Site-specific immunosuppression in vascularized composite allotransplantation: Prospects and potential

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Schnider, Jonas T ^a   Weinstock, Matthias ^a,b   Plock, Jan A ^a,c   Solari, Mario G ^a   Venkataramanan, Raman ^d   Zheng, Xin Xiao ^a,e   Gorantla, Vijay S ^a,f  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e TONGJI UNIVERSITY   (China)

^f Pittsburgh Reconstructive Transplantation Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CALCINEURIN INHIBITOR; CLOBETASOL; CLOBETASOL PROPIONATE; CYCLOSPORIN; ESTROGEN; EVEROLIMUS; FENTANYL; GLYCERYL TRINITRATE; INSULIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; NICOTINE; PIMECROLIMUS; RAPAMYCIN; STEROID; TACROLIMUS;

ACUTE GRAFT REJECTION; ALLOTRANSPLANTATION; ATOPIC DERMATITIS; DRUG EFFECT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; SEBORRHEIC DERMATITIS; SKIN BIOPSY; SKIN DISEASE; ANGIOGENESIS; ANIMAL; DRUG FORMULATION; GRAFT REJECTION; IMMUNOLOGY; METHODOLOGY; PLASTIC SURGERY; POSTOPERATIVE COMPLICATION; SKIN TRANSPLANTATION;

ANIMALS; DRUG COMPOUNDING; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; NEOVASCULARIZATION, PHYSIOLOGIC; POSTOPERATIVE COMPLICATIONS; RECONSTRUCTIVE SURGICAL PROCEDURES; SKIN TRANSPLANTATION; TACROLIMUS; TRANSPLANTATION, HOMOLOGOUS;

MLCS; MLOWN;

EID: 84874916319     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/495212     Document Type: Review

References (58)

1. Lee W. P. A., Yaremchuk M. J., Pan Y. C., Randolph M. A., Tan C. M., Weiland A. J., Relative antigenicity of components of a vascularized limb allograft. Plastic and Reconstructive Surgery 1991 87 3 401 411 2-s2.0-0025971311
2. Schneeberger S., Lucchina S., Lanzetta M., Brandacher G., Bösmüller C., Steurer W., Baldanti F., Dezza C., Margreiter R., Bonatti H., Cytomegalovirus-related complications in human hand transplantation. Transplantation 2005 80 4 441 447 2-s2.0-23944448047 10.1097/01.tp.0000168454. 68139.0a (Pubitemid 41209410)
3. Lanzetta M., Petruzzo P., Margreiter R., Dubernard J. M., Schuind F., Breidenbach W., Lucchina S., Schneeberger S., Van Holder C., Granger D., Pei G., Zhao J., Zhang X., The international registry on hand and composite tissue transplantation. Transplantation 2005 79 9 1210 1214 2-s2.0-20844457620 10.1097/01.TP.0000157118.28394.FA (Pubitemid 40664026)
4. Breidenbach W. C., Tobin G. R., Gorantla V. S., Gonzalez R. N., Granger D. K., A position statement in support of hand transplantation. Journal of Hand Surgery 2002 27 5 760 770 2-s2.0-0036739906 10.1053/jhsu.2002.35306
5. Gruber S. A., Shirbacheh M. V., Jones J. W., Barker J. H., Breidenbach W. C., Local drug delivery to composite tissue allografts. Microsurgery 2000 20 8 407 411 (Pubitemid 32044148)
6. Gorantla V. S., Brandacher G., Schneeberger S., Favoring the risk-benefit balance for upper extremity transplantation-the Pittsburgh Protocol. Hand Clinics 2011 27 4 511 520
7. Solari M. G., Washington K. M., Sacks J. M., Daily topical tacrolimus therapy prevents skin rejection in a rodent hind limb allograft model. Plastic and Reconstructive Surgery 2009 123 2, supplement 17S 25S 2-s2.0-61749088006 10.1097/PRS.0b013e318191bcbd
8. Black K. S., Nguyen D. K., Proctor C. M., Patel M. P., Hewitt C. W., Site-specific suppression of cell-mediated immunity by cyclosporine. Journal of Investigative Dermatology 1990 94 5 644 648 (Pubitemid 20141283)
9. Luger T., Paul C., Potential new indications of topical calcineurin inhibitors. Dermatology 2007 215 1 45 54 2-s2.0-37349125327 10.1159/000102119 (Pubitemid 350308379)
10. Ang-Tiu C. U., Meghrajani C. F., Maano C. C., Pimecrolimus 1% cream for the treatment of seborrheic dermatitis: a systematic review of randomized controlled trials. Expert Review of Clinical Pharmacology 2012 5 1 91 97
11. McCaughey C., Machan M., Bennett R., Zone J. J., Hull C. M., Pimecrolimus 1% cream for oral erosive lichen planus: a 6-week randomized, double-blind, vehicle-controlled study with a 6-week open-label extension to assess efficacy and safety. Journal of the European Academy of Dermatology and Venereology 2010 25 9 1061 1067
12. Lebwohl M., Freeman A. K., Chapman M. S., Feldman S. R., Hartle J. E., Henning A., Tacrolimus ointment is effective for facial and intertriginous psoriasis. Journal of the American Academy of Dermatology 2004 51 5 723 730 2-s2.0-8744240726 10.1016/j.jaad.2004.07.011 (Pubitemid 39516886)
13. Gorantla V. S., Barker J. H., Jones J. W., Prabhune K., Maldonado C., Granger D. K., Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies. Microsurgery 2000 20 8 420 429 (Pubitemid 32044150)
14. Truchuelo T., Díaz-Ley B., Ríos L., Alcántara J., Jaén P., Facial angiofibromas treated with topical rapamycin: an excellent choice with fast response. Dermatology Online Journal 2012 18 1 15
15. Ormerod A. D., Shah S. A. A., Copeland P., Omar G., Winfield A., Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial. British Journal of Dermatology 2005 152 4 758 764 2-s2.0-17644374126 10.1111/j.1365-2133.2005.06438.x (Pubitemid 40571311)
16. Soria A., Agbo-Godeau S., Taïeb A., Francès C., Treatment of refractory oral erosive lichen planus with topical rapamycin: 7 Cases. Dermatology 2008 218 1 22 25 2-s2.0-58149094346 10.1159/000172830
17. Allison A. C., Eugui E. M., Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunological Reviews 1993 136 5 28 2-s2.0-12044254339 (Pubitemid 24033096)
18. Bertelmann E., De Ruijter M., Gong N., Knapp S., Pleyer U., Survival of corneal allografts following topical treatment with the immunomodulator mycophenolate mofetil. Ophthalmologica 2009 224 1 38 41 2-s2.0-68349085668 10.1159/000233237
19. Shoji Y., Fukumura T., Kudo M., Yanagawa A., Shimada J., Mizushima Y., Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene. Journal of Pharmacy and Pharmacology 1994 46 8 643 646 2-s2.0-0028136980 (Pubitemid 24249351)
20. Prausnitz M. R., Langer R., Transdermal drug delivery. Nature Biotechnology 2008 26 11 1261 1268
21. Williams A. C., Barry B. W., Penetration enhancers. Advanced Drug Delivery Reviews 2004 56 5 603 618 (Pubitemid 38326936)
22. Kalia Y. N., Naik A., Garrison J., Guy R. H., Iontophoretic drug delivery. Advanced Drug Delivery Reviews 2004 56 5 619 658 2-s2.0-1542298892 10.1016/j.addr.2003.10.026 (Pubitemid 38326937)
23. Prausnitz M. R., Microneedles for transdermal drug delivery. Advanced Drug Delivery Reviews 2004 56 5 581 587 2-s2.0-1542358759 10.1016/j.addr.2003. 10.023 (Pubitemid 38326934)
24. Hautz T., Zelger B., Grahammer J., Krapf C., Amberger A., Brandacher G., Landin L., Müller H., Schön M. P., Cavadas P., Lee A. W. P., Pratschke J., Margreiter R., Schneeberger S., Molecular markers and targeted therapy of skin rejection in composite tissue allotransplantation. American Journal of Transplantation 2010 10 5 1200 1209 2-s2.0-77951227495 10.1111/j.1600-6143.2010. 03075.x
25. Schön M. P., Krahn T., Schön M., Rodriguez M. L., Antonicek H., Schultz J. E., Ludwig R. J., Zollner T. M., Bischoff E., Bremm K. D., Schramm M., Henninger K., Kaufmann R., Gollnick H. P. M., Parker C. M., Boehncke W. H., Efomycine M, a new specific inhibitor of selectin, impairs leukocyte adhesion and alleviates cutaneous inflammation. Nature Medicine 2002 8 4 366 372 2-s2.0-0036117531 10.1038/nm0402-366 (Pubitemid 34407031)
26. Gruber S. A., The case for local immunosuppression. Transplantation 1992 54 1 1 11
27. Gruber S. A., Hrushesky W. J. M., Cipolle R. J., Erdmann G. R., Burke B. A., Skjei K. L., Mueller R. P., Fryd D. S., Matas A. J., Simmons R. L., Canafax D. M., Local immunosuppression with reduced systemic toxicity in a canine renal allograft model. Transplantation 1989 48 6 936 943 2-s2.0-0024797959 (Pubitemid 20018344)
28. Gruber S. A., Cipolle R. J., Canafax D. M., Erdmann G. R., Burke B. A., Rabatin J. T., Hynes P. E., Ritz J. A., Gould F. H., Ascher N. L., Simmons R. L., Hrushesky W. J. M., An implantable pump for intrarenal infusion of immunosuppressants in a canine autotransplant model. Pharmaceutical Research 1988 5 12 781 785 2-s2.0-0024247542 (Pubitemid 19060808)
29. Ruers T. J. M., Buurman W. A., Smits J. F. M., Local treatment of renal allografts, a promising way to reduce the dosage of immunosuppressive drugs. Comparison of various ways of administering prednisolone. Transplantation 1986 41 2 156 161 2-s2.0-0022651506 (Pubitemid 16115304)
30. Yano K., Fukuda Y., Sumimoto R., Sumimoto K., Ito H., Dohi K., Suppression of liver allograft rejection by administration of 15-deoxyspergualin. Comparison of administration via the hepatic artery, portal vein, or systemic circulation. Transplant International 1994 7 3 149 156 2-s2.0-0028289211 (Pubitemid 24111673)
31. Stepkowski S. M., Goto S., Ito T., Reynolds K., Didlake R., Kim E. K., Kahan B. D., Prolongation of heterotopic heart allograft survival by local delivery of continuous low-dose cyclosporine therapy. Transplantation 1989 47 1 17 23 2-s2.0-0024543566 (Pubitemid 19049136)
32. Wang X., Alfrey E. J., Posselt A., Tafra L., Alak A. M., Dafoe D. C., Intraportal delivery of immunosuppression to intrahepatic islet allograft recipients. Transplant International 1995 8 4 268 272 2-s2.0-0029035025 10.1007/BF00346879
33. Iacono A. T., Keenan R. J., Duncan S. R., Smaldone G. C., Dauber J. H., Paradis I. L., Ohori N. P., Grgurich W. F., Burckart G. J., Zeevi A., Delgado E., O'riordan T. G., Zendarsky M. M., Yousem S. A., Griffith B. P., Aerosolized cyclosporine in lung recipients with refractory chronic rejection. American Journal of Respiratory and Critical Care Medicine 1996 153 4 1451 1455 2-s2.0-0029940870 (Pubitemid 26112616)
34. Iacono A. T., Smaldone G. C., Keenan R. J., Diot P., Dauber J. H., Zeevi A., Burckart G. J., Griffith B. P., Dose-related reversal of acute lung rejection by aerosolized cyclosporine. American Journal of Respiratory and Critical Care Medicine 1997 155 5 1690 1698 2-s2.0-0030955946 (Pubitemid 27216679)
35. Iacono A. T., Johnson B. A., Grgurich W. F., Youssef J. G., Corcoran T. E., Seiler D. A., Dauber J. H., Smaldone G. C., Zeevi A., Yousem S. A., Fung J. J., Burckart G. J., McCurry K. R., Griffith B. P., A randomized trial of inhaled cyclosporine in lung-transplant recipients. The New England Journal of Medicine 2006 354 2 141 150 2-s2.0-30444434900 10.1056/NEJMoa043204 (Pubitemid 43076711)
36. Deuse T., Blankenberg F., Haddad M., Reichenspurner H., Phillips N., Robbins R. C., Schrepfer S., Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation. American Journal of Respiratory Cell and Molecular Biology 2010 43 4 403 412 2-s2.0-77958140446 10.1165/rcmb.2009-0208OC
37. Furtado A., Perdigoto R., Oliveira F., Local immunosuppression in clinical small bowel transplantation (report of two cases). TPS 2000 32 6 1206 1208
38. Swann G., The skin is the body's largest organ. Journal of Visual Communication in Medicine 2010 33 4 148 149
39. Jensen J. M., Proksch E., The skin's barrier. Giornale Italiana di Dermatologia. Minerva Dermatologica 2009 144 6 689 700
40. Bos J. D., The skin as an organ of immunity. Clinical & Experimental Immunology 1997 107 3 5
41. Cendales L. C., Kirk A. D., Moresi J. M., Ruiz P., Kleiner D. E., Composite tissue allotransplantation: classification of clinical acute skin rejection. Transplantation 2006 81 3 418 422 2-s2.0-32844466214 10.1097/01.tp.0000185304.49987.d8 (Pubitemid 43255728)
42. Kanitakis J., Jullien D., Petruzzo P., Hakim N., Claudy A., Revillard J. P., Owen E., Dubernard J. M., Clinicopathologic features of graft rejection of the first human hand allograft. Transplantation 2003 76 4 688 693 2-s2.0-0041835978 10.1097/01.TP.0000079458.81970.9A (Pubitemid 37072004)
43. Mathes D. W., Randolph M. A., Solari M. G., Nazzal J. A., Nielsen G. P., Arn J. S., Sachs D. H., Lee W. P. A., Split tolerance to a composite tissue allograft in a swine model. Transplantation 2003 75 1 25 31 2-s2.0-0037439805 10.1097/00007890-200301150-00005 (Pubitemid 36139690)
44. Schneeberger S., Gorantla V. S., Hautz T., Pulikkottil B., Margreiter R., Lee W. P. A., Immunosuppression and rejection in human hand transplantation. Transplantation Proceedings 2009 41 2 472 475 2-s2.0-62849103131 10.1016/j.transproceed.2009.01.019
45. Siemionow M., Ozturk C., Face transplantation. Journal of Craniofacial Surgery 2012 23 1 254 259
46. Ravindra K. V., Buell J. F., Kaufman C. L., Blair B., Marvin M., Nagubandi R., Breidenbach W. C., Hand transplantation in the United States: experience with 3 patients. Surgery 2008 144 4 638 644 2-s2.0-51449083858 10.1016/j.surg.2008.06.025
47. Morelon E., Kanitakis J., Petruzzo P., Immunological issues in clinical composite tissue allo. Transplantation, Transplantation 2012 93 9 855 859
48. Siemionow M., Ozturk C., An update on facial transplantation cases performed between 2005 and 2010. Plastic and Reconstructive Surgery 2011 128 6 707e 720e
49. Reitamo S., Rissanen J., Remitz A., Granlund H., Erkko P., Elg P., Autio P., Lauerma A. I., Tacrolimus ointment does not affect collagen synthesis: results of a single-center randomized trial. Journal of Investigative Dermatology 1998 111 3 396 398 2-s2.0-0031657805 10.1046/j.1523-1747.1998.00323. x (Pubitemid 28400083)
50. Banchereau J., Steinman R. M., Dendritic cells and the control of immunity. Nature 1998 392 6673 245 252 2-s2.0-0032546352 10.1038/32588 (Pubitemid 28155090)
51. Wollenberg A., Sharma S., Von Bubnoff D., Geiger E., Haberstok J., Bieber T., Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. Journal of Allergy and Clinical Immunology 2001 107 3 519 525 2-s2.0-0035093545 10.1067/mai.2001.112942 (Pubitemid 32210034)
52. Panhans-Groß A., Novak N., Kraft S., Bieber T., Human epidermal Langerhans' cells are targets for the immunosuppressive macrolide tacrolimus (FK506). Journal of Allergy and Clinical Immunology 2001 107 2 345 352 2-s2.0-0035116403 10.1067/mai.2001.112600 (Pubitemid 32173914)
53. Hoetzenecker W., Ecker R., Kopp T., Stuetz A., Stingl G., Elbe-Bürger A., Pimecrolimus leads to an apoptosis-induced depletion of T cells but not Langerhans cells in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology 2005 115 6 1276 1283 2-s2.0-20444457467 10.1016/j.jaci.2005.02.011 (Pubitemid 40824602)
54. Caproni M., Torchia D., Schincaglia E., Volpi W., Frezzolini A., Schena D., Marzano A., Quaglino P., De Simone C., Parodi A., Barletta E., Fabbri P., Expression of cytokines and chemokine receptors in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis. British Journal of Dermatology 2006 155 4 722 728 2-s2.0-33748451121 10.1111/j.1365-2133.2006.07398.x (Pubitemid 44352552)
55. Shirbacheh M. V., Ren X., Jones J. W., Breidenbach W. C., Jevans A. W., Fernandez-Botran G. R., Maldonado C., Barker J. H., Gruber S. A., Pharmacokinetic advantage of intra-arterial cyclosporin A delivery to vascularly isolated rabbit forelimb. I. Model development. Journal of Pharmacology and Experimental Therapeutics 1999 289 3 1185 1190 2-s2.0-0033022760 (Pubitemid 29246642)
56. Shirbacheh M. V., Harralson T. A., Jones J. W., Breidenbach W. C., Jevans A. W., Maldonado C., Barker J. H., Gruber S. A., Pharmacokinetic advantage of intra-arterial cyclosporin A delivery to vascularly isolated rabbit forelimb. II. Dose dependence. Journal of Pharmacology and Experimental Therapeutics 1999 289 3 1191 1195 2-s2.0-0033065381 (Pubitemid 29246643)
57. Shirbacheh M. V., Jones J. W., Harralson T. A., Edelstein J., Tecimer T., Breidenbach W. C., Jevans A. W., Maldonado C., Barker J. H., Gruber S. A., Pharmacokinetics of intra-arterial delivery of tacrolimus to vascularly isolated rabbit forelimb. Journal of Pharmacology and Experimental Therapeutics 1999 289 3 1196 1201 2-s2.0-0032994133 (Pubitemid 29246644)
58. Shirbacheh M. V., Jones J. W., Breidenbach W. C., McCabe S., Barker J. H., Gruber S. A., The case for local immunosuppression in composite tissue allotransplantation. Transplantation Proceedings 1998 30 6 2739 2742 2-s2.0-0031706442 10.1016/S0041-1345(98)00800-8 (Pubitemid 28459812)