105
    • Lau, W.L.1    Ix, J.H.2
  • 8
    • 0032893268 scopus 로고    scopus 로고
    • Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
    • Kool M, Van Der Linden M, De Haas M, Baas F, Borst P: Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res 1999; 59: 175-182
    • (1999) Cancer Res , vol.59 , pp. 175-182
    • Kool, M.1    Van Der Linden, M.2    De Haas, M.3    Baas, F.4    Borst, P.5
  • 9
    • 28844498292 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: A clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations
    • Chassaing N, Martin L, Calvas P, Le Bert M, Hovnanian A: Pseudoxanthoma elasticum: A clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet 2005; 42: 881-892
    • (2005) J Med Genet , vol.42 , pp. 881-892
    • Chassaing, N.1    Martin, L.2    Calvas, P.3    Le Bert, M.4    Hovnanian, A.5
  • 10
    • 79959529113 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Progress in diagnostics and research towards treatment: Summary of the 2010 PXE International Research Meeting
    • Uitto J, Bercovitch L, Terry SF, Terry PF: Pseudoxanthoma elasticum: Progress in diagnostics and research towards treatment: Summary of the 2010 PXE International Research Meeting. Am J Med Genet A 2011; 155A:1517-1526
    • (2011) Am J Med Genet A. , vol.155 A , pp. 1517-1526
    • Uitto, J.1    Bercovitch, L.2    Terry, S.F.3    Terry, P.F.4
  • 12
    • 34248390171 scopus 로고    scopus 로고
    • Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics
    • Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, et al: Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci USA 2007; 104: 4530-4535
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4530-4535
    • Meng, H.1    Vera, I.2    Che, N.3    Wang, X.4    Wang, S.S.5    Ingram-Drake, L.6
  • 13
    • 77449137135 scopus 로고    scopus 로고
    • Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice
    • Wang SS, Martin LJ, Schadt EE, Meng H, Wang X, Zhao W, et al: Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet 2009; 2: 573-582
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 573-582
    • Wang, S.S.1    Martin, L.J.2    Schadt, E.E.3    Meng, H.4    Wang, X.5    Zhao, W.6
  • 14
    • 55449101447 scopus 로고    scopus 로고
    • Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis
    • Shroff R, McNair R, Figg N, Skepper J, Schurgers L, Gupta A, et al: Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 2008; 118: 1748-1757
    • (2008) Circulation , vol.118 , pp. 1748-1757
    • Shroff, R.1    McNair, R.2    Figg, N.3    Skepper, J.4    Schurgers, L.5    Gupta, A.6
  • 15
    • 34248390171 scopus 로고    scopus 로고
    • Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics
    • Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, et al: Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci USA 2007; 104: 4530-4535
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4530-4535
    • Meng, H.1    Vera, I.2    Che, N.3    Wang, X.4    Wang, S.S.5    Ingram-Drake, L.6
  • 17
    • 49849089138 scopus 로고    scopus 로고
    • Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
    • Miller JD, Chu Y, Brooks RM, Richenbacher WE, Pena-Silva R, Heistad DD: Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol 2008; 52: 843-850
    • (2008) J Am Coll Cardiol , vol.52 , pp. 843-850
    • Miller, J.D.1    Chu, Y.2    Brooks, R.M.3    Richenbacher, W.E.4    Pena-Silva, R.5    Heistad, D.D.6
  • 18
    • 57649232758 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Clinical phenotypes, molecular genetics and putative pathomechanisms
    • Li Q, Jiang Q, Pfendner E, Varadi A, Uitto J: Pseudoxanthoma elasticum: Clinical phenotypes, molecular genetics and putative pathomechanisms. Exp Dermatol 2009; 18: 1-11
    • (2009) Exp Dermatol , vol.18 , pp. 1-11
    • Li, Q.1    Jiang, Q.2    Pfendner, E.3    Varadi, A.4    Uitto, J.5
  • 19
    • 31844441584 scopus 로고    scopus 로고
    • Role of serum fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum
    • Hendig D, Schulz V, Arndt M, Szliska C, Kleesiek K, Gotting C: Role of serum fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum. Clin Chem 2006; 52: 227-234
    • (2006) Clin Chem , vol.52 , pp. 227-234
    • Hendig, D.1    Schulz, V.2    Arndt, M.3    Szliska, C.4    Kleesiek, K.5    Gotting, C.6
  • 20
    • 77951090808 scopus 로고    scopus 로고
    • Overexpression of fetuin-A counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (ABCC6-/-)
    • Jiang Q, Dibra F, Lee MD, Oldenburg R, Uitto J: Overexpression of fetuin-A counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (ABCC6-/-). J Invest Dermatol 2010; 130: 1288-1296
    • (2010) J Invest Dermatol , vol.130 , pp. 1288-1296
    • Jiang, Q.1    Dibra, F.2    Lee, M.D.3    Oldenburg, R.4    Uitto, J.5
  • 21
    • 33847067547 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity
    • Vanakker OM, Martin L, Gheduzzi D, Leroy BP, Loeys BL, Guerci VI, et al: Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity. J Invest Dermatol 2007; 127: 581-587
    • (2007) J Invest Dermatol , vol.127 , pp. 581-587
    • Vanakker, O.M.1    Martin, L.2    Gheduzzi, D.3    Leroy, B.P.4    Loeys, B.L.5    Guerci, V.I.6
  • 22
    • 77958565641 scopus 로고    scopus 로고
    • Fibroblast growth factor 23 and fetuin-A are independent predictors for the coronary artery disease extent in mild chronic kidney disease
    • Kanbay M, Nicoleta M, Selcoki Y, Ikizek M, Aydin M, Eryonucu B, et al: Fibroblast growth factor 23 and fetuin-A are independent predictors for the coronary artery disease extent in mild chronic kidney disease. Clin J Am Soc Nephrol 2010; 5: 1780-1786
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1780-1786
    • Kanbay, M.1    Nicoleta, M.2    Selcoki, Y.3    Ikizek, M.4    Aydin, M.5    Eryonucu, B.6
  • 24
    • 0037426081 scopus 로고    scopus 로고
    • Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study
    • Ketteler M, Bongartz P, Westenfeld R, Wildberger JE, Mahnken AH, Bohm R, et al: Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: A cross-sectional study. Lancet 2003; 361: 827-833
    • (2003) Lancet , vol.361 , pp. 827-833
    • Ketteler, M.1    Bongartz, P.2    Westenfeld, R.3    Wildberger, J.E.4    Mahnken, A.H.5    Bohm, R.6
  • 25
    • 20844432154 scopus 로고    scopus 로고
    • Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease
    • Moe SM, Reslerova M, Ketteler M, O'Neill K, Duan D, Koczman J, et al: Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease. Kidney Int 2005; 67: 2295-2304
    • (2005) Kidney Int , vol.67 , pp. 2295-2304
    • Moe, S.M.1    Reslerova, M.2    Ketteler, M.3    O'Neill, K.4    Duan, D.5    Koczman, J.6
  • 26
    • 64849110662 scopus 로고    scopus 로고
    • Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification
    • Koos R, Krueger T, Westenfeld R, Kuhl H, Brandenburg V, Mahnken A, et al: Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification. Thromb Haemost 2009; 101: 706-713
    • (2009) Thromb Haemost , vol.101 , pp. 706-713
    • Koos, R.1    Krueger, T.2    Westenfeld, R.3    Kuhl, H.4    Brandenburg, V.5    Mahnken, A.6
  • 28
    • 84890275902 scopus 로고    scopus 로고
    • ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release
    • Jansen RS, Kucukosmanoglu A, De Haas M, Sapthu S, Otero JA, Hegman IE, et al: ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci USA 2013; 110: 20206-20211
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 20206-20211
    • Jansen, R.S.1    Kucukosmanoglu, A.2    De Haas, M.3    Sapthu, S.4    Otero, J.A.5    Hegman, I.E.6
  • 29
    • 0028248384 scopus 로고
    • Immunochemical identification of abnormal constituents in the dermis of pseudoxanthoma elasticum patients
    • Baccarani-Contri M, Vincenzi D, Cicchetti F, Mori G, Pasquali-Ronchetti I: Immunochemical identification of abnormal constituents in the dermis of pseudoxanthoma elasticum patients. Eur J Histochem 1994; 38: 111-123
    • (1994) Eur J Histochem , vol.38 , pp. 111-123
    • Baccarani-Contri, M.1    Vincenzi, D.2    Cicchetti, F.3    Mori, G.4    Pasquali-Ronchetti, I.5
  • 30
    • 40849119733 scopus 로고    scopus 로고
    • Circulating P-L-And E-selectins in pseudoxanthoma elasticum patients
    • Gotting C, Adam A, Szliska C, Kleesiek K: Circulating P-, L-And E-selectins in pseudoxanthoma elasticum patients. Clin Biochem 2008; 41: 368-374
    • (2008) Clin Biochem , vol.41 , pp. 368-374
    • Gotting, C.1    Adam, A.2    Szliska, C.3    Kleesiek, K.4
  • 31
    • 79958091562 scopus 로고    scopus 로고
    • Elevated circulating levels of matrix metalloproteinases MMP-2 and MMP-9 in pseudoxanthoma elasticum patients
    • Diekmann U, Zarbock R, Hendig D, Szliska C, Kleesiek K, Gotting C: Elevated circulating levels of matrix metalloproteinases MMP-2 and MMP-9 in pseudoxanthoma elasticum patients. J Mol Med (Berl) 2009; 87: 965-970
    • (2009) J Mol Med (Berl , vol.87 , pp. 965-970
    • Diekmann, U.1    Zarbock, R.2    Hendig, D.3    Szliska, C.4    Kleesiek, K.5    Gotting, C.6
  • 32
    • 0031019202 scopus 로고    scopus 로고
    • Aortic changes in experimental renal failure: Hyperplasia or hypertrophy of smooth muscle cells?
    • Amann K, Wolf B, Nichols C, Tornig J, Schwarz U, Zeier M, et al: Aortic changes in experimental renal failure: Hyperplasia or hypertrophy of smooth muscle cells?. Hypertension 1997; 29: 770-775
    • (1997) Hypertension , vol.29 , pp. 770-775
    • Amann, K.1    Wolf, B.2    Nichols, C.3    Tornig, J.4    Schwarz, U.5    Zeier, M.6
  • 33
    • 79951823118 scopus 로고    scopus 로고
    • Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease
    • Pai A, Leaf EM, El-Abbadi M, Giachelli CM: Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Am J Pathol 2011; 178: 764-773
    • (2011) Am J Pathol , vol.178 , pp. 764-773
    • Pai, A.1    Leaf, E.M.2    El-Abbadi, M.3    Giachelli, C.M.4
  • 34
    • 0018748311 scopus 로고
    • Arterial calcification and pathology in uremic patients undergoing dialysis
    • Ibels L, Alfrey A, Huffer W, Craswell P, Anderson J, Weil RR: Arterial calcification and pathology in uremic patients undergoing dialysis. Am J Med 1979; 66: 790-796
    • (1979) Am J Med , vol.66 , pp. 790-796
    • Ibels, L.1    Alfrey, A.2    Huffer, W.3    Craswell, P.4    Anderson, J.5    Weil, R.R.6
  • 35
    • 70349317144 scopus 로고    scopus 로고
    • Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease
    • Chung A, Yang H, Kim J, Sigrist M, Chum E, Gourlay W, et al: Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease. Circulation 2009; 120: 792-801
    • (2009) Circulation , vol.120 , pp. 792-801
    • Chung, A.1    Yang, H.2    Kim, J.3    Sigrist, M.4    Chum, E.5    Gourlay, W.6
  • 36
    • 80052153431 scopus 로고    scopus 로고
    • Genetics in arterial calcification: Pieces of a puzzle and cogs in a wheel
    • Rutsch F, Nitschke Y, Terkeltaub R: Genetics in arterial calcification: Pieces of a puzzle and cogs in a wheel. Circ Res 2011; 109: 578-592
    • (2011) Circ Res , vol.109 , pp. 578-592
    • Rutsch, F.1    Nitschke, Y.2    Terkeltaub, R.3
  • 37
    • 0037053355 scopus 로고    scopus 로고
    • Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-Associated mutants of human ABCC6 (MRP6
    • Ilias A, Urban Z, Seidl TL, Le Saux O, Sinko E, Boyd CD, et al: Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-Associated mutants of human ABCC6 (MRP6). J Biol Chem 2002; 277: 16860-16867
    • (2002) J Biol Chem , vol.277 , pp. 16860-16867
    • Ilias, A.1    Urban, Z.2    Seidl, T.L.3    Le Saux, O.4    Sinko, E.5    Boyd, C.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.