Overexpression of fetuin-A counteracts ectopic mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6-/-)

Journal of Investigative Dermatology

Volumn 130, Issue 5, 2010, Pages 1288-1296

  Jiang, Qiujie ^a   Dibra, Florian ^a   Lee, Michael D ^a   Oldenburg, Reid ^a   Uitto, Jouni ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FETUIN A; POLYHISTIDINE TAG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULATION; CONNECTIVE TISSUE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE TARGETING; GENE THERAPY; GENE VECTOR; HYPOTHESIS; LIVER; MALE; MINERALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSEUDOXANTHOMA ELASTICUM; SOFT TISSUE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD PROTEINS; CALCINOSIS; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; LAC OPERON; LIVER; MALE; MICE; MICE, MUTANT STRAINS; PSEUDOXANTHOMA ELASTICUM; TRANSFECTION; VIBRISSAE;

EID: 77951090808     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.423     Document Type: Article

References (29)

1. Belinsky MG, Kruh GD (1999) MOAT-E (ARA) is a full length MRP/cMOAT subfamily transporter expressed in kidney and liver. Br J Cancer 80: 1342-1349
2. Chassaing N, Martin L, Bourthoumieu S et al. (2007) Contribution of ABCC6 genomic rearrangements to the diagnosis of pseudoxanthoma elasticum in French patients. Hum Mutat 28:1046
3. Gorgels TG, Hu X, Scheffer GL et al. (2005) Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum. Hum Mol Genet 14:1763-1773
4. 2-HS glycoprotein/fetuin-A. J Biol Chem 278: 13333-13341
5. Hendig D, Schulz V, Arndt M et al. (2006) Role of serum fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum. Clin Chem 52:227-234
6. Hendig D, Schulz V, Eichgrün J et al. (2005) New ABCC6 gene mutations in German pseudoxanthoma elasticum patients. J Mol Med 83:140-147 (Pubitemid 40379302)
7. Jahnen-Dechent W, Schinke T, Trindl A et al. (1997) Cloning and targeted deletion of the mouse fetuin gene. J Biol Chem 272:31496-31503
8. Jiang Q, Endo M, Dibra F et al. (2009) Pseudoxanthoma elasticum is a metabolic disease. J Invest Dermatol 129:348-356
9. Jiang Q, Li Q, Uitto J (2007) Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: systemic and local regulatory factors. J Invest Dermatol 127:1392-1402
10. Jiang Q, Matsuzaki Y, Li K et al. (2006) Transcriptional regulation and characterization of the promoter region of the human ABCC6 gene. J Invest Dermatol 126:325-335
11. Jiang Q, Uitto J (2006) Pseudoxanthoma elasticum: a metabolic disease? J Invest Dermatol 126:1440-1441
12. Kazi JA, Nakamura O, Ohnishi T et al. (1998) Changes with age of the rat fetuin concentration in serum and its mRNA expression. J Biochem 124:179-186
13. Klement JF, Matsuzaki Y, Jiang Q-J et al. (2005) Targeted ablation of the ABCC6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol 25:8299-8310
14. LaRusso J, Jiang Q, Li Q et al. (2008) Ectopic mineralization of connective tissue in Abcc6 mice: effects of dietary modifications and a phosphate binder-a preliminary study. Exp Dermatol 17:203-7
15. -/~). J Invest Dermatol 129:1388-1394
16. Li Q, Jiang Q, Pfendner E et al. (2009) Pseudoxanthoma elasticum: clinical phenotypes, molecular genetics and putative pathomechanisms. Exp Derm 18:1-11
17. Luo G, Ducy P, McKee MD et al. (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78-81
18. Miksch S, Lunsden A, Guenther UP et al. (2005) Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat 26:235-248
19. Neldner KH (1988) Pseudoxanthoma elasticum. Clin Dermatol 6:1-159
20. Neldner KH, Struk B (2002) Pseudoxanthoma elasticum. In: Connective Tissue and its Heritable Disorders: Molecular, Genetic and Medical Aspects (Royce PM, Steinmann B, eds), Wiley-Liss: New York, pp 561-583
21. Pfendner E, Uitto J, Gerard GF et al. (2008) Pseudoxanthoma elasticum: genetic diagnostic markers. Expert Opinion Med Diagn 2:1-17
22. Pfendner EG, Vanakker O, Terry SF et al. (2007) Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. J Med Genet 44: 621-628
23. Ryan LM (2001) The ank gene story. Arthritis Res 3:77-79
24. 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 112:357-366
25. Uitto J, Pulkkinen L, Ringpfeil F (2001) Molecular genetics of pseudoxan-thoma elasticum: a metabolic disorder at the environment-genome interface? Trends Mol Med 7:13-17
26. Vanakker OM, Leroy BP, Coucke P et al. (2008) Novel clinico-molecular insights in pseudoxanthoma elasticum provide an efficient molecular screening method and a comprehensive diagnostic flowchart. Hum Mutat 29:205
27. Wang W, Xu J, Du B et al. (2005) Role of the progressive ankylosis gene (ank) in cartilage mineralization. Mol Cell Biol 25:312-323
28. Yang F, Chen ZL, Bergeron JM et al. (1992) Human a2-HS-glycoprotein/ bovine fetuin homologue in mice: identification and developmental regulation of the gene. Biochim Biophys Acta 1130:149-156
29. Zhang G, Budker V, Wolff JA (1999) High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 10:1735-1737