Protective effects of low-intensity pulsed ultrasound on aluminum-induced cerebral damage in Alzheimer's disease rat model

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Lin, Wei Ting ^a   Chen, Ran Chou ^a,c   Lu, Wen Wei ^a   Liu, Shing Hwa ^b   Yang, Feng Yi ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; ALUMINUM; AMYLOID BETA PROTEIN; NERVE GROWTH FACTOR;

ALZHEIMER DISEASE; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; BRAIN CORTEX; DISEASE MODEL; DRUG EFFECTS; ENZYME ACTIVATION; GENE EXPRESSION; GENETICS; MALE; MEMORY; METABOLISM; PATHOLOGY; PERMEABILITY; RADIATION RESPONSE; RAT; ULTRASOUND;

ACETYLCHOLINESTERASE; ALUMINUM; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE EXPRESSION; MALE; MEMORY; NERVE GROWTH FACTORS; PERMEABILITY; RATS; ULTRASONIC WAVES;

EID: 84928142821     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09671     Document Type: Article

References (45)

1. Campbell, A. The potential role of aluminium in Alzheimer's disease. Nephrol Dial Transplant 17 Suppl 2, 17-20 (2002).
2. Yokel, R. A. & McNamara, P. J. Aluminium toxicokinetics: an updated minireview. Pharmacol Toxicol 88, 159-67 (2001).
3. Kawahara, M. Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases. J Alzheimers Dis 8, 171-82; discussion 209-15 (2005).
4. Bharathi. et al. Molecular toxicity of aluminium in relation to neurodegeneration. Indian J Med Res 128, 545-56 (2008).
5. Bharathi. et al. A new insight on Al-maltolate-treated aged rabbit as Alzheimer's animal model. Brain Res Rev 52, 275-92 (2006).
6. Ricchelli, F., Drago, D., Filippi, B., Tognon, G. & Zatta, P. Aluminum-triggered structural modifications and aggregation of beta-amyloids. Cell Mol Life Sci 62, 1724-33 (2005).
7. Drago, D. et al. Comparative effects of Abeta(1-42)-Al complex from rat and human amyloid on rat endothelial cell cultures. J Alzheimers Dis 11, 33-44 (2007).
8. Kumar, A., Dogra, S. & Prakash, A. Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behav Brain Res 205, 384-90 (2009).
9. Prakash, A. & Kumar, A. Effect of N-acetyl cysteine against aluminium-induced cognitive dysfunction and oxidative damage in rats. Basic Clin Pharmacol Toxicol 105, 98-104 (2009).
10. Carter, M. D., Simms, G. A. & Weaver, D. F. The development of new therapeutics for Alzheimer's disease. Clin Pharmacol Ther 88, 475-86 (2010).
11. Raschetti, R., Albanese, E., Vanacore, N. & Maggini, M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med 4, e338 (2007).
12. Stahl, S. M. The new cholinesterase inhibitors for Alzheimer's disease, Part 2: illustrating their mechanisms of action. J Clin Psychiatry 61, 813-4 (2000).
13. Wilcock, D. M. & Colton, C. A. Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. J Alzheimers Dis 15, 555-69 (2008).
14. Opar, A. Mixed results for disease-modification strategies for Alzheimer's disease. Nat Rev Drug Discov 7, 717-8 (2008).
15. Connor, B. et al. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res 49, 71-81 (1997).
16. Lee, J. et al. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol 194, 91-6 (2005).
17. Howells, D. W. et al. Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra. Exp Neurol 166, 127-35 (2000).
18. Simmons, D. A. et al. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A 106, 4906-11 (2009).
19. Greenberg, D. A. & Jin, K. From angiogenesis to neuropathology. Nature 438, 954-9 (2005).
20. Zuccato, C. & Cattaneo, E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5, 311-22 (2009).
21. Lin, L. F., Doherty, D. H., Lile, J. D., Bektesh, S. & Collins, F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-2 (1993).
22. Pardridge, W. M. Blood-brain barrier delivery. Drug Discov Today 12, 54-61 (2007).
23. Yang, F. Y., Lin, Y. S., Kang, K. H. & Chao, T. K. Reversible blood-brain barrier disruption by repeated transcranial focused ultrasound allows enhanced extravasation. J Control Release 150, 111-6 (2011).
24. Yang, F. Y. et al. Micro-SPECT/CT-based pharmacokinetic analysis of 99mTc-diethylenetriaminepentaacetic acid in rats with blood-brain barrier disruption induced by focused ultrasound. J Nucl Med 52, 478-84 (2011).
25. Yang, F. Y. et al. Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound. PLoS One 7, e45468 (2012).
26. Jordao, J. F. et al. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. PLoS One 5, e10549 (2010).
27. Baseri, B. et al. Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubbles. Phys Med Biol 57, N65-81 (2012).
28. Huang, Q. et al. Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Exp Neurol 233, 350-6 (2012).
29. Koyama, R. & Ikegaya, Y. To BDNF or not to BDNF: that is the epileptic hippocampus. Neuroscientist 11, 282-7 (2005).
30. Lang, A. E. et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol 59, 459-66 (2006).
31. Tufail, Y. et al. Transcranial pulsed ultrasound stimulates intact brain circuits. Neuron 66, 681-94 (2010).
32. Bekinschtein, P. et al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A 105, 2711-6 (2008).
33. Flaten, T. P. Aluminium as a risk factor in Alzheimer's disease, with emphasis on drinking water. Brain Res Bull 55, 187-96 (2001).
34. Martyn, C. N. The epidemiology of Alzheimer's disease in relation to aluminium. Ciba Found Symp 169, 69-79; discussion 79-86 (1992).
35. Wang, L. et al. Effects of Aluminium on beta-Amyloid (1-42) and Secretases (APP-Cleaving Enzymes) in Rat Brain. Neurochem Res 39, 1338-45 (2014).
36. Yang, F. Y. et al. Pharmacokinetic Analysis and Uptake of 18F-FBPA-Fr After Ultrasound-Induced Blood-Brain Barrier Disruption for Potential Enhancement of Boron Delivery for Neutron Capture Therapy. J Nucl Med 55, 616-21 (2014).
37. Yang, F. Y. et al. Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. J Control Release 160, 652-8 (2012).
38. Raymond, S. B. et al. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models. PLoS One 3, e2175 (2008).
39. Tyler, W. J. et al. Remote excitation of neuronal circuits using low-intensity, low-frequency ultrasound. PLoS One 3, e3511 (2008).
40. Bailey, T. L., Rivara, C. B., Rocher, A. B. & Hof, P. R. The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease. Neurol Res 26, 573-8 (2004).
41. Wu, Z. et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med 11, 959-65 (2005).
42. Yang, F. Y., Chang, W. Y., Chen, J. C., Lee, L. C. & Hung, Y. S. Quantitative assessment of cerebral glucose metabolic rates after blood-brain barrier disruption induced by focused ultrasound using FDG-MicroPET. Neuroimage 90, 93-8 (2014).
43. Zumkley, H., Bertram, H. P., Lison, A., Knoll, O. & Losse, H. Aluminum, zinc and copper concentrations in plasma in chronic renal insufficiency. Clin Nephrol 12, 18-21 (1979).
44. Morris, R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11, 47-60 (1984).
45. Sharma, A. C. & Kulkarni, S. K. Evaluation of learning and memory mechanisms employing elevated plus-maze in rats and mice. Prog Neuropsychopharmacol Biol Psychiatry 16, 117-25 (1992).