Topical sirolimus for oral pemphigus vulgaris: 3 unresponsive cases

Journal of the American Academy of Dermatology

Volumn 67, Issue 5, 2012, Pages e228-e229

  Poot, Angelique M ^a   Jonkman, Marcel F ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; MOUTHWASH; RAPAMYCIN;

ADULT; DRUG EFFECT; FEMALE; HUMAN; LETTER; MIDDLE AGED; MOUTH DISEASE; MOUTH MUCOSA; PATHOLOGY; PEMPHIGUS; TOPICAL DRUG ADMINISTRATION; TREATMENT FAILURE;

ADMINISTRATION, TOPICAL; ADULT; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MIDDLE AGED; MOUTH DISEASES; MOUTH MUCOSA; MOUTHWASHES; PEMPHIGUS; SIROLIMUS; TREATMENT FAILURE;

EID: 84872683506     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2012.04.032     Document Type: Article

References (4)

1. Scully C, Paes De Almeida O, Porter SR, Gilkes JJ. Pemphigus vulgaris: The manifestations and long-term management of 55 patients with oral lesions. Br J Dermatol 1999;140:84-9
2. Soria A, Agbo-Godeau S, Taieb A, Frances C. Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 cases. Dermatology 2009;218:22-5
3. Pretel M, Espana A, Marquina M, Pelacho B, Lopez-Picazo JM, Lopez-Zabalza MJ. An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris. Exp Dermatol 2009;18:771-80
4. Grando SA, Laquer VT, Le HM. Sirolimus for acute pemphigus vulgaris: A case report and discussion of dualistic action providing for both immunosuppression and keratinocyte protection. J Am Acad Dermatol 2011;65:684-6.