메뉴 건너뛰기




Volumn 72, Issue 5, 2015, Pages 879-889

Advances in the therapeutic use of mammalian target of rapamycin (mTOR) inhibitors in dermatology

Author keywords

antiproliferative; autoimmune; drug repurposing; genodermatosis; immunosuppression; inflammatory; mammalian target of rapamycin; neoplasia; percutaneous therapy; rapamycin; sirolimus; vascular anomalies

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; VASCULOTROPIN; IMMUNOSUPPRESSIVE AGENT; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

EID: 84928268474     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2015.01.014     Document Type: Review
Times cited : (49)

References (78)
  • 1
    • 36048990293 scopus 로고    scopus 로고
    • Sirolimus (rapamycin): from the soil of Easter Island to a bright future
    • K.V. Paghdal, and R.A. Schwartz Sirolimus (rapamycin): from the soil of Easter Island to a bright future J Am Acad Dermatol 57 2007 1046 1050
    • (2007) J Am Acad Dermatol , vol.57 , pp. 1046-1050
    • Paghdal, K.V.1    Schwartz, R.A.2
  • 2
    • 70449390905 scopus 로고    scopus 로고
    • Rapamycin and mTOR kinase inhibitors
    • L.M. Ballou, and R.Z. Lin Rapamycin and mTOR kinase inhibitors J Chem Biol 1 2008 27 36
    • (2008) J Chem Biol , vol.1 , pp. 27-36
    • Ballou, L.M.1    Lin, R.Z.2
  • 3
    • 84928272921 scopus 로고    scopus 로고
    • Online Accessed August 1, 2014
    • Pfizer. Rapamune package insert. Online2012. Available at: http://labeling.pfizer.com/showlabeling.aspx?id=139. Accessed August 1, 2014.
    • (2012) Rapamune package insert
    • Pfizer1
  • 4
    • 70349987628 scopus 로고    scopus 로고
    • Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
    • R.P. Hickerson, D. Leake, L.N. Pho, S.A. Leachman, and R.L. Kaspar Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients J Dermatol Sci 56 2009 82 88
    • (2009) J Dermatol Sci , vol.56 , pp. 82-88
    • Hickerson, R.P.1    Leake, D.2    Pho, L.N.3    Leachman, S.A.4    Kaspar, R.L.5
  • 5
    • 84856956808 scopus 로고    scopus 로고
    • Topical 0.1% rapamycin for angiofibromas in pediatric patients with tuberous sclerosis: a pilot study of four patients
    • R.S. Foster, L.J. Bint, and A.R. Halbert Topical 0.1% rapamycin for angiofibromas in pediatric patients with tuberous sclerosis: a pilot study of four patients Australas J Dermatol 53 2012 52 56
    • (2012) Australas J Dermatol , vol.53 , pp. 52-56
    • Foster, R.S.1    Bint, L.J.2    Halbert, A.R.3
  • 6
    • 77249103572 scopus 로고    scopus 로고
    • Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment
    • W. Jia, V. Sun, and N. Tran et al. Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment Lasers Surg Med 42 2010 105 112
    • (2010) Lasers Surg Med , vol.42 , pp. 105-112
    • Jia, W.1    Sun, V.2    Tran, N.3
  • 7
    • 17644374126 scopus 로고    scopus 로고
    • Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial
    • A.D. Ormerod, S.A. Shah, P. Copeland, G. Omar, and A. Winfield Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial Br J Dermatol 152 2005 758 764
    • (2005) Br J Dermatol , vol.152 , pp. 758-764
    • Ormerod, A.D.1    Shah, S.A.2    Copeland, P.3    Omar, G.4    Winfield, A.5
  • 8
    • 33644689608 scopus 로고    scopus 로고
    • Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment
    • J. Jozwiak, S. Jozwiak, and M. Oldak Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment Med Res Rev 26 2006 160 180
    • (2006) Med Res Rev , vol.26 , pp. 160-180
    • Jozwiak, J.1    Jozwiak, S.2    Oldak, M.3
  • 9
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: a new generation of mTOR inhibitors
    • D. Benjamin, M. Colombi, C. Moroni, and M.N. Hall Rapamycin passes the torch: a new generation of mTOR inhibitors Nat Rev Drug Discov 10 2011 868 880
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4
  • 10
    • 77951700065 scopus 로고    scopus 로고
    • Online: U.S. Food and Drug Administration;. Accessed August 1, 2014
    • Drugs@FDA: FDA-approved drug products. Online: U.S. Food and Drug Administration; 2014. Available at: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Accessed August 1, 2014.
    • (2014) Drugs@FDA: FDA-approved drug products
  • 11
    • 84863784970 scopus 로고    scopus 로고
    • Onychopathy induced by temsirolimus, a mammalian target of rapamycin inhibitor
    • L. Peuvrel, G. Quereux, A. Brocard, M. Saint-Jean, and B. Dreno Onychopathy induced by temsirolimus, a mammalian target of rapamycin inhibitor Dermatology 224 2012 204 208
    • (2012) Dermatology , vol.224 , pp. 204-208
    • Peuvrel, L.1    Quereux, G.2    Brocard, A.3    Saint-Jean, M.4    Dreno, B.5
  • 13
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • D.N. Franz, J. Leonard, and C. Tudor et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex Ann Neurol 59 2006 490 498
    • (2006) Ann Neurol , vol.59 , pp. 490-498
    • Franz, D.N.1    Leonard, J.2    Tudor, C.3
  • 14
    • 80052313178 scopus 로고    scopus 로고
    • Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis
    • D.N. Franz Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis Expert Rev Anticancer Ther 11 2011 1181 1192
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 1181-1192
    • Franz, D.N.1
  • 15
    • 79955498414 scopus 로고    scopus 로고
    • Regression of a cardiac rhabdomyoma in a patient receiving everolimus
    • D. Tiberio, D.N. Franz, and J.R. Phillips Regression of a cardiac rhabdomyoma in a patient receiving everolimus Pediatrics 127 2011 e1335 e1337
    • (2011) Pediatrics , vol.127 , pp. e1335-e1337
    • Tiberio, D.1    Franz, D.N.2    Phillips, J.R.3
  • 16
    • 79959262531 scopus 로고    scopus 로고
    • Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial
    • D.M. Davies, P.J. de Vries, and S.R. Johnson et al. Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial Clin Cancer Res 17 2011 4071 4081
    • (2011) Clin Cancer Res , vol.17 , pp. 4071-4081
    • Davies, D.M.1    De Vries, P.J.2    Johnson, S.R.3
  • 18
    • 84885692467 scopus 로고    scopus 로고
    • Birt-Hogg-Dube syndrome is a novel ciliopathy
    • M.N. Luijten, S.G. Basten, and T. Claessens et al. Birt-Hogg-Dube syndrome is a novel ciliopathy Hum Mol Genet 22 2013 4383 4397
    • (2013) Hum Mol Genet , vol.22 , pp. 4383-4397
    • Luijten, M.N.1    Basten, S.G.2    Claessens, T.3
  • 19
    • 84928286779 scopus 로고    scopus 로고
    • U. N. I. o. Health editor. Online. Accessed August 1, 2014
    • Steense Mv. Topical rapamycin for fibrofolliculomas. In: U. N. I. o. Health editor. Online2013. Available at: http://clinicaltrials.gov/ct2/show/NCT00928798?term=birt+hogg+dube&rank=2. Accessed August 1, 2014.
    • (2013) Topical rapamycin for fibrofolliculomas
    • Steense, Mv.1
  • 20
    • 84855846998 scopus 로고    scopus 로고
    • Familial multiple discoid fibromas: a look-alike of Birt-Hogg-Dube syndrome not linked to the FLCN locus
    • T.M. Starink, A.C. Houweling, and M.B. van Doorn et al. Familial multiple discoid fibromas: a look-alike of Birt-Hogg-Dube syndrome not linked to the FLCN locus J Am Acad Dermatol 66 2012 259.e1 259.e9
    • (2012) J Am Acad Dermatol , vol.66 , pp. 259e1-259e9
    • Starink, T.M.1    Houweling, A.C.2    Van Doorn, M.B.3
  • 21
    • 2342458960 scopus 로고    scopus 로고
    • Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome
    • R. Pilarski, and C. Eng Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome J Med Genet 41 2004 323 326
    • (2004) J Med Genet , vol.41 , pp. 323-326
    • Pilarski, R.1    Eng, C.2
  • 22
    • 52049126174 scopus 로고    scopus 로고
    • Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin
    • C.H. Squarize, R.M. Castilho, and J.S. Gutkind Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin Cancer Res 68 2008 7066 7072
    • (2008) Cancer Res , vol.68 , pp. 7066-7072
    • Squarize, C.H.1    Castilho, R.M.2    Gutkind, J.S.3
  • 23
    • 44649203072 scopus 로고    scopus 로고
    • Rapamycin treatment for a child with germline PTEN mutation
    • D.J. Marsh, T.N. Trahair, and J.L. Martin et al. Rapamycin treatment for a child with germline PTEN mutation Nat Clin Pract Oncol 5 2008 357 361
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 357-361
    • Marsh, D.J.1    Trahair, T.N.2    Martin, J.L.3
  • 24
    • 84862728364 scopus 로고    scopus 로고
    • T. U. S. N. I. o. Health editor. Accessed August 1, 2014
    • Rajan A. Sirolimus to treat Cowden syndrome and other PTEN hamartomatous tumor syndromes. In: T. U. S. N. I. o. Health editor. ClinicalTrials.gov2009. Available at: http://www.clinicaltrials.gov/ct2/show/results/NCT00971789?term=pten+rapamycin&rank=1§=X736015#outcome2. Accessed August 1, 2014.
    • (2009) Sirolimus to treat Cowden syndrome and other PTEN hamartomatous tumor syndromes
    • Rajan, A.1
  • 26
    • 84878849124 scopus 로고    scopus 로고
    • Visible effects of rapamycin (sirolimus) on human skin explants in vitro
    • A. Peramo, and C.L. Marcelo Visible effects of rapamycin (sirolimus) on human skin explants in vitro Arch Dermatol Res 305 2013 163 171
    • (2013) Arch Dermatol Res , vol.305 , pp. 163-171
    • Peramo, A.1    Marcelo, C.L.2
  • 27
    • 84928286777 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Online: The United States National Institutes of Health; 2014
    • ClinicalTrials.gov. Online: The United States National Institutes of Health; 2014.
  • 28
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
    • M. Guba, P. von Breitenbuch, and M. Steinbauer et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor Nat Med 8 2002 128 135
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3
  • 29
    • 13944281689 scopus 로고    scopus 로고
    • Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo
    • Y.S. Kwon, H.S. Hong, J.C. Kim, J.S. Shin, and Y. Son Inhibitory effect of rapamycin on corneal neovascularization in vitro and in vivo Invest Ophthalmol Visl Sci 46 2005 454 460
    • (2005) Invest Ophthalmol Visl Sci , vol.46 , pp. 454-460
    • Kwon, Y.S.1    Hong, H.S.2    Kim, J.C.3    Shin, J.S.4    Son, Y.5
  • 30
    • 34247373748 scopus 로고    scopus 로고
    • AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo
    • B. Perry, J. Banyard, and E.R. McLaughlin et al. AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo Arch Dermatol 143 2007 504 506
    • (2007) Arch Dermatol , vol.143 , pp. 504-506
    • Perry, B.1    Banyard, J.2    McLaughlin, E.R.3
  • 31
    • 38949157092 scopus 로고    scopus 로고
    • Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks
    • T.L. Phung, D.A. Oble, W. Jia, L.E. Benjamin, M.C. Mihm Jr., and J.S. Nelson Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks Lasers Surg Med 40 2008 1 5
    • (2008) Lasers Surg Med , vol.40 , pp. 1-5
    • Phung, T.L.1    Oble, D.A.2    Jia, W.3    Benjamin, L.E.4    Mihm, M.C.5    Nelson, J.S.6
  • 32
    • 84877957142 scopus 로고    scopus 로고
    • Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ
    • M.D. Shirley, H. Tang, and C.J. Gallione et al. Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ N Engl J Med 368 2013 1971 1979
    • (2013) N Engl J Med , vol.368 , pp. 1971-1979
    • Shirley, M.D.1    Tang, H.2    Gallione, C.J.3
  • 33
    • 38149000984 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) is activated in cutaneous vascular malformations in vivo
    • F. Shirazi, C. Cohen, L. Fried, and J.L. Arbiser Mammalian target of rapamycin (mTOR) is activated in cutaneous vascular malformations in vivo Lymph Res Biol 5 2007 233 236
    • (2007) Lymph Res Biol , vol.5 , pp. 233-236
    • Shirazi, F.1    Cohen, C.2    Fried, L.3    Arbiser, J.L.4
  • 34
    • 0029816721 scopus 로고    scopus 로고
    • Dynamic epidermal cooling in conjunction with laser-induced photothermolysis of port wine stain blood vessels
    • J.S. Nelson, T.E. Milner, B. Anvari, B.S. Tanenbaum, L.O. Svaasand, and S. Kimel Dynamic epidermal cooling in conjunction with laser-induced photothermolysis of port wine stain blood vessels Lasers Surg Med 19 1996 224 229
    • (1996) Lasers Surg Med , vol.19 , pp. 224-229
    • Nelson, J.S.1    Milner, T.E.2    Anvari, B.3    Tanenbaum, B.S.4    Svaasand, L.O.5    Kimel, S.6
  • 35
    • 84871754469 scopus 로고    scopus 로고
    • Topical rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of photocoagulated cutaneous blood vessels
    • W. Tan, W. Jia, V. Sun, M.C. Mihm Jr., and J.S. Nelson Topical rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of photocoagulated cutaneous blood vessels Lasers Surg Med 44 2012 796 804
    • (2012) Lasers Surg Med , vol.44 , pp. 796-804
    • Tan, W.1    Jia, W.2    Sun, V.3    Mihm, M.C.4    Nelson, J.S.5
  • 36
    • 77949824396 scopus 로고    scopus 로고
    • Stem cell marker upregulation in normal cutaneous vessels following pulsed-dye laser exposure and its abrogation by concurrent rapamycin administration: implications for treatment of port-wine stain birthmarks
    • R. Loewe, D.A. Oble, T. Valero, L. Zukerberg, M.C. Mihm Jr., and J.S. Nelson Stem cell marker upregulation in normal cutaneous vessels following pulsed-dye laser exposure and its abrogation by concurrent rapamycin administration: implications for treatment of port-wine stain birthmarks J Cutan Pathol 37 Suppl 1 2010 76 82
    • (2010) J Cutan Pathol , vol.37 , pp. 76-82
    • Loewe, R.1    Oble, D.A.2    Valero, T.3    Zukerberg, L.4    Mihm, M.C.5    Nelson, J.S.6
  • 37
    • 84872293610 scopus 로고    scopus 로고
    • Propranolol use in PHACE syndrome with cervical and intracranial arterial anomalies: collective experience in 32 infants
    • D. Metry, I.J. Frieden, and C. Hess et al. Propranolol use in PHACE syndrome with cervical and intracranial arterial anomalies: collective experience in 32 infants Pediatr Dermatol 30 2013 71 89
    • (2013) Pediatr Dermatol , vol.30 , pp. 71-89
    • Metry, D.1    Frieden, I.J.2    Hess, C.3
  • 38
    • 84887624690 scopus 로고    scopus 로고
    • Treatment of infantile hemangiomas with sirolimus in a patient with PHACE syndrome
    • S. Kaylani, A.J. Theos, and J.G. Pressey Treatment of infantile hemangiomas with sirolimus in a patient with PHACE syndrome Pediatr Dermatol 30 2013 e194 e197
    • (2013) Pediatr Dermatol , vol.30 , pp. e194-e197
    • Kaylani, S.1    Theos, A.J.2    Pressey, J.G.3
  • 40
    • 33344458887 scopus 로고    scopus 로고
    • TIE2 gain-of-function mutation in a patient with pancreatic lymphangioma associated with blue rubber-bleb nevus syndrome: report of a case
    • Y. Nobuhara, N. Onoda, and K. Fukai et al. TIE2 gain-of-function mutation in a patient with pancreatic lymphangioma associated with blue rubber-bleb nevus syndrome: report of a case Surg today 36 2006 283 286
    • (2006) Surg today , vol.36 , pp. 283-286
    • Nobuhara, Y.1    Onoda, N.2    Fukai, K.3
  • 41
    • 84859386796 scopus 로고    scopus 로고
    • Blue rubber bleb nevus syndrome: successful treatment with sirolimus
    • H. Yuksekkaya, O. Ozbek, M. Keser, and H. Toy Blue rubber bleb nevus syndrome: successful treatment with sirolimus Pediatrics 129 2012 e1080 e1084
    • (2012) Pediatrics , vol.129 , pp. e1080-e1084
    • Yuksekkaya, H.1    Ozbek, O.2    Keser, M.3    Toy, H.4
  • 42
    • 80052651179 scopus 로고    scopus 로고
    • Sirolimus for the treatment of complicated vascular anomalies in children
    • A.M. Hammill, M. Wentzel, and A. Gupta et al. Sirolimus for the treatment of complicated vascular anomalies in children Pediatr Blood Cancer 57 2011 1018 1024
    • (2011) Pediatr Blood Cancer , vol.57 , pp. 1018-1024
    • Hammill, A.M.1    Wentzel, M.2    Gupta, A.3
  • 43
    • 84870710500 scopus 로고    scopus 로고
    • Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival
    • T.D. Carr, J. DiGiovanni, C.J. Lynch, and L.M. Shantz Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival Cancer Prev Res 5 2012 1394 1404
    • (2012) Cancer Prev Res , vol.5 , pp. 1394-1404
    • Carr, T.D.1    DiGiovanni, J.2    Lynch, C.J.3    Shantz, L.M.4
  • 44
    • 79960103054 scopus 로고    scopus 로고
    • Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
    • L.A. Checkley, O. Rho, T. Moore, S. Hursting, and J. DiGiovanni Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate Cancer Prev Res 4 2011 1011 1020
    • (2011) Cancer Prev Res , vol.4 , pp. 1011-1020
    • Checkley, L.A.1    Rho, O.2    Moore, T.3    Hursting, S.4    DiGiovanni, J.5
  • 45
    • 77956839364 scopus 로고    scopus 로고
    • Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium
    • J.D. Hainsworth, J.R. Infante, and D.R. Spigel et al. Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium Cancer 116 2010 4122 4129
    • (2010) Cancer , vol.116 , pp. 4122-4129
    • Hainsworth, J.D.1    Infante, J.R.2    Spigel, D.R.3
  • 46
    • 77955730714 scopus 로고    scopus 로고
    • Cutaneous T-cell lymphoma cells are sensitive to rapamycin
    • M. Kremer, K. Sliva, C.D. Klemke, and B.S. Schnierle Cutaneous T-cell lymphoma cells are sensitive to rapamycin Exp Dermatol 19 2010 800 805
    • (2010) Exp Dermatol , vol.19 , pp. 800-805
    • Kremer, M.1    Sliva, K.2    Klemke, C.D.3    Schnierle, B.S.4
  • 47
    • 84869010521 scopus 로고    scopus 로고
    • Sirolimus for the treatment of Kaposi sarcoma after renal transplantation: a series of 10 cases
    • S. Yaich, K. Charfeddine, and S. Zaghdane et al. Sirolimus for the treatment of Kaposi sarcoma after renal transplantation: a series of 10 cases Transplant Proc 44 2012 2824 2826
    • (2012) Transplant Proc , vol.44 , pp. 2824-2826
    • Yaich, S.1    Charfeddine, K.2    Zaghdane, S.3
  • 48
    • 1642371460 scopus 로고    scopus 로고
    • Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma
    • J.M. Campistol, A. Gutierrez-Dalmau, and J.V. Torregrosa Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma Transplantation 77 2004 760 762
    • (2004) Transplantation , vol.77 , pp. 760-762
    • Campistol, J.M.1    Gutierrez-Dalmau, A.2    Torregrosa, J.V.3
  • 49
    • 20144367584 scopus 로고    scopus 로고
    • Sirolimus for Kaposi's sarcoma in renal-transplant recipients
    • G. Stallone, A. Schena, and B. Infante et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients N Engl J Med 352 2005 1317 1323
    • (2005) N Engl J Med , vol.352 , pp. 1317-1323
    • Stallone, G.1    Schena, A.2    Infante, B.3
  • 50
    • 79955632748 scopus 로고    scopus 로고
    • Consensus Conference on Clinical Practice in Chronic GVHD: second-line treatment of chronic graft-versus-host disease
    • D. Wolff, M. Schleuning, and S. von Harsdorf et al. Consensus Conference on Clinical Practice in Chronic GVHD: second-line treatment of chronic graft-versus-host disease Biol Blood Marrow Transplant 17 2011 1 17
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1-17
    • Wolff, D.1    Schleuning, M.2    Von Harsdorf, S.3
  • 51
    • 84874916319 scopus 로고    scopus 로고
    • Site-specific immunosuppression in vascularized composite allotransplantation: prospects and potential
    • J.T. Schnider, M. Weinstock, and J.A. Plock et al. Site-specific immunosuppression in vascularized composite allotransplantation: prospects and potential Clini Dev Immunol 2013 2013 495212
    • (2013) Clini Dev Immunol , vol.2013 , pp. 495212
    • Schnider, J.T.1    Weinstock, M.2    Plock, J.A.3
  • 52
    • 73249139173 scopus 로고    scopus 로고
    • Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study
    • T.I. Su, D. Khanna, and D.E. Furst et al. Rapamycin versus methotrexate in early diffuse systemic sclerosis: results from a randomized, single-blind pilot study Arthritis Rheum 60 2009 3821 3830
    • (2009) Arthritis Rheum , vol.60 , pp. 3821-3830
    • Su, T.I.1    Khanna, D.2    Furst, D.E.3
  • 54
    • 58149094346 scopus 로고    scopus 로고
    • Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 cases
    • A. Soria, S. Agbo-Godeau, A. Taieb, and C. Frances Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 cases Dermatology 218 2009 22 25
    • (2009) Dermatology , vol.218 , pp. 22-25
    • Soria, A.1    Agbo-Godeau, S.2    Taieb, A.3    Frances, C.4
  • 55
    • 84879365605 scopus 로고    scopus 로고
    • A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex
    • J.W. Wheless, and H. Almoazen A novel topical rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex J Child Neurol 28 2013 933 936
    • (2013) J Child Neurol , vol.28 , pp. 933-936
    • Wheless, J.W.1    Almoazen, H.2
  • 57
    • 84879935940 scopus 로고    scopus 로고
    • Familial multiple discoid fibromas: unique histological features and therapeutic response to topical rapamycin
    • J.S. Wee, H. Chong, J. Natkunarajah, P.S. Mortimer, and Y. Moosa Familial multiple discoid fibromas: unique histological features and therapeutic response to topical rapamycin Br J Dermatol 169 2013 177 180
    • (2013) Br J Dermatol , vol.169 , pp. 177-180
    • Wee, J.S.1    Chong, H.2    Natkunarajah, J.3    Mortimer, P.S.4    Moosa, Y.5
  • 58
    • 84872683506 scopus 로고    scopus 로고
    • Topical sirolimus for oral pemphigus vulgaris: 3 unresponsive cases
    • A.M. Poot, and M.F. Jonkman Topical sirolimus for oral pemphigus vulgaris: 3 unresponsive cases J Am Acad Dermatol 67 2012 e228 e229
    • (2012) J Am Acad Dermatol , vol.67 , pp. e228-e229
    • Poot, A.M.1    Jonkman, M.F.2
  • 59
    • 77954830298 scopus 로고    scopus 로고
    • Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis
    • A.K. Haemel, A.L. O'Brian, and J.M. Teng Topical rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis Arch Dermatol 146 2010 715 718
    • (2010) Arch Dermatol , vol.146 , pp. 715-718
    • Haemel, A.K.1    O'Brian, A.L.2    Teng, J.M.3
  • 60
    • 80053078020 scopus 로고    scopus 로고
    • Dramatic improvement of facial angiofibromas in tuberous sclerosis with topical rapamycin: optimizing a treatment protocol
    • C.M. DeKlotz, A.E. Ogram, S. Singh, S. Dronavalli, and J.L. MacGregor Dramatic improvement of facial angiofibromas in tuberous sclerosis with topical rapamycin: optimizing a treatment protocol Arch Dermatol 147 2011 1116 1117
    • (2011) Arch Dermatol , vol.147 , pp. 1116-1117
    • DeKlotz, C.M.1    Ogram, A.E.2    Singh, S.3    Dronavalli, S.4    MacGregor, J.L.5
  • 61
    • 80053550251 scopus 로고    scopus 로고
    • Treatment of facial angiofibromas with topical application of oral rapamycin solution (1mgmL(-1)) in two patients with tuberous sclerosis
    • M.M. Mutizwa, D.R. Berk, and M.J. Anadkat Treatment of facial angiofibromas with topical application of oral rapamycin solution (1mgmL(-1)) in two patients with tuberous sclerosis Br J Dermatol 165 2011 922 923
    • (2011) Br J Dermatol , vol.165 , pp. 922-923
    • Mutizwa, M.M.1    Berk, D.R.2    Anadkat, M.J.3
  • 62
    • 80053517662 scopus 로고    scopus 로고
    • A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity
    • M. Wataya-Kaneda, M. Tanaka, A. Nakamura, S. Matsumoto, and I. Katayama A topical combination of rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients with TSC of different disease severity Br J Dermatol 165 2011 912 916
    • (2011) Br J Dermatol , vol.165 , pp. 912-916
    • Wataya-Kaneda, M.1    Tanaka, M.2    Nakamura, A.3    Matsumoto, S.4    Katayama, I.5
  • 63
    • 84856014473 scopus 로고    scopus 로고
    • Successful treatment of angiofibromata of tuberous sclerosis complex with rapamycin
    • E. Kaufman McNamara, A.R. Curtis, and A.B. Fleischer Jr. Successful treatment of angiofibromata of tuberous sclerosis complex with rapamycin J Dermatolog Treat 23 2012 46 48
    • (2012) J Dermatolog Treat , vol.23 , pp. 46-48
    • Kaufman McNamara, E.1    Curtis, A.R.2    Fleischer, A.B.3
  • 64
    • 84865839005 scopus 로고    scopus 로고
    • Topical rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex: a double-blind, randomized, controlled trial to evaluate the safety and efficacy of topically applied rapamycin
    • M.K. Koenig, A.A. Hebert, and J. Roberson et al. Topical rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex: a double-blind, randomized, controlled trial to evaluate the safety and efficacy of topically applied rapamycin Drugs R D 12 2012 121 126
    • (2012) Drugs R D , vol.12 , pp. 121-126
    • Koenig, M.K.1    Hebert, A.A.2    Roberson, J.3
  • 65
    • 84866236400 scopus 로고    scopus 로고
    • Sustained clinical effectiveness and favorable safety profile of topical sirolimus for tuberous sclerosis-associated facial angiofibroma
    • R. Salido, G. Garnacho-Saucedo, and I. Cuevas-Asencio et al. Sustained clinical effectiveness and favorable safety profile of topical sirolimus for tuberous sclerosis-associated facial angiofibroma J Eur Acad Dermatol Venereol 26 2012 1315 1318
    • (2012) J Eur Acad Dermatol Venereol , vol.26 , pp. 1315-1318
    • Salido, R.1    Garnacho-Saucedo, G.2    Cuevas-Asencio, I.3
  • 66
    • 84856546231 scopus 로고    scopus 로고
    • Facial angiofibromas treated with topical rapamycin: an excellent choice with fast response
    • T. Truchuelo, B. Diaz-Ley, L. Rios, J. Alcantara, and P. Jaen Facial angiofibromas treated with topical rapamycin: an excellent choice with fast response Dermatol Online J 18 2012 15
    • (2012) Dermatol Online J , vol.18 , pp. 15
    • Truchuelo, T.1    Diaz-Ley, B.2    Rios, L.3    Alcantara, J.4    Jaen, P.5
  • 67
    • 84862939164 scopus 로고    scopus 로고
    • A novel application of topical rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex
    • M. Wataya-Kaneda, M. Tanaka, A. Nakamura, S. Matsumoto, and I. Katayama A novel application of topical rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex Arch Dermatol 148 2012 138 139
    • (2012) Arch Dermatol , vol.148 , pp. 138-139
    • Wataya-Kaneda, M.1    Tanaka, M.2    Nakamura, A.3    Matsumoto, S.4    Katayama, I.5
  • 68
    • 84889015080 scopus 로고    scopus 로고
    • First left-right comparative study of topical rapamycin vs vehicle for facial angiofibromas in patients with tuberous sclerosis complex
    • M. Tanaka, M. Wataya-Kaneda, A. Nakamura, S. Matsumoto, and I. Katayama First left-right comparative study of topical rapamycin vs vehicle for facial angiofibromas in patients with tuberous sclerosis complex Br J Dermatol 169 2013 1314 1318
    • (2013) Br J Dermatol , vol.169 , pp. 1314-1318
    • Tanaka, M.1    Wataya-Kaneda, M.2    Nakamura, A.3    Matsumoto, S.4    Katayama, I.5
  • 69
    • 84892834133 scopus 로고    scopus 로고
    • Topical rapamycin for angiofibromas in pediatric patients with tuberous sclerosis: follow up of a pilot study and promising future directions
    • J. Tu, R.S. Foster, L.J. Bint, and A.R. Halbert Topical rapamycin for angiofibromas in pediatric patients with tuberous sclerosis: follow up of a pilot study and promising future directions Australas J Dermatol 55 2014 63 69
    • (2014) Australas J Dermatol , vol.55 , pp. 63-69
    • Tu, J.1    Foster, R.S.2    Bint, L.J.3    Halbert, A.R.4
  • 70
    • 84864245430 scopus 로고    scopus 로고
    • Sirolimus and secondary skin-cancer prevention in kidney transplantation
    • S. Euvrard, E. Morelon, and L. Rostaing et al. Sirolimus and secondary skin-cancer prevention in kidney transplantation N Engl J Med 367 2012 329 339
    • (2012) N Engl J Med , vol.367 , pp. 329-339
    • Euvrard, S.1    Morelon, E.2    Rostaing, L.3
  • 71
    • 0034786155 scopus 로고    scopus 로고
    • Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial
    • S. Reitamo, P. Spuls, and B. Sassolas et al. Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial Br J Dermatol 145 2001 438 445
    • (2001) Br J Dermatol , vol.145 , pp. 438-445
    • Reitamo, S.1    Spuls, P.2    Sassolas, B.3
  • 72
    • 64049090204 scopus 로고    scopus 로고
    • The role of the Birt-Hogg-Dube protein in mTOR activation and renal tumorigenesis
    • T.R. Hartman, E. Nicolas, and A. Klein-Szanto et al. The role of the Birt-Hogg-Dube protein in mTOR activation and renal tumorigenesis Oncogene 28 2009 1594 1604
    • (2009) Oncogene , vol.28 , pp. 1594-1604
    • Hartman, T.R.1    Nicolas, E.2    Klein-Szanto, A.3
  • 73
    • 79954613636 scopus 로고    scopus 로고
    • The cutaneous effects of post-transplant immunosuppression with cyclosporine in Muir-Torre syndrome
    • E.A. Griffard, H.H. McCoppin, J. Wieberg, and M. Feldman The cutaneous effects of post-transplant immunosuppression with cyclosporine in Muir-Torre syndrome J Am Acad Dermatol 64 2011 e86 e87
    • (2011) J Am Acad Dermatol , vol.64 , pp. e86-e87
    • Griffard, E.A.1    McCoppin, H.H.2    Wieberg, J.3    Feldman, M.4
  • 75
    • 84865063149 scopus 로고    scopus 로고
    • Efficacy of rapamycin for refractory hemangioendotheliomas in Maffucci's syndrome
    • S. Riou, E. Morelon, L. Guibaud, F. Chotel, F. Dijoud, and P. Marec-Berard Efficacy of rapamycin for refractory hemangioendotheliomas in Maffucci's syndrome J Clin Oncol 30 2012 e213 e215
    • (2012) J Clin Oncol , vol.30 , pp. e213-e215
    • Riou, S.1    Morelon, E.2    Guibaud, L.3    Chotel, F.4    Dijoud, F.5    Marec-Berard, P.6
  • 76
    • 22944489580 scopus 로고    scopus 로고
    • Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis
    • W. Baumer, B. Sulzle, and H. Weigt et al. Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis Br J Dermatol 153 2005 136 144
    • (2005) Br J Dermatol , vol.153 , pp. 136-144
    • Baumer, W.1    Sulzle, B.2    Weigt, H.3
  • 77
    • 80051764465 scopus 로고    scopus 로고
    • Sirolimus for acute pemphigus vulgaris: a case report and discussion of dualistic action providing for both immunosuppression and keratinocyte protection
    • S.A. Grando, V.T. Laquer, and H.M. Le Sirolimus for acute pemphigus vulgaris: a case report and discussion of dualistic action providing for both immunosuppression and keratinocyte protection J Am Acad Dermatol 65 2011 684 686
    • (2011) J Am Acad Dermatol , vol.65 , pp. 684-686
    • Grando, S.A.1    Laquer, V.T.2    Le, H.M.3
  • 78
    • 84876667562 scopus 로고    scopus 로고
    • Potent dual inhibitors of TORC1 and TORC2 complexes (KU-0063794 and KU-0068650) demonstrate in vitro and ex vivo anti-keloid scar activity
    • F. Syed, H.J. Sanganee, A. Bahl, and A. Bayat Potent dual inhibitors of TORC1 and TORC2 complexes (KU-0063794 and KU-0068650) demonstrate in vitro and ex vivo anti-keloid scar activity J Invest Dermatol 133 2013 1340 1350
    • (2013) J Invest Dermatol , vol.133 , pp. 1340-1350
    • Syed, F.1    Sanganee, H.J.2    Bahl, A.3    Bayat, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.