Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 16, 2015, Pages 5129-5134

  Mandel Brehm, Caleigh ^a   Salogiannis, John ^a   Dhamne, Sameer C ^a   Rotenberg, Alexander ^a   Greenberg, Michael E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Angelman syndrome; ARC; EEG; EPHEXIN5; Ultrasonic vocalizations

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; AMPA RECEPTOR; ACTIVITY REGULATED CYTOSKELETAL-ASSOCIATED PROTEIN; CYTOSKELETON PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; NERVE PROTEIN; UBE3A PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ACOUSTIC STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; EEG ABNORMALITY; ELECTROENCEPHALOGRAM; GENOTYPE; GROOMING; HAPPY PUPPET SYNDROME; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; OPEN FIELD BEHAVIOR; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE SUSCEPTIBILITY; SEPARATION-INDUCED ULTRASONIC VOCALIZATION TEST; TONIC CLONIC SEIZURE; VOCALIZATION; WALKING; ACTION POTENTIAL; AGING; ALLELE; ANIMAL; ANIMAL BEHAVIOR; AUDITORY STIMULATION; BRAIN CORTEX; C57BL MOUSE; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; GENETICS; HETEROZYGOTE; INHERITANCE; METABOLISM; MOTOR ACTIVITY; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; SEIZURE; TIME; ULTRASOUND;

MUS;

ACOUSTIC STIMULATION; ACTION POTENTIALS; AGING; ALLELES; ANGELMAN SYNDROME; ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; CEREBRAL CORTEX; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HETEROZYGOTE; INHERITANCE PATTERNS; MICE, INBRED C57BL; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; PHENOTYPE; RNA, MESSENGER; SEIZURES; TIME FACTORS; UBIQUITIN-PROTEIN LIGASES; ULTRASONICS; VOCALIZATION, ANIMAL;

EID: 84928242152     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504809112     Document Type: Article

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