Autoinhibition of MDMX by intramolecular p53 mimicry

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 15, 2015, Pages 4624-4629

  Chen, Lihong ^a   Borcherds, Wade ^b   Wu, Shaofang ^a,c   Becker, Andreas ^a   Schonbrunn, Ernst ^a   Daughdrill, Gary W ^b   Chen, Jiandong ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Acidic domain; Intramolecular; MDMX; p53; Protease

Indexed keywords

PROTEIN MDMX; PROTEIN P53; TRYPTOPHAN; MDM4 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PEPTIDE; PROTEIN BINDING; PROTEIN MDM2;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; MOLECULAR MIMICRY; NUCLEAR IMPORT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEOLYTIC FRAGMENT RELEASE ASSAY; RELEASE ASSAY; RING FINGER MOTIF; TRANSACTIVATION; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN DEGRADATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CELL LINE, TUMOR; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84928138159     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1420833112     Document Type: Article

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