Polychlorinated dibenzo-p-dioxins and dibenzofurans formed from sucralose at high temperatures

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Dong, Shujun ^a   Liu, Guorui ^a   Hu, Jicheng ^a   Zheng, Minghui ^a  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84928166085     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02946     Document Type: Article

References (27)

1. Knight, I. The development and applications of sucralose, a new high-intensity sweetener. Can. J. Physiol. Pharm. 72, 435-439 (1994).
2. Grotz, V. L. & Munro, I. C. An overview of the safety of sucralose. Regul. Toxicol. Pharm. 55, 1-5 (2009).
3. Torres, C. I. et al. Fate of sucralose during wastewater treatment. Environ. Eng. Sci. 28, 325-331 (2011).
4. Tollefsen, K. E., Nizzetto, L. & Huggett, D. B. Presence, fate and effects of the intense sweetener sucralose in the aquatic environment. Sci. Total Environ. 438, 510-516 (2012).
5. Barndt, R. L. & Jackson, G. Stability of Sucralose in Baked Goods. Food Technol. 44, 62-66 (1990).
6. Chapello, W. The use of sucralose in baked goods and mixes. Cereal Food World 43, 716-717 (1998).
7. Brown, R. J., Walter, M. & Rother, K. I. Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion. Diabetes Care 32, 2184-2186 (2009).
8. Brown, R. J., Walter, M. & Rother, K. I. Effects of diet soda on gut hormones in youths with diabetes. Diabetes Care 35, 959-964 (2012).
9. Pepino, M. Y., and Tiemann, C. D., Patterson, B. W., Wice, B. M. & Klein, S. Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care April 30, DOI: 10.2337/dc12-2221 (2013).
10. Abou-Donia, M. B., El-Masry, E. M., Abdel-Rahman, A. A., McLendon, R. E. & Schiffman, S. S. Splenda alters gut microflora and increases intestinal P-glycoprotein and cytochrome P-450 in male rats. J. Toxicol. Environ. Heal. A 71, 1415-1429 (2008).
11. US FDA (United States Food and Drug Administration). Food additives permitted for direct addition to food for human consumption; sucralose. 21CFR Part 172 [Docket No. 87F-0086]. Federal Register Vol. 63 (No. 64) April 3, 16417-16433 (1998).
12. Sasaki, Y. F. et al. The comet assay with 8 mouse organs: results with 39 currently used food additives. Mutat. Res. 519, 103-119 (2002).
13. Schiffman, S. S. Rationale for further medical and health research on high-potency sweeteners. Chem. Senses 37, 671-679 (2012).
14. Bannach, G., and Almeida, R. R., Lacerda, L., Schnitzler, E. & Ionashiro, M. Thermal stability and thermal decomposition of sucralose. Eclética Química 34, 21-26 (2009).
15. Rahn, A. & Yaylayan, V. A. Thermal degradation of sucralose and its potential in generating chloropropanols in the presence of glycerol. Food Chem. 118, 56-61 (2010).
16. Dong, S., Wu, J., Liu, G., Zhang, B. & Zheng, M. Unintentionally produced dioxin-like polychlorinated biphenyls during cooking. Food Cont. 22, 1797-1802 (2011).
17. Wu, J., Dong, S., Liu, G., Zhang, B. & Zheng, M. Cooking process: Anew source of unintentionally produced dioxins? J. Agric. Food Chem. 59, 5444-5449 (2011).
18. Dong, S., Liu, G., Zhang, B., Gao, L. & Zheng, M. Formation of polychlorinated naphthalenes during the heating of cooking oil in the presence of high amounts of sucralose. Food Cont. 31, 1-5 (2013).
19. Altarawneh, M., and Dlugogorski, B. Z., Kennedy, E. M. & Mackie, J. C. Mechanisms for formation, chlorination, dechlorination and destruction of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). Prog. Energ. Combust. 35, 245-274 (2009).
20. Hisham, M. W. M. & Benson, S. W. Thermochemistry of the Deacon process. J. Phys. Chem. 99, 6194-6198 (1995).
21. Gullett, B. K., and Bruce, K. R., Beach, L. O. & Drago, A. M. Mechanistic steps in the production of PCDD and PCDF during waste combustion. Chemosphere 25, 1387-1392 (1992).
22. Gullett, B., Sarofim, A., Smith, K. & Procaccini, C. The role of chlorine in dioxin formation. Process Saf. Environ. 78, 47-52 (2000).
23. Iino, F., Imagawa, T., Takeuchi, M. & Sadakata, M. De novo synthesis mechanism of polychlorinated dibenzofurans from polycyclic aromatic hydrocarbons and the characteristic isomers of polychlorinated naphthalenes. Environ. Sci. Technol. 33, 1038-1043 (1999).
24. Everaert, K. & Baeyens, J. The formation and emission of dioxins in large scale thermal processes. Chemosphere 46, 439-448 (2002).
25. Sommeling, P. M., Mulder, P. & Louw, R. Formation of PCDFs during chlorination and oxidation ofchlorobenzene in chlorine/oxygen mixtures around 340uC. Chemosphere 29, 2015-2018 (1994).
26. Weber, R. et al. Formation of PCDF, PCDD, PCB, and PCN in de novo synthesis from PAH: Mechanistic aspects and correlation to fluidized bed incinerators. Chemosphere 44, 1429-1438 (2001).
27. Wen, S. et al. Elevated levels of urinary 8-hydroxy-2'-deoxyguanosine in male electrical and electronic equipment dismantling workers exposed to high concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans, polybrominated diphenyl ethers, and polychlorinated biphenyls. Environ. Sci. Technol. 42, 4202-4207 (2008).