Circulating fetuin-A predicts early mortality in chronic hemodialysis patients

Clinical Biochemistry

Volumn 42, Issue 10-11, 2009, Pages 996-1000

  Bláha, Vladimír ^a   Mistrík, Erik ^a   Dusilová Sulková, Sylvie ^a   Kalousová, Marta ^b   Andrýs, Ctirad ^a   Bláha, Milan ^a   Sobotka, Luboš ^a  

^a UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Biochemical markers; Fetuin A; Hemodialysis; Mortality; Prognosis; Risk factors

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BIOCHEMICAL MARKER; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FETUIN A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; ORAL ANTIDIABETIC AGENT; PHOSPHATE BINDING AGENT; SEVELAMER;

ADULT; AGED; ARTICLE; BLOOD VESSEL CALCIFICATION; CHEMICAL ANALYSIS; COMORBIDITY; DIABETES MELLITUS; FEMALE; FOLLOW UP; HEMODIALYSIS; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; PROBABILITY; PROGNOSIS; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; SURVIVAL TIME;

ADULT; AGED; AGED, 80 AND OVER; BLOOD PROTEINS; C-REACTIVE PROTEIN; CHRONIC DISEASE; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; RENAL DIALYSIS;

EID: 67349136483     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2009.03.021     Document Type: Article

References (17)

1. US Renal Data System. USRDS 1998 Annual Data Report (1999), National Institute of Diabetes and Kidney Diseases, Bethesda 63-90
2. Block G.A., Hulbert-Shearon T.E., Levin N.W., and Port F.K. Association of serum phosphorus and calcium phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am. J. Kidney Dis. 31 (1998) 607-617
3. Schinke T., Amendt C., Trindl A., et al. The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells: a possible role in mineralization and calcium homeostasis. J. Biol. Chem. 271 (1996) 20789-20796
4. Wang A.Y.M., Woo J., Lam W.K.C., et al. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol. Dial. Transplant 20 (2005) 1676-1685
5. Ketteler M., Bongartz P., Westenfeld R., et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet 361 (2003) 827-833
6. Honda H., Qureshi A.R., Heimbürger O., et al. Serum albumin, C-reactive protein, interleukin 6, and fetuin A as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am. J. Kidney Dis. 47 (2006) 139-148
7. Hermans M.M.H., Brandenburg V., Ketteler M., et al. Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int. 72 (2007) 202-207
8. Ix J.H., Shlipak M.G., Sarnak M.J., et al. Fetuin-A is not associated with mortality in chronic kidney disease. Kidney Int. 72 (2007) 1394-1399
9. Daugirdas J.T. Simplified equations for monitoring Kt/V, PCRn, eKt/V and ePCRn. Adv. Ren. Replac. Ther. 2 (1995) 295-304
10. Stenvinkel P., Ketteler M., Johnson R.J., et al. IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia - the good, the bad, and the ugly. Kidney Int. 67 (2005) 1216-1233
11. Suliman M.E., García-López E., Anderstam B., Lindholm B., and Stenvinkel P. Vascular calcification inhibitors in relation to cardiovascular disease with special emphasis on fetuin-A in chronic kidney disease. Adv. Clin. Che. 46 (2008) 217-262
12. Dervisoglu E., Kir H.M., Kalender B., Caglayan C., and Eraldemir C. Serum fetuin-A concentrations are inversely related to cytokine concentrations in patients with chronic renal failure. Cytokine 44 (2008) 323-327
13. Metry G., Stenvinkel P., Qureshi A.R., Carrero J.J., Yilmaz M.I., Bárány P., Snaedal S., Heimbürger O., Lindholm B., and Suliman M.E. Low serum fetuin-A concentration predicts poor outcome only in the presence of inflammation in prevalent haemodialysis patients. Eur. J. Clin. Invest. 38 (2008) 804-811
14. Shroff R.C., McNair R., Figg N., et al. Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 118 (2008) 1748-1757
15. Osawa M., Yuasa I., Kitano T., et al. Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene. Ann. Hum. Genet. 65 (2001) 27-34
16. Stenvinkel P., Wang K., Qureshi A.R., et al. Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin. Kidney Int. 67 (2005) 2383-2392
17. Stenvinkel P., Pecoits-Filho R., and Lindholm B. Gene polymorphism association studies in dialysis: the nutrition-inflammation axis. Semin. Dial 18 (2005) 322-330