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Volumn 39, Issue , 2015, Pages 20-25

Targeting extrinsic apoptosis in cancer: Challenges and opportunities

Author keywords

Apoptosis; Cancer; Caspase 8; TRAIL

Indexed keywords

CASPASE 8; DEATH RECEPTOR; FLICE INHIBITORY PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

EID: 84928212128     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2015.01.006     Document Type: Review
Times cited : (95)

References (87)
  • 1
    • 38349194472 scopus 로고    scopus 로고
    • Cell death in health and disease
    • Lockshin R.A., Zakeri Z. Cell death in health and disease. J Cell Mol Med 2007, 11:1214-1224.
    • (2007) J Cell Mol Med , vol.11 , pp. 1214-1224
    • Lockshin, R.A.1    Zakeri, Z.2
  • 2
    • 84255210700 scopus 로고    scopus 로고
    • Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
    • Galluzzi L., Vitale I., Abrams J.M., Alnemri E.S., Baehrecke E.H., Blagosklonny M.V., et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012, 19:107-120.
    • (2012) Cell Death Differ , vol.19 , pp. 107-120
    • Galluzzi, L.1    Vitale, I.2    Abrams, J.M.3    Alnemri, E.S.4    Baehrecke, E.H.5    Blagosklonny, M.V.6
  • 3
    • 58149296552 scopus 로고    scopus 로고
    • Tumor resistance to apoptosis
    • Fulda S. Tumor resistance to apoptosis. Int J Cancer 2009, 124:511-515.
    • (2009) Int J Cancer , vol.124 , pp. 511-515
    • Fulda, S.1
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda S., Debatin K.M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006, 25:4798-4811.
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 6
    • 44749085513 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis pathway in cancer
    • Ashkenazi A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev 2008, 19:325-331.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 325-331
    • Ashkenazi, A.1
  • 8
    • 34247345833 scopus 로고    scopus 로고
    • The apoptosome: signalling platform of cell death
    • Riedl S.J., Salvesen G.S. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 2007, 8:405-413.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 405-413
    • Riedl, S.J.1    Salvesen, G.S.2
  • 9
    • 84856495152 scopus 로고    scopus 로고
    • Targeting IAP proteins for therapeutic intervention in cancer
    • Fulda S., Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 2012, 11:109-124.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 109-124
    • Fulda, S.1    Vucic, D.2
  • 10
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: controlled demolition at the cellular level
    • Taylor R.C., Cullen S.P., Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008, 9:231-241.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 231-241
    • Taylor, R.C.1    Cullen, S.P.2    Martin, S.J.3
  • 11
    • 84872248771 scopus 로고    scopus 로고
    • Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer
    • Fulda S. Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer. Expert Opin Ther Targets 2013, 17:195-201.
    • (2013) Expert Opin Ther Targets , vol.17 , pp. 195-201
    • Fulda, S.1
  • 12
    • 84880316942 scopus 로고    scopus 로고
    • The dark side of TRAIL signaling
    • Fulda S. The dark side of TRAIL signaling. Cell Death Differ 2013, 20:845-846.
    • (2013) Cell Death Differ , vol.20 , pp. 845-846
    • Fulda, S.1
  • 13
    • 79955620753 scopus 로고    scopus 로고
    • High TRAIL-R3 expression on leukemic blasts is associated with poor outcome and induces apoptosis-resistance which can be overcome by targeting TRAIL-R2
    • Chamuleau M.E., Ossenkoppele G.J., van Rhenen A., van Dreunen L., Jirka S.M., Zevenbergen A., et al. High TRAIL-R3 expression on leukemic blasts is associated with poor outcome and induces apoptosis-resistance which can be overcome by targeting TRAIL-R2. Leuk Res 2011, 35:741-749.
    • (2011) Leuk Res , vol.35 , pp. 741-749
    • Chamuleau, M.E.1    Ossenkoppele, G.J.2    van Rhenen, A.3    van Dreunen, L.4    Jirka, S.M.5    Zevenbergen, A.6
  • 14
    • 79956318603 scopus 로고    scopus 로고
    • TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT
    • Lalaoui N., Morle A., Merino D., Jacquemin G., Iessi E., Morizot A., et al. TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT. PLoS ONE 2011, 6:e19679.
    • (2011) PLoS ONE , vol.6 , pp. e19679
    • Lalaoui, N.1    Morle, A.2    Merino, D.3    Jacquemin, G.4    Iessi, E.5    Morizot, A.6
  • 15
    • 0034136792 scopus 로고    scopus 로고
    • The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis
    • Meng R.D., McDonald E.R., Sheikh M.S., Fornace A.J., El-Deiry W.S. The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol Ther 2000, 1:130-144.
    • (2000) Mol Ther , vol.1 , pp. 130-144
    • Meng, R.D.1    McDonald, E.R.2    Sheikh, M.S.3    Fornace, A.J.4    El-Deiry, W.S.5
  • 16
    • 33749164762 scopus 로고    scopus 로고
    • Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2
    • Merino D., Lalaoui N., Morizot A., Schneider P., Solary E., Micheau O. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol 2006, 26:7046-7055.
    • (2006) Mol Cell Biol , vol.26 , pp. 7046-7055
    • Merino, D.1    Lalaoui, N.2    Morizot, A.3    Schneider, P.4    Solary, E.5    Micheau, O.6
  • 17
    • 3543035176 scopus 로고    scopus 로고
    • Rare loss-of-function mutation of a death receptor gene in head and neck cancer
    • Pai S.I., Wu G.S., Ozoren N., Wu L., Jen J., Sidransky D., et al. Rare loss-of-function mutation of a death receptor gene in head and neck cancer. Cancer Res 1998, 58:3513-3518.
    • (1998) Cancer Res , vol.58 , pp. 3513-3518
    • Pai, S.I.1    Wu, G.S.2    Ozoren, N.3    Wu, L.4    Jen, J.5    Sidransky, D.6
  • 18
    • 1642460584 scopus 로고    scopus 로고
    • Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines
    • Dechant M.J., Fellenberg J., Scheuerpflug C.G., Ewerbeck V., Debatin K.M. Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines. Int J Cancer 2004, 109:661-667.
    • (2004) Int J Cancer , vol.109 , pp. 661-667
    • Dechant, M.J.1    Fellenberg, J.2    Scheuerpflug, C.G.3    Ewerbeck, V.4    Debatin, K.M.5
  • 19
    • 4143115887 scopus 로고    scopus 로고
    • Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis
    • Jin Z., McDonald E.R., Dicker D.T., El-Deiry W.S. Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J Biol Chem 2004, 279:35829-35839.
    • (2004) J Biol Chem , vol.279 , pp. 35829-35839
    • Jin, Z.1    McDonald, E.R.2    Dicker, D.T.3    El-Deiry, W.S.4
  • 20
    • 69949106920 scopus 로고    scopus 로고
    • Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas
    • Elias A., Siegelin M.D., Steinmuller A., von Deimling A., Lass U., Korn B., et al. Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas. Clin Cancer Res 2009, 15:5457-5465.
    • (2009) Clin Cancer Res , vol.15 , pp. 5457-5465
    • Elias, A.1    Siegelin, M.D.2    Steinmuller, A.3    von Deimling, A.4    Lass, U.5    Korn, B.6
  • 21
    • 21344474349 scopus 로고    scopus 로고
    • Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer
    • Horak P., Pils D., Haller G., Pribill I., Roessler M., Tomek S., et al. Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer. Mol Cancer Res 2005, 3:335-343.
    • (2005) Mol Cancer Res , vol.3 , pp. 335-343
    • Horak, P.1    Pils, D.2    Haller, G.3    Pribill, I.4    Roessler, M.5    Tomek, S.6
  • 22
    • 50549105199 scopus 로고    scopus 로고
    • HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase 1 and PK study
    • Chow L.Q., Eckhardt S.G., Gustafson D.L., O'Bryant C., Hariharan S., Diab S., et al. HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase 1 and PK study. J Clin Oncol 2006, 24:2515.
    • (2006) J Clin Oncol , vol.24 , pp. 2515
    • Chow, L.Q.1    Eckhardt, S.G.2    Gustafson, D.L.3    O'Bryant, C.4    Hariharan, S.5    Diab, S.6
  • 24
    • 34248187996 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • Tolcher A.W., Mita M., Meropol N.J., von Mehren M., Patnaik A., Padavic K., et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J Clin Oncol 2007, 25:1390-1395.
    • (2007) J Clin Oncol , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3    von Mehren, M.4    Patnaik, A.5    Padavic, K.6
  • 25
    • 33847167668 scopus 로고    scopus 로고
    • A phase I safety and pharmacokinetic (PK) study of recombinant Apo2L/TRAIL, an apoptosis-inducing protein in patients with advanced cancer
    • Herbst R.S., Mendolson D.S., Ebbinghaus S., Gordon M.S., O'Dwyer P., Lieberman G., et al. A phase I safety and pharmacokinetic (PK) study of recombinant Apo2L/TRAIL, an apoptosis-inducing protein in patients with advanced cancer. J Clin Oncol 2006, 24:3013.
    • (2006) J Clin Oncol , vol.24 , pp. 3013
    • Herbst, R.S.1    Mendolson, D.S.2    Ebbinghaus, S.3    Gordon, M.S.4    O'Dwyer, P.5    Lieberman, G.6
  • 26
    • 84890475775 scopus 로고    scopus 로고
    • APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcgamma receptors
    • Gieffers C., Kluge M., Merz C., Sykora J., Thiemann M., Schaal R., et al. APG350 induces superior clustering of TRAIL receptors and shows therapeutic antitumor efficacy independent of cross-linking via Fcgamma receptors. Mol Cancer Ther 2013, 12:2735-2747.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2735-2747
    • Gieffers, C.1    Kluge, M.2    Merz, C.3    Sykora, J.4    Thiemann, M.5    Schaal, R.6
  • 27
    • 0037468930 scopus 로고    scopus 로고
    • Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells
    • Lacour S., Micheau O., Hammann A., Drouineaud V., Tschopp J., Solary E., et al. Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Oncogene 2003, 22:1807-1816.
    • (2003) Oncogene , vol.22 , pp. 1807-1816
    • Lacour, S.1    Micheau, O.2    Hammann, A.3    Drouineaud, V.4    Tschopp, J.5    Solary, E.6
  • 29
    • 0034652486 scopus 로고    scopus 로고
    • Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo
    • Nagane M., Pan G., Weddle J.J., Dixit V.M., Cavenee W.K., Huang H.J. Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo. Cancer Res 2000, 60:847-853.
    • (2000) Cancer Res , vol.60 , pp. 847-853
    • Nagane, M.1    Pan, G.2    Weddle, J.J.3    Dixit, V.M.4    Cavenee, W.K.5    Huang, H.J.6
  • 30
    • 0032522463 scopus 로고    scopus 로고
    • P53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha
    • Sheikh M.S., Burns T.F., Huang Y., Wu G.S., Amundson S., Brooks K.S., et al. P53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha. Cancer Res 1998, 58:1593-1598.
    • (1998) Cancer Res , vol.58 , pp. 1593-1598
    • Sheikh, M.S.1    Burns, T.F.2    Huang, Y.3    Wu, G.S.4    Amundson, S.5    Brooks, K.S.6
  • 31
    • 0033566163 scopus 로고    scopus 로고
    • The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
    • Sheikh M.S., Huang Y., Fernandez-Salas E.A., El-Deiry W.S., Friess H., Amundson S., et al. The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene 1999, 18:4153-4159.
    • (1999) Oncogene , vol.18 , pp. 4153-4159
    • Sheikh, M.S.1    Huang, Y.2    Fernandez-Salas, E.A.3    El-Deiry, W.S.4    Friess, H.5    Amundson, S.6
  • 32
    • 0141705424 scopus 로고    scopus 로고
    • Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo
    • Singh T.R., Shankar S., Chen X., Asim M., Srivastava R.K. Synergistic interactions of chemotherapeutic drugs and tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand on apoptosis and on regression of breast carcinoma in vivo. Cancer Res 2003, 63:5390-5400.
    • (2003) Cancer Res , vol.63 , pp. 5390-5400
    • Singh, T.R.1    Shankar, S.2    Chen, X.3    Asim, M.4    Srivastava, R.K.5
  • 33
    • 0345598868 scopus 로고    scopus 로고
    • Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy
    • Wang S., El-Deiry W.S. Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. Proc Natl Acad Sci U S A 2003, 100:15095-15100.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15095-15100
    • Wang, S.1    El-Deiry, W.S.2
  • 34
    • 34250332128 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells
    • Liu X., Yue P., Chen S., Hu L., Lonial S., Khuri F.R., et al. The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells. Cancer Res 2007, 67:4981-4988.
    • (2007) Cancer Res , vol.67 , pp. 4981-4988
    • Liu, X.1    Yue, P.2    Chen, S.3    Hu, L.4    Lonial, S.5    Khuri, F.R.6
  • 35
    • 33750865641 scopus 로고    scopus 로고
    • Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria
    • Nagy K., Szekely-Szuts K., Izeradjene K., Douglas L., Tillman M., Barti-Juhasz H., et al. Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria. Pathol Oncol Res 2006, 12:133-142.
    • (2006) Pathol Oncol Res , vol.12 , pp. 133-142
    • Nagy, K.1    Szekely-Szuts, K.2    Izeradjene, K.3    Douglas, L.4    Tillman, M.5    Barti-Juhasz, H.6
  • 36
    • 79955992274 scopus 로고    scopus 로고
    • Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway
    • Naumann I., Kappler R., von Schweinitz D., Debatin K.M., Fulda S. Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway. Clin Cancer Res 2011, 17:3204-3218.
    • (2011) Clin Cancer Res , vol.17 , pp. 3204-3218
    • Naumann, I.1    Kappler, R.2    von Schweinitz, D.3    Debatin, K.M.4    Fulda, S.5
  • 37
    • 15944387964 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
    • Nikrad M., Johnson T., Puthalalath H., Coultas L., Adams J., Kraft A.S. The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol Cancer Ther 2005, 4:443-449.
    • (2005) Mol Cancer Ther , vol.4 , pp. 443-449
    • Nikrad, M.1    Johnson, T.2    Puthalalath, H.3    Coultas, L.4    Adams, J.5    Kraft, A.S.6
  • 38
    • 0035849785 scopus 로고    scopus 로고
    • CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release
    • Rohn T.A., Wagenknecht B., Roth W., Naumann U., Gulbins E., Krammer P.H., et al. CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release. Oncogene 2001, 20:4128-4137.
    • (2001) Oncogene , vol.20 , pp. 4128-4137
    • Rohn, T.A.1    Wagenknecht, B.2    Roth, W.3    Naumann, U.4    Gulbins, E.5    Krammer, P.H.6
  • 39
    • 0038240386 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP
    • Sayers T.J., Brooks A.D., Koh C.Y., Ma W., Seki N., Raziuddin A., et al. The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP. Blood 2003, 102:303-310.
    • (2003) Blood , vol.102 , pp. 303-310
    • Sayers, T.J.1    Brooks, A.D.2    Koh, C.Y.3    Ma, W.4    Seki, N.5    Raziuddin, A.6
  • 40
    • 44049107707 scopus 로고    scopus 로고
    • Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody
    • Shanker A., Brooks A.D., Tristan C.A., Wine J.W., Elliott P.J., Yagita H., et al. Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. J Natl Cancer Inst 2008, 100:649-662.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 649-662
    • Shanker, A.1    Brooks, A.D.2    Tristan, C.A.3    Wine, J.W.4    Elliott, P.J.5    Yagita, H.6
  • 41
    • 79959255983 scopus 로고    scopus 로고
    • Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis
    • Unterkircher T., Cristofanon S., Vellanki S.H., Nonnenmacher L., Karpel-Massler G., Wirtz C.R., et al. Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis. Clin Cancer Res 2011, 17:4019-4030.
    • (2011) Clin Cancer Res , vol.17 , pp. 4019-4030
    • Unterkircher, T.1    Cristofanon, S.2    Vellanki, S.H.3    Nonnenmacher, L.4    Karpel-Massler, G.5    Wirtz, C.R.6
  • 42
    • 33748887599 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio
    • Muhlethaler-Mottet A., Flahaut M., Bourloud K.B., Auderset K., Meier R., Joseph J.M., et al. Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. BMC Cancer 2006, 6:214.
    • (2006) BMC Cancer , vol.6 , pp. 214
    • Muhlethaler-Mottet, A.1    Flahaut, M.2    Bourloud, K.B.3    Auderset, K.4    Meier, R.5    Joseph, J.M.6
  • 43
    • 4344666663 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
    • Nakata S., Yoshida T., Horinaka M., Shiraishi T., Wakada M., Sakai T. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 2004, 23:6261-6271.
    • (2004) Oncogene , vol.23 , pp. 6261-6271
    • Nakata, S.1    Yoshida, T.2    Horinaka, M.3    Shiraishi, T.4    Wakada, M.5    Sakai, T.6
  • 44
    • 0346725822 scopus 로고    scopus 로고
    • Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation
    • Neuzil J., Swettenham E., Gellert N. Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation. Biochem Biophys Res Commun 2004, 314:186-191.
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 186-191
    • Neuzil, J.1    Swettenham, E.2    Gellert, N.3
  • 45
    • 33645239495 scopus 로고    scopus 로고
    • HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL
    • Pathil A., Armeanu S., Venturelli S., Mascagni P., Weiss T.S., Gregor M., et al. HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL. Hepatology 2006, 43:425-434.
    • (2006) Hepatology , vol.43 , pp. 425-434
    • Pathil, A.1    Armeanu, S.2    Venturelli, S.3    Mascagni, P.4    Weiss, T.S.5    Gregor, M.6
  • 46
    • 33845810433 scopus 로고    scopus 로고
    • Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade
    • Reddy R.M., Yeow W.S., Chua A., Nguyen D.M., Baras A., Ziauddin M.F., et al. Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. Apoptosis 2007, 12:55-71.
    • (2007) Apoptosis , vol.12 , pp. 55-71
    • Reddy, R.M.1    Yeow, W.S.2    Chua, A.3    Nguyen, D.M.4    Baras, A.5    Ziauddin, M.F.6
  • 47
    • 33644876853 scopus 로고    scopus 로고
    • Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy
    • Schuchmann M., Schulze-Bergkamen H., Fleischer B., Schattenberg J.M., Siebler J., Weinmann A., et al. Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. Oncol Rep 2006, 15:227-230.
    • (2006) Oncol Rep , vol.15 , pp. 227-230
    • Schuchmann, M.1    Schulze-Bergkamen, H.2    Fleischer, B.3    Schattenberg, J.M.4    Siebler, J.5    Weinmann, A.6
  • 48
    • 78651097203 scopus 로고    scopus 로고
    • Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
    • Haag C., Stadel D., Zhou S., Bachem M.G., Moller P., Debatin K.M., et al. Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. Gut 2011, 60:225-237.
    • (2011) Gut , vol.60 , pp. 225-237
    • Haag, C.1    Stadel, D.2    Zhou, S.3    Bachem, M.G.4    Moller, P.5    Debatin, K.M.6
  • 49
    • 79960922705 scopus 로고    scopus 로고
    • CIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    • Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011, 43:449-463.
    • (2011) Mol Cell , vol.43 , pp. 449-463
    • Feoktistova, M.1    Geserick, P.2    Kellert, B.3    Dimitrova, D.P.4    Langlais, C.5    Hupe, M.6
  • 51
    • 79952810024 scopus 로고    scopus 로고
    • Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
    • Oberst A., Dillon C.P., Weinlich R., McCormick L.L., Fitzgerald P., Pop C., et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011, 471:363-367.
    • (2011) Nature , vol.471 , pp. 363-367
    • Oberst, A.1    Dillon, C.P.2    Weinlich, R.3    McCormick, L.L.4    Fitzgerald, P.5    Pop, C.6
  • 52
    • 0034660874 scopus 로고    scopus 로고
    • Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression
    • Fulda S., Meyer E., Debatin K.M. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res 2000, 60:3947-3956.
    • (2000) Cancer Res , vol.60 , pp. 3947-3956
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 53
    • 26444560914 scopus 로고    scopus 로고
    • MTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells
    • Panner A., James C.D., Berger M.S., Pieper R.O. mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Mol Cell Biol 2005, 25:8809-8823.
    • (2005) Mol Cell Biol , vol.25 , pp. 8809-8823
    • Panner, A.1    James, C.D.2    Berger, M.S.3    Pieper, R.O.4
  • 54
  • 55
    • 84869087920 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
    • Bangert A., Cristofanon S., Eckhardt I., Abhari B.A., Kolodziej S., Hacker S., et al. Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. Oncogene 2012, 31:4677-4688.
    • (2012) Oncogene , vol.31 , pp. 4677-4688
    • Bangert, A.1    Cristofanon, S.2    Eckhardt, I.3    Abhari, B.A.4    Kolodziej, S.5    Hacker, S.6
  • 56
    • 84862266657 scopus 로고    scopus 로고
    • Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL
    • Yerbes R., Lopez-Rivas A. Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL. Invest New Drugs 2012, 30:541-547.
    • (2012) Invest New Drugs , vol.30 , pp. 541-547
    • Yerbes, R.1    Lopez-Rivas, A.2
  • 57
    • 84863717308 scopus 로고    scopus 로고
    • Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis
    • Kerr E., Holohan C., McLaughlin K.M., Majkut J., Dolan S., Redmond K., et al. Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis. Cell Death Differ 2012, 19:1317-1327.
    • (2012) Cell Death Differ , vol.19 , pp. 1317-1327
    • Kerr, E.1    Holohan, C.2    McLaughlin, K.M.3    Majkut, J.4    Dolan, S.5    Redmond, K.6
  • 58
    • 33847169497 scopus 로고    scopus 로고
    • PPARgamma ligands enhance TRAIL-induced apoptosis through DR5 upregulation and c-FLIP downregulation in human lung cancer cells
    • Zou W., Liu X., Yue P., Khuri F.R., Sun S.Y. PPARgamma ligands enhance TRAIL-induced apoptosis through DR5 upregulation and c-FLIP downregulation in human lung cancer cells. Cancer Biol Ther 2007, 6:99-106.
    • (2007) Cancer Biol Ther , vol.6 , pp. 99-106
    • Zou, W.1    Liu, X.2    Yue, P.3    Khuri, F.R.4    Sun, S.Y.5
  • 59
    • 39949085436 scopus 로고    scopus 로고
    • Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
    • Kim Y.H., Jung E.M., Lee T.J., Kim S.H., Choi Y.H., Park J.W., et al. Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med 2008, 44:1055-1068.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1055-1068
    • Kim, Y.H.1    Jung, E.M.2    Lee, T.J.3    Kim, S.H.4    Choi, Y.H.5    Park, J.W.6
  • 60
    • 0034672278 scopus 로고    scopus 로고
    • Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression
    • Kinoshita H., Yoshikawa H., Shiiki K., Hamada Y., Nakajima Y., Tasaka K. Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression. Int J Cancer 2000, 88:986-991.
    • (2000) Int J Cancer , vol.88 , pp. 986-991
    • Kinoshita, H.1    Yoshikawa, H.2    Shiiki, K.3    Hamada, Y.4    Nakajima, Y.5    Tasaka, K.6
  • 61
    • 49649110459 scopus 로고    scopus 로고
    • Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells
    • Abedini M.R., Muller E.J., Brun J., Bergeron R., Gray D.A., Tsang B.K. Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells. Cancer Res 2008, 68:4511-4517.
    • (2008) Cancer Res , vol.68 , pp. 4511-4517
    • Abedini, M.R.1    Muller, E.J.2    Brun, J.3    Bergeron, R.4    Gray, D.A.5    Tsang, B.K.6
  • 62
    • 67349160732 scopus 로고    scopus 로고
    • Caspase-8 in cancer biology and therapy
    • Fulda S. Caspase-8 in cancer biology and therapy. Cancer Lett 2009, 281:128-133.
    • (2009) Cancer Lett , vol.281 , pp. 128-133
    • Fulda, S.1
  • 64
    • 0030800823 scopus 로고    scopus 로고
    • A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma
    • Mandruzzato S., Brasseur F., Andry G., Boon T., Van der Bruggen P. A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J Exp Med 1997, 186:785-793.
    • (1997) J Exp Med , vol.186 , pp. 785-793
    • Mandruzzato, S.1    Brasseur, F.2    Andry, G.3    Boon, T.4    Van der Bruggen, P.5
  • 65
    • 13444309090 scopus 로고    scopus 로고
    • CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas
    • Soung Y.H., Lee J.W., Kim S.Y., Jang J., Park Y.G., Park W.S., et al. CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Res 2005, 65:815-821.
    • (2005) Cancer Res , vol.65 , pp. 815-821
    • Soung, Y.H.1    Lee, J.W.2    Kim, S.Y.3    Jang, J.4    Park, Y.G.5    Park, W.S.6
  • 66
    • 0034066405 scopus 로고    scopus 로고
    • Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
    • Teitz T., Wei T., Valentine M.B., Vanin E.F., Grenet J., Valentine V.A., et al. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 2000, 6:529-535.
    • (2000) Nat Med , vol.6 , pp. 529-535
    • Teitz, T.1    Wei, T.2    Valentine, M.B.3    Vanin, E.F.4    Grenet, J.5    Valentine, V.A.6
  • 67
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • Fulda S., Kufer M.U., Meyer E., van Valen F., Dockhorn-Dworniczak B., Debatin K.M. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001, 20:5865-5877.
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.M.6
  • 68
    • 0034662625 scopus 로고    scopus 로고
    • Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • Hopkins-Donaldson S., Bodmer J.L., Bourloud K.B., Brognara C.B., Tschopp J., Gross N. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2000, 60:4315-4319.
    • (2000) Cancer Res , vol.60 , pp. 4315-4319
    • Hopkins-Donaldson, S.1    Bodmer, J.L.2    Bourloud, K.B.3    Brognara, C.B.4    Tschopp, J.5    Gross, N.6
  • 69
    • 0034699330 scopus 로고    scopus 로고
    • Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression
    • Grotzer M.A., Eggert A., Zuzak T.J., Janss A.J., Marwaha S., Wiewrodt B.R., et al. Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression. Oncogene 2000, 19:4604-4610.
    • (2000) Oncogene , vol.19 , pp. 4604-4610
    • Grotzer, M.A.1    Eggert, A.2    Zuzak, T.J.3    Janss, A.J.4    Marwaha, S.5    Wiewrodt, B.R.6
  • 70
    • 0035866396 scopus 로고    scopus 로고
    • Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression
    • Eggert A., Grotzer M.A., Zuzak T.J., Wiewrodt B.R., Ho R., Ikegaki N., et al. Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res 2001, 61:1314-1319.
    • (2001) Cancer Res , vol.61 , pp. 1314-1319
    • Eggert, A.1    Grotzer, M.A.2    Zuzak, T.J.3    Wiewrodt, B.R.4    Ho, R.5    Ikegaki, N.6
  • 72
    • 31444450128 scopus 로고    scopus 로고
    • Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma
    • Miller M.A., Karacay B., Zhu X., O'Dorisio M.S., Sandler A.D. Caspase 8L, a novel inhibitory isoform of caspase 8, is associated with undifferentiated neuroblastoma. Apoptosis 2006, 11:15-24.
    • (2006) Apoptosis , vol.11 , pp. 15-24
    • Miller, M.A.1    Karacay, B.2    Zhu, X.3    O'Dorisio, M.S.4    Sandler, A.D.5
  • 73
    • 20144389573 scopus 로고    scopus 로고
    • Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis
    • Mohr A., Zwacka R.M., Jarmy G., Buneker C., Schrezenmeier H., Dohner K., et al. Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis. Oncogene 2005, 24:2421-2429.
    • (2005) Oncogene , vol.24 , pp. 2421-2429
    • Mohr, A.1    Zwacka, R.M.2    Jarmy, G.3    Buneker, C.4    Schrezenmeier, H.5    Dohner, K.6
  • 74
    • 33646542701 scopus 로고    scopus 로고
    • Src kinase phosphorylates caspase-8 on Tyr380: a novel mechanism of apoptosis suppression
    • Cursi S., Rufini A., Stagni V., Condo I., Matafora V., Bachi A., et al. Src kinase phosphorylates caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. EMBO J 2006, 25:1895-1905.
    • (2006) EMBO J , vol.25 , pp. 1895-1905
    • Cursi, S.1    Rufini, A.2    Stagni, V.3    Condo, I.4    Matafora, V.5    Bachi, A.6
  • 75
    • 33947153003 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood
    • Furchert S.E., Lanvers-Kaminsky C., Juurgens H., Jung M., Loidl A., Fruhwald M.C. Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. Int J Cancer 2007, 120:1787-1794.
    • (2007) Int J Cancer , vol.120 , pp. 1787-1794
    • Furchert, S.E.1    Lanvers-Kaminsky, C.2    Juurgens, H.3    Jung, M.4    Loidl, A.5    Fruhwald, M.C.6
  • 76
    • 80053161379 scopus 로고    scopus 로고
    • Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL
    • Kaminskyy V.O., Surova O.V., Vaculova A., Zhivotovsky B. Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Carcinogenesis 2011, 32:1450-1458.
    • (2011) Carcinogenesis , vol.32 , pp. 1450-1458
    • Kaminskyy, V.O.1    Surova, O.V.2    Vaculova, A.3    Zhivotovsky, B.4
  • 77
    • 0037373901 scopus 로고    scopus 로고
    • Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB
    • Yang X., Merchant M.S., Romero M.E., Tsokos M., Wexler L.H., Kontny U., et al. Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB. Cancer Res 2003, 63:1122-1129.
    • (2003) Cancer Res , vol.63 , pp. 1122-1129
    • Yang, X.1    Merchant, M.S.2    Romero, M.E.3    Tsokos, M.4    Wexler, L.H.5    Kontny, U.6
  • 78
    • 1642514756 scopus 로고    scopus 로고
    • Expression of the caspase-8 gene in neuroblastoma cells is regulated through an essential interferon-sensitive response element (ISRE)
    • Casciano I., De Ambrosis A., Croce M., Pagnan G., Di Vinci A., Allemanni G., et al. Expression of the caspase-8 gene in neuroblastoma cells is regulated through an essential interferon-sensitive response element (ISRE). Cell Death Differ 2004, 11:131-134.
    • (2004) Cell Death Differ , vol.11 , pp. 131-134
    • Casciano, I.1    De Ambrosis, A.2    Croce, M.3    Pagnan, G.4    Di Vinci, A.5    Allemanni, G.6
  • 79
    • 2442538123 scopus 로고    scopus 로고
    • The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1
    • Ruiz-Ruiz C., Ruiz de Almodovar C., Rodriguez A., Ortiz-Ferron G., Redondo J.M., Lopez-Rivas A. The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1. J Biol Chem 2004, 279:19712-19720.
    • (2004) J Biol Chem , vol.279 , pp. 19712-19720
    • Ruiz-Ruiz, C.1    Ruiz de Almodovar, C.2    Rodriguez, A.3    Ortiz-Ferron, G.4    Redondo, J.M.5    Lopez-Rivas, A.6
  • 80
    • 84889271499 scopus 로고    scopus 로고
    • IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway
    • Fulda S., Debatin K.M. IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway. Oncogene 2002, 21:2295-2308.
    • (2002) Oncogene , vol.21 , pp. 2295-2308
    • Fulda, S.1    Debatin, K.M.2
  • 81
    • 33749349821 scopus 로고    scopus 로고
    • Evaluation of IFN-gamma effects on apoptosis and gene expression in neuroblastoma - preclinical studies
    • Tekautz T.M., Zhu K., Grenet J., Kaushal D., Kidd V.J., Lahti J.M. Evaluation of IFN-gamma effects on apoptosis and gene expression in neuroblastoma - preclinical studies. Biochim Biophys Acta 2006, 1763:1000-1010.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 1000-1010
    • Tekautz, T.M.1    Zhu, K.2    Grenet, J.3    Kaushal, D.4    Kidd, V.J.5    Lahti, J.M.6
  • 82
    • 34547801703 scopus 로고    scopus 로고
    • Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy
    • Meister N., Shalaby T., von Bueren A.O., Rivera P., Patti R., Oehler C., et al. Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy. Eur J Cancer 2007, 43:1833-1841.
    • (2007) Eur J Cancer , vol.43 , pp. 1833-1841
    • Meister, N.1    Shalaby, T.2    von Bueren, A.O.3    Rivera, P.4    Patti, R.5    Oehler, C.6
  • 83
    • 34447295403 scopus 로고    scopus 로고
    • Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity
    • Lissat A., Vraetz T., Tsokos M., Klein R., Braun M., Koutelia N., et al. Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity. Am J Pathol 2007, 170:1917-1930.
    • (2007) Am J Pathol , vol.170 , pp. 1917-1930
    • Lissat, A.1    Vraetz, T.2    Tsokos, M.3    Klein, R.4    Braun, M.5    Koutelia, N.6
  • 84
    • 8544224305 scopus 로고    scopus 로고
    • Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma
    • Merchant M.S., Yang X., Melchionda F., Romero M., Klein R., Thiele C.J., et al. Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma. Cancer Res 2004, 64:8349-8356.
    • (2004) Cancer Res , vol.64 , pp. 8349-8356
    • Merchant, M.S.1    Yang, X.2    Melchionda, F.3    Romero, M.4    Klein, R.5    Thiele, C.J.6
  • 85
    • 0034667357 scopus 로고    scopus 로고
    • Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program
    • Ruiz-Ruiz C., Munoz-Pinedo C., Lopez-Rivas A. Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program. Cancer Res 2000, 60:5673-5680.
    • (2000) Cancer Res , vol.60 , pp. 5673-5680
    • Ruiz-Ruiz, C.1    Munoz-Pinedo, C.2    Lopez-Rivas, A.3
  • 86
    • 69849094949 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8
    • Hacker S., Dittrich A., Mohr A., Schweitzer T., Rutkowski S., Krauss J., et al. Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8. Oncogene 2009, 28:3097-3110.
    • (2009) Oncogene , vol.28 , pp. 3097-3110
    • Hacker, S.1    Dittrich, A.2    Mohr, A.3    Schweitzer, T.4    Rutkowski, S.5    Krauss, J.6
  • 87
    • 43749104015 scopus 로고    scopus 로고
    • Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells
    • Jiang M., Zhu K., Grenet J., Lahti J.M. Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells. Biochim Biophys Acta 2008, 1783:1055-1067.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 1055-1067
    • Jiang, M.1    Zhu, K.2    Grenet, J.3    Lahti, J.M.4


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